Abstract: A Ligand-guided-Selection (LIGS) method for identifying highly specific aptamers against a predetermined antigen of a target is provided. LIGS uses a stronger and highly specific bivalent binder (e.g. an antibody) interacting with its cognate antigen to displace specific aptamers from an enriched SELEX pool. Elution of the displaced aptamers provides aptamers that are specific to the predetermined antigen.

Abstract: The present disclosure provides compositions and method targeting GPER for the treatment of cancers, such as breast cancers and leukemias, gallstone disease, and for conferring of neuroprotection on a subject. Also disclosed are high throughput assays for identifying antagonists of GPER.

Abstract: The invention discloses a method for measuring a semiconductor gas sensor based on virtual alternating current impedance. The method comprises: combining measurement parameters of virtual measurement frequencies in a first predetermined range and virtual parallel capacitance values in a second predetermined range, and measuring gas with known concentrations at each characteristic quantity among nine characteristic quantities in the case of each combination; obtaining multiple characteristic values corresponding to the same gas concentration at each characteristic quantity after traversing all parameter combinations and all nine characteristic quantities; and selecting virtual measurement frequencies in a third range, virtual parallel capacitance values in a fourth range and one or several corresponding characteristic quantities as the finally selected measurement parameters for measuring the unknown gas concentration.

Abstract: A flow cell can comprise a high-pressure, fluidic, flow-through housing that encloses and auto-aligns a heavy-walled, internally reflective low-cost glass capillary for concentrating and amplifying laser-excited spectra. The containment housing that encloses the capillaries can optionally sustain operational pressures of at least 10,000 psi. The pressure housing can be fitted with transparent optical windows that can accommodate laser-safe injection and spectra collection. The flow-cell design can adaptably accommodate different optical sampling configurations such as transmissive (forward scattering), reflective (backward scattering), or multipass, combined scattering. The flow cell size is scalable (lengthwise) to accommodate different applications or installations such as benchtop (lab), permanent (industrial), and portable (field).

Abstract: A multi-material inspection system and velocity measurement method of critically refracted longitudinal wave based on single-angle wedges belong to the field of nondestructive testing of high-end equipment. The method includes the following steps: designing a transmitting wedge and a receiving wedge with the same inclination angle, and building phased array ultrasonic-based inspection systems of critically refracted longitudinal wave; estimating a longitudinal wave velocity range of a material to be tested, calculating and optimizing a phased array ultrasonic delay law, and building a relation between a longitudinal wave velocity and an amplitude of critically refracted longitudinal wave; reading and interpolating the arrival time of a received signal, and calculating a longitudinal wave velocity of the material to be tested; determining an optimal delay law, and exciting and receiving a critically refracted longitudinal wave.

Abstract: The present invention provides laryngeal mask airway for sedative endoscopy, including: a laryngeal mask/endoscope guide unit which is positioned in a larynx region inlet through a patient's oral cavity and guides a supply of air to a respiratory tract and insertion of an endoscope into an esophagus; an airway unit which is connected to the laryngeal mask/endoscope guide unit to supply air to the patient's respiratory tract and to allow the patient's breathing state to be visually checked; a mouthpiece unit which is installed outside the airway unit and fixed between the patient's teeth to protect a tube of the airway and an endoscopic probe inserted into the oral cavity; and an indication end which is positioned at a portion of the mouthpiece positioned outside the oral cavity and moves in accordance with the patient's breathing state to allow spontaneous breathing to be checked, such that the patient's safe airway may be ensured, the insertion of the endoscopic probe and the procedure may be smoothly perfor

Abstract: The present invention discloses a selenium-doped MXene composite nano-material and a preparation method thereof, comprising the following steps: (1) adding MXene and an organic selenium source into a dispersant, and stirring to prepare a dispersion with a concentration of 1 mg/ml to 100 mg/ml; (2) transferring the dispersion into a reaction kettle, then heating, reacting, and then naturally cooling to a room temperature; (3) washing the product obtained in the step (2) with a cleaning agent, then centrifuging to collect a precipitate, and drying the precipitate under vacuum; and (4) placing the sample obtained in the step (3) into a tubular furnace for calcination, introducing protective gas, heating, and then cooling to a room temperature to obtain the selenium-doped MXene composite nano-material. The material prepared by the present invention has high specific surface area, good electrical conductivity, cycle stability performance, rate performance and high theoretical specific capacity.

Abstract: This invention discloses a boron-containing titanium-based composite powder for 3D printing, consisting of 0.5%-2% by weight of titanium diboride and 98%-99.5% by weight of titanium sponge. The invention further discloses a method of preparing such composite powder, where the element boron is introduced to the titanium powder through rapid solidification, which significantly improves the solid solubility of boron in Ti, enabling the introduction of part of the boron into the titanium matrix to form supersaturated solid solutions. The reinforcement phase TiB in the boron-containing titanium-based composite powder prepared herein can be precisely controlled in grain size ranging from the nanometer scale to the micrometer scale through temperature or energy density, thereby preparing the titanium-based composite materials with different sizes of reinforcement phases to meet different mechanical requirements.

