Patents Assigned to University of Wollongong
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Patent number: 11850449Abstract: An irradiation method and system for irradiating a target volume, the method comprising: providing thermal neutron absorbing nuclides (such as in the form of a high neutron cross-section agent) at the target volume; and producing neutrons by irradiating nuclei in or adjacent to the target volume with a beam of particles consisting of any one or more of protons, deuterons, tritons and heavy ions, thereby prompting production of the neutrons through non-elastic collisions between the atoms in the path of the beam (including the target) and the particles. The neutron absorbing nuclides absorb neutrons produced in the non-elastic collisions, thereby producing capture products or fragments that irradiate the target volume.Type: GrantFiled: September 14, 2018Date of Patent: December 26, 2023Assignees: Australian Nuclear Science and Technology Organisation, University of WollongongInventors: Mitra Safavi-Naeini, Andrew Stephen Chacon
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Patent number: 11819489Abstract: An anti-cancer agent is provided comprising a tumour homing peptide having, or having been modified to present, two cysteine residues, with an arsenic atom between, such that the tumour homing peptide cyclises to give an arsenic-containing anti-cancer agent. This allows for selection of an appropriate tumour homing peptide for treatment of a given cancer whereby the subsequent agent provides for a more targeted delivery of arsenic to the tumour microenvironment.Type: GrantFiled: October 17, 2018Date of Patent: November 21, 2023Assignee: University of WollongongInventors: Carolyn Therese Dillon, Judith Anne Carrall
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Patent number: 11311720Abstract: The present disclosure provides methods of making and applying metallized graphene fibers in bioelectronics applications. For example, platinized graphene fibers may be used as an implantable conductive suture for neural and neuro-muscular interfaces in chronic applications. In some embodiments, an implantable electrode includes a multi-layer graphene-fiber core, an insulative coating surrounding the multi-layer graphene-fiber core, and a metal layer disposed between the multi-layer graphene-fiber core and the insulative coating.Type: GrantFiled: November 21, 2019Date of Patent: April 26, 2022Assignees: University of Wollongong, Board of Regents, The University of Texas SystemInventors: Mario Romero-Ortega, Gordon Wallace, Maria Gonzalez Gonzalez, Rouhollah Ali Jalili
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Publication number: 20200155834Abstract: The present disclosure provides methods of making and applying metallized graphene fibers in bioelectronics applications. For example, platinized graphene fibers may be used as an implantable conductive suture for neural and neuro-muscular interfaces in chronic applications. In some embodiments, an implantable electrode includes a multi-layer graphene-fiber core, an insulative coating surrounding the multi-layer graphene-fiber core, and a metal layer disposed between the multi-layer graphene-fiber core and the insulative coating.Type: ApplicationFiled: November 21, 2019Publication date: May 21, 2020Applicants: Board of Regents, The University of Texas System, University of WollongongInventors: Mario ROMERO-ORTEGA, Gordon Wallace, Maria Gonzalez Gonzalez, Rouhollah Ali Jalili
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Publication number: 20180140693Abstract: Isolated proteins and immunogenic fragments thereof, for use in the treatment and prevention of a Group A Streptococcus infection are provided. In particular, the invention provides pharmaceutical compositions and methods of prophylactic and/or therapeutic treatment of a Group A Streptococcus infection.Type: ApplicationFiled: January 5, 2018Publication date: May 24, 2018Applicant: University of WollongongInventors: Mark Walker, Jason Cole, Anna Henningham
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Patent number: 9156855Abstract: The present invention relates generally to methods and compounds for regulating the release of nitric oxide in the vicinity of biofilm-forming microorganisms to regulate programmed cell death in the microorganisms and thereby promote dispersal of microorganism from biofilms and/or inhibit biofilm formation or development. More particularly, the invention relates to the use of compounds to provide spatial and temporal control over nitric oxide release.Type: GrantFiled: May 16, 2012Date of Patent: October 13, 2015Assignees: Newsouth Innovation Pty Limited, University of WollongongInventors: Nicolas Barraud, Bharat Gangadhar Kardak, Michael John Kelso, Staffan Kjelleberg, Scott Rice
