Abstract: Coated iron oxide (10) nanocrystal structures, superparamagnetic 10 nanoparticles, methods for synthesizing coated 10 nanocrystal structures, and methods for synthesizing superparamagnetic 10 nanoparticles are described herein. A coated 10 nanocrystal structure may comprise an iron oxide core, a manganese ferrite shell layer surrounding the core, and a bilayer coating surrounding the shell layer. The bilayer coating may include an inner oleic acid layer surrounding the shell layer and an outer layer surrounding the inner oleic acid layer.

Abstract: Provided is a fabrication method for a composite planar pH sensor modified by graphene film including: slotting into substrate, setting copper foil on both sides, and setting leads on the copper foil; coating graphene film on the copper foils using micro mechanical stripping method to form the first graphene film and the second graphene film; depositing Sb layer and Sb2O3 layer successively on the first graphene film by magnetron sputtering method, and coating Nafion™ perfluorinated sulfonic acid membrane on the Sb2O3 layer by spin-coating method to fabricate pH working electrode; depositing Ag layer on the second graphene film and dipping in FeCl3 solution to form AgCl layer; coating the third graphene film on the AgCl layer to fabricate reference electrode. The composite planar pH sensor modified by graphene film may be used in pH measurement for solid, semisolid, mash and solution samples.

Abstract: The application relates to a reservoir chip and a method for producing the same. The method includes: scanning a three-dimensional structure of a real oil reservoir core and reconstructing the three-dimensional structure, extracting pore size distribution characteristics, analyzing formation of a pore structure of the real oil reservoir core and accumulation morphology of rock particles, extracting the morphology of main large particles in the rock particles and establishing a large particle morphology database; distributing and projecting particles in a porous medium of the reservoir chip, to obtain a picture of the reservoir chip structure; importing the picture into a drawing software, and drawing import and export regions of the reservoir chip structure to obtain a design drawing of the reservoir chip; and making the design drawing etched on a substrate and bonded with a heat-resistant glass anode to obtain the reservoir chip.

Abstract: A clock and data recovery (CDR) device includes a data sampler configured to output a data signal by sampling an input signal according to a first clock signal; an edge sampler configured to output an edge signal by sampling the input signal according to a second clock signal, the second clock signal having substantially the same frequency as the first clock signal and having substantially an opposite phase to the first clock signal; an error detection circuit configured to identify a plurality of patterns based on the data signal and the edged signal and generate an error signal according to occurrence frequencies of the identified plurality of patterns; and an oscillation control circuit configured to generate a first oscillation control signal to control an oscillator generating the first and second clock signal according to the error signal.

Abstract: A non-invasive computer-aided diagnosis system generates a diagnosis of mild cognitive impairment, a disease state which often leads to the development of Alzheimer's disease. The system uses as inputs both functional positron emission tomography and structural magnetic resonance imaging data, reconstructs a model of the patient's cortex, uses machine-learning techniques to generate probabilities for mild cognitive impairments for local cortical regions, uses machine-learning techniques to fuse the local diagnoses to generate a global diagnosis based on each imaging modality, then uses machine-learning techniques to fuse the modality-specific global diagnoses to generate a final global diagnosis.

Abstract: Provided herein are clear aqueous colonoscopy irrigation compositions, and methods for visualization of colonic mucosa during colonoscopy procedure. The composition comprises indigo, blue or green colored contrast dye, polydimethylsiloxane, and muscle relaxant.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.

Abstract: The present invention is directed to a method of endoscopically ablating/resecting/excluding (A/R/E) the mucosa of the gastric fundus and body. The method of the present invention is intended to cause cellular death to the X/A-like, ghrelin producing and other hormone cells. This is in contrast to present methods to provide only transient ischemia. The use of the method of the present invention results in a more permanent and robust method of reducing ghrelin and other hormone levels. In addition, a method according to the present invention can be used to induce scarring of the gastric fundus which will reduce gastric accommodation of excess food and result in early satiety.

Abstract: An apparatus comprises: a photonic cavity; a substrate comprising a waveguide layer, wherein the waveguide layer comprises waveguides configured to direct light towards the photonic cavity; and a wafer comprising: a top side, and a nanowire array affixed to the top side. A method of performing a surface-enhanced Raman scattering (SERS) analysis, the method comprises: directing, using a waveguide layer of a SERS device, an incident light towards a photonic cavity of the SERS device; permitting, using the photonic cavity, a fluid to flow freely into and out of the SERS device; causing, within the photonic cavity, an interaction among the incident light, the fluid, and a nanowire array of the SERS device to create scattered light; converting the scattered light into an electrical signal; and analyzing the electrical signal to determine whether a contaminant exists in the fluid.

