Abstract: Stable, macroscopic single-crystal chiral liquid crystal compositions are described. The compositions include a single-crystal chiral liquid crystal material on a patterned surface. The patterned surface seeds a particular crystallographic orientation at the substrate-liquid crystal interface. Also described are methods of forming the single-crystal chiral liquid crystal compositions.

Abstract: A support and corresponding system and method of using and producing the support, the support being for supporting a joint or body part of a wearer, the support having at least one rigid first support member, at least one fixing device for attaching the support to the wearer, and at least one second support member extending at an angle from the first support member.

Abstract: Systems and methods including bonding two or more separately formed circuit layers are provided using, for example, cold welding techniques. Processing techniques may be provided for combining inorganic and/or organic semiconductor devices in apparatus including, for example, microchips, optoelectronic devices, such as solar cells, photodetectors and organic light emitting diodes (OLEDs), and other apparatus with multi-layer circuitry. Methods of bonding preformed circuit layers may include the use of stamping and pressure bonding contacts of two or more circuit layers together. Such methods may find applicability, for example, in bonding circuitry to shaped substrates, including various rounded and irregular shapes, and may be used to combine devices with different structural properties, e.g. from different materials systems.

Abstract: The invention discloses a method and a device for identifying pathological pictures, wherein the method comprises: obtaining sample data including a positive sample that is a pathological picture of malignant lesion and a negative sample that is a picture of normal tissue or a pathological picture of benign lesion, with a lesion area marked on the pathological picture of a malignant lesion; dividing the sample data into a training set and a testing set; training a deep neural network model using the training set; testing a trained deep neural network model using the testing set; adjusting parameters of the trained deep neural network model according to a testing result; identifying the pathological picture using the trained deep neural network model. The invention can improve the efficiency and accuracy of pathological picture identification.

Abstract: Methods of identifying compounds that increase ? cell number and/or proliferation by determining the effect of compounds on ? cell number or proliferation in zebrafish pancreas are provided.

Abstract: A leg support exoskeleton is strapped on as a wearable device to support its user during squatting and/or lunging. The exoskeleton includes a knee joint connected to a first link and a second link, which is configured to allow flexion and extension motion between the first link and the second link. A force generator has a first end that is rotatable connected to the first link. A constraining mechanism is connected to the second link and has at least two operational positions. In a first operational position, the second end of the force generator engages the constraining mechanism, where the first link and the second link flex relative to each other. In a second operational position, the second end of the force generator does not engage the constraining mechanism; the first link and the second link are free to flex and extend relative to each other.

Abstract: The invention relates, in part, to compounds, compositions, and methods to assess characteristics of mitochondrial antiviral-signaling (MAVS) polypeptides and also to methods of modulating MAVS polypeptide characteristics. In addition, the invention relates, in part, to assays to assess characteristics of polypeptides.

Abstract: A neural network based learning system for designing a circuit, the design system including at least one memory, at least one processor in communication with said at least one memory, said at least one processor configured to generate a mathematical model of the circuit, determine a structural definition of the circuit from the mathematical model, define a mapping of a plurality of components of the circuit to a plurality of neurons representing the plurality of components of the circuit using at least the structural definition, synthesize, on a hardware substrate, the plurality of neurons, and execute, using the synthesized plurality of neurons on the hardware substrate, at least one test using at least one optimization constraint to determine an optimal arrangement of the plurality of components.

Abstract: An AUC-maximized high-accuracy classification method and system for imbalanced datasets integrates an under-sampling-and-ensemble strategy, a true-outliers-removing strategy and a fake-outliers-concealing strategy, with the hope to effectively and robustly enhance both the AUC and the accuracy metrics in imbalanced classification. Applying under-sampling to construct multiple sub-datasets and assembling classification results of multiple classifiers greatly decline the risk of misclassification and lead to highly accurate and robust results in imbalanced classification task. Moreover, this invention pays attention to detect and identify extremely hidden outliers in a sub-dataset which includes a sub-majority dataset and the entire minority dataset. In this way, more hidden outliers can be located and thus exert less influence on the decision boundary, which contributes to both high AUC and accuracy.

