Abstract: Small molecule compounds and corresponding dimers having inhibitory activity against pre-miR-21 RNA and related methods for treatment of neoplastic disease such as cancer and especially cancers expressing miR-21 are disclosed.

Abstract: Aspects of the disclosure relate to compositions and methods of treating certain genetic disease (e.g., Neurofibromatosis type I) by delivering functional neurofibromin 1(NF1) protein (e.g., mini-NF1 protein and/or full-length NF1 protein) to target cell (e.g., cells and/or tissue of a subject). The disclosure is based, in part, on isolated nucleic acids (e.g., rAAV vectors) and rAAVs engineered to express a functional NF1 protein (e.g., mini-NF1 protein and/or full-length NF1 protein) or variants thereof.

Abstract: A variable assembly PC member includes: a plurality of hollow PC modules, each of which has an upper flange and a lower flange spaced apart from each other, and a pair of webs connecting both ends of the upper flange and the lower flange to form a hollow therein; and connectors connecting the plurality of hollow PC modules with each other in the width direction.

Abstract: An apparatus includes a rotating pole, a first set of photovoltaic modules; and a second set of photovoltaic modules. At least one of the first set of photovoltaic modules is perpendicular to at least one of the second set of photovoltaic modules.

Abstract: A composite membrane with nanostructured inorganic and organic phases is applied as an ion-selective layer to prove processability, prevent dendrite shorting, and increase power output of lithium-metal anodes through better Li-ion conductivity. Nanoconfinement, as opposed to macroscale confinement, is known to dramatically alter the properties of bulk materials. Control over a ceramic's size, shape, and properties is achieved with polymer templates. This is a new composition of matter and unique approach to composite membrane design.

Abstract: This invention relates to compositions for use in the treatment of diabetes, for example type-2 diabetes; obesity; and/or metabolic syndrome. Specifically, the invention relates to a composition for use in the treatment of diabetes, the composition comprising at least one of diindolylmethane; indole-3-carbinol; embelin; [6]-gingerol; and [6]-shogaol, or combinations each thereof. Also disclosed is use in the treatment of obesity and use in the treatment of metabolic syndrome.

Abstract: Embodiments of the present disclosure provide a secure communication method, a client and a non-public server. The secure communication method includes: generating a set of destination addresses of a non-public server based on an IPv6 prefix of the non-public server, and a signature string and a user ID of a client, wherein the signature string is obtained by signing an IPv6 address and the user ID of the client based on a private key of the client; initiating a set of connection request to the non-public server based on a set of communication connections containing the set of destination addresses, for the non-public server to determine a public key corresponding to a user ID based on the user ID in the set of destination addresses, verifying the set of communication connections based on the public key, and establishing communication when the verification of the set of communication connections passes.

Abstract: The present invention relates to compositions and methods for promoting the degradation of misfolded proteins and protein aggregates. The compositions and methods may be used to treat a disorder associated with misfolded proteins or protein aggregates. In certain instances, the compositions and methods relate to modulators of one or more TRIM proteins or one or more STUbLs.

Abstract: The subject disclosure provides a simple, fast, and high-yield method for encapsulating solar cells. This method can produce an encapsulation of solar cell(s) that is flat, bubble-free, lightweight, and flexible. In addition, it can also reduce equipment and material costs.

Abstract: A matrix thruster that may be used to reposition and/or stabilize a CubeSAT satellite. The matrix thruster includes a conductive plate with an opening, a plurality of wires within the opening, a power supply electrically connected to the conductive plate or each of the plurality of wires via an inductor, and an electrical switch. The electrical switch creates a current change that creates an electric potential spike across the inductor. The electric potential spike across the inductor initiates an arc discharge between one of the wires and the conductive plate, which forms plasma that ejects cathode particles from the matrix thruster. Using multiple wires (e.g., four titanium wires) extends the lifetime of the thruster, as each wire restores an inter-electrode film needed for the other wires to continue generating plasma.

Abstract: A system and method of propagating signal links by using artificial neural networks using a relay link selection protocol to predict an optimal link or path, providing a reliable mechanism to meet 5G-new radio requirements. The artificial neural networks used in the method classify training and testing datasets into sufficient signal strengths and insufficient signal strengths, such that paths are evaluated for predicted propagation links, and such that the strongest propagation link can be selected. Specifically, a multilayer perceptron method is used to identify and characterize new link candidates using the path loss parameter or the received signal strength, such that optimal links can be selected and updated. To determine the sufficiency of a signal, a threshold energy strength is determined (for example, a threshold of ?120 dBm can be used; any energy strength below the threshold is considered a poor propagation and is classified as an insufficient signal).

