Patents Assigned to University Research Corporation
  • Patent number: 11311600
    Abstract: Methods for treating obesity are provided and include administering a polypeptide antagonist of a Na/K ATPase/Src receptor complex to a subject in need thereof. Methods for reducing adiposity and adipogenesis are also provided and make use of a polypeptide antagonist of a Na/K ATPase/Src receptor complex to a subject.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: April 26, 2022
    Assignee: MARSHALL UNIVERSITY RESEARCH CORPORATION
    Inventors: Zijian Xie, Joseph I. Shapiro, Nader G. Abraham, Komal Sodhi
  • Patent number: 11306401
    Abstract: An apparatus containing at least one electrochemical cell with an electrode structure. The electrode structure contains at least one carbide chemical compound. The carbide chemical compound may be a salt-like carbide. The electrode may contain at least one electronically conductive element different from the carbide. Carbon compositions of various forms may be formed by the methods and apparatus using the electrode structure. Large pieces of pure carbon may be produced. Post-reaction processing of the carbon may be carried out such as exfoliation.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: April 19, 2022
    Assignee: West Virginia University Research Corporation
    Inventors: Alfred H. Stiller, Christopher L. Yurchick
  • Patent number: 11220528
    Abstract: Methods treating pulmonary hypertension, including pulmonary arterial hypertension, are provided, and include administering a polypeptide antagonist of a Na/K ATPase/Src receptor complex to a subject in need thereof. Administration of the polypeptide antagonist reduces pulmonary artery acceleration time, reduces an amount of right ventricular hypertrophy, reduces right ventricular wall thickness, reduces an amount of pulmonary vessel wall thickness, reduces an amount of plexiform lesions in a lung of the subject, reduces an amount of collagen deposition in a pulmonary blood vessel, reduces an amount of collagen deposition in a pulmonary blood vessel media or adventitia, and/or reduces an amount of right ventricular fibrosis. Methods of reducing pulmonary vessel wall thickness are also provided and include the administration of the polypeptide antagonist of a Na/K ATPase/Src receptor complex.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: January 11, 2022
    Assignee: MARSHALL UNIVERSITY RESEARCH CORPORATION
    Inventors: Zijian Xie, Jiayan Wang, Sandrine V. Pierre, Joseph I. Shapiro
  • Publication number: 20210163291
    Abstract: The disclosure provides for methods of oxidizing carbide anions, or negative ions, from salt like carbides at temperatures from about 150° C. to about 750° C. In another aspect, the disclosure provides for reactions with intermediate transition metal carbides. In yet another aspect, the disclosure provides for a system of reactions where salt-like carbide anions and intermediate carbide anions are oxidized to produce pure carbon of various allotropes.
    Type: Application
    Filed: November 25, 2019
    Publication date: June 3, 2021
    Applicant: WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION
    Inventor: Alfred H. STILLER
  • Patent number: 10993935
    Abstract: Methods of treating a bacterial lung infection are provided and comprise administering an effective amount of rifaximin to a subject in need thereof. The rifaximin can be delivered by inhalation therapy, such as by delivering the rifaximin in aerosol form. The rifaximin is administered alone or in combination with tobramycin, including in multiple doses. Methods of reducing biofilm formation are also provided and comprise contacting a bacteria with an effective amount of rifaximin. Pharmaceutical composition are also included and comprise rifaximin and a pharmaceutically-acceptable vehicle suitable for administering the rifaximin in aerosol form.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: May 4, 2021
    Assignee: MARSHALL UNIVERSITY RESEARCH CORPORATION
    Inventors: Hongwei Yu, Thomas Ryan Withers, Brandon Kirby
  • Patent number: 10973867
    Abstract: Methods for treating retinopathy are provided and include administering an effective amount of a polypeptide antagovist of a Na/K ATPase/Src receptor complex to a subject. The retinopathy can include diabetic retinopathy. Methods of decreasing angiogenesis in a retinal vasculature are also provided and include the step of administering, such as by intravitreous injection, a polypeptide antagonist of a Na/K ATPase/Src receptor complex to a subject in need thereof.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: April 13, 2021
    Assignee: MARSHALL UNIVERSITY RESEARCH CORPORATION
    Inventors: Zijian Xie, Joseph I. Shapiro
  • Patent number: 10906807
    Abstract: A method for producing elemental carbon and hydrogen gas directly from a hydrocarbon (for example, natural gas or methane) using a chemical reaction or series of reactions. In an aspect, other materials involved such as, for example, elemental magnesium, remain unchanged and function as a catalyst.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: February 2, 2021
