Patents Assigned to University of Washington
  • Publication number: 20230017777
    Abstract: Provided herein are compositions comprising aptamers that specifically bind monocytes and/or macrophage and methods for their use. These aptamer compositions can be used in methods for isolating and/or enriching monocytes and/or macrophages or depleting cell populations of monocytes and/or macrophages. Further provided are methods of using the aptamers or cell populations generated using them in the methods disclosed herein for therapies and/or drug delivery.
    Type: Application
    Filed: June 24, 2022
    Publication date: January 19, 2023
    Applicants: University of Washington, Seattle Children's Hospital d/b/a Seattle Children's Research Institute
    Inventors: Suzie Hwang Pun, Meilyn Sylvestre, Nataly Kacherovsky, Emmeline Cheng, Ian Cardle, Chris Saxby
  • Publication number: 20230014056
    Abstract: Zwitterionic carboxybetaine copolymers and their use in coatings to impart non-fouling and functionality to surfaces, particularly surfaces of blood-contacting medical devices.
    Type: Application
    Filed: September 12, 2022
    Publication date: January 19, 2023
    Applicant: University of Washington
    Inventors: Shaoyi Jiang, Xiaojie Lin, Jonathan Himmelfarb, Buddy D. Ratner
  • Patent number: 11555916
    Abstract: Examples of imaging systems are described herein which may implement microwave or millimeter wave imaging systems. Examples described may implement partitioned inverse techniques which may construct and invert a measurement matrix to be used to provide multiple estimates of reflectivity values associated with a scene. The processing may be partitioned in accordance with a relative position of the antenna system and/or a particular beamwidth of an antenna. Examples described herein may perform an enhanced resolution mode of imaging which may steer beams at multiple angles for each measurement position.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: January 17, 2023
    Assignee: University of Washington
    Inventors: Matthew S. Reynolds, Andreas Pedross-Engel, Claire Watts, Sandamali Devadithya
  • Patent number: 11555216
    Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
    Type: Grant
    Filed: March 15, 2022
    Date of Patent: January 17, 2023
    Assignee: University of Washington
    Inventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg
  • Patent number: 11549102
    Abstract: The present invention provides compositions of CD180 targeting molecules coupled to heterologous antigens, and their use in treating and/or limiting disease.
    Type: Grant
    Filed: December 31, 2019
    Date of Patent: January 10, 2023
    Assignee: University of Washington
    Inventors: Edward Clark, Jay Wesley Chaplin
  • Patent number: 11550084
    Abstract: Disclosed herein are metasurfaces formed on a substrate from a plurality of posts. The metasurfaces are configured to be optically active at one or more wavelengths and in certain embodiments are configured to form lenses having unexpectedly strong focusing power. In particular, the metasurfaces are formed from “low-contrast” materials, including CMOS-compatible materials such as silicon dioxide or silicon nitride. Accordingly, the disclosed metasurfaces are generally CMOS compatible and therefore embody a new paradigm in metasurface design and manufacturing.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: January 10, 2023
    Assignee: University of Washington
    Inventors: Alan Zhan, Shane Colburn, Arka Majumdar
  • Patent number: 11548875
    Abstract: Pyrazole compounds and piperazine compounds that are inhibitors of ALDH1A1 and ALDH1A2 and methods for using the pyrazole compounds and piperazine compounds in male contraceptive compositions for preventing spermatogenesis.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: January 10, 2023
    Assignee: University of Washington
    Inventors: Alex S. Goldstein, John K. Amory, Jisun Paik, Michael Haenisch, Nina Isoherranen, Piper Treuting, Charles H. Muller
  • Patent number: 11543681
    Abstract: Eyeglasses are disclosed that include eyeglass frames and a pair of ophthalmic lenses mounted in the frames. The lenses include a dot pattern distributed across each lens, the dot pattern including an array of dots spaced apart by a distance of 1 mm or less, each dot having a maximum dimension of 0.3 mm or less, the dot pattern including a clear aperture free of dots having a maximum dimension of more than 1 mm, the clear aperture being aligned with a viewing axis of a wearer of the pair of eyeglasses.
