Patents Assigned to University of Virginia Patent Foundation
  • Patent number: 10382448
    Abstract: Methods and systems are described for detecting command injection attacks. A positive, taint inference method includes receiving signature fragments on one hand, converting command injection instructions into command fragments on another hand, thus identifying potential attacks upon the condition that a command injection instruction includes critical untrusted parts by using signature fragments. A system detects command injection attacks using this kind of method, and remediates and rejects potential attacks.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: August 13, 2019
    Assignee: University of Virginia Patent Foundation
    Inventors: Anh Nguyen-Tuong, Jack W. Davidson, Michele Co, Jason D. Hiser, John C. Knight
  • Patent number: 10378861
    Abstract: An impulse mitigation system configured to mitigate blast impulse directed to a surface (or structure or target). The system includes a substrate in communication with the surface (or structure or target), wherein the substrate is configured to receive an impulse directed to the surface (or structure or target) and then relocate from the surface (or structure or target) in response to received impulse.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: August 13, 2019
    Assignee: University of Virginia Patent Foundation
    Inventors: Haydn N. G. Wadley, Vikram Deshpande
  • Publication number: 20190240434
    Abstract: A device and method that reduces impingement upon fragile airway structures and improves the performance and safety associated with endotracheal devices and related intubation procedures. The endotracheal device includes a lumen such that one end of the lumen includes an anterior beak that includes a distal tip of the anterior beak and a posterior beak having a distal tip of the posterior beak.
    Type: Application
    Filed: July 13, 2017
    Publication date: August 8, 2019
    Applicant: University of Virginia Patent Foundation
    Inventor: Randal S. Blank
  • Patent number: 10369120
    Abstract: The present invention provides novel T type calcium channel inhibitors of formula (I), the use thereof in the treatment of a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, wherein R1 is C1-C4 alkyl, hydroxy, or C1-C4 alkoxy; Z is NH, NCH3, O, S, or CH2; Y is NH, O, or CH2 with the proviso that Y and Z are not the same; R2 is H, halo, NH2, C1-C4 alkyl, hydroxy, or C1-C4 alkoxy; m and n are independently selected from integers ranging from 1-5 with the proviso that m+n=an integer ranging from 2-9; and R3 is H, halo, NH2, C1-C4 alkyl, hydroxy, or C1-C4 alkoxy.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: August 6, 2019
    Assignee: University of Virginia Patent Foundation
    Inventors: Lloyd S. Gray, Timothy L. Macdonald, Doris M. Haverstick, Jaclyn R. Patterson, William F. McCalmont
  • Patent number: 10368834
    Abstract: An ultrasonic transducer element can configured to generate ultrasonic energy directed into tissue of a subject and configured to receive a portion of the ultrasonic energy reflected by a target located within the tissue. The ultrasonic transducer can include a surface configured to provide or receive the ultrasonic energy, the surface including an area of greater than or equal to about 4?2, or the ultrasonic transducer element can be included in an array having a spacing between at least two adjacent ultrasound elements of less than or equal to about ½?, and the array comprising an aperture that is at least approximately symmetrical in two axes. A three-dimensional representation of one or more of a location, shape, or orientation of at least a portion of the target can be presented via the display.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: August 6, 2019
    Assignee: University of Virginia Patent Foundation
    Inventors: F. William Mauldin, Jr., John A. Hossack, Kevin Owen
  • Patent number: 10363299
    Abstract: An analysis of human CD4+ T-cell epitopes of RV capsid proteins with cross-reactive potential was performed, peptide epitopes of RV-A16 capsid proteins VP1 and VP2 were identified, RV-specific CD4+ T cells were phenotyped for surface markers and cytokine profiles using flow cytometry, and it was found that, among non-infected subjects, circulating RV-A16-specific CD4+ T cells detected at the highest frequencies targeted 10 unique epitopes with diverse HLA-DR binding capacity. T-cell epitopes localized to conserved regions of significance to the virus and were enriched for HLA class I and II binding motifs and were activated in vivo after experimental infection with RV-A16. RV-A16 epitopes constituted species-specific and pan-species varieties, together providing ˜90% coverage of the US population. Cross-reactivity was evidenced for RV-A16 and RV-A39.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: July 30, 2019
    Assignees: UNIVERSITY OF VIRGINIA PATENT FOUNDATION, BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON
    Inventors: Judith Ann Woodfolk, Lyndsey M. Muehling, William W. Kwok, Duy Tran Mai
  • Patent number: 10358528
    Abstract: The invention provides for new viscoelastic silicone rubbers and compositions and methods for making and using them. The invention provides for viscoelastic silicone rubbers that are stiffer on short timescales than they are on long timescales. When subjected to brief stresses, they are relatively stiff and elastic, and they resist changing shapes. When subjected to sustain stresses, however, they are relatively soft and accommodating, and they gradually change shapes. When those stresses are removed, they gradually return to their original shapes. These viscoelastic silicone rubbers resist compression set and they are extremely resilient in response to sudden impacts. They can be dense rubbers, foam rubbers, and particles.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: July 23, 2019
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventor: Louis A. Bloomfield
  • Publication number: 20190219503
    Abstract: An apparatus related method for measuring a property of a target material. The system may include a pump device that generates a pump beam. A modulation device may receive the pump beam and generate a modulated pump beam by modulating an intensity amplitude of the pump beam, which may be directed to the target material. A probe device may generate a probe beam, which is directed to the target material. A part of the probe beam may be reflected off of the target material, and has similar frequency characteristic as the modulated pump beam. A detection device may detect the reflected probe beam and produce a signal. An analyzing device may receive the signal and calculate the target material property by comparing the modulated frequency characteristics of the signal to those of the pump beam. At least one of the pump and the probe beams may be infrared light.
