Abstract: The present invention is a multilayered composite comprising porous metal oxide particles that are covalently bonded by way of inorganic ether groups to one or more sites of a first polyhydroxyl-functionalized polymer. This first polymer is in turn covalently bonded by way of inorganic ether groups to one or more sites of a second polyhydroxyl-functionalized polymer. The multilayered composites can be prepared by contacting porous inorganic-oxide particles with a sufficient amount of OH-reactive crosslinking agent to form metal oxide particles imbibed with the crosslinking agent, and then contacting the inorganic-oxide particles with a solution of polyhydroxyl-functionalized polymer under reactive conditions.

Abstract: The present invention provides compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane of the placenta. In certain embodiments, the composition comprises amniotic membrane powder or solubilized amniotic membrane (SAM). In some aspects, the composition is cell-free and rich in cytokines, extracellular matrix proteins, and other components that improve tissue regeneration. In one aspect, the composition is a hydrogel scaffold that comprises amniotic membrane. The present invention reduces contraction and improves blood vessel development in regenerating tissue.

Abstract: Systems and methods for forecasting of State of Charge (SOC) of lithium ion batteries are provided. A multi-step forecasting process with experimentally obtained decreasing C-Rate datasets together with machine learning can be used. The multi-step approach can combine a univariate technique with machine learning techniques. An Auto Regressive Integrated Moving Average (ARIMA) and/or Holt Winters Exponential Smoothing (HWES) can be combined with each other and/or with machine learning techniques such as Multilayer Perceptron (MLP) and Nonlinear autoregressive neural network with external input (NARX-net).

Abstract: A method for magnetic resonance (MR) imaging or spectroscopy on a MR scanner to detect tissue physiological parameters in one or more tissue areas in a human or non-human subject includes administering to the subject a contrast enhancing physiologically tolerable amount of a sugar that is non-labeled, subjecting the subject to an MR procedure capable of generating MR signals encoding at least one tissue area in the subject in which the sugar either passes or is taken up, detecting a temporal variation in the MR signals in the at least one tissue area after the administering the sugar, determining at least one tissue-related parameter from the temporal variation, and ascertaining whether the at least one tissue-related parameter is abnormal.

Abstract: Methods of formulating live biotherapeutics are disclosed in which a deficiency or excess of a specific bacterial strain in a person's microbiome is identified by comparing a gene-specific characterization of the person's microbiome against a comprehensive, non-redundant reference gene catalog, and the biotherapeutic is formulated by selecting bacteria to address the deficiency or excess. Embodiments include the formulation of live biotherapeutics for improving the health of a person's vaginal microbiome, i.e. using a vaginal reference gene catalog, and may be suitable for ameliorating, treating, or preventing a malignancy such as a cancer of the female genitourinary system.

Abstract: A PWM buck converter includes a first P-type transistor having a drain terminal connected to a first node, a first N-type transistor having a drain terminal connected to the first node, and a gate driver configured to apply a first gate voltage to a first gate terminal of the first P-type transistor and apply a second gate voltage to a second gate terminal of the first N-type transistor. The gate driver includes a first buffer configured to generate the first gate voltage applied to the gate terminal of the first P-type transistor, a second buffer configured to generate the second gate voltage applied to the gate terminal of the first N-type transistor, and a capacitor configured to accumulate a portion of electrical charges supplied from the first buffer to the first P-type transistor, and supply the accumulated electrical charges to the gate terminal of the first N-type transistor.

Abstract: This disclosure relates to methods, computer products, computer-implemented methods, and systems for predicting the probability or risk of prostate cancer recurrence and tumor aggressiveness in a patient. The method is based, in part, on the patient's risk profile that includes the presence/degree of specific copy number variations and predictive clinical factors. The methods and systems can be used to aid in treatment selection.

Abstract: Methods and systems for assessing a health state of a person via eye movement-driven biometric systems are provided. Examples of the health states that it would be possible to detect with such a system are but not limited to brain injuries (e.g., concussions), dementia, Parkinson's disease, post-traumatic stress syndrome, schizophrenia, fatigue, cybersickness, autism, Bipolar Disorder and other health conditions that manifest themselves in abnormal behavior of the human visual system. Described methods and systems can also detect influence of alcohol and/or drugs. The system extracts biometric template of a person by deriving features from the captured eye movement signal. The system may compare the difference between previous healthy state of a tested person and newly captured template or an averaged biometric template created from the records of multiple healthy people state of multiple people and a newly captured template from a person who needs to be tested.

Abstract: Certain embodiments of the present invention provide functionalized nanoparticles and methods of use thereof. Certain embodiments provide nanoparticles functionalized with streptokinase. Certain embodiments of the present invention provide methods for treating a pathological fibrin associated disorder (e.g., cancer) in an animal.

