Abstract: Modulation of inward potassium ion conductance with structurally diverse small-molecules in the arthropod salivary gland induces arthropod salivary gland failure that results in a reduction or elimination in the ability of the arthropod to feed. Administering Kir channel inhibitors reduces food intake, increases feeding time, reduces salivary gland secretion, induces mortality, and reduces transmission of vector-borne pathogens. Kir channel inhibitors induce these adverse effects in ticks, mosquitoes, horn flies, and aphids.

Abstract: The purpose of the present invention is to provide a thermoelectric conversion element having a film which not only maintains sufficient adhesion even when exposed to a high temperature but also exhibits excellent oxidation resistance and crack resistance. The problem is solved by a thermoelectric conversion element including a thermoelectric conversion component, in which the thermoelectric conversion component contains magnesium silicide and/or manganese silicide and is covered with a film containing Si and Zr.

Abstract: Exemplary quantitative susceptibility mapping methods, systems and computer-accessible medium can be provided to generate images of tissue magnetism property from complex magnetic resonance imaging data using the Bayesian inference approach, which minimizes a cost function consisting of a data fidelity term and two regularization terms. The data fidelity term is constructed directly from the complex magnetic resonance imaging data. The first prior is constructed from matching structures or information content in known morphology. The second prior is constructed from a region having an approximately homogenous and known susceptibility value and a characteristic feature on anatomic images. The quantitative susceptibility map can be determined by minimizing the cost function. Thus, according to the exemplary embodiment, system, method and computer-accessible medium can be provided for determining magnetic susceptibility information associated with at least one structure.

Abstract: Various embodiments relate to forming particles using undercooled metal particles in response to focused low power laser light. Particle growth can be initiated by utilizing the metastable and liquid nature of the particles, allowing for surface instability promoted by the laser light to induce liquid flow to translate to a neighboring particle. This event can cascade radially leading to accumulation of the liquid metal at the epicenter. The grown solidified particle size can be varied by using different power, exposure time, or working distance. Once the liquid has accumulated into a single region, it eventually solidifies either through homogeneous or heterogeneous nucleation to give a solid particle of larger size than the original. Such a method can be used to print patterns on a surface in four dimensions, where the fourth dimension (4D) is attained through gradient in size of the particles made. Additional systems and methods are disclosed.

Abstract: Method for quantifying the micronutrient profile of Moringa oleifera tree leaves (MOLs) using calibration free laser induced breakdown spectroscopy (CF-LIBS).

Abstract: The present disclosure provides infectious recombinant adeno-associated virus (rAAV) virions that comprise a variant capsid protein and a heterologous nucleic acid. The present disclosure further provides the variant adeno-associated virus (AAV) capsid proteins (and/or a nucleic acid encoding the variant AAV capsid proteins), which confer to an infectious rAAV virion an increased resistance to human AAV neutralizing antibodies. The present disclosure further provides host cells comprising an infectious rAAV virion and/or a nucleic acid encoding a subject variant AAV capsid protein. The present disclosure further provides methods of delivering a heterologous nucleic acid to a target cell where the target cell is contacted with a subject infectious rAAV virion. The present disclosure further provides methods of delivering a gene product to an individual, the methods generally involving administering an effective amount of a subject rAAV virion to an individual in need thereof.

Abstract: Provided herein are polymer materials that find use in, for example, delivery of short-chain fatty acids. In particular, polymers are provided that form stable nanoscale structures and release their payload, for example, by cleavage of a covalent bond (e.g., via hydrolysis or enzymatic cleavage). The polymers are useful, for example, for delivery of payloads (e.g., SCFAs) to the intestine for applications in health and treatment of disease, and have broad applicability in diseases linked to changes in the human microbiota including inflammatory, autoimmune, allergic, metabolic, and central nervous system diseases, among others.

Abstract: The present invention relates to a method for determining whether an HLA allele is lost in a tumour in a subject, wherein said method comprises the step of determining the specific copy number of said HLA allele in said tumour. The invention also relates to a method for treating cancer in a subject, comprising targeting a neoantigen which is predicted to be presented by an HLA molecule encoded by an HLA allele which has been determined not to have been lost in a tumour in said subject.

Abstract: The present invention relates to compositions and methods for delivering an oligonucleotide-functionalized nanoparticle.

Abstract: A rigid-flexible coupled unmanned aerial vehicle (UAV) morphing wing and an additive manufacturing method thereof are disclosed. A shape memory alloy (SMA) strip/wire for controlling the wing upward deformation and an SMA strip/wire for controlling the wing downward deformation are arranged alternately, and a plurality of reinforcing ribs are arranged at intervals on the SMA strips/wires for controlling the wing upward deformation and the SMA strips/wires for controlling the wing downward deformation. The SMA strips/wires for controlling the wing upward deformation and the SMA strips/wires for controlling the wing downward deformation are arranged on a flexible substrate, and are wrapped with an insulating covering. The SMA strips/wires for controlling the wing upward deformation and the SMA strips/wires for controlling the wing downward deformation each are provided with an electric heating element.