    Assignee: West Virginia University Research Corporation
    Inventor: Alfred H. Stiller
  • Patent number: 10806819
    Abstract: A wound covering is provided that comprises a substrate and vitamin D, or analogues or metabolites thereof, embedded in the substrate. Methods of making a wound covering are also provided and include the steps of providing a solution that includes a polymer; adding vitamin D, or analogues or metabolites thereof, to the solution to form a mixture; and forming one or more fibers from the mixture that are then embedded with the vitamin D, or analogues or metabolites thereof. Methods of treating a subject are further provided and include the step of applying a wound covering including one or more fibers embedded with vitamin D, or analogues or metabolites thereof, to a site on a subject.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: October 20, 2020
    Assignee: MARSHALL UNIVERSITY RESEARCH CORPORATION
    Inventor: Franklin D. Shuler
  • Patent number: 10781431
    Abstract: Non-naturally occurring peptides are provided that act as a Src SH2 domain antagonist of cardiotonic steroids. Pharmaceutical compositions comprising the peptides are also provided along with vectors encoding the peptides. Methods of treating a Src-associated disease and reducing Src activity in a cell are further provided and include administering or contacting a cell with an effective amount of the peptide.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: September 22, 2020
    Assignee: MARSHALL UNIVERSITY RESEARCH CORPORATION
    Inventors: Zijian Xie, Moumita Banerjee
  • Patent number: 10696555
    Abstract: The disclosure provides for methods of oxidizing carbide anions, or negative ions, from salt like carbides at low temperatures below about 600° C. In another aspect, the disclosure provides for reactions with intermediate transition metal carbides. In yet another aspect, the disclosure provides for a system of reactions where salt-like carbide anions and intermediate carbide anions are oxidized to produce pure carbon of various allotropes.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: June 30, 2020
    Assignee: WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION
    Inventor: Alfred H. Stiller
  • Patent number: 10494264
    Abstract: The disclosure provides for methods of oxidizing carbide anions, or negative ions, from salt like carbides at temperatures from about 150° C. to about 750° C. In another aspect, the disclosure provides for reactions with intermediate transition metal carbides. In yet another aspect, the disclosure provides for a system of reactions where salt-like carbide anions and intermediate carbide anions are oxidized to produce pure carbon of various allotropes.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: December 3, 2019
    Assignee: West Virginia University Research Corporation
    Inventor: Alfred H. Stiller
  • Patent number: 10398732
    Abstract: Compositions and methods for treating striated muscle injury, treating striated muscle atrophy, and/or for promoting striated muscle growth are provided and include administering zinc oxide nanoparticles to a subject in need thereof. The zinc oxide nanoparticles can be adminstered before, during, and/or after exposure to an injurious stimuli, such as radiation. Administration of the zinc oxide nanoparticles reduces activation of autophagy regulators, increases striated muscle anabolism, increases DNA repair signaling, and/or increases striated muscle protein synthesis and growth.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: September 3, 2019
    Assignee: MARSHALL UNIVERSITY RESEARCH CORPORATION
    Inventors: Miaozong Wu, Cuifen Wang, Eric Blough
  • Patent number: 10207922
    Abstract: A method for producing elemental carbon and hydrogen gas directly from a hydrocarbon (for example, natural gas or methane) using a chemical reaction or series of reactions. In an aspect, other materials involved such as, for example, elemental magnesium, remain unchanged and function as a catalyst.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: February 19, 2019
    Assignee: WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION
    Inventor: Alfred H. Stiller
  • Patent number: 10144648
    Abstract: The disclosure provides for methods of oxidizing carbide anions, or negative ions, from salt like carbides at low temperatures below about 600° C. In another aspect, the disclosure provides for reactions with intermediate transition metal carbides. In yet another aspect, the disclosure provides for a system of reactions where salt-like carbide anions and intermediate carbide anions are oxidized to produce pure carbon of various allotropes.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: December 4, 2018