Abstract: An end-to-end multimodal gait recognition method based on deep learning includes: first extracting gait appearance features (color, texture and the like) through RGB video frames, and obtaining a mask by semantic segmentation of the RGB video frames; then extracting gait mask features (contour and the like) through the mask; and finally performing fusion and recognition on the two kinds of features. The method is configured for extracting gait appearance feature and mask feature by improving GaitSet, improving semantic segmentation speed on the premise of ensuring accuracy through simplified FCN, and fusing the gait appearance feature and the mask feature to obtain a more complete information representation.

Abstract: The present disclosure relates to methods, devices, kits and systems for enhancing the efficacy and longevity of denervation procedures.

Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

Abstract: A system for breast computed tomography includes a table supporting a patient in a prone position with an opening positioned for a breast of the patient to extend downwards therethrough, a gantry assembly positioned beneath the table with a platform driven to rotate by a motor, an x-ray source assembly coupled to the platform to rotate therewith and positioned to irradiate with an x-ray beam at least a portion of the breast, and a detector assembly coupled to the platform to rotate therewith and positioned to receive the x-ray beam from the x-ray source assembly. The system includes a shielding enclosure rigidly mounted atop the platform to rotate therewith, enclosing during rotation of the platform the detector assembly, the breast, and the x-ray beam, and having walls composed of a material and a thickness to attenuate an x-ray beam of a predetermined energy and intensity by a predetermined amount.

Abstract: The present disclosure relates to a method and apparatus for phase unwrapping of an SAR interferogram based on an SAR offset tracking surface displacement model, in which the apparatus according to the present disclosure includes a Synthetic Aperture Radar (SAR) image acquisition unit that acquires two SAR images of a same object acquired at different times, a single look complex (SLC) image production unit that produces two SLC images corresponding to each of the two SAR images, an interferogram production unit that generates an SAR interferogram using SAR interferometry for the two SLC images, a surface displacement model production unit that produces an offset tracking surface displacement model using SAR offset tracking method for the two SLC images, an unwrapped residual interferogram generation unit that generates a residual interferogram by subtracting the SAR interferogram and the offset tracking surface displacement model, and generates an unwrapped residual interferogram by unwrapping the generated

Abstract: A flexible pavement structure comprises a surface layer, a base layer, a sub-base layer, and a subgrade layer. Herein, the surface layer is adjacent to and above the base layer, and the sub-base layer is adjacent to and above the subgrade layer. The flexible pavement structure further comprises a layered system composed of first, second, and third materials different from each other, and is disposed as an interface layer between the base layer and the sub-base layer. The first material is a geotextile fabric selected from a group consisting of polypropylene and polyethylene, providing ground stabilization or reinforcement properties. The second material is a waterproof heat insulation material selected from a group consisting of cross-linked polyethylene foam and laminated aluminum foil, providing waterproofing or impermeability properties. The third material is a glass foamed insulation material.

Abstract: Disclosed is a method for preparing nanoscale electrodes comprised of electrochemically grown noble metal nanowires, and use of the same for the detection of extremely small concentrations of molecules. Such nanoscale electrodes provide target molecule release information from submicron areas on the cell surface, significantly increasing the spatial resolution of the target molecule mapping of a cell surface to enable localization of target molecules on the cell surface, which can be critical for the detection of certain cells with different properties in a given group of cells, such as circulating tumor cells.

Abstract: A mechanical rotary steering drilling tool for steering a drill string includes a test section, a clutch device, a control mechanism, and an execution part. The test section is used as an upper joint in cooperation with the tool. The clutch device is externally connected with a guide body and internally coupled with a mandrel. A groove on a cylindrical surface of a switch control cylinder is matched with a control screw to determine rotation of a fluid channel switch. A pushing block of the execution part extends out against a wellbore wall to push a drill bit for steering drilling after the fluid channel is opened.

Abstract: With applications such as soft robotics being severely hindered by the lack of strong soft actuators, the invention provides a new soft-actuator material—Electrically Actuated Hydraulic Solid (EAHS) material—with a stress-density that outperforms any known electrically-actuatable material. One type of actuator is fabricated by making a closed cell that acts as highly paralyzed version of a standard paraffin actuator. Each cell exhibits microscopic expansion, which is summed to produce macroscopic motion. The closed cellular nature of the material allows the system to be cut and punctured and still operate. It can be produced in a lab or industrial scale, and can be formed using molding, 3D printing or cutting.