    Type: Grant
    Filed: January 9, 2020
    Date of Patent: January 3, 2023
    Assignee: University of Washington
    Inventors: Jay Neitz, James Kuchenbecker, Maureen Neitz
  • Patent number: 11541386
    Abstract: An example fluidic device includes an elastic tube, a first actuator coupled to an outer surface of the elastic tube between a first end and a second end of the elastic tube, and a second actuator coupled to the outer surface of the elastic tube between the first actuator and the second end of the elastic tube. The first actuator and the second actuator are configured to move apart from one another to transition a portion of the elastic tube positioned between the first actuator and the second actuator from a first condition to a second condition. A diameter of the elastic tube is greater in the first condition than in the second condition. The fluidic device also includes one or more rotatable components coupled to the first actuator and the second actuator which are configured to rotate the portion of the elastic tube positioned between the first actuator and the second actuator.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: January 3, 2023
    Assignee: University of Washington
    Inventors: Mark E. Fauver, Eric J. Seibel
  • Patent number: 11540783
    Abstract: In some embodiments, a self-monitoring intravenous catheter system is provided. An alarm controller is provided that receives signals representing a pH value, an oxygen saturation value, and a pressure value in proximity to the distal end of the catheter. By performing a fuzzy logic analysis of the values, the alarm controller is able to detect that the catheter is about to fail or has failed, and can cause alerts to be presented. In some embodiments, an intravenous catheter is provided that has a pH sensor and an oximeter disposed at a distal end of the catheter to obtain the pH value and oxygen saturation values analyzed by the alarm controller. Embodiments of the catheter and self-monitoring intravenous catheter system may be particularly useful in treating neonates, who are sensitive to catheter failure and are not capable of detecting the signs of failure themselves.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: January 3, 2023
    Assignee: University of Washington
    Inventor: Elena M. Bosque
  • Patent number: 11540778
    Abstract: A method for suppressing sensor noise in a spatially oversampled sensor array includes receiving spatially oversampled multi-channel sensor data from a region of interest and building a spatial model from the data for essential spatial degrees of freedom. The method further includes decomposing the data into the underlying spatial model to obtain associated amplitude components containing a mixture of original temporal waveforms of the data and, for each channel of the multi-channel sensor, estimating time-domain amplitude components using cross-validation. Next, for each channel, based on the estimated time-domain amplitude components, sensor noise and/or artifacts for that channel are identified. Finally, for each channel, the identified sensor noise and/or artifacts can be suppressed from the data.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: January 3, 2023
    Assignee: University of Washington
    Inventors: Samu Taulu, Eric D. Larson
  • Publication number: 20220409056
    Abstract: An imaging system may include: a first light source configured to emit a first source spectrum of collimated light; a second light source configured to emit a second source spectrum of light; a probe head configured to direct the first source spectrum and the second source spectrum toward tissue in an oral cavity and to collect a first feedback spectrum of light and a second feedback spectrum of light; an interferometry sub-system to generate an optical feedback signal using the first source spectrum; at least one optical sensor array for receiving the optical feedback signal and the second feedback spectrum; and at least one programmable processor to generate: a first diagnostic image of the tissue using the optical feedback signal; a second diagnostic image of the tissue using the second feedback spectrum; and a third diagnostic image from a combination of the first diagnostic image and the second diagnostic image.
    Type: Application
    Filed: October 16, 2020
    Publication date: December 29, 2022
    Applicants: Colgate-Palmolive Company, University of Washington
    Inventors: Hrebesh Molly SUBHASH, LaTonya KILPATRICK-LIVERMAN, Ruikang WANG, Nhan LE
  • Publication number: 20220401355
    Abstract: Devices for and related methods of treating a subject having a neurological injury to prevent or mitigate secondary injury are described. In an example, the devices include a base and a plurality of microneedles protruding from the base, the microneedles including a biocompatible and biodegradable matrix, and a neurologically active ingredient disposed within the matrix. In an example, a portion of the plurality of microneedles is shaped to penetrate the dura when the device is placed in contact with the dura.
    Type: Application
    Filed: May 13, 2022
    Publication date: December 22, 2022
    Applicants: University of Washington, The Regents of the University of California
    Inventors: Rajiv Saigal, Jessica Johnson, Tianyu Zhao, Maximilian Walter
  • Publication number: 20220401736
    Abstract: Embodiments of the disclosure are drawn to implantable stimulator with machine learning based classifier. An implantable system includes sensors which provide sensor information to an implantable unit. The implantable unit uses a classifier on the sensor information to select a stimulation procedure which is applied via a stimulation electrode. The classifier may be generated by a trained machine learning model. The classifier may be trained on an external unit which is not implanted in the subject. The classifier may be trained based on sensor information from the implanted sensors as well as symptom information.
