Abstract: An object of the present invention is to provide a novel therapeutic or preventive agent for human T cell leukemia virus type-1 associated myelopathy (HAM) containing an anti-human CC-chemokine receptor 4 (CCR4) antibody or an antibody fragment thereof as an active ingredient, and characterized by the administration and dosage of the antibody or the antibody fragment thereof. The present invention relates to a therapeutic or preventative agent for HAM characterized in that an anti-human CCR4 antibody or an antibody fragment thereof is contained as an active ingredient and the antibody or the antibody fragment thereof is administered at a low dose.

Abstract: A system and method of illuminating one or more foot pedals with an optically brightened layer positioned to fluoresce responsive to activation of one or more ultraviolet (UV) illuminating devices positioned adjacent or attached to the one or more foot pedals. The optically brightened layer may include an optically brightened coating covering at least a portion of each of the one or more foot pedals, or may include an optically brightened material layer positioned to cover and protect each of the one or more foot pedals from debris or moisture during use. A friction portion may be attached to the optically brightened material layer, the friction portion being positioned adjacent a lower surface of the foot pedal when the optically brightened material layer surrounds the foot pedal, the friction portion being configured to prevent sliding of the foot pedal against the floor or other surface.

Abstract: The present invention provides a pharmaceutical composition containing an inhibitor selected from the group consisting of an EZH1 inhibitor, an EZH2 inhibitor and an EZH1/2 dual inhibitor as an active ingredient, for use in treating HTLV-1-associated myelopathy. The present invention provides a pharmaceutical composition for use in treating HTLV-1-associated myelopathy, containing a 1,3-benzodioxole derivative or a pharmaceutically acceptable salt thereof.

Abstract: An instrument for fixedly transplanting a living body embryo into a uterus has an instrument, for transplanting the living body embryo into the uterus, which is to be inserted into a uterus and a magnetic embryo accommodation container holding instrument (transferred embryo fixing instrument) to be attached to the living body. The instrument for transplanting the living body embryo into the uterus has an embryo accommodation container having an embryo accommodation part having an embryo insertion portion communicating with outside and a magnetic material and a shaft-shaped container transfer tool for separably holding the embryo accommodation container at its distal end portion. The magnetic container holding instrument has an attaching part to be attached to an epidermis of the living body and a magnet capable of attracting the magnetic material of the embryo accommodation container thereto.

Abstract: A system and method of illuminating one or more foot pedals with an optically brightened layer positioned to fluoresce responsive to activation of one or more ultraviolet (UV) illuminating devices positioned adjacent or attached to the one or more foot pedals. The optically brightened layer may include an optically brightened coating covering at least a portion of each of the one or more foot pedals, or may include an optically brightened material layer positioned to cover and protect each of the one or more foot pedals from debris or moisture during use. A friction portion may be attached to the optically brightened material layer, the friction portion being positioned adjacent a lower surface of the foot pedal when the optically brightened material layer surrounds the foot pedal, the friction portion being configured to prevent sliding of the foot pedal against the floor or other surface.

Abstract: An inattention measurement device, system, and method wherein an index value indicating an inattention level of a subject is calculated based on information relating to a history of a gazing point of a subject when presented with a task of searching for a prescribed target.

Abstract: A kit for performing a reduced radiation percutaneous procedure is provided. The kit includes a needle access device having a needle connected to a hub portion having an opaque cap portion, a non-opaque body portion positioned between the opaque cap portion and the needle, and a channel extending through the opaque cap portion; a sticker having an adhesive side adapted to adhere to the skin of a patient, and a display surface opposite the adhesive side configured to enhance visualization of the sticker in low light; and a guidewire having a floppy portion with a distal end, an intermediate region connected to the floppy portion, such that the intermediate region is less floppy than the floppy portion; and an ultrasonic-profile-enhancing feature disposed within 3 centimeters of the distal end of the floppy portion.

Abstract: A system and method of illuminating a foot pedal with an illuminated protective covering. The illuminated protective covering can include a plurality of illuminating devices surrounding at least a majority of a perimeter of the foot pedal. The illuminated protective covering can also include a sheet surrounding the upper surface and the lower surface of the foot pedal and the plurality of illuminating devices, the sheet being configured to protect the foot pedal from debris during use. A friction portion can be attached to the sheet, the friction portion being positioned on the sheet such that the friction portion is adjacent the bottom surface of the foot pedal when the sheet surrounds the foot pedal, the friction portion being configured to prevent sliding of the foot pedal against the floor or other surface.

Abstract: The invention provides novel compounds and methods of using such compounds to treat or prevent cancer.