Abstract: Devices and methods for the removal of bone implant tips from within a bony structure in a body. The device or method includes a shaft with an internal grasping feature capable of being inserted while remaining in an un-expanded, un-deployed state. This permits a surgeon or operator to insert the device while in a small profile state, avoiding or reducing damage to adjacent bone tissue during insertion. Upon insertion of the shaft to the proper position within a patient's bone, the grasping feature may then be expanded or deployed from the distal end of the shaft by a surgeon or operator using an actuator in a handle attached to the proximal end of the shaft. Following deployment, the grasping feature may be used to manipulate and/or remove a bone implant tip from a patient's bone tissue. Embodiments of the grasping feature include one or more hooks, wires, articulating fingers, and/or net-based designs formed of metal, polymer, composite, or a combination thereof.

Abstract: The present invention relates to methods for evaluating and/or predicting the outcome of a clinical condition, such as cancer, metastasis, AIDS, autism, Alzheimer's, and/or Parkinson's disorder. The methods can also be used to monitor and track changes in a patient's DNA and/or RNA during and following a clinical treatment regime. The methods may also be used to evaluate protein and/or metabolite levels that correlate with such clinical conditions. The methods are also of use to ascertain the probability outcome for a patient's particular prognosis.

Abstract: The present invention belongs to the technical field of health monitoring for civil structures, and a performance alarming method for bridge expansion joints based on temperature displacement relationship model is proposed. First, the canonically correlated temperature is proposed to maximize the correlation between bridge temperature field and expansion joint displacement; second, a temperature displacement relationship model for bridge expansion joints is established based on canonically correlated temperatures; then, a mean-value control chart is constructed to the error of temperature displacement relationship model; finally, reasonable control limits are determined for the mean-value control chart. A more accurate temperature displacement relationship model can be established based on canonically correlated temperatures, which is of important value to improve the performance alarming ability for expansion joint.

Abstract: Isoquinoline ether compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

Abstract: The disclosed apparatus, systems and methods relate to a framelet-based iterative algorithm for polychromatic CT which can reconstruct two components using a single scan. The algorithm can have various steps including a scaled-gradient descent step of constant or variant step sizes; a non-negativity step; a soft thresholding step; and a color reconstruction step.

Abstract: Improved cross-calibration between magnetic resonance imaging (MRI) coordinates and optical tracking coordinates is provided. Initial calibration is performed with a calibration tool that includes wireless active markers that can be tracked using the MRI scanner, and an optical marker that can be tracked using the optical tracking system. Data from one or more poses of this tool are used to provide an initial cross-calibration. In use, this initial calibration is corrected to account for differences between actual camera position and the reference location. Here the reference location is the camera location at which the initial calibration was performed.

Abstract: The custard apple peel nanoparticles may be manufactured by extracting custard apple peels in a solvent, spraying the custard apple peel extracts into boiling water under ultrasonic conditions to produce a first mixture, sonicating the mixture, stirring the mixture, and drying the mixture to obtain custard apple peel nanoparticles. In an embodiment, the custard apple peel may be peel of Annona reticulata. In an embodiment, the custard apple peel nanoparticles may have improved antibacterial or antioxidant properties.

Abstract: A plasma polymerized thin film having low dielectric constant prepared by depositing a first precursor material represented by the following Chemical Formula 1: wherein in the above Chemical Formula 1, R1 to R14 are each independently H or a substituted or non-substituted C1-C5 alkyl group, and when the R1 to R14 are substituted, their substituents comprise an amino group, a hydroxyl group, a cyano group, a halogen group, a nitro group, or a methoxy group.

Abstract: Described herein are pyrimidinyl-pyridyloxy-naphthyl compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I or I? structure: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I or I? compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.

Abstract: ‘UCD Moxie’ is a day-neutral cultivar of a strawberry plant that provides high yields, has resistance to Fusarium wilt and Verticillium wilt, and produces fewer runners than many high-yielding day-neutral cultivars.