Abstract: The subject matter described herein relates to methods, systems, and computer readable media for visualization of a resection target during epilepsy surgery and for real time spatiotemporal visualization of neurophysiologic biomarkers. One exemplary method includes a real time neurophysiologic biomarker visualization system implemented by at least one computer, receiving, as input, a pre-electrode-implantation MRI of an epilepsy patient's brain.

Abstract: This disclosure relates to methods and compositions for managing vascular conditions by targeting microRNA. In certain embodiments, the disclosure relates to antisense, RNA interference, and blocking oligonucleotide therapeutic compositions and uses related thereto.

Abstract: The conjugated polymer laser with temperature-controlled power output uses a triphenylamine dimer-based conjugated polymer as the laser medium to produce an output laser beam having a beam energy tunable between approximately 20 ?J and approximately 325 ?J over a temperature range of the triphenylamine dimer-based conjugated polymer between approximately 40° C. and approximately 85° C. The triphenylamine dimer-based conjugated polymer laser medium is a solution of poly[N,N?-bis(4-butylphenyl)-N,N?-bisphenylbenzidine], known as poly-TPD(4B), dissolved in toluene. Poly-TPD(4B) has a long side chain of butyl (C4H9), providing temperature-dependent dimerization, which may not be found with shorter chains of butyl, such as in poly-TPD(4E) or poly-TPD(4M). The molar concentration of the poly-TPD in the solution is between approximately 5 ?M and approximately 100 ?M.

Abstract: There is provided a ligament reconstruction type artificial knee joint that can exert a function of an anterior cruciate ligament in an original knee joint. In an artificial knee joint 1 used in a total knee replacement, the artificial knee joint 1 includes: a femur member 10 mounted on a femur distal end DT; a tibia member 20 mounted on a tibia proximal end PE; and an artificial ligament 30 coupling the tibia member 20 and the femur member 10 together. One end of the artificial ligament 30 is coupled to a position where once an anterior cruciate ligament ACL exists in a knee replaced for the artificial knee joint 1 on an inside of a lateral condyle of the femur member 10, and the other end of the artificial ligament 30 is coupled to a position where once the anterior cruciate ligament ACL exists in the knee replaced for the artificial knee joint 1 on an upper side of the tibia member 20.

Abstract: An object of the present invention is to develop and provide a lung cancer differential marker with which lung cancer can be diagnosed conveniently and highly sensitively without depending only on increase or decrease in protein expression level between cancer patients and healthy persons. Another object of the present invention is to develop and provide a glycan marker capable of distinguishing histological types of lung cancer. Of serum glycoproteins, glycopeptide and glycoprotein groups whose glycan structures were altered specifically in lung cancer cell culture supernatants were identified, and they are provided as lung cancer differential markers.

Abstract: A microfluidic device capable of trapping contents in a manner suitable for high-throughput imaging is described herein. The microfluidic device may include one or more trapping devices, with each trapping device having a plurality of trapping channels. The trapping channels may be configured to receive contents via an inlet channel that connects a sample reservoir to the trapping channels via fluid communication. The trapping channels are shaped such that contents within the trapping channels are positioned for optimal imaging purposes. The trapping channels are also connect to at least one exit channel via fluid communication. The fluid, and contents within the fluid, may be controlled via hydraulic pressure.

Abstract: The invention provides a compound of formula (I): (I) wherein R1-R4 have any of the values defined in the specification, as well as compositions comprising a compound of formula (I) and methods for treating diseases (e.g. cancer).

Abstract: A system and method for thermally exchanging heat between waste air being expelled from a poultry barn and fresh outside/outdoor ambient air being introduced into the poultry barn.

Abstract: A three-dimensional image reconstruction method associated with the present invention includes the steps of: obtaining a first transmission electron microscope image of a sample containing the membrane proteins present within a lipid membrane, the image having been taken by illuminating an electron beam on the sample from a direction tilted relative to a line normal to the membrane surface of the lipid membrane; obtaining a second transmission electron microscope image of the sample taken by illuminating the electron beam on the sample perpendicularly to the membrane surface of the lipid membrane; identifying orientations of the membrane proteins of the first transmission electron microscope image on a basis of the second transmission electron microscope image; and analyzing a three-dimensional structure of the membrane proteins from the first transmission electron microscope image on a basis of information about the identified orientations of the membrane proteins.

Abstract: Disclosed are exosomes that include a packaging protein and a cargo RNA in which the packaging protein binds specifically to the cargo RNA. The packaging protein is a fusion protein that includes an RNA-binding domain and an exosome-targeting domain. The cargo RNA includes an RNA-motif that the RNA-binding domain of the fusion protein binds specifically such that the cargo RNA is packaged in the lumen of the exosomes.

