Patents Assigned to University
  • Regulating calcium in excitable cells with a novel protein
    Patent number: 10543252
    Abstract: Embodiments of the disclosure concern methods and compositions related to the small Ankyrin 1 (sAnk1) protein and its role as a regulatory protein in at least muscle cells. In particular embodiments, its expression and/or activity are modulated with one or more compositions. In specific embodiments, compositions such as nucleic acids that inhibit expression of sAnk1 are utilized for a variety of methods, whereas in other embodiments compositions such as polypeptides, peptides, or sAnk1-encoding nucleic acids that enhance sAnk1 levels are utilized for certain methods.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: January 28, 2020
    Assignee: University of Maryland, Baltimore
    Inventors: Patrick F. Desmond, Robert J. Bloch, Mark A. Rizzo, Joaquin Muriel, Michele L. Markwardt
  • DNA vaccine containing VEGF-specific epitope and/or angiopoietin-2-specific epitope
    Patent number: 10543261
    Abstract: The present invention provides a therapeutic or prophylactic agent for cancer, containing an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of VEGF and/or a specific epitope of angiopoietin-2, wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: January 28, 2020
    Assignees: Osaka University, AnGes, Inc.
    Inventors: Hironori Nakagami, Mariko Kyutoku, Ryuichi Morishita, Hideki Tomioka
  • Beta-lactamase inhibitors, formulations, and uses thereof
    Patent number: 10543221
    Abstract: Provided herein are heterocyclic compounds and pharmaceutical formulations that can be used to treat bacterial infections. Also provided herein are methods of making and using the heterocyclic compounds and pharmaceutical formulations.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: January 28, 2020
    Assignees: University of South Florida, The Regents of the University of California
    Inventors: Yu Chen, Orville Antonio Pemberton, Adam Renslo, Priyadarshini Jaishankar
  • Reactors and methods for processes involving partial oxidation reactions
    Patent number: 10543470
    Abstract: Described herein are improved chemical reactors for carrying out partial oxidation reactions. The chemical reactor permits the use of levels of oxygen above the lower explosion limit (LEL) typically used in partial oxidation reactions, which increases both volumetric reactivity and conversion per pass, resulting in reduced separation and reactant recycle costs. Also described are methods of using the reactors.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: January 28, 2020
    Assignees: IntraMicron, Inc., Auburn University
    Inventors: Bruce Tatarchuk, David Scarborough, Paul Dimick, Hongyun Yang
  • bacteriophage lysins for detection and treatment of gram positive bacteria
    Patent number: 10544407
    Abstract: The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including Streptococcus and Staphylococcus, and related conditions. The invention provides compositions and methods incorporating and utilizing Streptococcus suis derived bacteriophage lysins, particularly PlySs2 and/or PlySs1 lytic enzymes and variants thereof, including truncations thereof. Methods for treatment of humans are provided.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: January 28, 2020
    Assignee: The Rockefeller University
    Inventors: Vincent A. Fischetti, Jonathan Schmitz, Daniel Gilmer, Chad Euler
  • 3D printer having dual stage structure
    Patent number: 10543642
    Abstract: A 3D printer has a dual stage structure and includes: a frame; an extrusion unit having a nozzle configured to extrude a raw material; a stacking base unit positioned under the extrusion unit and configured to receive the raw material on a surface thereof so that an object is formed in a layer-by-layer manner on the surface; and a cutting unit positioned between the stacking base unit and the extrusion unit and configured to grind or cut the object formed on the surface of the stacking base unit, wherein the frame is configured to be connected to outer sides of the stacking base unit, the extrusion unit, and the cutting unit, the stacking base unit and the cutting unit are configured to be vertically movable along the frame, and the nozzle is configured to be movable on a plane.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: January 28, 2020
    Assignee: Foundation of Soongsil University-Industry Cooperation
    Inventor: Dong Hun Lee
  • Method, system and computer simulation environment for testing of monitoring and control strategies in diabetes
    Patent number: 10546659
    Abstract: A simulation environment for in silico testing of monitoring methods, open-loop and closed-loop treatment strategies in type 1 diabetes. Some exemplary principal components of the simulation environment comprise, but not limited thereto, the following: 1) a “population” of in silico “subjects” with type 1 diabetes in three age groups; 2) a simulator of CGM sensor errors; 3) a simulator of insulin pumps and discrete insulin delivery; 4) an interface allowing the input of user-specified treatment scenarios; and 5) a set of standardized outcome measures and graphs evaluating the quality of the tested treatment strategies. These components can be used separately or in combination for the preclinical evaluation of open-loop or closed-loop control treatments of diabetes.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: January 28, 2020
    Assignee: University of Virginia Patent Foundation
    Inventors: Boris P. Kovatchev, Marc D. Breton, Claudio Cobelli, Chiara Dalla Man
  • Method and terminal device for executing radio application
