Abstract: Modified alginates are described herein along with hydrogels comprising the same. A modified alginate may be prepared by reacting alginate and an aromatic compound (e.g., an aromatic amine) and/or pH sensitive compound. The modified alginates, hydrogels, and/or methods described herein may be used to coat and/or encapsulate at least a portion of a bioactive substance, optionally for oral delivery in humans and other animals.
Type:
Application
Filed:
June 30, 2017
Publication date:
December 12, 2019
Applicants:
Wake Forest University Health Sciences, Wake Forest University
Inventors:
Mark E. WELKER, Emmanuel C. OPARA, Surya R. BANKS, Amber N. WEISSENENFLUH
Abstract: The present disclosure provides a low-cost beam scanning antenna and method of beam scanning in which two phase shifts are performed in an array of antenna elements. One of the phase shifts is performed in discrete stepwise increments in a feedline of the antenna element and another phase shift is performed by radiating a signal through variable phase shifters. The amount of phase shift provided by the variable phase shifters is varied by changing a rotation angle of the variable phase shifters.
Abstract: Provided is an apparatus and method for frontal audio rendering in interaction with a screen size, the method including measuring playback environment information used to play back input content; and correcting an audio signal to be output based on the measured playback environment information and production environment information included in the input content.
Type:
Application
Filed:
August 26, 2019
Publication date:
December 12, 2019
Applicants:
Electronics and Telecommunications Research Institute, Kyonggi University Industry & Academia Cooperation Foundation
Abstract: An electrolysis device including a housing, an electrolysis plate, and a rotating element is provided. The housing has a first surface and a second surface that are opposite to each other. The electrolysis plate disposed in the housing includes a rotating plate, a working electrode, and a counter electrode. The working electrode and the counter electrode are respectively disposed on the rotating plate and separated from each other. The rotating element is pivotally disposed on the rotating plate, so that the electrolysis plate is able to rotate in the housing.
Type:
Application
Filed:
June 6, 2019
Publication date:
December 12, 2019
Applicant:
National Taiwan University of Science and Technology
Abstract: Disclosed are multi-compartmental nanoparticulate systems for imaging as well as the diagnosis, monitoring, and treatment of inflammation and/or disease. These multicompartmental nanoparticulate systems can be used to target specific cells or cellular structures. Furthermore, these systems are capable of simultaneous delivery of hydrophilic and lipophilic compositions. Finally, these systems also allow for temporal control of drug delivery.
Type:
Grant
Filed:
March 24, 2011
Date of Patent:
December 10, 2019
Assignee:
Northeastern University
Inventors:
Mansoor M. Amiji, Mayur Kalariya, Shardool Jain, Husain Attarwala
Abstract: The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating CD2 into the CAR to alter the cytokine production of CAR-T cells in both negative and positive directions.
Type:
Grant
Filed:
August 4, 2017
Date of Patent:
December 10, 2019
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
Carl H. June, John Scholler, Avery D. Posey, Jr.
Abstract: The present invention reduces encoding distortion in frequency domain encoding compared to conventional techniques, and obtains LSP parameters that correspond to quantized LSP parameters for the preceding frame and are to be used in time domain encoding from coefficients equivalent to linear prediction coefficients resulting from frequency domain encoding. When p is an integer equal to or greater than 1, a linear prediction coefficient sequence which is obtained by linear prediction analysis of audio signals in a predetermined time segment is represented as a[1], a[2], . . . , a[p], and ?[1], ?[2], . . . , ?[p] are a frequency domain parameter sequence derived from the linear prediction coefficient sequence a[1], a[2], . . . , a[p], an LSP linear transformation unit (300) determines the value of each converted frequency domain parameter {tilde over (?)}?[i] (i=1, 2, . . . , p) in a converted frequency domain parameter sequence {tilde over (?)}w[1], {tilde over (?)}w[2], . . .
Type:
Grant
Filed:
April 30, 2019
Date of Patent:
December 10, 2019
Assignees:
NIPPON TELEGRAPH AND TELEPHONE CORPORATION, The University of Tokyo
Abstract: Materials and methods for improving the DC and RF performance of off-state step-stressed high electron mobility transistors (HEMTs) and devices are provided. A semiconductor device can include at least one HEMT and an on-chip heating source. A method of recovering the DC and RF performance of a stressed semiconductor device can include annealing the device with a built-in heating source of the device.
