Abstract: The present disclosure relates to multispecific antibodies targeting the human immunodeficiency virus-1 (HIV-1) envelope, methods for their production, pharmaceutical compositions containing said antibodies and uses thereof in treatment and prevention of HIV infection.

Abstract: Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes administering a compound comprising a RNA directly conjugated to an albumin-binding group to a subject in need thereof.

Abstract: An electrode and an energy storage device including the electrode, the electrode including: an active material including a material structure of metal sulfides; a conductive polymer including an ionic liquid disposed on the active material; wherein the combination of the conductive polymer and the ionic liquid is arranged to maintain integrity of the material structure and facilitate ion transportation across the material structure during an operation of charging and discharging cycle of the energy storage device.

Abstract: Described herein are membrane permeabilizing peptides, polynucelotides encoding the peptides, and lipid vesicles comprising the peptides. Furthermore, described herein are methods for using the peptides, polynucleotides, and lipid vesicles for research, diagnosis, disease prevention, and therapeutic treatment.

Abstract: A method of oscillating a pressure in a borehole is provided that includes determining a hydraulic diffusivity, using injection tests, in a borehole, calculating a pressure field using a programmed computer at a proximal distance to the borehole using a first forced oscillation result in a porous media, calculating a flow rate at the proximal distance from the borehole by multiplying a gradient of the pressure field by a measured permeability and dividing by a viscosity of a fluid, computing, using the programmed computer, a volumetrically averaged flow rate by integrating a square of the flow rate over a volume around the borehole, outputting a value of an angular frequency for which the volumetrically-averaged flow rate is maximum, and operating a pump at a second forced oscillation according to the angular frequency on the fluid.

Abstract: The present invention relates to variants of herpes simplex virus (HSV) that selectively infect and replicate in cancer cells, including HSV strains that selectively infect and replicate in bladder cancer cells. Preferred HSV of the invention have intact endogenous Us11 and Us12 genes and have genes encoding ICP34.5 replaced with a gene encoding Us11 fused to an HSV immediate early (IE) promoter. The variant HSV of the invention also comprise one or more additional heterologous genes encoding immunomodulatory polypeptides. Methods and compositions using these variant HSV, for example, for treating cancer in a subject, are also provided.

Abstract: The present invention is directed to the use of microfluidics in the preparation of cells and compositions for therapeutic uses.

Abstract: A system for creating an endoluminal valve from a blood vessel wall, includes: a tubular assembly having a longitudinal axis, a proximal end, a distal portion with a distal end, and a first lumen extending from the proximal end to a distal port located proximate the distal portion, the distal port located along the longitudinal axis, the distal portion having a supporting surface on a same side of the tubular assembly as the distal port, the supporting surface extending in a longitudinal direction and offset from a surface of the tubular assembly proximal the distal port and configured to contact the blood vessel wall; and a tissue dissection probe disposed within the first lumen, the tissue dissection probe having a fluid delivery lumen extending to a fluid delivery port located at a distal end of the tissue dissection probe, the tissue dissection probe configured to be inserted into the blood vessel wall.

Abstract: Various embodiments of a systems and methods for a triplet network having speaker diarization are disclosed.

Abstract: A technology is described for spatially estimating thermal emissivity. A method can include obtaining spectral emissivity data and satellite imaging data for a geographic area. A weighted emissivity model of emissivity values may be generated for surfaces included in the geographic area from the spectral emissivity data and the satellite imaging data, wherein the spectral emissivity data is mapped to the satellite imaging data to generate the weighted emissivity model. Thermal imaging data for the geographic area may be received from an airborne thermal imaging sensor and a thermal emissivity map can be generated for the geographic area using the thermal imaging data and the weighted emissivity model. The emissivity values from the weighted emissivity model can be used to estimate thermal emissivity values.

Abstract: A method of producing an ultraviolet laser diode with a low oscillation threshold current density includes stacking a first cladding layer, a light-emitting layer, and a second cladding layer on a substrate in this order to form a nitride semiconductor laminate (step S101), etching at least a portion of the nitride semiconductor laminate to form a mesa structure and setting the ratio between the length of the resonator end faces and the length of the side surfaces of the mesa structure in plan view between 1:5 and 1:500 (step S102), disposing first conductive material on a portion of a first area and applying heat treatment of 400° C. or higher to form a first electrode (step S103), and disposing a second conductive material in an area on the second cladding layer, at a distance of 5 um or more from the side surfaces, to form a second electrode (step S104).