Abstract: Embodiments facilitate prediction of anti-vascular endothelial growth (anti-VEGF) therapy response in DME or RVO patients. A first set of embodiments discussed herein relates to training of a machine learning classifier to determine a prediction for response to anti-VEGF therapy based on a vascular network organization via Hough transform (VaNgOGH) descriptor generated based on FA images of tissue demonstrating DME or RVO. A second set of embodiments discussed herein relates to determination of a prediction of response to anti-VEGF therapy for a DME or RVO patient (e.g., non-rebounder vs. rebounder, response vs. non-response) based on a VaNgOGH descriptor generated based on FA imagery of the patient.

Abstract: A free-standing electrically conductive porous structure suitable to be used as a cathode of a battery, including an electrically conductive porous substrate with sulfur diffused into the electrically conductive porous substrate to create a substantially uniform layer of sulfur on a surface of the electrically conductive porous substrate. The free-standing electrically conductive porous structure has a high performance when used in a rechargeable battery. A method of manufacturing the electrically conductive porous structure is also provided.

Abstract: A 3-dimensional PDMS cell sorter having multiple passages in a PDMS layer that follow the same path in a DEP separation region and that are in fluid communication with each other within that region. The passages may differ in width transverse to the flow direction within the passages. Flat plates may sandwich the PDMS layer; each plate may have a planar electrode used to generate a DEP field within a sample fluid flowed within the passages. The DEP field may concentrate target cells or particulates within one of the passages within the DEP separation region. The passages may diverge after the DEP-separation region, leaving one passage with a high concentration of target cells or particulates. Techniques for manufacturing such structures, as well as other micro-fluidic structures, are also provided.

Abstract: The present invention relates to bispecific molecules that are capable of localizing an immune effector cell that expresses an activating receptor to a virally infected cell, so as to thereby facilitate the killing of the virally infected cell. In a preferred embodiment, such localization is accomplished using bispecific molecules that are immunoreactive with an activating receptor of an immune effector cell and to an antigen expressed by a cell infected with a virus wherein the antigen is detectably present on the cell infected with the virus at a level that is greater than the level at which the antigen is detected on the virus by the bispecific molecules, and to the use of such bispecific molecules in the treatment of latent viral infections.

Abstract: The present invention relates to a novel crystalline form of deltamethrin, which is a pyrethroid compound useful as a pest control agent. The present invention further relates to a process of preparing the novel crystalline form, and to methods of controlling pests using the novel crystalline form.

Abstract: The present invention discloses a deflector disc of a disc tube membrane module, including a deflector disc body, radial water distribution ribs, an inner support ring and an outer support ring. a first end and a second end of the radial water distribution rib are respectively fixedly connected with an inner edge of the deflector disc body and an outer edge of the inner support ring, an annular boss is arranged on the front side of the inner support ring, a seal ring groove is respectively arranged at corresponding positions of the front side and back side of the inner support ring multiple yielding water collecting grooves are annularly and uniformly distributed on the inner surface of the inner support ring and an inner edge of the outer support ring is fixedly connected with an outer edge of the deflector disc body.

Abstract: Provided are compounds that include a ligand LA of Formula I

Abstract: A multiplication accumulating device and a method thereof are provided. The multiplication accumulating device includes a product generator, a plurality of registers, a product reducer, and an adder. The product generator performs a product operation on a multiplicand and a multiplier to generate a product result of 2N?1 columns. The product reducer is used to append data from a portion of the plurality of registers to the columns in the product result to generate an appending result of 2N?1 columns. The product reducer performs a reduction operation on the appending result according to a column height of each column in the appending result to obtain a reduced result. The product reducer renews the data in the plurality of registers according to the reduced result. The adder adds the data in the plurality of registers according to an accumulation signal to generate a multiplication accumulating operation result.

Abstract: A magnetically driven hopping soft robot based on magnetically programmed temperature-sensitive hydrogels includes first moving bodies and a second moving body. Several first moving bodies are distributed evenly on a bottom portion of the second moving body. The first moving bodies are made of a temperature-responsive hydrogel containing magnetic particles. An alternating magnetic field is applied to the first moving bodies to cause the first moving bodies to deform due to magnetocaloric effect. The first moving bodies have a two-layered structure. A first layer is made of a double-network cross-linked hydrogel and a second layer is made of a magnetic temperature-responsive hydrogel with added magnetic nanoparitcles. An alternating magnetic field is applied to the first moving bodies in a manner that an amount of deformation of the second layer is greater than that of the first layer. The second layer is made of a temperature-responsive hydrogel with added magnetic nanoparticles.

Abstract: Modular pressurized hotbox for use and substitution in a variety of pressurized electrochemical applications to include reversible solid oxide electrolyzer and fuel cells, energy storage systems, renewable fuel production, solid-state hydrogen pumping and liquefaction, and oxygen transport membranes. This is enabled by mixed electronic and ionic conducting compositions of vanadia-yttria and vanadia-calcia stabilized zirconia and a dry powder method of manufacture for ceramic core stacks.

Abstract: Provided herein are fiber reinforced cementitious materials and mixtures with increased crack resistance. The cementitious materials and mixtures include a cement and at least one carbon fiber. Also provide is a fiber reinforced cementitious mortar that includes the fiber reinforced cementitious material to which at least one of water, an aggregate material or a chemical admixture is added.