    Type: Application
    Filed: May 12, 2017
    Publication date: July 18, 2019
    Applicant: University of Virginia Patent Foundation
    Inventors: Brian M. Foley, John T. Gaskins, Patrick E. Hopkins
  • Publication number: 20190218258
    Abstract: Compositions and methods for modifying the production levels of alkaloids in plants are provided. Alkaloid production can be genetically controlled by modulating the transcriptional activation of PMT genes mediated by members of the ERF family and/or Myc family of transcription factors. Novel nucleotide sequences encoding the Myc family of transcription factors are also provided.
    Type: Application
    Filed: March 29, 2019
    Publication date: July 18, 2019
    Applicant: University of Virginia Patent Foundation
    Inventors: Michael Paul Timko, Paul J Rushton, Sheng-Cheng Han, Hongbo Zhang, Marta Tatiana Bokowiec
  • Patent number: 10340972
    Abstract: An apparatus comprises a system on a chip (SoC). In some embodiments, the SoC includes a power supply circuit, a power management circuit operatively coupled to the power supply circuit, a first wireless communications circuit and a second wireless communications circuit. The first wireless communications circuit is configured to receive an RF signal and is operatively coupled to the power supply circuit and the power management circuit. The first wireless communications circuit has a net radio frequency (RF) power gain no more than unity before at least one of downconversion of the RF signal or detection of the RF signal. The second wireless communications circuit is operatively coupled to the power supply circuit and the power management circuit.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: July 2, 2019
    Assignees: University of Virginia Patent Foundation, The Regents of the University of Michigan
    Inventors: Benton H. Calhoun, Yousef Shakhsheer, Yanqing Zhang, Alicia Klinefelter, David D. Wentzloff, Nathan E. Roberts, Seunghyun Oh
  • Publication number: 20190199730
    Abstract: Methods and systems are described for detecting command injection attacks. A positive, taint inference method includes receiving signature fragments on one hand, converting command injection instructions into command fragments on another hand, thus identifying potential attacks upon the condition that a command injection instruction includes critical untrusted parts by using signature fragments. A system detects command injection attacks using this kind of method, and remediates and rejects potential attacks.
    Type: Application
    Filed: April 20, 2017
    Publication date: June 27, 2019
    Applicant: University of Virginia Patent Foundation
    Inventors: Anh Nguyen-Tuong, Jack W. Davidson, Michele Co, Jason D. Hiser, John C. Knight
  • Publication number: 20190192165
    Abstract: A temporary aortic occlusion device is disclosed, having an expandable locator portion and an expandable occlusion portion. The expandable locator portion assists a user in determining whether the distal end of the device has been advanced within a patient's aorta, and the occlusion portion is expanded to occlude the patient's aorta, preferably below the renal arteries.
    Type: Application
    Filed: February 28, 2019
    Publication date: June 27, 2019
    Applicants: MicroVention, Inc., University of Virginia Patent Foundation, United States of America As Represented By The Secretary Of The Navy
    Inventors: George R. Greene, JR., Ivan Sepetka, Cathy Lei, Rupal Nguyen, Matthew J. Bradley, Stephen T. Ahlers, Carl W. Goforth, James R. Stone
  • Publication number: 20190194345
    Abstract: The present disclosure provides anti-SAS1B antibodies, antigen-binding fragments thereof, and antibody-drug conjugates and methods of their use. This present disclosure also provides an isolated antibody or antigen-binding portion thereof having at least one of SB antibodies binding to surface exposed SAS1B, and 6B1 antibodies identifying at least one set of cancer patients testing positive for SAS1B expression.