Type:
Grant
Filed:
March 25, 2016
Date of Patent:
December 10, 2019
Assignee:
University of Florida Research Foundation, Incorporated
Abstract: The present invention generally concerns decomposing a ternary metal hydride to isolate nanoparticles to use in a fuel grain. More specifically, the present invention harnesses increased energy densities from two distinct nanoparticles isolated by a precise decomposition of LiAlH4. The singular material is air stable and is a nanocomposite of Li3AlH6 nanoparticles, elemental Al nanoparticles, an amount of Ti metal, and a nanoscale organic layer. We call this nanocomposite nMx, which protects and preserves the high energy densities of the core metals isolated from the controlled reaction, making the nanoparticles safe to handle in air. The narrow distribution of nanoparticles has no byproducts or phase transitions that decrease energy output. The unique burning characteristics of nMx enhance the combustion of solid propellant formulations compatible with solid or hybrid rocket motors, where fuel grains are cast, pressed, or 3D printed with nMx powder, a polymeric binder, or optional additives.
Type:
Grant
Filed:
August 19, 2017
Date of Patent:
December 10, 2019
Assignee:
Saint Louis University
Inventors:
Steven Wayne Buckner, Paul Jelliss, Stephen Chung, Jacob M Laktas, Gregory J Place, Albert Michael Becksted, Jr.
Abstract: Systems and methods for integrating ultra-fast programmable networks in microgrid are disclosed to provide flexible and easy-to-manage communication solutions, thus enabling resilient microgrid operations in face of various cyber and physical disturbances. The system is configured to establish a novel software-defined networking (SDN) based communication architecture which abstracts the network infrastructure from the upper-level applications to significantly expedite the development of microgrid applications, develop three functions of the SDN controller for microgrid emergency operations, including time delay guarantee, failover reconfiguration and rate limit and create a hardware-in-the-loop cyber-physical platform for evaluating and validating the performance of the presented architecture and control techniques.
Type:
Grant
Filed:
February 19, 2019
Date of Patent:
December 10, 2019
Assignee:
University of Connecticut
Inventors:
Peng Zhang, Bing Wang, Peter B. Luh, Lingyu Ren, Yanyuan Qin
Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.
Type:
Grant
Filed:
February 10, 2016
Date of Patent:
December 10, 2019
Assignees:
The United States of America, as represented by the Secretary, Department of Health and Human Services, University of Louisville Research Foundation, Inc., University of Pittsburgh—Of the Commonwealth System of Higher Education
Inventors:
Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
Abstract: Optomechanical device for frequency doubling enhancement are described. The devices include a substrate through which light of a first wavelength is introduced, a first reflector mirror, a conductive layer disposed on the first reflector mirror, and a second mirror spaced apart from the conductive layer, thereby forming an optical cavity between the second mirror and the conductive layer. The devices also include a power source coupled to the second mirror and the conductive layer and a monolayer of non-linear optical material disposed within the optical cavity, the monolayer being configured to produce light of a second wavelength upon interaction with the light of the first wavelength. The second mirror is deformable upon introduction of voltage from the power source and deformation of the second mirror changes a length of the optical cavity, thereby enhancing a power output of the light of the second wavelength produced by the monolayer.
Type:
Grant
Filed:
June 9, 2016
Date of Patent:
December 10, 2019
Assignee:
The Trustees of the University of Pennsylvania
Abstract: Various embodiments disclosed relate to aziridinated triglycerides and polymers formed therefrom. In various embodiments, the present invention provides an aziridinated triglyceride having the structure described herein. In various embodiments, the present invention provides a method of making the aziridinated triglyceride, a method of crosslinking the aziridinated triglyceride to form a polymer, the polymer formed from the aziridinated triglyceride, a triglyceride with at least one pendent unsaturated group that can be used to form the aziridinated triglyceride, and a method of making the triglyceride having at least one pendent unsaturated group.
Type:
Grant
Filed:
July 23, 2018
Date of Patent:
December 10, 2019
Assignee:
Iowa State University Research Foundation, Inc.