    Assignee: WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION
    Inventor: Alfred H. Stiller
  • Patent number: 10059700
    Abstract: A supported catalyst for aldehyde coupling reaction, comprising a carrier having supported thereon a catalyst comprising at least one azolium compound selected from the group consisting of a thiazolium salt, an imidazolium salt, a benzimidazolium salt and a triazolium salt, the azolium compound having, at a nitrogen atom thereof, a substituent selected from the group consisting of an aliphatic group having 6 or more carbon atoms and an aromatic group having 6 or more carbon atoms.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: August 28, 2018
    Assignees: SEKISUI CHEMICAL CO., LTD., COLORADO STATE UNIVERSITY RESEARCH CORPORATION
    Inventors: Eugene Y. X. Chen, Lu Wang, Yuji Eguchi
  • Patent number: 10035709
    Abstract: The disclosure provides for methods of oxidizing carbide anions, or negative ions, from salt like carbides at temperatures from about 150° C. to about 750° C. In another aspect, the disclosure provides for reactions with intermediate transition metal carbides. In yet another aspect, the disclosure provides for a system of reactions where salt-like carbide anions and intermediate carbide anions are oxidized to produce pure carbon of various allotropes.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: July 31, 2018
    Assignee: WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION
    Inventor: Alfred H. Stiller
  • Patent number: 9909222
    Abstract: Method comprising providing at least one solid carbide chemical compound and reducing a metal cation with use of the solid carbide chemical compound. A method comprising producing elemental carbon material from the oxidation of carbide in at least one carbide chemical compound (e.g., calcium carbide) in at least one anode of an electrochemical cell apparatus, such as a galvanic cell apparatus. The cathode can be a variety of metals such as zinc or tin. The reaction can be carried out at room temperature and normal pressure. An external voltage also can be applied, and different forms of carbon can be produced depending on the reactants used and voltage applied. For carrying out the method, an apparatus comprising at least one galvanic cell comprising: at least one anode comprising at least one carbide chemical compound, and at least one cathode.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: March 6, 2018
    Assignee: WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION
    Inventors: Alfred H. Stiller, Christopher L. Yurchick
  • Patent number: 9832851
    Abstract: The optical resonator as intends to generate coherent X-ray by irradiation of polarized laser interference fringes with electron beam has been unknown. The present invention provides an optical resonator that is capable of preparing polarization laser, polarization X-ray and coherent X-ray. The optical resonator is characterized by comprising an optical resonator that is capable of circulating two or more polarization lasers and irradiation of the polarization lasers with electron beam introduced by an electron beam feed port which is inserted in the intersection of laser paths inside the optical resonator.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: November 28, 2017
    Assignee: INTER-UNIVERSITY RESEARCH CORPORATION HIGH ENERGY ACCELERATOR RESEARCH ORGANIZATION
    Inventors: Junji Urakawa, Yosuke Honda
  • Patent number: 9764958
    Abstract: The disclosure provides for methods of oxidizing carbide anions, or negative ions, from salt like carbides at temperatures from about 150° C. to about 750° C. In another aspect, the disclosure provides for reactions with intermediate transition metal carbides. In yet another aspect, the disclosure provides for a system of reactions where salt-like carbide anions and intermediate carbide anions are oxidized to produce pure carbon of various allotropes.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 19, 2017
    Assignee: WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION
    Inventor: Alfred Stiller
  • Patent number: 9707304
    Abstract: The subject invention provides materials and methods useful in safely and effectively preventing pathological proliferation of blood vessels. The prevention of the over-proliferation of blood vessels according to the subject invention is particularly advantageous for treatment of certain ocular conditions including age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and diabetic retinopathy. In preferred embodiments, the subject invention provides materials and methods for effective treatment of pathological ocular neovascularization using gene therapy. In a specific embodiment the materials and methods of the subject invention can be used to treat AMD.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: July 18, 2017
    Assignee: FLORIDA ATLANTIC UNIVERSITY RESEARCH CORPORATION
    Inventors: Janet C. Blanks, Howard M. Prentice, C. Kathleen Dorey