Abstract: Systems and methods to selectively protect therapeutic cells by reducing CD33 expression in the therapeutic cells using base editors and targeting non-therapeutic cells with an anti-CD33 therapy are described. The selective protection results in the enrichment of the therapeutic cells while simultaneously targeting any diseased, malignant and/or non-therapeutic CD33 expressing cells within a subject.

Abstract: Compositions, systems and methods for delivering CRISPR/Cas9-based genome editing system to a cell.

Abstract: Provided are scan device and method of diagnosing scan chain fault. The scan device for diagnosing a fault includes a scan partition including a plurality of scan chains which include path control scan flipflops connected to scan flipflops in cascade. In the scan partition, connection paths of the scan flipflops are controllable. The connection paths of the path control scan flipflops are controlled to detect a position of a fault such that a fault range in the scan partition is reduced to diagnose the fault.

Abstract: A composition comprising a compound of formula I: wherein n is 5, and R is methyl; and the composition is in an essentially guest-free solid form.

Abstract: The present invention provides an energy-storing temperature control material, and belongs to the technical field of temperature control materials. In the energy-storing temperature control material provided in the present invention, the organic synthetic fiber based phase-change material has a three-dimensional dispersion effect, and can form a network constraint for remaining phase-change materials to reinforce mechanical properties of the materials, thereby fixing shapes of the materials and avoiding a liquid-crystal phase separation phenomenon in the phase-change process. The phase-change energy storage agent can absorb and release the heat by means of solid-liquid phase conversion of the material, to achieve the temperature control effect; and the phase-change temperature regulator can regulate a phase-change temperature range of the phase-change material, to make the energy-storing temperature control material suitable for climatic features of northern China.

Abstract: Systems and methods are provided for controlling heat stress and accumulations in livestock using the application of water sprays onto the animal in conjunction with fan induced airflow. The system has a controller with sensor inputs of the ambient environment including temperature, humidity, wind speed, and surrounding surface temperature sensors and fan and spray control outputs. To achieve savings in water and electricity, a transient, one-dimensional simultaneous heat and mass transfer model of evaporation within the wetted fur layer of a dairy cow is used to estimate drying time and heat rejection rate based on ambient conditions along with a control algorithm to predict the fan speed and sprinkler operation frequency needed to meet specified cooling load thresholds given the outdoor conditions. Estimated savings demonstrated that the model-based controller could reduce annual electricity and water consumption by 20% and 40%, respectively.

Abstract: A method is described for determining the structure of a surfactant complex formed at an immiscible liquid-liquid interface. The surfactant complex forms and crystallizes at the interface between an aqueous phase comprising a divalent metal salt and a non-aqueous phase comprising an anionic surfactant. The non-aqueous phase may be in the form of a droplet surrounded by the aqueous phase. The structure of the surfactant complex is determined by X-ray crystallography.

Abstract: Provided herein, inter alia, are methods and compositions for identifying major histocompatibility class II (MEW II) complex binding peptides.

Abstract: This present invention is directed to variable affinity chromatography apparatus and methods for using the same. In particular, the polarity of the stationary phase or the mobile phase is modulated using an external stimulus. Exemplary external stimulus that can be used in the invention include, but are not limited to, electric field, electromagnetic radiation including UV, Vis, and infrared wavelengths, as well other stimuli that are known to one skilled in the art. Generally, any external stimulation that changes the polarity of a stimulus responsive material can be used.

Abstract: The present invention relates to a method for calculating a time history wind load in accordance with correlation, the method in which an artificial time history load close to reality can be generated without relying on a wind tunnel test, by applying the correlation between wind loads in two directions and adjusting the ratio of a maximum value of any one wind load relative to a maximum value of the other wind load.

Abstract: A compound comprising a first ligand LA, where LA comprises a structure of Formula I, is provided. In Formula I, each of X1, X2, X3, and X4 represents CR, CRR?, NR, or N; Y is selected from a linking group; each of R, R?, R?, R1, R1?, R2, R2?, R3, R3?, R4, and R4? is hydrogen or a substituent; each represents a single bond or a double bond; any two adjacent substituents may be joined or fused to form a ring; two adjacent ones of R1, R2, R3, and R4 are joined together to form a fused 5-membered heterocyclic ring, Ring A, while the remaining two of R1, R2, R3, and R4 cannot be joined to form an aromatic ring; and Ring A is joined to a metal M by a direct bond. Formulations, OLEDs, and consumer products comprising the compound are also provided.

Abstract: Provided herein are methods for the treatment of polycystic kidney disease, including autosomal dominant polycystic kidney disease, using modified oligonucleotides targeted to miR-17.

