Patents Assigned to University Research Corporation
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Patent number: 10696555Abstract: The disclosure provides for methods of oxidizing carbide anions, or negative ions, from salt like carbides at low temperatures below about 600° C. In another aspect, the disclosure provides for reactions with intermediate transition metal carbides. In yet another aspect, the disclosure provides for a system of reactions where salt-like carbide anions and intermediate carbide anions are oxidized to produce pure carbon of various allotropes.Type: GrantFiled: September 24, 2018Date of Patent: June 30, 2020Assignee: WEST VIRGINIA UNIVERSITY RESEARCH CORPORATIONInventor: Alfred H. Stiller
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Patent number: 10494264Abstract: The disclosure provides for methods of oxidizing carbide anions, or negative ions, from salt like carbides at temperatures from about 150° C. to about 750° C. In another aspect, the disclosure provides for reactions with intermediate transition metal carbides. In yet another aspect, the disclosure provides for a system of reactions where salt-like carbide anions and intermediate carbide anions are oxidized to produce pure carbon of various allotropes.Type: GrantFiled: June 28, 2018Date of Patent: December 3, 2019Assignee: West Virginia University Research CorporationInventor: Alfred H. Stiller
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Patent number: 10398732Abstract: Compositions and methods for treating striated muscle injury, treating striated muscle atrophy, and/or for promoting striated muscle growth are provided and include administering zinc oxide nanoparticles to a subject in need thereof. The zinc oxide nanoparticles can be adminstered before, during, and/or after exposure to an injurious stimuli, such as radiation. Administration of the zinc oxide nanoparticles reduces activation of autophagy regulators, increases striated muscle anabolism, increases DNA repair signaling, and/or increases striated muscle protein synthesis and growth.Type: GrantFiled: October 13, 2017Date of Patent: September 3, 2019Assignee: MARSHALL UNIVERSITY RESEARCH CORPORATIONInventors: Miaozong Wu, Cuifen Wang, Eric Blough
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Patent number: 10207922Abstract: A method for producing elemental carbon and hydrogen gas directly from a hydrocarbon (for example, natural gas or methane) using a chemical reaction or series of reactions. In an aspect, other materials involved such as, for example, elemental magnesium, remain unchanged and function as a catalyst.Type: GrantFiled: January 25, 2017Date of Patent: February 19, 2019Assignee: WEST VIRGINIA UNIVERSITY RESEARCH CORPORATIONInventor: Alfred H. Stiller
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Patent number: 10144648Abstract: The disclosure provides for methods of oxidizing carbide anions, or negative ions, from salt like carbides at low temperatures below about 600° C. In another aspect, the disclosure provides for reactions with intermediate transition metal carbides. In yet another aspect, the disclosure provides for a system of reactions where salt-like carbide anions and intermediate carbide anions are oxidized to produce pure carbon of various allotropes.Type: GrantFiled: June 9, 2017Date of Patent: December 4, 2018Assignee: WEST VIRGINIA UNIVERSITY RESEARCH CORPORATIONInventor: Alfred H. Stiller
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Patent number: 10059700Abstract: A supported catalyst for aldehyde coupling reaction, comprising a carrier having supported thereon a catalyst comprising at least one azolium compound selected from the group consisting of a thiazolium salt, an imidazolium salt, a benzimidazolium salt and a triazolium salt, the azolium compound having, at a nitrogen atom thereof, a substituent selected from the group consisting of an aliphatic group having 6 or more carbon atoms and an aromatic group having 6 or more carbon atoms.Type: GrantFiled: May 31, 2016Date of Patent: August 28, 2018Assignees: SEKISUI CHEMICAL CO., LTD., COLORADO STATE UNIVERSITY RESEARCH CORPORATIONInventors: Eugene Y. X. Chen, Lu Wang, Yuji Eguchi
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Patent number: 10035709Abstract: The disclosure provides for methods of oxidizing carbide anions, or negative ions, from salt like carbides at temperatures from about 150° C. to about 750° C. In another aspect, the disclosure provides for reactions with intermediate transition metal carbides. In yet another aspect, the disclosure provides for a system of reactions where salt-like carbide anions and intermediate carbide anions are oxidized to produce pure carbon of various allotropes.Type: GrantFiled: June 9, 2017Date of Patent: July 31, 2018Assignee: WEST VIRGINIA UNIVERSITY RESEARCH CORPORATIONInventor: Alfred H. Stiller
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Patent number: 9909222Abstract: Method comprising providing at least one solid carbide chemical compound and reducing a metal cation with use of the solid carbide chemical compound. A method comprising producing elemental carbon material from the oxidation of carbide in at least one carbide chemical compound (e.g., calcium carbide) in at least one anode of an electrochemical cell apparatus, such as a galvanic cell apparatus. The cathode can be a variety of metals such as zinc or tin. The reaction can be carried out at room temperature and normal pressure. An external voltage also can be applied, and different forms of carbon can be produced depending on the reactants used and voltage applied. For carrying out the method, an apparatus comprising at least one galvanic cell comprising: at least one anode comprising at least one carbide chemical compound, and at least one cathode.Type: GrantFiled: October 19, 2015Date of Patent: March 6, 2018Assignee: WEST VIRGINIA UNIVERSITY RESEARCH CORPORATIONInventors: Alfred H. Stiller, Christopher L. Yurchick
