Abstract: The present disclosure provides methods for proximity-induced antibody conjugation of target agents).

Abstract: Products derived from and methods of micelle templating that allow for orthogonal control over structural features.

Abstract: High-frequency supercapacitors that can respond at kilohertz frequencies (AC-supercapacitors). The electrodes of the AC-supercapacitors include edge oriented graphene (EOG) electrodes or carbon nanofiber network (CNN) electrodes. The EOG electrodes are formed by utilizing a plasma and feedstock carbon gas to carbonize cellulous paper and deposit graphene implemented in one step. The CNN electrodes are formed by pyrolyzing a carbon nanofiber network utilizing a plasma.

Abstract: Disclosed herein are multi-layer structures comprising a first composite layer disposed over a second composite layer, wherein the first composite layer contains a first active material dispersed in a first polymer containing an elastomeric polymer and the second composite layer contains a second polymer which may have a second active material dispersed therein, wherein the first active material chemically or physically interacts with at least one toxic chemical and is selected from the group consisting of metal-organic frameworks (MOFs), metal oxides, metal hydroxides, zeolites, and combinations thereof, and wherein the active material and the second active material (if present) are the same as or different from each other, and the first polymer and second polymer are the same as or different from each other, subject to the proviso that the first composite layer and the second composite layer compositionally differ from each other in at least one respect.

Abstract: Disclosed are materials and methods for treating diseases of the mammalian eye, and in particular, Usher syndrome 1B (USH1B). The invention provides AAV-based, dual-vector systems that facilitate the expression of full-length proteins whose coding sequences exceed that of the polynucleotide packaging capacity of an individual AAV vector. In one embodiment, vector systems are provided that include i) a first AAV vector polynucleotide that includes an inverted terminal repeat at each end of the polynucleotide and a suitable promoter followed by a partial coding sequence that encodes an N-terminal portion of a full-length polypeptide: and ii) a second AAV vector polynucleotide that includes an inverted terminal repeat at each end of the polynucleotide and a partial coding sequence that encodes a C-terminal portion of a full-length polypeptide, optionally followed by a polyadenylation (pA) signal sequence.

Abstract: The present invention generally relates to compositions and methods for treating or preventing an endoplasmic reticulum stress disorder in subjects, including compositions and methods for treating or preventing Wolfram syndrome. The present invention also relates to methods for treating symptoms of neurodegenerative diseases.

Abstract: The present invention relates to a learning and creation system based on social network, comprising: a central server installed with a social network based learning creation computer program product comprising a concept map collaborative module and an instant messaging module; and a plurality of user devices, each of which the plurality of user devices executes an internet browser, in communication with the central server through an internet, and accesses the social network based learning creation computer program product through the internet browser and provides the concept map collaborative module and the instant messaging module for a user to operate in response to an operation from the user, wherein the concept map collaborative module is configured to provide a plurality of graphical objects based on a graphical concept map for a plurality of the users to perform a co-construction for the same concept and provide for the plurality of the users to engage an instant messaging by enabling the instant messag

Abstract: Systems and methods for production of externally-pore-blocked, internally-pore-opened modified zeolite crystals, the method including mixing zeolite crystals with an organic pore blocking agent; heating the zeolite crystals mixed with the organic pore blocking agent to block internal pores of the zeolite crystals and produce internally-pore-blocked zeolite crystals; mixing the internally-pore-blocked zeolite crystals with an external pore blocking agent; and calcining the internally-pore-blocked zeolite crystals mixed with the external pore blocking agent, to re-open internal pores via decomposition of the organic pore blocking agent and to block external pores via formation of a silica layer over external pores of the zeolite crystals, forming the externally-pore-blocked, internally-pore-opened modified zeolite crystals.

Abstract: Disclosed is a memory device including a multi-bit perpendicular magnetic tunnel junction, wherein the multi-bit perpendicular magnetic tunnel junction includes an upper synthetic antiferromagnetic layer, pinned layer, lower dual free layer, and upper free layer formed in a laminated manner between a top electrode and a bottom electrode.