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Patent number: 9140810Abstract: A proton computed tomography (pCT) detector system, including two tracking detectors in sequence on a first side of an object to be imaged, two tracking detectors in sequence on an opposite side of the object to be imaged, a calorimeter, and a computer cluster, wherein the tracking detectors include plastic scintillation fibers. All fibers in the detector system are read out by Silicon Photomultipliers (SiPM). A method of imaging an object by emitting protons from a source through two tracking detectors, through and around the object, and through two opposite tracking detectors, detecting energy of the protons with a calorimeter, and imaging the object.Type: GrantFiled: June 30, 2014Date of Patent: September 22, 2015Assignees: Board of Trustees of Northern Illinois University, Fermi Research Alliance, LLC, University of WollongongInventors: Nicholas Karonis, George Coutrakon, Kirk Duffin, Bela Erdelyi, Kevin Naglich, Scott Penfold, Paul Rubinov, Victor Rykalin, Vishnu Zutshi
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Patent number: 8742357Abstract: A semiconductor radiation sensor (100), comprising a substrate (102), a carrier material (104) mounted to the substrate (102), and a semiconductor detector (106) mounted to the carrier material (104). A radiation sensitive portion of the semiconductor detector (106) is oriented towards the carrier material (104) and generally away from the substrate (102), and the carrier material is adapted to transmit radiation to the radiation sensitive portion of the semiconductor detector (106). A dosimeter comprising the radiation sensor (100) and a method of manufacturing the radiation sensor (100) are also provided.Type: GrantFiled: June 2, 2008Date of Patent: June 3, 2014Assignee: University of WollongongInventor: Anatoly Rozenfeld
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Patent number: 8715610Abstract: The present invention relates to a process for the preparation of graphene which can be used in the development of graphene paper or films, graphene-based composites and articles for nanoelectronics, nanocomposites, batteries, supercapacitors, hydrogen storage and bioapplications. This process comprises reducing purified exfoliated graphite oxide in the presence of a base.Type: GrantFiled: October 17, 2008Date of Patent: May 6, 2014Assignee: University of WollongongInventors: Gordon George Wallace, Dan Li
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Patent number: 8524657Abstract: The present invention provides a compound of formula I, II, III and IV as defined herein and pharmaceutically acceptable derivatives thereof. The present invention further provides use of the compounds of the present invention in the treatment of bacterial infection and in the treatment of HIV infection. Also provided are pharmaceutical compositions comprising the compounds of the present invention.Type: GrantFiled: August 2, 2011Date of Patent: September 3, 2013Assignee: University of WollongongInventors: Timothy Patrick Boyle, John Barnard Bremmer, Zinka Brkic, Jonathan Alan Victor Coates, Neal Kevin Dalton, John Joseph Deadman, Paul Anthony Keller, Jody Morgan, Stephen Geoffrey Pyne, David Ian Rhodes, Mark James Robertson
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Patent number: 8421022Abstract: A microdosimeter, comprising an array of three-dimensional p-n junction semiconductor detectors, each providing a sensitive volume-target and a tissue equivalent medium for generating secondary charged particles. The array is manufactured from a semiconductor on insulator wafer and the detectors are located to detect secondary charged particles generated in the tissue equivalent medium.Type: GrantFiled: December 19, 2007Date of Patent: April 16, 2013Assignee: University of WollongongInventor: Anatoly Rozenfeld
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Patent number: 8372834Abstract: The present invention relates to compositions comprising 5-fluorouracil, or a pharmaceutically acceptable salt or analogue thereof, folinic acid, or a pharmaceutically acceptable salt thereof and a cyclodextrin, or a pharmaceutically acceptable salt or derivative thereof. The invention also relates to methods for the treatment of cancer using such compositions.Type: GrantFiled: February 29, 2008Date of Patent: February 12, 2013Assignee: University of WollongongInventors: John Barnard Bremner, Philip Clingan, Julie Myree Locke
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Patent number: 8242439Abstract: A mass spectrometric method for determining the position of unsaturation in a compound is disclosed.Type: GrantFiled: June 29, 2010Date of Patent: August 14, 2012Assignee: The University of WollongongInventors: Stephen James Blanksby, David Grant Harman, Michael Christopher Thomas, Todd William Mitchell
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Patent number: 8212220Abstract: A radiation detection apparatus and method, the apparatus (100) comprising a first scintillator (112) for interacting with radiation and outputting light in response thereto, a first photodetector (102) adjacent to the first scintillator (112) for receiving and detecting light from the first scintillator (112) and outputting (108) a first output signal in response thereto, a second scintillator (114) located around the first scintillator (112), for interacting with radiation and outputting light in response thereto, and a second photodetector (104) adjacent to the second scintillator (114) for receiving and detecting light from the second scintillator (114) and outputting (110) a second output signal in response thereto.Type: GrantFiled: February 8, 2008Date of Patent: July 3, 2012Assignee: University of WollongongInventors: Michael Lloyd Franz Lerch, Anatoly Rozenfeld, Olexander Gektin
