Abstract: A method reuses produced water resulting from a fossil fuel extraction operation. The method includes providing the produced water as an input to an electrodialysis system. The method also includes running the electrodialysis system to produce a diluate and a concentrate. The diluate is contaminated so as to have a conductivity of no less than 0.1 Siemens/meter. The method also includes reformulating the diluate to produce fossil fuel extraction fluid. The method also includes using the produced fossil fuel extraction fluid in the fossil fuel extraction operation. An electrodialysis system includes first and second stacks. The electrodialysis system also includes first and second voltage sources, coupled to the first and second stacks, so as to apply a first voltage to the first stack lower by at least about 10% than a second voltage to the second stack.

Abstract: Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.

Abstract: Thienopyridinone compounds of Formula (I) and pharmaceutically acceptable salts thereof are described. In these compounds, one of X1; X2, and X3 is S and the other two are each independently CR, wherein R and all other variables are as defined herein. The compounds are shown to inhibit HPK1 kinase activity and to have in vivo antitumor activity. The compounds can be effectively combined with pharmaceutically acceptable carriers and also with other immunomodulatory approaches, such as checkpoint inhibition or inhibitors of tryptophan oxidation. Formula (I).

Abstract: Provided is a method for producing a beta zeolite, which is a seed crystal addition method that is capable of reducing the environmental load as much as possible. A method for producing a beta zeolite according to the present invention comprises a step wherein a reaction mixture that contains a silica source, an alumina source, an alkali source and water and a seed crystal that is composed of a beta zeolite are mixed with each other and heated. A beta zeolite which comprises particles having a particle size of 10 ?m or less in an amount of 90% or more on a volume basis in the particle size distribution as determined by a laser diffraction/scattering particle size distribution measuring method, and which is synthesized without using an organic structure-directing agent is used as the seed crystal.

Abstract: Biological tissue such as skeletal and cardiac muscle can be imaged by using an objective-based probe in the tissue and scanning at a sufficiently fast rate to mitigate motion artifacts due to physiological motion. According to one example embodiment, such a probe is part of a system that is capable of reverse-direction high-resolution imaging without needing to stain or otherwise introduce a foreign element used to generate or otherwise increase the sensed light. The probe can include a light generator for generating light pulses that are directed towards structures located within the thick tissue. The system can additionally include aspects that lessen adverse image-quality degradation. Further, the system can additionally be constructed as a hand-held device.

Abstract: An event-driven neural network includes a plurality of interconnected core circuits is provided. Each core circuit includes an electronic synapse array has multiple digital synapses interconnecting a plurality of digital electronic neurons. A synapse interconnects an axon of a pre-synaptic neuron with a dendrite of a post-synaptic neuron. A neuron integrates input spikes and generates a spike event in response to the integrated input spikes exceeding a threshold. Each core circuit also has a scheduler that receives a spike event and delivers the spike event to a selected axon in the synapse array based on a schedule for deterministic event delivery.

Abstract: The present invention discloses use of a polyenylpyrrole derivative in preparation of an anti-oral cancer drugs. The polyenylpyrrole derivative synthesized by polyvinylpyrrole, auxarconjugatin A and 12E-isorumbrin inhibits the cell proliferation, migration, tumor sphere formation abilities and xenograft tumorigenicity of oral cancer cells.

Abstract: Benzimidazole compounds that increase the rate of SOS-mediated nucleotide exchange on Ras by binding to a functionally relevant, chemically tractable pocket on the SOS protein, as part of the Ras:SOS:Ras complex.

Abstract: Embodiments may provide a cache for query results that can adapt the cache-space utilization to the popularity of the various topics represented in the query stream. For example, a method for query processing may perform receiving a plurality of queries for data, determining at least one topic associated with each query, and requesting data responsive to each query from a data cache comprising a plurality of partitions, including at least a static cache partition, a dynamic cache partition, and a temporal cache partition, the temporal cache partition may store data based on a topic associated with the data, and may be further partitioned into a plurality of topic portions, each portion may store data relating to an associated topic, wherein the associated topic may be selected from among determined topics of queries received by the computer system, and the data cache may retrieve data for the queries from the computer system.

Abstract: Methods for preventing, delaying the onset of, or treating rejection of an allograft using a DNA vaccine, where the vaccine can comprise a polynucleotide encoding a pro-apoptotic protein, like BAX and/or a polynucleotide encoding an autoantigen or donor antigen, like secreted glutamic acid decarboxylase 55. Administering one of the DNA vaccines to a transplant recipient, as described herein, can induce a donor specific tolerogenic response.