Abstract: Biomarkers and methods for identifying, verifying and confirming circulating serum-based microRNAs. The microRNAs (PARKmiRs) can be used to differentiate patient's suffering from Alzheimer's disease (AD) from non-AD patients.

Abstract: A device includes an input converter, an output converter, and a controller. The input converter is electrically coupled to an electrical meter and an energy production array. The output converter is electrically coupled to the energy production array and a load. The controller is communicatively coupled to the input converter, the output converter, the energy production array, and the load. The input converter and the output converter are positioned between the electrical meter and the load.

Abstract: The present invention provides a technique for treating the cornea. More specifically, the present invention is an agent for the treatment or prevention of a state of corneal endothelial disease, the agent including at least one factor selected from the group consisting of laminin and fragments thereof, wherein the problem is solved by also providing a technique characterized in that this agent is administered together with corneal endothelial cells. Specifically, the present invention can include laminin 511 (?5?1?1), laminin 521 (?5?2?1), or a fragment of these.

Abstract: A method for use in traversing a vehicle transportation network by an autonomous vehicle (AV) includes traversing, by the AV, the vehicle transportation network. Traversing the vehicle transportation network includes identifying a distinct vehicle operational scenario; instantiating a first decision component instance; receiving a first set of candidate vehicle control actions from the first decision component instance; selecting an action; and controlling the AV to traverse a portion of the vehicle transportation network based on the action. The first decision component instance is an instance of a first decision component modeling the distinct vehicle operational scenario.

Abstract: In a real-time traceability method of a width of a defect based on divide-and-conquer provided by the present invention, through the calibration transfer function, the multidimensional eigenvector analysis technology based on the electromagnetic field simulation database of defect scattered dark-field imaging and the adaptive threshold segmentation method, the real-time traceability of the width of the defect greater than and close to the diffraction limit of the system is performed, respectively. The extreme random tree regression model is trained by multidimensional eigenvector analysis technology based on the multidimensional eigenvectors in the electromagnetic field simulation database of the defect scattered dark-field imaging.

Abstract: Chromophores with large hyperpolarizabilities, films with electro-optic activity comprising the chromophores, and electro-optic devices comprising the chromophores are disclosed.

Abstract: The present application describes a waveform processor for control of quantum mechanical systems. The waveform processor may be used to control quantum systems used in quantum computation, such as qubits. According to some embodiments, a waveform processor includes a first sequencer configured to sequentially execute master instructions according to a defined order and output digital values in response to the executed master instructions, and a second sequencer coupled to the first sequencer and configured to generate analog waveforms at least in part by transforming digital waveforms according to digital values received from the first sequencer. The analog waveforms are applied to a quantum system. In some embodiments, the waveform processor further includes a waveform analyzer configured to integrate analog waveforms received from a quantum system and output results of said integration to the first sequencer.

Abstract: The present disclosure relates to a traceable in-situ micro- and nano-indentation testing instrument and method under variable temperature conditions. A macro-micro switchable mechanical loading module, a nano mechanical loading module and an indentation position optical positioning module are fixed on a gantry beam, an optical imaging axis of an optical microscopic in-situ observation or alignment module and a loading axis of the nano mechanical loading module are coplanar, the optical microscopic in-situ observation or alignment module and the function switchable module are mounted on a table top of a marble pedestal, and a contact or ambient mixed variable temperature module is fixedly mounted on the function switchable module. A modular design is adopted, the micro- and nano-indentation testing instrument is used as a core, in combination with a multi-stage vacuum or ambient chamber, an indentation depth traceability calibration module and multiple sets of optical microscopic imaging assemblies.

Abstract: The present invention provides an interval error observer-based aircraft engine active fault tolerant control method, and belongs to the technical field of aircraft control. The method comprises: tracking the state and the output of a reference model of an aircraft engine through an error feedback controller; compensating a control system of the aircraft engine having a disturbance signal and actuator and sensor faults through a virtual sensor and a virtual actuator; observing an error between a system with fault of the aircraft engine and the reference model through an interval error observer, and feeding back the error to the error feedback controller; and finally, using a difference between the output of the reference model of the system with fault and the output of the virtual actuator as a control signal to realize active fault tolerant control of the aircraft engine.

Abstract: The invention relates to a nanosecond-scale power resource allocation method and system for microservices. In order to eliminate the macro-control delays, it uses an auto power budgeting module to distribute the limited power resource to each microservice according to its unique power-performance model. On the other side, it deploys an agile power regulation module to bypass the slow power control procedures at the server system layer. By directly invoking the voltage regulation circuit on the processor, this can remove the micro-execution delays. It also leverages a transparent mapping mechanism to coordinate the work of the auto power budgeting module and the agile power regulation module to achieve the optimal allocation of power resources. The present invention can exploit the intra-application variability brought by microservices, thus further break the energy-saving limitation of traditional data centers.