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Patent number: 9832851Abstract: The optical resonator as intends to generate coherent X-ray by irradiation of polarized laser interference fringes with electron beam has been unknown. The present invention provides an optical resonator that is capable of preparing polarization laser, polarization X-ray and coherent X-ray. The optical resonator is characterized by comprising an optical resonator that is capable of circulating two or more polarization lasers and irradiation of the polarization lasers with electron beam introduced by an electron beam feed port which is inserted in the intersection of laser paths inside the optical resonator.Type: GrantFiled: December 4, 2014Date of Patent: November 28, 2017Assignee: INTER-UNIVERSITY RESEARCH CORPORATION HIGH ENERGY ACCELERATOR RESEARCH ORGANIZATIONInventors: Junji Urakawa, Yosuke Honda
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Patent number: 9764958Abstract: The disclosure provides for methods of oxidizing carbide anions, or negative ions, from salt like carbides at temperatures from about 150° C. to about 750° C. In another aspect, the disclosure provides for reactions with intermediate transition metal carbides. In yet another aspect, the disclosure provides for a system of reactions where salt-like carbide anions and intermediate carbide anions are oxidized to produce pure carbon of various allotropes.Type: GrantFiled: March 14, 2014Date of Patent: September 19, 2017Assignee: WEST VIRGINIA UNIVERSITY RESEARCH CORPORATIONInventor: Alfred Stiller
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Patent number: 9707304Abstract: The subject invention provides materials and methods useful in safely and effectively preventing pathological proliferation of blood vessels. The prevention of the over-proliferation of blood vessels according to the subject invention is particularly advantageous for treatment of certain ocular conditions including age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and diabetic retinopathy. In preferred embodiments, the subject invention provides materials and methods for effective treatment of pathological ocular neovascularization using gene therapy. In a specific embodiment the materials and methods of the subject invention can be used to treat AMD.Type: GrantFiled: December 15, 2015Date of Patent: July 18, 2017Assignee: FLORIDA ATLANTIC UNIVERSITY RESEARCH CORPORATIONInventors: Janet C. Blanks, Howard M. Prentice, C. Kathleen Dorey
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Patent number: 9701539Abstract: The disclosure provides for methods of oxidizing carbide anions, or negative ions, from salt like carbides at low temperatures below about 600° C. In another aspect, the disclosure provides for reactions with intermediate transition metal carbides. In yet another aspect, the disclosure provides for a system of reactions where salt-like carbide anions and intermediate carbide anions are oxidized to produce pure carbon of various allotropes.Type: GrantFiled: March 14, 2014Date of Patent: July 11, 2017Assignee: WEST VIRGINIA UNIVERSITY RESEARCH CORPORATIONInventor: Alfred Stiller
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Patent number: 9669055Abstract: Methods for treating sepsis are provided and include the administration an effective amount of cerium oxide nanoparticles to a subject in need thereof. The sepsis being treated can include polymicrobial sepsis and can include the administration of about 0.1 mg/kg to about 1.0 mg/kg of the cerium oxide nanoparticles. The administration of the cerium oxide nanoparticles further allows one or more of the symptoms of sepsis to be treated. Methods of treating an inflammatory disorder that make use of cerium oxide nanoparticles are further provided.Type: GrantFiled: April 13, 2015Date of Patent: June 6, 2017Assignee: Marshall University Research CorporationInventors: Eric Blough, Nandini Manne, Selvaraj Vellaisamy
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Patent number: 9655995Abstract: Compositions are provided comprising a nanofiber scaffold that is seeded with one or more relevant cells and has a basketweave configuration that mimics the structure of a tissue, such as a cardiac tissue. Methods for treating damaged cardiac tissue in a subject are also provided and include applying an effective amount of the composition to damaged cardiac tissue. Methods for making nanofiber scaffold compositions are further provided and include electrospinning a biodegradable polymer onto a mandrel to create a mat of electrospun nanofibers, dividing the mat into nanofiber strips; and weaving the strips into a nanofiber scaffold having a basketweave configuration that mimics the structure of a tissue.Type: GrantFiled: January 16, 2013Date of Patent: May 23, 2017Assignee: Marshall University Research CorporationInventor: Jingwei Xie