Abstract: Transient molecules in the gastrointestinal (GI) tract, such as nitric oxide and hydrogen sulfide, are important signals and mediators of inflammatory bowel disease (IBD). Because these molecules may be short-lived in the body, they are difficult to detect. To track these reactive molecules in the GI tract, a miniaturized device has been developed that integrates genetically engineered probiotic biosensors with a custom-designed photodetector and readout chip. Leveraging the molecular specificity of living sensors, bacteria were genetically encoded to respond to IBD-associated molecules by luminescing. Low-power electronic readout circuits (e.g., using nanowatt power) integrated into the device convert the light from just 1 ?L of bacterial culture into a wireless signal. Biosensor monitoring was demonstrated in the GI tract of small and large animal models and integration of all components into a sub-1.4 cm3 ingestible form factor capable of supporting wireless communication.

Abstract: Described herein are kits and methods for quantifying the amount of at least one nucleic acid of interest in a sample. The kits include a mixture of synthetic spike-in internal standards (IS) reagents, where the spike-in IS reagents comprise a complexity calibration ladder (CCL) that includes synthetic internal standard competitors for at least one target gene.

Abstract: A high-temperature and high-pressure equipment and method for microscopic visual sulfur deposit seepage test is provided by the present disclosure, the equipment comprises an injection system, a high-temperature and high-pressure visual kettle, a pressure supply system, a data acquisition and analysis system, a fluid recovery system, and an injection branch pipe; the injection system comprises an ISCo micro-injection pump, an intermediate container, a thermostatic heating oven and a pressure meter; the intermediate container is arranged in the thermostatic heating oven, the ISCo micro-injection pump is connected to the intermediate container; the data acquisition and analysis system comprises a microscope, a high-brightness light source and a computer; the pressure supply system comprises an annular pressure tracking pump, a back pressure pump, a back pressure valve and a pressure gauge; the fluid recovery system comprises a wide neck flask with rubber stopper, a balance, a flowmeter and an exhaust gas absorb

Abstract: A magnetic logic device having two magnetic elements and a conductive element coupled to the two magnetic elements and arranged at least substantially perpendicular to the magnetic elements, wherein the device is configured, for each magnetic element, to have a magnetisation state with a perpendicular easy axis, and to switch the magnetisation state in response to a spin current generated in the magnetic element in response to a write current applied to the magnetic element, and configured to generate, as an output, a Hall voltage across the conductive element in response to a respective read current applied to each magnetic element, wherein a magnitude of the Hall voltage is variable, depending on a direction of the magnetisation state of each magnetic element and a direction of the respective read current applied to each magnetic element, for the device to provide outputs corresponding to one of a plurality of logical operations.

Abstract: A double-sided cold plate includes a manifold comprising openings extending from a first surface of the manifold through the manifold to a second surface of the manifold forming recesses within the manifold and an inlet channel and an outlet channel fluidly coupled to the recesses within the manifold, a plurality of first heat sinks coupled to the first surface of the manifold enclosing the openings on the first surface, and a plurality of second heat sinks positioned adjacent each other along a length of the manifold and coupled to the second surface of the manifold, enclosing the openings on the second surface, a width of the plurality of second heat sinks is greater than a width of the manifold thereby forming an overhanging portion on each lengthwise side of the manifold, the overhanging portion configured to mechanically support a plurality of electrical components positioned around a perimeter of the manifold.

Abstract: Compositions including an antibiotic factor from Malassezia are provided. In some examples, the compositions include a Malassezia exoproduct, a Malassezia cell-free supernatant, or a Malassezia cell and a pharmaceutically acceptable carrier. Methods of treating an infection in a subject, such as a Staphylococcus infection are also provided.

Abstract: Provided herein are polypeptides comprising membrane-anchored IL-12. Also provided herein are T cells expressing the membrane-anchored IL-12. Further, methods of treating cancer comprising administering T cells expressing membrane-anchored IL-12 are provided herein. Also provided are combination treatments comprising T cells expressing membrane-anchored IL-12 and T cell chemoattractant-inducing chemokines. In addition, methods are provided for activating T cells to express NKG2D and methods of their use in the treatment of cancer.

Abstract: A high strength and wear resistant multi-element copper alloy is disclosed. The multi-element copper alloy comprises: 80-90 atomic percent Cu, 0.1-4 atomic percent Al, 6-10 atomic percent Ni, 0.1-3 atomic percent Si, 0.1-2 atomic percent V and/or Nb, and 0.1-2 atomic percent M. Experimental data reveal that, after being applied with an aging treatment under 450 degrees Celsius for 50 hours, hardness and strength of the multi-element copper alloy are both significantly enhanced because of age hardening, and softening due to overaging is not observed on the multi-element copper alloy. Moreover, measurement data have indicated that, this novel multi-element copper alloy exhibits better wear resistance superior to that of the conventional copper alloys.