Abstract: Provided is a luminous, apparatus such as a display, having a function of preventing attraction of insects. A display apparatus 1 has a light emission surface 1 whose peripheral edge region is at least partially formed as a low-attraction region which is less capable of attracting bugs, wherein the low-attraction region is composed of an optical property gradient region whose at least one optical property gradually changes in a direction from an inward side to an outward side of the light emission surface.

Abstract: Provided are uses of Bacteroides in preparation of a medicament. The medicament is for use in treatment or prevention of obesity and obesity-related diseases. Also provided are a pharmaceutical composition, a medicament, a food product, and an animal feed that comprise Bacteroides, uses thereof in treatment or prevention of obesity and obesity-related diseases, and a method for treatment or prevention of obesity and obesity-related diseases.

Abstract: A biological measurement device includes a probe including a contact surface that includes a plurality of light input portions that input light to a measurement target part and a plurality of light receiving portions that receive measurement light output from the measurement target part, the contact surface being pressed against the measurement target part, and a calculation unit that calculates internal information on the basis of a result of detecting the measurement light obtained for each combination of the light input portion and the light receiving portion, wherein the plurality of light input portions and the plurality of light receiving portions constitute lattices having an interval d in a first direction and a second direction orthogonal to each other on the contact surface.

Abstract: The present invention can provide a controlled drug release carrier formed by using a silk fibroin porous material, which has high drug controlled release rate, controllability of the drug controlled release speed, high strength, easy handleability, skin care properties from high biocompatibility, high water retentivity, and capability of efficiently retaining a drug.

Abstract: Surgical tools for use during scarless or near scarless surgical procedures. At least some of the surgical tools can include a handle portion and a working end removably connected to the handle portion.

Abstract: The object of the present invention is to provide a new therapeutic method and a new therapeutic agent that are different from known therapeutic medicines for human T cell leukemia virus type-1 (also known as human T lymphotropic virus type-1) associated myelopathy (HAM) patients and asymptomatic HTLV-1 carriers. The present invention relates to a therapeutic method and a therapeutic agent for human T cell leukemia virus type-1 (HTLV-1) associated myelopathy (HAM) patients and asymptomatic HTLV-1 carriers (ACs), which is characterized by reducing HTLV-1 virus-infected cells using an anti-human CC-chemokine receptor 4 (CCR4) antibody.

Abstract: A cell observation system observes a cell moving in a flow path with a fluid, and includes a first observation apparatus, a second observation apparatus, and a control device. The first observation apparatus includes an objective lens and a line camera. The second observation apparatus includes an objective lens and an area camera. The control device analyzes first imaging data output from the first observation apparatus to determine whether the cell satisfies a specific condition, instructs the area camera to output second imaging data of the cell determined to satisfy the specific condition, and analyzes the second imaging data output from the second observation apparatus to determine whether the cell is a specific cell.

Abstract: The identification apparatus includes a quantitative phase image acquisition unit, a feature quantity extraction unit, a learning unit, a storage unit, and an identification unit. The feature quantity extraction unit extracts a feature quantity of a quantitative phase image of a cell. The learning unit performs machine learning for a quantitative phase image of a known cell of which a type is known based on the feature quantity extracted by the extraction unit. The storage unit stores a result of the machine learning by the learning unit. The identification unit determines, based on the feature quantity extracted by the extraction unit for the quantitative phase image of an unknown cell of which a type is unknown, the type of the unknown cell using the learning result stored by the storage unit.

Abstract: A system and method of illuminating a foot pedal with an illuminated protective covering. The illuminated protective covering can include a plurality of illuminating devices surrounding at least a majority of a perimeter of the foot pedal. The illuminated protective covering can also include a sheet surrounding the upper surface and the lower surface of the foot pedal and the plurality of illuminating devices, the sheet being configured to protect the foot pedal from debris during use. A friction portion can be attached to the sheet, the friction portion being positioned on the sheet such that the friction portion is adjacent the bottom surface of the foot pedal when the sheet surrounds the foot pedal, the friction portion being configured to prevent sliding of the foot pedal against the floor or other surface.

Abstract: Surgical tools for use during scarless or near scarless surgical procedures. At least some of the surgical tools can include a handle portion and a working end removably connected to the handle portion.

Abstract: A fluorescence detection device comprises: a plurality of light sources that apply an excitation light from an outside of a living body toward fluorescent dye previously injected into the living body; and a plurality of detectors that detect fluorescence emitted from the fluorescent dye by the excitation light, and output the detected fluorescence as an electric signal. The plurality of light sources and the plurality of detectors are arranged in at least one line. At least one detector is placed between two light sources, and at least one light source is placed between two detectors.