Abstract: Position information estimation in a distributed radio frequency (RF) communications system is provided. Embodiments disclosed herein facilitate high-precision estimations of positions, orientations, velocities, and acceleration of network nodes in a distributed RF network. The distributed RF communications system incorporates a series of estimation processes which makes it susceptible to propagation of errors. To ensure robustness of the distributed RF communications system, relative positions of network nodes are tracked by iteratively tracking parameters used for estimating position information. Some embodiments take advantage of Kalman filtering algorithms by leveraging principles directed by physics. At every network node, several filtering algorithms can be employed to synchronize clocks, track delay between multiple-input multiple-output (MIMO) antennas and estimate position and orientation of other network nodes.

Abstract: The present disclosure relates to an electronic vehicle height clearance system, comprising: an infrared emission bar; a photo-sensor bar; an entrance gate and an electronic sign, wherein the system help in managing a vehicle with height above or below a permissible level for an area where the system is installed. The system generates an infrared line, wherein if the vehicle pass through the entrance without crossing the infrared line, it indicates that the vehicle in within the permissible height, however if the vehicle crosses the infrared lines it indicates that the vehicle is above the permissible height and thus should not or cannot pass the entrance gate.

Abstract: Methods for increasing immune therapy response and predicting likelihood of cancer metastasis by analyzing the expression of genes associated with replication stress response. In some aspects, cancers are treated with immune checkpoint inhibitors and/or MEK inhibitors. Methods for selecting patients by analyzing the expression of genes associated with a defect in replication stress response are also provided.

Abstract: According to various embodiments, a method for generating an optimal hidden-layer long short-term memory (H-LSTM) architecture is disclosed. The H-LSTM architecture includes a memory cell and a plurality of deep neural network (DNN) control gates enhanced with hidden layers. The method includes providing an initial seed H-LSTM architecture, training the initial seed H-LSTM architecture by growing one or more connections based on gradient information and iteratively pruning one or more connections based on magnitude information, and terminating the iterative pruning when training cannot achieve a predefined accuracy threshold.

Abstract: A cell-penetrating peptide (CPP) comprising comprises a plurality of mono(amino acid)s, oligo(amino acid)s, or poly(amino acid)s where a plurality of the amino acids comprise a positively charged guanylurea unit with a small molecule fragment and each of the mono(amino acid)s, oligo(amino acid)s, or poly(amino acid)s comprising a drug attached through a linker. The CPP can be used for treating cancers.

Abstract: CD206-positive M2 macrophage-targeting exosomes and methods of use thereof are provided. One embodiment provides a CD206-positive M2 macrophage-targeting exosome expressing a CD206 binding peptide and an Fc portion of IgG2b. In some embodiments, the CD206 binding peptide is encoded by a nucleic acid sequence having 95%, 99%, or 100% sequence identity to SEQ ID NO:2 and the IgG2b is encoded by a sequence having 95%, 99%, or 100% sequence identity to SEQ ID NO:6.

Abstract: A new and distinct variety of grapevine plant named ‘Errante Noir’, particularly selected for its high resistance to Pierce's disease, as well as quality of fruit and wines produced is disclosed.

Abstract: A polymer infrared polarizer (100) comprising a transparent polymer substrate (110) formed of a high sulfur content polymeric material, and a metal layer (130) fixed to an upper surface (120) of the transparent polymer substrate (110).

Abstract: A method of manufacturing an electrode by disposing a three-dimensional substrate in a metal nitrate solution, drying, and thermally phosphatizing with a phosphorus source under inert gas to form a metal based phosphate catalyst on the substrate. An electrocatalyst and electrode produced via the method are also provided.

Abstract: The present disclosure relates to a single stranded RNA vector suitable for introducing a therapeutic agent, such as a peptide, a protein or a small RNA, into a host plant. The vector does not encode for any movement protein or coat protein, but is capable of capable of systemic and phloem-limited movement and replication within the host plant.

Abstract: A single phase single stage level-1 electric vehicle (EV) battery charger can control the power flow in both directions. The converter efficiency is high as the devices undergo ZCS which reduces switching loss in the devices. This converter does not require any intermediate DC link capacitor stage and the power density of the converter is high.