    Type: Application
    Filed: October 5, 2016
    Publication date: June 27, 2019
    Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: John C. HERR, Eusebio PIRES, Ryan D'SOUZA, Arabinda MANDAL, Kiley ANDERSON-KNAPP
  • Patent number: 10332615
    Abstract: A method, system and computer readable medium for tracking changes in average glycemia in diabetes is based on a conceptually new approach to the retrieval of SMBG data. Using the understanding of HbA1c fluctuation as the measurable effect of the action of an underlying dynamical system, SMBG provides occasional glimpses at the state of this system and, using these measurements, the hidden underlying system trajectory can be reconstructed for individual diabetes patients. Using compartmental modeling a new two-step algorithm is provided that includes: (i) real-time estimate of HbA1c from fasting glucose readings, updated with any new incoming fasting SMBG data point(s), and (ii) initialization and calibration of the estimated HbA1c trace with daily SMBG profiles obtained periodically. The estimation of these profiles includes a factorial model capturing daily BG variability within two latent factors.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: June 25, 2019
    Assignee: University of Virginia Patent Foundation
    Inventors: Boris P. Kovatchev, Marc D. Breton
  • Patent number: 10314511
    Abstract: A method is provided for identifying a muscle abnormality. The method may include acquiring image data associated with a plurality of muscles in an area of interest of a living subject and generating a data model for the plurality of muscles based on the image data. The method further includes calculating the volume and/or length of one of the plurality of muscles based on the data model, and determining if the volume and/or length for the muscle, as calculated, deviates from volume and/or length associated with a healthy muscle. If it is determined that the volume and/or length for the muscle deviates from the volume and/or length associated with a healthy muscle, a muscle abnormality can be identified based on the deviation.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: June 11, 2019
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Craig Meyer, Silvia Blemker, Geoffrey Handsfield, Mark F. Abel
  • Patent number: 10314883
    Abstract: Both purinergic signaling through nucleotides such as ATP and noradrenergic signaling through molecules such as norepinephrine regulate vascular tone and blood pressure. Pannexin1 (Panx1), which forms large-pore, ATP-releasing channels, is present in vascular smooth muscle cells in peripheral blood vessels and participates in noradrenergic responses. Using pharmacological approaches and mice conditionally lacking Panx1 in smooth muscle cells, we found that Panx1 contributed to vasoconstriction mediated by the ?1 adrenoreceptor (?1AR), whereas vasoconstriction in response to serotonin or endothelin-1 was independent of Panx1. Analysis of the Panx1-deficient mice showed that Panx1 contributed to blood pressure regulation especially during the night cycle when sympathetic nervous activity is highest. Using mimetic peptides and site-directed mutagenesis, we identified a specific amino acid sequence in the Panx1 intracellular loop that is essential for activation by ?1AR signaling.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: June 11, 2019
    Assignee: University of Virginia Patent Foundation
    Inventors: Brant E. Isakson, Marie Billaud, Leon J. DeLalio, Thu Le
  • Publication number: 20190169582
    Abstract: Compositions and methods related to anucelate cells (e.g., bacterial minicells) for pesticide degradation applications including related cells, polypeptides, and vectors.
    Type: Application
    Filed: April 11, 2017
    Publication date: June 6, 2019
    Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: PAYAM POURTAHERI, SEPEHR ZOMORODI, ZACHERY GEORGE DAVIS, AMEER HAMZA SHAKEEL, JOSEPH FRANK, SHAUN RAFIE MOSHASHA, ANDREI KHOKHLACHEV, MARK KESTER
  • Patent number: 10310047
    Abstract: Some aspects of the present disclosure relate to systems and methods for free-breathing cine DENSE MRI using self-navigation. In one embodiment, a method includes acquiring magnetic resonance data for an area of interest of a subject, wherein the acquiring comprises performing sampling with phase-cycled, cine displacement encoding with stimulated echoes (DENSE) during free-breathing of the subject; identifying, from the acquired magnetic resonance data, a plurality of phase-cycling data pairs corresponding to matched respiratory phases of the free-breathing of the subject; reconstructing, from the plurality of phase-cycling data pairs, a plurality of intermediate self-navigation images; performing motion correction by estimating, from the plurality of intermediate self-navigation images, the respiratory position associated with the plurality of phase-cycling data pairs; and reconstructing a plurality of motion-corrected cine DENSE images of the area of interest of the subject.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: June 4, 2019
    Assignee: University of Virginia Patent Foundation
    Inventors: Xiaoying Cai, Frederick H. Epstein, Xiaodong Zhong
  • Patent number: 10308663
    Abstract: The invention provides protein tyrosine phosphatase inhibitor compounds, Their pharmaceutical compositions, uses, and methods of use, such as in the treatment of various cancers, and process for making the compounds. Also disclosed is an improved synthesis of protein tyrosine phosphatase inhibitor and precursor compound thienopyridone (5).
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: June 4, 2019
    Assignees: University of Virginia Patent Foundation, University of Pittsburgh —Of the Commonwealth System of Higher Education
    Inventors: John S. Lazo, Elizabeth R. Sharlow, Kelley E. McQueeney, Peter Wipf, Joseph M. Salamoun
  • Publication number: 20190159427
    Abstract: A feeding and weight resistance apparatus for an animal that includes a platform configured to move in response to lifting force exerted by the animal onto the platform; a food repository configured to store food; and a feeding interface. The feeding interface may be configured to: impair food to be dispensed in response to retrieval force exerted by the animal, and regulate food dispensed from the food repository for a predetermined duration in response to the lifting force exerted by the animal toward the platform. A method of feeding and applying weight resistance for an animal. A method of diagnosing or evaluating an animal using the feeding and weight lifting apparatus and method for the study and application in the field of biomedicine, including but not limited thereto, the field of exercise physiology.
    Type: Application
    Filed: September 19, 2016
    Publication date: May 30, 2019
    Applicant: University of Virginia Patent Foundation
    Inventor: Zhen Yan