Patents Assigned to University of Washington through its Center for Commercialization
  • Patent number: 10570451
    Abstract: Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: February 25, 2020
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Jesse Salk, Lawrence A. Loeb, Michael Schmitt
  • Publication number: 20200054811
    Abstract: Apparatus and method for photo-chemical oxidation are disclosed herein. In one embodiment, a method for regenerating a dialysis fluid includes: flowing the dialysis fluid between an anode and a cathode of a dialysis system, where the anode comprises a plurality of nanostructures; illuminating the anode with a source of light; flowing oxygen through the cathode toward the dialysis fluid; and converting urea in the dialysis fluid into CO2, N2 and H2O thereby regenerating the dialysis fluid.
    Type: Application
    Filed: August 8, 2019
    Publication date: February 20, 2020
    Applicant: University of Washington Through its Center for Commercialization
    Inventors: Bruce Hinds, Guozheng Shao
  • Publication number: 20200054810
    Abstract: Apparatus and method for photo-chemical oxidation are disclosed herein. In one embodiment, a dialysis fluid regeneration system includes: a nanostructured anode; a source of light configured to illuminate the anode; and a cathode that is oxygen permeable.
    Type: Application
    Filed: August 8, 2019
    Publication date: February 20, 2020
    Applicant: University of Washington Through its Center for Commercialization
    Inventors: Bruce Hinds, Guozheng Shao
  • Patent number: 10563179
    Abstract: The present invention provides compositions of CD180 targeting molecules coupled to heterologous antigens, and their use in treating and/or limiting disease.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: February 18, 2020
    Assignee: University of Washington Through Its Center for Commercialization
    Inventors: Edward Clark, Jay Wesley Chaplin
  • Patent number: 10542209
    Abstract: Methods and systems for acquiring and/or projecting images from and/or to a target area are provided. Such a method or system can includes an optical fiber assembly which may be driven to scan the target area in a scan pattern. The optical fiber assembly may provide multiple effective light sources (e.g., via a plurality of optical fibers) that are axially staggered with respect to an optical system located between the optical fiber and the target area. The optical system may be operable to focus and/or redirect the light from the multiple light sources onto separate focal planes. A composite image may be generated based on light reflected from and/or projected onto the separate focal planes. The composite image may have an extended depth of focus or field spanning over a distance between the separate focal planes while maintaining or improving image resolution.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: January 21, 2020
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Eric J. Seibel, Brian T. Schowengerdt
  • Patent number: 10536036
    Abstract: An integrated circuit, such as included as a portion of a sensor node, can include a regulator circuit having an input coupleable to an energy harvesting transducer. The integrated circuit can include a wireless receiver circuit coupled to the regulator circuit and configured to wirelessly receive at least enough operating energy to establish operation of the sensor node without requiring the energy harvesting transducer. The integrated circuit can include a digital processor circuit coupled to the regulator circuit and a power management processor circuit. The digital processor circuit or one or more other circuits can include a subthreshold operational mode established by the power management processor circuit based on the selected energy consumption level. For example, establishing the subthreshold operational mode can include adjusting or selecting a supply voltage so as to establish subthreshold operation of a field effect transistor (FET) in the digital processor circuit or other circuits.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: January 14, 2020
    Assignees: University of Virginia Patent Foundation, University of Washington through its Center for Commercialization
    Inventors: Benton H. Calhoun, Brian Otis
  • Patent number: 10527626
    Abstract: Provided herein, among other aspects, are methods and apparatuses for analyzing particles in a sample. In some aspects, the particles can be analytes, cells, nucleic acids, or proteins and contacted with a tag, partitioned into aliquots, detected by a ranking device, and isolated. The methods and apparatuses provided herein may include a microfluidic chip. In some aspects, the methods and apparatuses may be used to quantify rare particles in a sample, such as cancer cells and other rare cells for disease diagnosis, prognosis, or treatment.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: January 7, 2020
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Daniel T. Chiu, Mengxia Zhao, Wyatt Nelson, Perry G. Schiro
  • Patent number: 10514381
    Abstract: Lyophilized chromophoric polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions, methods of dispersing the lyophilized compositions in aqueous solutions and kits supplying the compositions.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: December 24, 2019
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Daniel T. Chiu, Wei Sun, Jiangbo Yu, Changfeng Wu, Fangmao Ye
  • Patent number: 10502733
    Abstract: Compositions of, methods of making, and methods of using hybrid nanoparticles comprise at least one semiconducting polymer and at least one nonsemiconducting polymer. Compositions of, methods of making and methods of using hybrid nanoparticles comprise at least one semiconducting polymer and non-semiconducting polymers wherein the non-semiconducting polymer comprises more than one non-semiconducting polymer such that at least one non-semiconducting polymer is functionalized for bioconjugation. The hybrid nanoparticles are polarization-sensitive and have low mass ratios with large fluorescence.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: December 10, 2019
    Assignee: University of Washington Through Its Center For Commercialization
    Inventors: Daniel T. Chiu, Maxwell Zeigler
  • Publication number: 20190365906
    Abstract: Provided herein are particles assemblies including a shell surrounding a core. The shell includes a particle-stabilizing random copolymer. The core includes a core random copolymer. The particle assemblies have a biomimetic design in which the polymeric components containing discrete chemical and biological functionalities are designed to spontaneously self-assemble into particles. Also provided herein are random copolymers having conjugated therapeutic agents that can be cleaved from the copolymers by an enzyme or water.