    Patent number: 10547334
    Abstract: A method and a terminal device for executing a radio application are disclosed. The method for executing a radio application comprises the steps of: allowing a radio virtual machine (RVM) of a reconfigurable mobile device to reference a radio programming interface (RPI); and replacing at least one abstract processing element (APE) of the RVM with at least one elementary RVM according to an RVM hierarchical structure referenced by the RPI.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: January 28, 2020
    Assignee: Industry-University Cooperation Foundation Hanyang University
    Inventors: Seung Won Choi, Yong Jin, Dong Hyun Kuem, Kyung Hoon Kim, Heung Seop Ahn
  • Cas9-nucleic acid complexes and uses related thereto
    Patent number: 10544405
    Abstract: This disclosure relates to Cas9-nucleic acid complexes and uses related thereto. In certain embodiments, the disclosure contemplates transgenic plants and animals genetically engineered to express Cas9-nucleic acid complexes disclosed herein. In certain embodiments, the disclosure relates to methods of treating or preventing, diseases, conditions, cancer, viral infections or other pathogenic infection using vectors configured to express a Cas9-nucleic acid complex disclosed herein.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: January 28, 2020
    Assignee: Emory University
    Inventors: David S. Weiss, Arash Grakoui, Timothy R. Sampson, Aryn Alaine Price
  • Phase separated composite layers and applications thereof
    Patent number: 10547006
    Abstract: In one aspect, composite layers are described herein demonstrating phase-separated architectures which, in some embodiments, can mitigate performance disadvantages of prior organic layers of optoelectronic devices. A composite organic layer described herein comprises nanocluster nodes and carbon nanoparticles disposed in a conjugated polymeric host, wherein the carbon nanoparticles are substantially phase separated from the conjugated polymeric host forming lamellar structures of carbon nanofibrils radiating from the nanocluster nodes.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: January 28, 2020
    Assignee: Wake Forest University
    Inventor: David Carroll
  • Solid tumor methylation markers and uses thereof
    Patent number: 10544467
    Abstract: Disclosed herein are methods and kits for identifying a subject as having esophagus cancer, pancreatic cancer, or stomach cancer. Also provided herein are methods and kits for generating the methylation profile of a biomarker associated with esophagus cancer, pancreatic cancer, or stomach cancer.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: January 28, 2020
    Assignees: YouHealth Oncotech, Limited, The Regents of the University of California
    Inventors: Kang Zhang, Rui Hou, Lianghong Zheng
  • Methanol extract of grape seed nanoparticles
    Patent number: 10542758
    Abstract: The methanol extract of grape seed nanoparticles is prepared from grape seeds washed in distilled water and oven-dried at 60° C. for 12 hours. The seeds are milled or ground to a powder and sieved to a maximum size of 0.355 mm. The powder is added to concentrated HCl and stirred at 3000 rpm at 30° C. for one hour, and then distilled water is added with stirring for an additional 2 hours. The mixture is filtered, and the marc is dried to recover grape seed nanoparticles. The nanoparticles are added to methanol at the rate of 100 mg/ml, left in a shaker for 24 hours at room temperature, centrifuged, filtered, and the resulting extract (the supernatant) is recovered. Agar well diffusion testing showed that the nanoparticle extract exhibited greater antibacterial activity than a methanol extract of grape seeds alone, and testing showed greater antioxidant levels in the nanoparticle extract as well.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: January 28, 2020
    Assignee: King Saud University
    Inventors: Hany Mohamed Yehia, Reem Atta Alajmi, Hatem Salama Mohamed Ali, Manal Fawzy Elkhadragy, Dina Mahmoud Metwally Hasanin, Mohamed Fekry Serag El-Din, Manal Ahmed Gasmelseed Awad
  • Methods and compositions for treating cancers and enhancing therapeutic immunity by selectively reducing immunomodulatory M2 monocytes
    Patent number: 10543226
    Abstract: The present disclosure provides pharmaceutical compositions comprising nucleic acids capable of targeting IGF-1R expression in M2 cells. The present disclosure also provides methods for the selective reduction of M2 cells by targeting expression of IGF-1R in these cells. The present disclosure further provides methods for treating cancer and enhancing therapeutic by targeting expression of IGF-1R in M2 cells in patients. The pharmaceutical composition of the present invention is effective when administered systemically to subjects in need thereof. The ease of administration of the pharmaceutical composition facilitates treatment and enhances patient compliance.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: January 28, 2020
    Assignee: Thomas Jefferson University
    Inventors: David W. Andrews, Douglas C. Hooper
  • Compounds capable of antagonizing islet amyloid polypeptide (IAPP) induced beta-cell damage and impaired glucose tolerance
    Patent number: 10544213
    Abstract: Described are molecules specifically binding to human islet amyloid polypeptide (hIAPP) also known as amylin, particularly human-derived antibodies as well as fragments, derivatives and variants thereof for antagonizing islet amyloid polypeptide (IAPP) induced ?-cell damage and impaired glucose tolerance which are symptoms typically associated with diabetes mellitus type 2 (T2D).
