Abstract: The preparation and properties of liquid crystal compounds having an achiral core and chiral tail units composed of the 1-cyanoalkoyl grouping (chiral cyanohydrin ethers) are described. The newly made compounds are shown to be useful as components of ferroelectric liquid crystal mixtures which exhibit high speed, multistate electro-optic switching properties making them ideally suited to certain electro-optic display device applications.

Abstract: An AC gas discharge display panel is described which employs the phenomenon of plasma spreading. In the panel, plasma spreading or "coupling" is employed to couple the plasma to an addressed cell to one of a plurality of pixels to be illuminated. The spreading is controlled by assuring that the cell wall voltages are properly related so that the plasma's electrons migrate to a region where the voltages are approximately equal to or more positive than the wall voltages where the plasma originated. Paired sustain electrodes are selectively energized to enable diversion of the coupled plasma to the desired pixel, so that upon subsequent applications of a sustain voltage, the desired pixel is illuminated (or erased) as the case may be.

Abstract: Specific DNA sequence insertions, deletions and substitutions (i.e., combinations of sequence deletion and insertion) in eukaryotic cell or viral genomes are stably effected through use of selectable DNA sequences comprising a herpesvirus thymidine kinase (tk) gene.

Abstract: Disclosed are immunologically active preparations of Herpes simplex virus envelope glycoproteins, gD-1 and gD-2. Preferably purified through use of a monoclonal anti-gD antibody immunoadsorbent, gD-1 and gD-2 preparations are incorporated in vaccines useful in generating immunological responses protective against Herpes simplex disease states. Disclosed also is the preparation and use in vaccination procedures of synthetic polypeptides comprising amino acid sequences which are: (1) substantially common to both gD-1 and gD-2; cumulatively hydrophilic in nature; and (3) specifically immunoreactive with a type common, monoclonal anti-gD antibody of Group VII classification.

Abstract: The present invention relates to new synthetic compounds of the cannabinoid class, specifically carenadiol and its derivatives. This compound and its derivatives have been shown to have biological activity which indicates their usefulness in the treatment of patients with various neurological disorders.

Abstract: A reverse osmosis membrane process or hybrid membrane - complementary separator process for producing enriched product or waste streams from concentrated and dilute feed streams for both solvent/solvent and solute/solvent systems is described.

Abstract: Novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula IIIa, ##STR1## wherein: Y is hydrogen or lower alkyl; and Z is an hydroxy substitited 1-pyrrolidinyl radical, ora lower alkyl substituted piperidyl radical, ora 1-piperazinyl radical or an acetamino, acetyl, carbamido, cyano, carboxy lower alkylamino, di-lower alkoxy, nitro, sulfamyl, or lower alkyl substituted anilino radical, ora radical of the formula, ##STR2## wherein R is hydrogen or lower alkyl and R.sup.1 is a nitrogen containing heterocyclic radical selected from the group consisting of amino substituted triazolyl, lower alkyl substituted isothiazolyl, benzothiazolyl, and nitro and halo substituted derivatives of benzothiazolyl, or R.sup.

Abstract: Disclosed are antibody substances displaying unique, multi-specific immunoreactivities with respect to glycoprotein D of Herpes Simplex Virus types 1 and 2 (HSV gD-1 and gD-2) and structurally related compounds. Illustratively, an IgG Type 2 monoclonal antibody material produced by mouse-mouse hybridoma cell line A.T.C.C. No. HB8606 is capable of in vitro neutralization of HSV-1 and HSV-2 infectivity and of specific immunological reactivity and reversible immunobinding with natrually-occuring and recombinant gD-1 and gD-2 in both native and denatured conformations as well as with proteinaceous materials (produced, e.g., by proteolytic digestion of naturally-occurring materials, by recombinant methods, or by polymerization of amino acids) which comprise a primary structural conformation substantially duplicating part or all of that which is predicted to be extant at residues 266 through 287 of gD-1 and gD-2 [i.e., PELA(or V)PEDPEDSALLEDPV(or A)GTVA(or S)].

Abstract: A pulsed-field gradient gel electrophoretic apparatus is described wherein a free standing gel is employed. Electrode arrays are oriented to provide three dimensional fields across the face of the gel rather than in the plane of the gel. The electrodes produce three dimensional fields which are orthogonally oriented with respect to each other and cause the molecules to proceed down the lanes in the gel in a generally saw-tooth manner oscillating between the surfaces thereof. Alternately, three dimensional, electric fields are arranged at angles greater than 90.degree. to one another across the face of the gel in separating the molecules, following which transfer electrodes are substituted for the separation electrodes in order to transfer the molecules from their separation lanes onto a separate substrate.