    Type: Application
    Filed: April 11, 2019
    Publication date: December 5, 2019
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Patrick S. Stayton, Anthony Convertine, Daniel M. Ratner, Selvi Srinivasan, Debobrato Das, Fang-Yi Su, Jasmin Chen, David Yee-Shawn Chiu, Daniel Douglas Lane
  • Patent number: 10487318
    Abstract: The invention provides compositions and methods for treating celiac sprue.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: November 26, 2019
    Assignee: University of Washington Through its Center for Commercialization
    Inventors: Justin Bloomfield Siegel, David Baker, Ingrid Swanson Pultz
  • Patent number: 10457936
    Abstract: Contiguity information is important to achieving high-quality de novo assembly of mammalian genomes and the haplotype-resolved resequencing of human genomes. The methods described herein pursue cost-effective, massively parallel capture of contiguity information at different scales.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: October 29, 2019
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Jay Ashok Shendure, Jerrod Joseph Schwartz, Andrew Colin Adey, Cho Ii Lee, Joseph Brian Hiatt, Jacob Otto Kitzman, Akash Kumar
  • Patent number: 10444243
    Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: October 15, 2019
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Daniel T. Chiu, Changfeng Wu, Jiangbo Yu
  • Patent number: 10434164
    Abstract: Compositions and methods are provided that enable activation of innate immune responses through RIG-I like receptor signaling. The compositions and methods incorporate synthetic nucleic acid pathogen associated molecular patterns (PAMPs) that comprise elements initially characterized in, and derived from, the hepatitis C virus genome.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: October 8, 2019
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Michael J. Gale, Jr., Gretja Schnell, Yueh-Ming Loo
  • Publication number: 20190282201
    Abstract: A stylet includes a handle assembly with an indicator display and a stiff wire assembly extending distally from the handle assembly having a non-imaging ultrasonic device on a distal end. The stylet includes a circuit assembly having one or more of a pulser, a transmit/receive chip, a bandpass filter, a differential amplifier, an ADC, and an MCU, operable to control the operation of the ultrasonic device and to receive and analyze data from the ultrasonic device to facilitate implantation of a device such as a catheter.
    Type: Application
    Filed: October 17, 2018
    Publication date: September 19, 2019
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Pierre D. Mourad, Samuel R. Browd, Brian MacConaghy, Revathi Murthy, Nathaniel Coulson
  • Patent number: 10416624
    Abstract: Described herein are methods and systems for selecting surgical approaches. One example method involves (1) receiving data indicating (a) one or more surgical target regions and (b) one or more surgical portals; (2) determining a plurality of surgical pathways; (3) determining a plurality of surgical approaches; (4) for each surgical approach in the plurality of surgical approaches, determining at least one approach characteristic, for each determined surgical pathway in the respective surgical approach, determining at least one pathway characteristic, and determining a surgical-approach ranking based on the determined at least one approach characteristic and the determined at least one pathway characteristic; (5) selecting a subset of the plurality of surgical approaches based on the determined surgical approach rankings; and (6) causing an output device to provide a representation of the selected subset of the plurality of surgical approaches.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: September 17, 2019
    Assignee: University of Washington Through its Center for Commercialization
    Inventors: Randall Bly, Blake Hannaford, Kris S. Moe
  • Publication number: 20190280527
    Abstract: An adaptive system for efficient and long-range wireless power delivery using magnetically coupled resonators responds to changes in a dynamic environment, and maintains high efficiency over a narrow or fixed frequency range. The system uses adaptive impedance matching to maintain high efficiency. The wireless power transfer system includes a drive inductor coupled to a high-Q transmitter coil, and a load inductor coupled to a high-Q receiver coil. The transmitter coil and receiver coil for a magnetically coupled resonator. A first matching network is (i) operably coupled to the drive inductor and configured to selectively adjust the impedance between the drive inductor and the transmitter coil, or (ii) is operably coupled to the load inductor and configured to selectively adjust the impedance between the load inductor and the receiver coil.
    Type: Application
    Filed: March 19, 2019
    Publication date: September 12, 2019
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Joshua R. Smith, Benjamin H. Waters, Scott Wisdom, Alanson P. Sample
  • Patent number: 10385393
    Abstract: Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: August 20, 2019
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Jesse Salk, Lawrence A. Loeb, Michael Schmitt
  • Patent number: 10370713
    Abstract: Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: August 6, 2019
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Jesse Salk, Lawrence A. Loeb, Michael Schmitt
  • Patent number: 10358667
    Abstract: Embodiments of the disclosure provide for unique lipooligosaccharide/lipid A-based mimetics for use as adjuvants. Methods of generating lipooligosaccharide/lipid A-based mimetics are provided that utilize recombinantly engineered bacteria to produce the mimetics, including, for example, addition of one or more particular enzymes such as acyltransferases, deacylases, phosphatases, or glycosyltransferases.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: July 23, 2019
    Assignees: University of Maryland, Baltimore, University of Washington through its Center for Commercialization
    Inventors: Robert K. Ernst, Mark Pelletier, Adeline Hajjar