Abstract: An allophone inspection device and inspection method thereof are provided. An allophone inspection device includes an array microphone unit in which a plurality of array microphones are disposed at predetermined intervals, and a controller configured to build reference data by quantifying analyzed allophone by collecting sound signals generated from surrounding based on a position where the array microphone unit is installed in advance and measure a surrounding sound signal through the array microphone unit to estimate whether or not noise is generated and a position of the sound source where the noise is generated based on the reference data.

Abstract: The invention relates to method of diagnosis a subject suffering from Adult-onset Still's disease and further to determine the disease course of the subject suffering from Adult-onset Still's disease.

Abstract: The present invention relates generally to an apparatus that is able to provide a sealed chamber system including a cell sorter, that allows for various oxygen tensions of choice to be maintained during cell harvest, sorting (and isolation of sub-populations of cells), analysis, etc.

Abstract: A method for analyzing planar sample is provided. In some cases the method comprises: (a) labelling the planar sample with a capture agent that is linked to a nucleic acid, wherein the capture agent specifically binds to complementary sites in the planar sample; (b) reading a fluorescent signal caused by extension of a primer that is hybridized to the nucleic acid, using fluorescence microscopy. Several implementations of the method, and multiplexed versions of the same, are also provided.

Abstract: A system for electrical ventilation stimulation of a patient including an implantable nerve stimulator including a stimulation circuit and a pulse generator that produces biphasic charge-balanced pulses to stimulate a phrenic nerve, an external digital programming device having near field communication transmission and a digital interface, and wherein the external digital programming device is used to control settings of the implantable nerve stimulator.

Abstract: Disclosed herein are recombinant polypeptides derived from FBP1 and FBP2. Also disclosed herein are recombinant expression vectors and recombinant host cells for producing the aforesaid recombinant polypeptides. The recombinant polypeptides are proven to be useful and effective in producing a picornavirus with a type I internal ribosome entry site (IRES), so as to facilitate the preparation of a viral vaccine.

Abstract: An inkjet printable ionic conductive ink for producing a touch sensor device is provided. The inkjet printable ionic conductive ink includes a hydrophilic polymer and an ionic salt, a mixture of solvents in which the hydrophilic polymer and the ionic salt are dissolved therein to form a solution, and a surfactant to render the solution inkjet printable. A method of producing the inkjet printable ionic conductive ink is also provided. The method includes dissolving a hydrophilic polymer and an ionic salt in a mixture of solvents to form a solution, and mixing the solution with a surfactant to render the solution inkjet printable. A touch sensor panel comprising the ionic conductive ink and a method of producing the touch sensor panel are also provided.

Abstract: A method for analyzing survivability of an infrastructure link includes determining an optimal path arrangement of the infrastructure link between two geographic locations; and determining a risk index associated with the determined optimal path arrangement based on one or more quantified cost factors and one or more quantified risk factors associated with the determined optimal path arrangement. The risk index represents a survivability of the infrastructure link.

Abstract: The invention relates generally to a pharmacological therapy for a human genetic diseases, specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxyribonucleoside monophosphate, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine monophosphate (dTMP) or deoxycytidine monophosphate (dCMP), or mixtures thereof. This molecular bypass approach is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome.

Abstract: An organic light-emitting device and a heterocyclic compound, the device including a first electrode; a second electrode facing the first electrode; and an organic layer between the first electrode and the second electrode and including an emission layer, wherein the organic layer includes a heterocyclic compound represented by Formula 1:

Abstract: The disclosure relates to a plant that is tolerant or resistant to species of Ca. Liberibacter. Specifically exemplified are citrus and solanaceous plants. Provided by the disclosure is a modified citrus or solanaceous plant that is resistant or tolerant to Sec-dependent effectors secreted by bacteria. Also provided by the disclosure are methods of modifying a plant genome plant to provide tolerance or resistance to species of Ca. Liberibacter. Still further provided by the disclosure are methods conferring a population of plants with tolerance or resistance to species of Ca. Liberibacter and screening that population for the plants that are tolerant or resistant to species of Ca. Liberibacter.

Abstract: Aspects of the present disclosure include methods of producing modified polypeptides and modified polypeptide-ribosome or polypeptide-mRNA complexes, and methods of screening polynucleotide and polypeptide libraries. The present disclosure also provides polypeptide libraries useful in screening for single molecule phenotypes. Also provided are kits useful for producing polypeptides capable of being modified using methods disclosed herein.