Abstract: A flexible endoscopic ligating instrument comprises a flexible fiberoptic endoscope on the end of which is secured an outer tube and an inner tube inserted and reciprocally movable within the outer tube. An elastic ring is mounted peripherally on the end of the inner tube which projects beyond the outer tube. A trip wire is fastened to the inner tube to provide rearward motion to the inner tube and thereby cause the elastic ring to slide off and effect ligation. The instrument is particularly suited for ligating lesions deep within the alimentary tract such as esophageal varices.

Abstract: DNA sequences encoding for novel human lymphoblastoid-leukocyte hybrid interferons. Methods of making nucleotide sequences comprising ribosome binding sites, promoter regions, and segments of human lymphoblastoid and leukocyte interferons are described. DNA sequences for hybrid interferons are cloned and expressed in plasmid vectors. Transformed microorganisms and novel lymphoblastoid-leukocyte polypeptide interferons having biological or immunological acitivity are disclosed.

Abstract: A secondary battery comprises at least one electrode having as an active materials a conjugated polymer, the polymer being doped to an electrically conducting state. Particularly, the battery may comprise the polymer as a cathode and a lithium anode.

Abstract: DNA sequences encoding for novel human lymphoblastoid-leukocyte hybrid interferons. Methods of making nucleotide sequences comprising ribosome binding sites, promoter regions, and segments of human lymphoblastoid and leukocyte interferons are described. DNA sequences for hybrid interferons are cloned and expressed in plasmid vectors. Transformed microorganisms and novel lymphoblastoid-leukocyte polypeptide interferons having biological or immunological activity are disclosed.

Abstract: Disclosed are immunologically active preparations of Herpes simplex virus envelope glycoproteins, gD-1 and gD-2. Preferably purified through use of a monoclonal anti-gD antibody immunodsorbent, gD-1 and gD-2 preparations are incorporated in vaccines useful in generating immunological responses protective against Herpes simplex virus disease states. Disclosed also is the preparation and use in vaccination procedures of synthetic polypeptides comprising amino acid squences which are: (1) substantially common to both gD-1 and gD-2; (2) cumulatively hydrophilic in nature; (3) specifically immunoreactive with a type common, monoclonal anti-gD antibody of Group VII classification. Vaccines incorporating the synthetic polypeptides give rise to protective immunological responses, e.g., they protect mice against Herpes simplex.

Abstract: Ferroelectric (chiral) smectic liquid crystal compounds having an achiral core and chiral tail units derived from (2,3)-epoxyalkyloxiranemethanols possess a high ferroelectric polarization density. These newly made compounds exhibit high speed, multistate electro-optic switching properties which make them ideally suited to certain electro-optic display device applications.

Abstract: Food supplement compositions for the enhanced absorption of nutrient mineral components additionally include a complex carbohydrate fraction, having an average molecular weight in the range from about 750 to about 3500, and a suitable carrier agent. The compositions are particularly includable in the diets of subjects who have a shortened interstinal length and need additional absorption of calcium and other mineral elements.

Abstract: The synthesis of novel strained bicyclic lactones and their ring-opening polymerization to high molecular weight polyester polymers is disclosed.

Abstract: A dc to three phase ac switched mode converter is described wherein a six switch bridge is provided to interconnect the dc source to a three-phase load. A plurality of dc sources are described, each of which employs an inductor/capacitor combination for energy storage, which stored energy is subsequently applied to the output load. The stored energy is delivered by connecting the capacitor across two legs of the three-phase load, while assuring that the third leg is invariably short-circuited back upon itself. As a result, three of the six switches in the bridge are closed at any instant to prevent any current interruption in the load.

Abstract: Disclosed is a method of conducting affinity chromatographic separations of biomaterials which comprises contacting the biomaterial with a solid support comprising a generally spherical bead having a generally central magnetic core and a surrounding exterior coat about the core comprising a material capable of binding with the biomaterial.

Abstract: Disclosed are novel methods and materials for generating in vitro cultured populations of human epidermal keratinocyte cells having a characteristic colony-forming efficiency of greater than 20%. Novel media preparations and procedures are disclosed that permit isolation, serum-free primary culture and serum-free serial subculture of human epidermal keratinocytes. Also disclosed are procedures and products employing keratinocyte cells grown in serum-free conditions for medical application, i.e., skin grafting.