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: January 28, 2020
    Assignees: Neurimmune Holding AG, University of Zurich
    Inventors: Jan Grimm, Fabrice Heitz, Fabian Wirth, Tobias Welt
  • Method of forming an enclosure
    Patent number: 10543372
    Abstract: The present disclosure provides a method of forming a hermetically sealed enclosure that comprises a diamond material. The method comprises providing first and second enclosure components comprising the diamond material and having first and second recesses, respectively, at edge portions. At least one of the first and second enclosure components has a cavity. The enclosure components have respective contact surfaces at the first and second recesses and are shaped such that an outer channel is formed by the co-operation of the first and second recesses when the first and second enclosure components are contacted at the contact surfaces to form the enclosure. The method further comprises bonding a first type of material to at least surface portions of the first and second recesses of the first and second enclosure components, respectively.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: January 28, 2020
    Assignees: The University of Melbourne, National ICT Australia Limtied
    Inventors: Steven Prawer, Kumaravelu Ganesan, David Garrett, Nicholas Apollo, Alastair Stacey, Mathilde Escudie, Hamish Meffin, Samantha Lichter
  • Skin and surface disinfectant compositions containing botanicals
    Patent number: 10542760
    Abstract: The present invention relates to a skin or surface disinfectant composition with broad spectrum antimicrobial activity comprising one or more essential oil (and/or one or more component thereof) and one or more fruit acid. The compositions of the invention may be used as non-toxic alternatives to conventional disinfectants or may be added to other antimicrobial agents to enhance their activity. The invention provides effective alternatives to harsher products which may be particularly useful in personal care and household products and where children and/or pet exposure may be a concern.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: January 28, 2020
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Shanta M. Modak, Nayana Baiju, Lauserpina A. Caraos
  • Methods, systems, and computer readable media for modeling garments using single view images
    Patent number: 10546433
    Abstract: Methods, systems, and computer readable media for modeling garments using single view images are disclosed. According to one method, the method includes receiving an image depicting a person wearing at least one garment. The method also includes constructing a body model based on the person in the image and a template from a body model database. The method further includes constructing at least one garment model based on the at least one garment in the image and at least one template from a garment model database. The method also includes constructing a combined model based on the body model and the at least one garment model. The method further includes adjusting the combined model by modifying body pose parameters and determining garment material properties and sizing parameters.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: January 28, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Ming C. Lin, Shan Yang
  • Marine coatings
    Patent number: 10544312
    Abstract: Marine coatings including cationic polymers hydrolyzable to nonfouling zwitterionic polymers, coated marine surfaces, and methods for making and using the marine coatings.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: January 28, 2020
    Assignee: University of Washington
    Inventors: Shaoyi Jiang, Yuting Li, Hong Xue, Shengfu Chen
  • Antisense compounds targeting genes associated with cystic fibrosis
    Patent number: 10544417
    Abstract: The present disclosure relates generally to compounds comprising oligonucleotides complementary to a cystic fibrosis transmembrane conductance regulator (CFTR) RNA transcript. Certain such compounds are useful for hybridizing to a CFTR RNA transcript, including but not limited to a CFTR RNA transcript in a cell. In certain embodiments, such hybridization results in modulation of splicing of the CFTR transcript. In certain embodiments, such compounds are used to treat one or more symptoms associated with Cystic Fibrosis.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: January 28, 2020
    Assignee: Rosalind Franklin University of Medicine and Science
    Inventor: Michelle L. Hastings
  • Muscadine grape plant named ‘Florida Onyx’
    Patent number: PP31407
    Abstract: A new and distinct cultivar of the muscadine grape plant, Vitis rotundifolia Michx., which is highly productive, resistant to Pierce's disease, low fruit ripening rot, and relatively low wet scar. The new and distinct cultivar has a very large deep black-red colored berry with an extremely pleasant fruit flavor. The cultivar has moderate vine growth with high fruit yield, and very good disease resistance. The cultivar also has an extended shelf life.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: January 28, 2020
    Assignee: Florida A&M University
    Inventors: Zhongbo Ren, Jiang Lu, Violeta Tsolova