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Patent number: 9316632Abstract: Methods for selecting chemotherapeutic agents for treating a cancer are provided that include the steps of providing a cancer cell sample having a population of bulk cancer cells and a population of cancer stem-like cells, culturing a first portion of the cancer cell sample in a hydrodynamic focusing bioreactor under microgravity conditions and for a period of time to selectively enhance the population of cancer stem-like cells and selectively kill the population of bulk cancer cells, contacting the cancer stem-like cells with one or more chemotherapeutic agents, and then selecting the one or more chemotherapeutic agents for treating the cancer if there is an increase in an amount of cytotoxicity. Methods for treating a cancer are also provided in which the identified chemotherapeutic agents are administered to a subject. Further provided are methods for identifying a test compound useful for treating a cancer.Type: GrantFiled: March 19, 2013Date of Patent: April 19, 2016Assignee: MARSHALL UNIVERSITY RESEARCH CORPORATIONInventors: Pier Paolo Claudio, Jagan Valluri
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Patent number: 9175322Abstract: Methods for mass producing bacterial alginate, bacterial cultures for producing alginate, and pharmaceutical compositions containing bacterial alginate are contemplated.Type: GrantFiled: April 29, 2009Date of Patent: November 3, 2015Assignee: Marshall University Research CorporationInventors: Hongwei D. Yu, Dongru Qiu, F. Heath Damron
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Patent number: 8993231Abstract: The present invention relates to methods for rapidly expanding a stem cell population with or without culture supplements in simulated microgravity conditions. The present invention relates to methods for rapidly increasing the life span of stem cell populations without culture supplements in simulated microgravity conditions. The present invention also relates to methods for increasing the sensitivity of cancer stem cells to chemotherapeutic agents by culturing the cancer stem cells under microgravity conditions and in the presence of omega-3 fatty acids. The methods of the present invention can also be used to proliferate cancer cells by culturing them in the presence of omega-3 fatty acids. The present invention also relates to methods for testing the sensitivity of cancer cells and cancer stem cells to chemotherapeutic agents by culturing the cancer cells and cancer stem cells under microgravity conditions.Type: GrantFiled: March 17, 2009Date of Patent: March 31, 2015Assignee: Marshall University Research CorporationInventors: Pier Paolo Claudio, Jagan V. Valluri
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Patent number: 8986982Abstract: A thermal cycle system and method suitable for mass production of DNA comprising a temperature control body having at least two sectors. Each sector has at least one heater, cooler, or other means for changing temperature. A path traverses the sectors in a cyclical fashion. In use, a piece of tubing or other means for conveying is placed along the path and a reaction mixture is pumped or otherwise moved along the path such that the reaction mixture is repetitively heated or cooled to varying temperatures as the reaction mixture cyclically traverses the sectors. The reaction mixture thereby reacts to form a product. In particular, polymerase chain reaction reactants may continuously be pumped through the tubing to amplify DNA. The temperature control body is preferably a single aluminum cylinder with a grooved channel circling around its exterior surface, and preferably has wedge-shaped or pie-shaped sectors separated by a thermal barrier.Type: GrantFiled: September 19, 2012Date of Patent: March 24, 2015Assignee: Marshall University Research CorporationInventors: Derek A. Gregg, Elizabeth E. Murray, Michael L. Norton, Justin T. Swick, Herbert Tesser
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Publication number: 20150080458Abstract: The subject invention provides materials and methods useful in safely and effectively preventing pathological proliferation of blood vessels. The prevention of the over-proliferation of blood vessels according to the subject invention is particularly advantageous for treatment of certain ocular conditions including age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and diabetic retinopathy. In preferred embodiments, the subject invention provides materials and methods for effective treatment of pathological ocular neovascularization using gene therapy. In a specific embodiment the materials and methods of the subject invention can be used to treat AMD.Type: ApplicationFiled: July 18, 2014Publication date: March 19, 2015Applicant: FLORIDA ATLANTIC UNIVERSITY RESEARCH CORPORATIONInventors: Janet C. Blanks, Howard M. Prentice, C. Kathleen Dorey
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Publication number: 20140271441Abstract: The disclosure provides for methods of oxidizing carbide anions, or negative ions, from salt like carbides at low temperatures below about 600° C. In another aspect, the disclosure provides for reactions with intermediate transition metal carbides. In yet another aspect, the disclosure provides for a system of reactions where salt-like carbide anions and intermediate carbide anions are oxidized to produce pure carbon of various allotropes.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: West Virginia University Research CorporationInventor: Alfred STILLER