Abstract: An antenna assembly, a wireless-communication-enabled device and an intelligent home or office appliance including such antenna assembly. The antenna assembly includes an antenna including an antenna body and a feeder, and at least one functional module arranged to operate with a function different from that provided by the antenna; wherein the at least one functional module includes at least one electrical connection module arranged to connects with an external electrical connector.

Abstract: The present invention provides compounds and methods for mitigating a clinical condition associated with a neurodegenerative disease or a locomotor dysfunction in a subject. In one particular aspect, the invention relates to compounds and methods for reducing TDP-43 aggregation or toxicity in a subject.

Abstract: Provided herein are small molecules that bind to ASH1L and inhibit ASH1L activity, and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.

Abstract: A polypeptide, a pharmaceutical composition including a polypeptide, and a method for treating a condition using a polypeptide are provided. The polypeptide includes an amino acid sequence according to the general formula X1-X2-X3, wherein X1 and X3 are independently absent or comprise a transduction domain, X2 includes Z3, and Z3 is selected from the group consisting of serine or phosphoserine analogs. The pharmaceutical composition includes a polypeptide including an amino acid sequence according to the general formula X1-X2-X3 and one or more components selected from the group consisting of a pharmaceutically acceptable carrier, a calcium channel blocker, and a combination thereof. X1 and X3 are independently absent or comprise a transduction domain, X2 includes Z3, and Z3 is selected from the group consisting of serine or phosphoserine analogs.

Abstract: Provided herein are methods for generating reversion free attenuated and/or replication incompetent vaccine vectors and their use in vaccine compositions and vaccination. In particular, the use of a codon shuffled helper gene is used to produce compositions comprising replication incompetent virus.

Abstract: Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.

Abstract: Aspects of the present disclosure include anonymous, asynchronous, and randomized control schemes for distributed energy resources (DERs). Such control schemes may include packetized energy management (PEM) control schemes for managing DERs that may provide near-optimal tracking performance under imperfect information and consumer quality of service (QoS) constraints.

Abstract: The present disclosure discloses a system for measuring a charge-to-mass ratio of an electrostatic atomization nozzle and a measurement method using the same. The system includes an electrostatic atomization nozzle, an upper cylinder, a lower cylinder, an ammeter, a liquid level tube, an ultrasonic level meter, a water storage tank, and a liquid pump. The electrostatic atomization nozzle, the upper cylinder, and the lower cylinder are sequentially connected from top to bottom. The ammeter is connected to the lower-cylinder flange. The liquid level tube is communicated with the lower cylinder. The ultrasonic level meter is mounted on an upper end of the liquid level tube. The water storage tank is located below a lower-cylinder water outlet pipe. The liquid pump can deliver a liquid in the water storage tank to the electrostatic atomization nozzle. Measurement data of the ammeter is acquired and processed by a computer in real time.

Abstract: An apparatus and method for the dry separation of bulk particulate material, especially coarse particles, is provided. The apparatus comprises a chamber, a screen adjacent the chamber and a fluidising device fluidly connected to the chamber. The screen has a screen surface, a plurality of apertures and an opening larger in size than the aperture. A mixture of the coarse particles and a fine particulate medium is fed into the chamber. The fluidising device directs a fluidising fluid to fluidise a fine particulate medium and create a fluidised bed directed towards the screen. The fine particulate medium and the coarse particles pass from the chamber through the openings. The fine particulate medium passes back through the apertures to the chamber. Relatively high density coarse particles also pass back through the openings to the chamber. Relatively low density coarse particles are retained on the screen surface. Vibrations may also be used.

Abstract: A method for providing a 3D shape model for a new process in an additive manufacturing system includes receiving an unoptimized 3D model of one or more shapes based on a first process (P1); receiving deviation information based on P1; baseline deviation modeling of P1 based on the received unoptimized 3D model and the received deviation information to thereby generate an optimized 3D model for the one or more shapes based on P1; applying a transfer function that connects deviation information of P1 to deviation information of a second process (P2); receiving deviation information based on P2; adaptively modeling the deviations of P2 based on the transformed baseline model and the deviation information of P2; generating an optimized 3D model for the one or more shapes based on P2; and generating a compensation plan for additively manufacturing the one or more shapes between P1 and P2.

Abstract: This invention relates to a feedback predictive controller, systems comprising and methods employing the same. Preferably the feedback predictive controller and/or systems comprising the feedback predictive controller are part of an automatic insulin delivery system. The methods described herein can be used to control blood glucose concentration in a patient with diabetes. Preferably, the insulin delivery system is an artificial pancreas.