Inventors:
Ruqi Chen, Jason Shih-Hao Chen, Chaoqun Zhang, Michael Richard Kessler
Abstract: A zero-power digital chemical analyzer can include a chemically-selective percolation switch. The chemically selected percolation switch can include a positive electrode and a negative electrode separated from the positive electrode by a gap. A binding agent can be located at binding sites in the gap. The binding agent can be selective for binding to a target chemical compound. The binding sites can be distributed in the gap so that target chemical molecules binding to the binding sites can form an electrically conductive pathway via a natural percolation phenomenon between the electrodes when the ambient concentration of the target chemical compound reaches a threshold concentration.
Abstract: The present invention provides gene expression profiles indicative of whether a patient afflicted with PR driven malignancies is likely to be responsive to treatment with a therapeutic compound that is an anti-progestin. By identifying such responsiveness, a treatment provider may determine in advance those patients who would benefit from such treatment, as well as identify alternative therapies for non-responders. Also, provided are methods of using gene expression profiles and assays for identifying the presence of a gene expression profile in a patient.
Type:
Grant
Filed:
March 15, 2013
Date of Patent:
December 10, 2019
Assignee:
Regents of the University of Minnesota
Inventors:
Carol Ann Lange, Todd Philip Knutson, Jason Basil Nikas
Abstract: Data characterizing a mother video feed acquired by an endoscopic video capture device can be received. The mother video feed can be for characterizing an operative field within a patient. One or more predefined markers can be identified within the mother video feed. Each of the one or more predefined markers can be associated with a surgical instrument in the operative field. Using the data characterizing the mother video feed, a daughter video feed comprising a sub-portion of the mother video feed can be generated. At least one of a location of the daughter video feed within the mother video feed and a zoom of the daughter video feed can be based on the identified one or more predefined markers. The daughter video feed can be provided. Related apparatus, systems, techniques, and articles are also described.
Abstract: An orthotic obstructive sleep apnea treatment device is provided that includes a hyoid bone attachment element disposed to attach a ferric element to a hyoid bone, where the ferric element is disposed to face along a treatment vector from the hyoid bone, and the treatment vector is oriented relative to a sagittal plane of a human. The orthotic obstructive sleep apnea treatment device further includes an external orthotic neck device having a contoured housing with a shape disposed to conform about a neck of the human subject, where the housing includes a force delivery element disposed at an exterior-front neck region of the human subject and is disposed to provide an attractive force to the ferric element along the treatment vector. A force sensor is disposed to measure a force exerted on the hyoid bone, a skin contact pressure, tissue compression between the ferric element and the force delivery element.
Type:
Grant
Filed:
May 22, 2017
Date of Patent:
December 10, 2019
Assignee:
The Regents of the University of California
Inventors:
Michael R. Harrison, Kathryn H. Rosenbluth, Dillon A. Kwiat, Eric J. Kezirian, Richard J. Fechter, Darrell Christensen
Abstract: Compositions comprising an alginate, a source of sodium ions and a carrier (e.g., a pharmaceutically acceptable carrier), which are characterized by reduced association of the alginate chains and hence by at least one of: (i) a zeta potential weaker than ?25 mV, at a concentration of 0.5% (w/v) alginate in the carrier; and (ii) a diffusion coefficient of at least 10?8 cm2/second, at a concentration of 0.5% (w/v) alginate in the carrier, are disclosed. Also disclosed are uses of the composition and methods utilizing the composition for treating inflammatory bowel disease; liver damage, diseases and disorders, for treating a medical condition treatable by a hepatotoxic agent and for reducing or preventing liver damage, including liver damage caused by a hepatotoxic agent.
Type:
Grant
Filed:
December 30, 2013
Date of Patent:
December 10, 2019
Assignees:
Hadasit Medical Research Services and Development Ltd., B.G. Negev Technologies & Applications Ltd., at Ben-Gurion University
Inventors:
Smadar Cohen, Yaron Ilan, Eyal Shteyer, Ami Ben-Ya'Acov
Abstract: The present invention relates to use an Inertial Measurement Unit (IMU) to record the acceleration trajectory of a person's gait or pen-less handwriting motion or any predesignated gestures, and to convert the data to a unique biometric pattern. The pattern is unique for each case and can be used as biometric security authentication.