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Patent number: 8172998Abstract: Ionic liquids are incorporated into transducers, actuators or sensors which employ the ionic polymer membranes. The ionic liquids have superior electrochemical stability, low viscosity and low vapor pressure. The transducers, actuators and sensors which utilize ionic polymer membranes solvated with ionic liquids have long term air stability. Superior results are achieved when a conductive powder and ionomer mixture is applied to the ionic polymer membrane to form the electrodes during or after the ionic liquid is imbibed into the ionic polymer membrane.Type: GrantFiled: August 19, 2004Date of Patent: May 8, 2012Assignees: Virginia Tech Intellectual Properties, Inc., University of WollongongInventors: Matthew Bennett, Donald Leo, Gordon Wallace, Geoff Spinks
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Publication number: 20120108499Abstract: The invention relates to new peptoid compounds of formula (I), as well as their use in the treatment of bacterial infections, such as those caused by vancomycin resistant microorganisms, and to compositions thereof.Type: ApplicationFiled: September 6, 2011Publication date: May 3, 2012Applicant: University of WollongongInventors: John BREMNER, Stephen PYNE, Paul KELLER, Dan COGHLAN, Adel GARAS, Helen WITCHARD, Tim BOYLE, Jonathan COATES
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Patent number: 8039430Abstract: The present invention provides a compound of formula (I), (II), (III) and (IV) as defined herein and pharmaceutically acceptable derivatives thereof. The present invention further provides use of the compounds of the present invention in the treatment of bacterial infection and in the treatment of HIV infection. Also provided are pharmaceutical compositions comprising the compounds of the present invention.Type: GrantFiled: September 21, 2005Date of Patent: October 18, 2011Assignee: University of WollongongInventors: Timothy Patrick Boyle, John Barnard Bremner, Zinka Brkic, Jonathan Alan Victor Coates, Neal Kevin Dalton, John Joseph Deadman, Paul Anthony Keller, Jody Morgan, Stephen Geoffrey Pyne, David Ian Rhodes, Mark James Robertson
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Patent number: 7998934Abstract: A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises PAI-2 or a functional derivative, homologue, analogue, chemical equivalent or mimetic thereof, which PAI-2 is bound, linked, or otherwise associated with a toxin or label.Type: GrantFiled: October 14, 2008Date of Patent: August 16, 2011Assignees: PAI-2 Pty Limited, University of Wollongong, Medical Scitec Australia Pty Ltd.Inventors: Marie Ranson, Barry John Allen, Clive Leighton Bunn
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Publication number: 20110111962Abstract: Improved magnesium diboride superconducting materials and methods of synthesis are disclosed. Embodiments of the superconducting material comprise at least two starting materials capable of forming MgB2 and at least one dopant compound comprising silicon, carbon, hydrogen and oxygen. The starting materials and the at least one dopant compound are heated and mixed at an atomic level to produce a silicon-doped MgB2 superconducting material. Examples of the dopant compound include silicone oil, Triacetoxy(methyl)silane (2), 1,7-Dichloro-octamethyltetrasiloxane (2) and Tetramethyl orthosilicate (6).Type: ApplicationFiled: July 23, 2007Publication date: May 12, 2011Applicant: University of WollongongInventors: Xiaolin Wang, Shi Xue Dou, Md. Shahriar Al Hossain, Zhenxiang Cheng
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Patent number: 7853412Abstract: A method of estimating contact forces between the wheels of a railway wagon and a rail track, for use in determining information such as the likelihood of derailment. Accelerations of the body of the wagon are measured using motion sensors located at suitable points on the body. Forces on the side frames of the wagon are calculated based on the accelerations of the body and predetermined parameters of the body. Forces on the wheels of the wagon are calculated based on the accelerations of the body and predetermined parameters of the body. The contact forces between the wheels and the rails are then calculated based on the forces calculated for the side frames and the wheels. The calculations are carried out using an inverse model of the wagon system. Equipment which implements the method is also described.Type: GrantFiled: June 8, 2006Date of Patent: December 14, 2010Assignees: QR Limited, Australian Rail Track Corporation Ltd, Pacific National (Victoria) Ltd, Asciano Services Pty Ltd, TMG Rail Technology Pty Ltd, Rail Corporation NSW, Central Queensland University, University of Wollongong, Monash University, University of South Australia, Queensland University of Technology, The University of QueenslandInventors: Fujie Xia, Peter Joseph Wolfs