    Type: Application
    Filed: March 23, 2022
    Publication date: December 22, 2022
    Applicant: University of Washington
    Inventors: Jeffrey Andrew Herron, Benjamin Isaac Ferleger, Howard Jay Chizeck, Andrew L. Ko
  • Publication number: 20220395838
    Abstract: Fluidic devices, systems, and methods for analyzing an analyte are described. In an embodiment, the fluidic devices include a housing defining a lysis chamber shaped to receive a biological sample; a lysis buffer storage chamber disposed within the housing and carrying a lysis buffer configured to lyse cells of the biological sample; a cap configured to cooperatively couple to the housing; a compressor configured to compress the lysis buffer storage chamber and expel the lysis buffer from the lysis buffer storage chamber and into the lysis chamber when the cap is uncoupled from the housing; and a porous membrane in selective fluidic communication with the lysis chamber.
    Type: Application
    Filed: June 13, 2022
    Publication date: December 15, 2022
    Applicant: University of Washington
    Inventors: Paul Yager, Steven Bennett, Erin K. Heiniger, Sujatha Kumar, Kamal Girish Shah
  • Publication number: 20220397664
    Abstract: Examples of active millimeter-wave imaging systems are described which may utilize modulation schemes to provide illumination signals. The use of modulation techniques may allow for the use of direct-conversion receivers while retaining an ability to separate desired received signal from self-jamming and/or DC offset signal(s) generated by the direct-conversion receivers. In some examples, modulation schemes include the use of balanced orthogonal codes which may support MIMO or massive MIMO imaging systems.
    Type: Application
    Filed: August 19, 2022
    Publication date: December 15, 2022
    Applicant: University of Washington
    Inventors: Andreas Pedross-Engel, Daniel Arnitz, Matthew S. Reynolds
  • Patent number: 11524275
    Abstract: The present disclosure features a composition, including molecularly imprinted crosslinked polymers that have been imprinted with trimethylamine N-oxide. The molecularly imprinted crosslinked polymers have specific binding sites for trimethylamine N-oxide, and a trimethylamine N-oxide absorption capacity of at least 0.5 mg/g.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: December 13, 2022
    Assignee: University of Washington
    Inventors: Buddy D. Ratner, Runbang Tang
  • Patent number: 11524979
    Abstract: Disclosed herein are macrocyclic polypeptides having no more than 3 ammo acid substitutions compared to the amino acid sequence of any one of SEQ ID NO: 1-2.37 or a mirror image thereof, wherein the polypeptide includes both L and D amino acids, libraries of such polypeptides, and uses thereof.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: December 13, 2022
    Assignee: University of Washington
    Inventors: Parisa Hosseinzadeh, David Baker, Gaurav Bhardwaj, Vikram K. Mulligan
  • Publication number: 20220389310
    Abstract: The present disclosure features a luminescent molecule, including a luminophore (e.g., a fluorescent dye); and a moiety including a heteroaryl core covalently and directly bonded to the luminophore. The luminescent molecule has an increased photoluminescence quantum yield relative to an analogous luminophore without a covalently bonded moiety including the heteroaryl core.
    Type: Application
    Filed: September 24, 2020
    Publication date: December 8, 2022
    Applicant: University of Washington
    Inventors: Yunping Huang, Christine Keiko Luscombe, III
  • Patent number: 11517729
    Abstract: Systems and methods are provided for fabricating microneedle arrays that includes electrospun fibers preferentially disposed within the microneedles of the array. Providing the electrospun fibers preferentially in the microneedles allows for more of a drug or other substance present in the fibers to be deposited into tissue or to provide other benefits. A mold for forming the microneedle arrays includes an insulating surface layer. The insulating surface layer affects the electric field during electrospinning such that electrospun fibers are deposited preferentially within the microneedle cavities of the mold relative to the surface of the mold. A bulk material can then be applied to the mold to form the bulk of the microneedles with electrospun fibers embedded within and a backing layer to which the microneedles are attached.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: December 6, 2022
    Assignee: University of Washington
    Inventors: Rachel Creighton, Kim Woodrow