Abstract: Microfluidic devices that are configured to use centrifugal forces to bias particles into one or more capture regions based on their individual sizes are described.

Abstract: A propulsion apparatus using sound radiation force according to an exemplary embodiment of the present invention includes: an ultrasound generation unit which is installed at one side of an object to be operated, generates ultrasound, and provides propulsive force to the object to be operated by using sound radiation force of the ultrasound; and an ultrasound control unit which is coupled to one side of the ultrasound generation unit, and increases propulsive force to be provided to the object to be operated by controlling intensity of the ultrasound generated by the ultrasound generation unit.

Abstract: Catalytic water treatment is provided using an active material driven with an optical and/or electrical excitation. The active material is MoS2, MoSe2, WS2, WSe2, MoxW1-xS2, MoxW1-xSe2, MoSySe2-y, WSySe2-y, or MoxW1-xSySe2-y; wherein 0<x<1 and 0<y<2. The active material is configured as one or more layered nanostructures having exposed layer edges. A metal catalyst is disposed on the active material. The combined structure of active material and metal catalyst is disposed in the water to be treated. The excitation is provided to the active material to generate one or more reactive oxygen species by dissociation of water, wherein the reactive oxygen species provide water treatment.

Abstract: 4,5-Substituted Picolinamide and picolinonitrile compounds of formula (I), where R4 is CONH2 or CN and R1 is an optionally substituted aryl or heteroaryl, are negative allosteric modulators of the metabotropic glutamate receptor 2 (mGlu2). The compounds and pharmaceutical compositions including the compounds may be useful for treating depression, anxiety, obsessive-compulsive disorder, cognitive disorders, Alzheimer's disease, or autism spectrum disorders in a subject.

Abstract: A segment for supporting electromagnetic coupling elements of a stator or rotor of an electrical machine comprises a plurality of elongate laminations which are stacked in a first direction to form a lamination stack with elongate edges of the laminations defining opposite first and second major faces of the lamination stack. The segment comprises a plurality of elongate compression devices passing internally through the lamination stack in the first direction and arranged to compress together the laminations in the lamination stack.

Abstract: 2-Acylindazole compounds of formula I or formula II are disclosed: These compounds inhibit Coagulation Factor XIIa. They are useful to treat autoimmune diseases.

Abstract: A multiple-gain transconductance amplifier circuit is presented. It is developed by utilizing programmable gain source-coupling differential pair output stage forming multiple-gain transconductance amplifier outputs. A reconfigurable nth-order filter based on a multi-gain transconductance amplifier where the multi-gain transconductance amplifier includes a linear voltage-to-current converter and a programmable current-folding output stage was implemented. The filter achieves independent programmability while still using a single active device per pole. Further, the proposed multiple-gain transconductance amplifier can be employed to design poly phase filters and transconductance amplifier cell for an amplifier-based low-dropout regulator.

Abstract: Methods described herein enable the production of numerous molecular species through decarboxylative cross-coupling via use of photoredox and transition metal catalysts. A method described herein, in some embodiments, comprises providing a reaction mixture including a photoredox catalyst, a transition metal catalyst, a coupling partner and a substrate having a carboxyl group. The reaction mixture is irradiated with a radiation source resulting in cross-coupling of the substrate and coupling partner via a mechanism including decarboxylation, wherein the coupling partner is selected from the group consisting of a substituted aromatic compound and a substituted aliphatic compound.

Abstract: Provided herein are compositions and methods for reducing expression of C9orf72 transcripts in cells containing expanded intronic GGGGCC regions, including those in subjects having or at risk of developing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Provided herein are a double-stranded oligonucleotides of 13 to 22 nucleobases in length targeting a GGGGCC expanded repeat region in an intron of C9orf72, comprises (a) 3-5 central mismatches (within bases 9-14) within a target sequence comprising the expanded repeat sequence, or (h) 3-5 mismatches outside of the seed sequence (bases 2-8 within the guide strand complementary to the expanded repeat sequence).

Abstract: An adjustable structural connection—a connection which can be adjusted to alter the location and angle of member attachment—transforms the traditional notion of connections as a static means of connecting members at specific angles to a dynamic means of assembling a variety of structurally efficient forms. The adjustable connection connects a diagonal member to a vertical or horizontal member using either curved plate mounted to both of the structural members or a temporarily rotatable link. The adjustable connection can be used in a kit-of-parts type system, using multiple versions of the adjustable connection, which can join members at a wide variety of angles using a small number of unique components.