Abstract: A device for non-contact measurement of blood oxygen saturation (SpO2) in a mammalian subject including a camera and one or more arrays of LEDs each having a first set of LEDs emitting near infrared (NIR), and the second set of LEDs emitting orange light located in an optical path adapted to transmit reflected light from a subject to the camera. A controller transmits a camera trigger to the camera, and is further coupled to transmit control signals to the one or more arrays of LEDs. A processor receives photoplethysmography (PPG) data signal values from the camera. The PPG data signal values are present in the reflected light and include pulsatile and non-pulsatile components. The processor determines SpO2 values from the PPG data signal values from the measured ratios of pulsatile to non-pulsatile components of the PPG signals.

Abstract: A method for coating a workpiece includes a step of applying a coating material to the workpiece and a step of friction welding the coating material to the workpiece.

Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

Abstract: Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology and up to 20% of patients on dialysis have this diagnosis. A large family with hereditary FSGS carries a missense mutation in the TRPC6 gene on chromosome 11q, encoding the ion channel protein Transient Receptor Potential Cation Channel 6. The missense mutation is a P112Q substitution, which occurs in a highly conserved region of the protein, enhances TRPC6-mediated calcium signals in response to agonists such as angiotensin II, and alters the intracellular distribution of TRPC6 protein. Previous work has emphasized the importance of cytoskeletal and structural proteins in proteinuric kidney diseases. Our findings suggest a novel mechanism for glomerular disease pathogenesis.

Abstract: A micro-needle device is applicable for a target tissue with a first area having a first parameter and a second area having a second parameter. The micro-needle device includes a substrate and a micro-needle array connected to the substrate. The micro-needle array includes a first micro-needle corresponding to the first area and a second micro-needle corresponding to the second area. One of the surfaces of the substrate having the micro-needle array corresponds to the surface curvature of the target tissue. The first micro-needle has a first configuration corresponding to the first parameter, and the second micro-needle has a second configuration corresponding to the second parameter and different from the first configuration. The configuration includes at least one selected from a group consisting of length, distribution density, diameter, and medicine-carrying amount of micro-needle. A method for manufacturing a micro-needle device and a method for manufacturing a micro-needle mold are also provided.

Abstract: Disclosed are systems and methods that include or utilize composable mammalian elements of transcription (COMET) including engineered recombinant proteins that regulate transcription and engineered DNA promoter sequences that are regulated by the engineered recombinant proteins. The elements may be composed to form logic gates, gene expression cascades and programs, and cell-based biosensors.

Abstract: A sensing electrode, and an electrochemical system and method utilizing same for detecting peroxide-containing compounds in a sample, are provided. The sensing electrode is a carbon electrode having ions of a metal that promotes decomposition of a peroxide absorbed to its surface, optionally along with a solid electrolyte membrane.

Abstract: Embodiments of the present invention are directed to various devices, systems and methods of providing a restartable, hybrid-rocket system that uses Acylonitrile Butadiene Styrene (ABS) and compressed air containing oxygen levels up to 40% as a propellant. Alternatively, embodiments of the present invention includes restartable hybrid rocket system that uses a heterogeneous matrix of ABS and a solid oxidizing agent in addition to compressed air as a propellant. When the ABS is exposed to an electrical potential field, the electrical field's effect on the ABS produces localized arcing between multiple layers of the ABS resulting in joule heating and pyrolysis of the ABS. The pyrolysis produces spontaneous combustion of the ABS once the oxidizer flow provides a local oxygen partial pressure greater than two atmospheres at the surface of the ABS.

Abstract: Exemplary thin-film optical devices have first and second layer groups disposed as a layer stack on a substrate. The first layer group comprises a first PPN layer, a first LCP layer, and a first barrier layer all superposed. The second layer group is superposed relative to the first layer group, and includes a second PPN layer, a second LCP layer, and a second barrier layer all superposed. The first and second layer groups cooperate to polarize multiple wavelengths of an incident light flux in a broadband and/or wide-angle manner Each of the layer groups has an alignment layer, a respective liquid-crystal polymer layer, and a barrier layer.

Abstract: An always-on, exchange-only (AEON) qubit is comprised of three two-level systems (e.g., semiconductor quantum dot or other spin encoded qubit) and can be operated at a “sweet spot” during both single qubit and two-qubit gate operations. The “sweet spot” operation is immune to variations in noise with respect to nontrivial detuning parameters defining the AEON. By operating at the “sweet spot,” both single and two-qubit gate operations can be performed using only exchange pulses (e.g., DC voltage pulses applied to tunneling gates).