Abstract: The present invention discloses a dynamic reliability evaluation method for coupling faults of a middle trough of a scraper conveyor. Approximation precision of a moment-based saddlepoint approximation method and a function attribute of dynamic t-copula are fully utilized, and the dynamic reliability evaluation method for the coupling faults of the middle trough of the scraper conveyor is provided, so that dynamic correlation between failure modes of the middle trough of the scraper conveyor under a small sample condition is more accurately described, and accuracy of dynamic reliability evaluation of the coupling faults of the middle trough of the scraper conveyor is improved.

Abstract: A geothermal heat utilization system includes a well that includes an upper opening, a lower opening, a water chamber capable of storing underground water inside, and a pump provided inside the water chamber and capable of pumping underground water; and a water suction pipe that extends from the pump toward a heat exchanger, wherein the water chamber includes an upper suction valve capable of being opened and closed toward the upper opening and a lower suction valve capable of being opened and closed toward the lower opening, and wherein the geothermal heat utilization system is configured such that, when any one of the upper suction valve and the lower suction valve is opened, the other is closed.

Abstract: Systems and methods for screening enzyme variants are described, wherein the enzyme variants may catalyze a reaction that is cofactor-dependent or cofactor-independent.

Abstract: In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive X chromosomes. In some embodiments, the compositions and methods described by the disclosure may be useful for the treatment of dominant X-linked diseases.

Abstract: A scaffold of hollow fibers comprising a mixture of polylactic acid (PLA) and polybutylene succinate (PBS) and cellulose nanofibers (CNF), medical products made of these scaffolds and methods of using the scaffolds in regenerative medicine. A method for producing the scaffolds is also disclosed.

Abstract: A system and method configures permission settings for applications (“apps”) running on a computing device of a user. A data center generates at least one model of collective privacy preferences. The computing device is in communication with the data center via a communications network. The computing device comprises a processor that execute at least a first app that requests access to at least one permission of the computing device and a personal privacy assistant app. The personal privacy assistant app receives the at least one model from the one or more servers of the data center; collects information about the user; identifies at least one recommended permission setting for the first app based on the at least one model and such that the recommended permission setting is user-specific; and configures the computing device to implement the received at least one user-specific recommended permission setting.

Abstract: An Ussing chamber assembly for assessing a tissue sample and for receiving a first fluid and a second fluid during such assessment is disclosed. The Ussing chamber assembly includes an Ussing chamber configured to be separated by the tissue sample into a first chamber portion and a second chamber portion. The assembly includes a first channel in fluidic communication with the first chamber portion, a second channel in fluidic communication with the second chamber portion, and at least three electrical conductors in fluidic communication with the first chamber portion.

Abstract: The disclosure provides a communication time allocation method using reinforcement learning for a wireless powered communication network and a base station. The method includes: determining a communication time allocation corresponding to the t-th time block according to an objective function associated with the total estimated throughput of the communication nodes; requesting each communication node to perform specific communication behaviors according to the corresponding communication time interval in the t-th time block; obtaining the actual throughput of each communication node in the t-th time block; generating the weight vector of each communication node in the (t+1)-th time block according to the actual throughput, the weight vector, and the estimated throughput of each communication node in the t-th time block.

Abstract: The invention provide isolated arrestin domain-containing protein 1 (ARRDC1)-mediated microvesicles (ARMMs). Methods for generating and for isolating ARMMs are also provided herein. ARMMs can be used to deliver agents, for example, nucleic acids (e.g., siRNAs, microRNAs, lincRNAs), proteins (e.g., transcription factors, chromatin modulators, kinases, phosphorylases, or recombinases), or small molecules to target cells in vitro and in vivo, and methods for such ARMM-mediated delivery are provided herein. Diagnostic and therapeutic methods using ARMMs are also described herein.