Abstract: This invention relates to methods and systems for estimating offset, skew and drift. Embodiments of the invention relate to methods and systems which allow these relationships between a slave clock and a master clock to be estimated based on the exchange of timestamped messages between the master and the slave. Further embodiments of the invention set out uses of these estimates to synchronize a local clock in a slave to a master and to steer the slave clock to stay aligned to the master clock when the master clock is temporarily unavailable or the communication path between slave and master is temporarily unavailable.

Abstract: The disclosure describes a tunneling field effect transistor having an overlapping structure between the source and drain regions providing a greater tunneling area. The source or drain region may be a doped region in a semi-conductive substrate. The other source or drain region may be formed by epitaxial deposition over the doped region. The gate is formed over the epitaxial region where the doped and epitaxial regions overlap. The doped region may be formed in a fin structure with the epitaxial region and gate being formed on the top and sides of the fin.

Abstract: A drilling fluid composition comprising an aqueous base fluid, a viscosifier, and a H2S scavenger comprising copper nitrate, wherein the drilling fluid composition has a H2S sorption capacity from about 4.0 to about 6.0 gram per one milliliter of the drilling fluid composition; and a method of drilling a subterranean geological formation using thereof are provided. Various embodiments of the drilling fluid composition and the method are also provided.

Abstract: The present invention discloses a method for interlocking a shared bicycle and an intelligent safety helmet, and the method comprises the following steps: (1) providing an electronic frame lock and an intelligent safety helmet for using cooperatively on a shared bicycle respectively, interlocking both of them when the shared bicycle is parked; (2) checking the current state information of an electric lock and a safety helmet lock simultaneously when a user uses the mobile intelligent terminal to scan the shared bicycle; (3) unlocking of the electric lock and the safety helmet lock when the verification is passed; (4) wearing an intelligent safety helmet before using the bicycle; (5) beginning to record the trip information by the intelligent helmet after the user puts on the intelligent safety helmet; (6) stopping the voice broadcast function and terminating the recording of the trip information when the state information of the electronic frame lock and the safety helmet lock which is checked shows that the

Abstract: The invention relates to oligopyridylamide alpha-helix mimetic compounds and their use to inhibit p53 aggregation and restore its tumor suppressor function for treating diseases, e.g., cancers, associated with p53 mutations, e.g., R248W p53 mutation.

Abstract: Disclosed is a method and an apparatus for quantifying vascular fluid motions from digital subtraction angiography (DSA) images, comprising: calculating an optical flow field between two temporal consecutive DSA images; and estimating a displacement of blood or tissue between the two temporal consecutive DSA images from the calculated optical flow field, wherein the optical flow field is calculated by solving a minimization problem of a CLG energy function, wherein the CLG energy function combines the temporally extended variant of Horn-Schunck approach with Lucas-Kanade approach non-linearly in spatiotemporal approach. The present disclosure provides a new optical flow solution significantly reducing the computation cost with a high robustness for quantifying vascular fluid motions from DSA.

Abstract: The invention relates to an antimicrobial surface, in particular a surface functionalised with a peptide comprising an antimicrobial moiety. The invention comprises a surface functionalised with a peptide comprising an antimicrobial moiety and a binder moiety, wherein the peptide is immobilized on the surface by electrostatic interactions between the binder moiety and the surface. Further provided is a medical device, a peptide and a method for the immobilization of a peptide.

Abstract: The method of making a supercapacitor using porous activated carbon from cow dung includes converting cow dung to porous activated carbon by, in a first step, preparing the dung waste by washing and drying the dung waste, and heating the dung waste in a vacuum environment to form pre-carbonized carbon. In a second step, the pre-carbonized carbon is impregnated with phosphoric acid to form a slurry, which is dried, ground, and heated in a vacuum to between 600-900° C. to form porous activated carbon. The porous activated carbon is mixed with a binder, acetylene black, and an organic solvent to form a paste, which is dried on a conductive metal foil to form an electrode. Two such electrodes (an anode and cathode) to are coated with an electrolyte gel (e.g., aqueous potassium hydroxide) and separated by a polymer (e.g., PTFE) membrane to form the supercapacitor.

Abstract: Provided is a cancer cell growth inhibition and killing device using a blue light LED. The present invention comprises: a bed part which has a top plate on which the body is laid to stand by; a main body part provided with a treatment space, which has a predetermined size and on which the bed part is disposed, and having a chamber which is divided by the treatment space and a transparent plate formed of a light-transmitting material to thus form a treatment light generation space; and a treatment light generation unit which generates a treatment light having a wavelength band of a predetermined size when power is applied so that the treatment light can penetrate the subcutaneous tissue of the body and thereby stimulate and kill cancer cells moving along blood vessels, and which is provided in the chamber so as to irradiate the treatment space with the treatment light after the treatment light has penetrated though the transparent plate.

Abstract: This invention relates generally to the discovery of an improved method to differentiate histiocytic malignancy from lymphoma or hemangiosarcoma in dogs.