Abstract: An apparatus for a shoe which provides information to a remote computing device having a user application. The apparatus includes a first insert configured to be disposed in the shoe having a wireless transmitter, at least one sensor for sensing pressure that provides an antialiased image of pressure, and a controller in communication with the sensor and the transmitter which receives the pressure sensed by the sensor and transmits data associated with the pressure sensed through the transmitter to the device. A method for providing information about a user disposed in a first shoe of the user. A wireless pressure sensitive shoe insert.

Abstract: The present disclosure relates to tungsten oxide composition. Specifically, the present disclosure relates to mesoporous tungsten oxide composition that is active for multiple reactions, including aromatic alkylation, alkene coupling, alkene cyclization, alkyne oxidation, alcohol dehydrogenation reactions.

Abstract: Devices and methods for mechanism-based feedback controller employed in a wind powered power system are provided. A controller can include a vector control-based voltage source converter with feedback control circuitry. The feedback control circuitry is configured to modulate either a power order or a dc-link voltage order to control coupling between voltage and power. The controller can be connected to a wind-based turbine generator of a wind farm and regulate power deployed to a power grid.

Abstract: Provided herein are compounds that act as histone deacetylase (HDAC) inhibitors, and can affect expression of genes in vivo and in vitro. These HDAC inhibitors are generally volatile compounds that can be administered as a gas or vapor. Such inhibitors can be used as therapeutics for numerous disease conditions, such as a variety of cancers, neural degenerative diseases, neurological diseases, senescence, and infectious diseases.

Abstract: A device for measuring strain and volume of a soil sample including an enclosure adapted to receive a soil sample within another enclosure. A base adapted to hold the sample enclosure. The device also has a plurality of moveable arms located between the enclosures which may be a spaced distance apart and adapted to move around the sample. Cameras as included on the arms.

Abstract: Systems and methods which provide a joint machine learning and game theory modeling (MLGT) framework for video coding rate control (RC) are described. A machine learning based R-D model classification scheme may be provided to facilitate improved R-D model prediction accuracy and a mixed R-D model based game theory approach may be implemented to facilitate improved RC performance. For example, embodiments may provide inter frame Coding Tree Units (CTUs) level bit allocation and RC optimization in HEVC. Embodiments provide for the CTUs being classified into a plurality of categories, such as by using a support vector machine (SVM) based multi-classification scheme. An iterative solution search method may be implemented for the mixed R-D models based bit allocation method. Embodiments may additionally or alternatively refine the intra frame QP determination and the adaptive bit ratios among frames to facilitate improving the coding quality smoothness.

Abstract: The disclosure provides brassinosteroid mimetics and method of using such mimetics.

Abstract: A sensing apparatus for sensing target materials including biological or chemical molecules in a fluid. One such apparatus includes a semiconductor-on-insulator (SOI) structure having an electrically-insulating layer, a fluidic channel supported by the SOI structure and configured and arranged to receive and pass a fluid including the target materials, and a semiconductor device including at least three electrically-contiguous semiconductor regions doped to exhibit a common polarity. The semiconductor regions include a sandwiched region sandwiched between two of the other semiconductor regions, and configured and arranged adjacent to the fluidic channel with a surface directed toward the fluidic channel for coupling to the target materials in the fluidic channel, and further arranged for responding to a bias voltage. The sensing apparatus also includes an amplification circuit in or on the SOI and that is arranged to facilitate sensing of the target material near the fluidic channel.

Abstract: A method is disclosed for transmitting data between a source node and destination node connected via multiple paths of a heterogeneous network, at least one of the paths delivering packets with a non-deterministic delivery time. Data is divided into frames, each frame comprising a number of packets, where processing by the destination node of an information packet p is conditional on receipt of the data for any information packet i where i<p. A number of sequential transmission slots s, each for transmitting a given packet p of a frame, are allocated for each network path k. A set D of possible assignments of packets to transmission slots for a frame are provided. The method comprises determining an assignment x with minimum in-order delivery delay of said packets based on expected arrival times of packets to their destination and expected reordering delay for packets. Packets are then transmitted in accordance with the determined assignment x.

Abstract: A system for classifying a user touch event by a user interacting with a device as an intended key is provided. For different hand postures (e.g., holding device with right hand and entering text with right thumb), the system provides a touch pattern model indicating how the user interacts using that hand posture. The system receives an indication of a user touch event and identifies the hand posture of the user. The system then determines the intended key based on the user touch event and a touch pattern model for the identified hand posture. A system is also provided for determining the amount a presser a user is applying to the device based on dampening of vibrations as measured by an inertial sensor. A system is provided that uses motion of the device as measured by an inertial sensor to improve the accuracy of text entry.