Abstract: Random number generator systems and method for tuning a randomness characteristic of the system are described. The random number generator system includes at least one programmable metallization cell (PMC) device and is configured to provide a random output word based on random telegraph noise caused by the at least one PMC device.
Type:
Grant
Filed:
May 8, 2018
Date of Patent:
November 5, 2019
Assignees:
Arizona Board of Regents on behalf of Arizona State University
Abstract: A dry composition, comprising three-dimensional porous microparticles, wherein the microparticles comprise: (i) an active substance (eg a poorly water soluble drug), (ii) polymeric nanoparticles such as those composed of a biocompatible and/or biodegradable polymer (eg a PLGA polymer) (iii) lipid droplets (eg droplets of a medium chain triglyceride (MCT)), (iv) a nanoparticle stabilizing agent such as PVA or DMAB, and optionally, (v) a cryoprotectant (eg mannitol); wherein said active substance is carried by said nanoparticles and/or lipid droplets. The composition of the present invention may be formulated into, for example, a medicament for the treatment and/or prevention of various diseases or disorders (eg human or veterinary therapeutics). The average diameter of the individual microparticles of the composition, may be in the order of 2.5-3.5 ?m which are particularly suitable for administration to the lung.
Type:
Grant
Filed:
March 11, 2016
Date of Patent:
November 5, 2019
Assignee:
University of South Australia
Inventors:
Clive Allan Prestidge, Paul Matthew Joyce
Abstract: The present invention provides compositions and methods for printing a predetermined pattern on silk fibroin materials using water based “inks.” Such technique may be useful for micro- and nano-engineering applications.
Type:
Grant
Filed:
March 14, 2014
Date of Patent:
November 5, 2019
Assignee:
Tufts University
Inventors:
Fiorenzo G. Omenetto, David L. Kaplan, Miaomiao Yang, Hu Tao, Benedetto Marelli, Sunghwan Kim
Abstract: The present disclosure provides a depth filter medium comprising at least one elastomeric nonwoven web strengthened by combination with one or more structural support layers. The resulting material is particularly useful in the field of filtration, wherein particulates captured within the elastomeric nonwoven web can be readily released, such as by applying pressure to the web through backwashing. The elastomeric nonwoven web advantageously can stretch under such pressure and return substantially to its original structure and shape upon the removal of the pressure, rendering the filter available for reuse.
Abstract: An energy harvester having a plurality of bimorph beams and a plurality of piezoelectric devices, wherein at least two of the piezoelectric devices are mounted to each of the plurality of bimorph beams. A plurality of rigid beams interconnect adjacent ends of the bimorph beams to define a stacked, fan-folded shape having a first end of one of the bimorph beams mounted to a structure. A tip mass is disposed on a free end of another of the plurality of bimorph beams. Upon movement of the energy harvester, the plurality of bimorph beams is caused to deflect and thereby output electrical power from the plurality of piezoelectric devices.
Type:
Grant
Filed:
September 14, 2016
Date of Patent:
November 5, 2019
Assignees:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, The Research Foundation for the State University of New York
Inventors:
Mohammad Amin Karami, David J. Bradley, Daniel J. Inman, Mohammad Hossein Ansari
Abstract: An object of the present invention to discover a short peptide having an anti-aging effect and to provide a novel anti-aging agent comprising the peptide as an active ingredient. The inventors have discovered that a peptide consisting of an amino acid sequence ELKLIFLHRLKRLRKRLKRK (SEQ ID NO: 1) or a partial sequence thereof and having one or more effects selected from the group consisting of promoting fibroblast growth, promoting hyaluronic acid production and contracting a collagen gel, or a derivative or salt of the peptide is useful as an active ingredient of an anti-aging agent.
Abstract: A power controller for an AC power converter connected in series with a load and receiving power from or delivering power to a power source, the power controller comprising: a radial control block controlling a radial component of an electrical parameter of the AC power converter; and a chordal control block controlling a chordal component of the electrical parameter of the AC power converter. Also provided is a power system comprising one or more loads each connected in series to a power converter each controlled by a power controller as described above. There is also provided a method of controlling an AC power converter connected in series with a load and receiving power from a power source, the method comprising: controlling a radial component of an electrical parameter of the AC power converter; and controlling a chordal component of the electrical parameter of the AC power converter.
Type:
Grant
Filed:
November 13, 2014
Date of Patent:
November 5, 2019
Assignee:
The University of Hong Kong
Inventors:
Kwan Tat Mok, Siew Chong Tan, Shu Yuen Ron Hui
Abstract: Provided is a method and apparatus of dynamic loading file extraction. The method for extracting a specific dynamic generated file of an application running in an Android container environment includes conducting first analysis to identify if a file extension that is stored in the Android container corresponds to a preset critical extension, to extract a file with the critical extension, and conducting second analysis to identify a deleted file standing for a file deleted after stored in the Android container, and running the application again and extracting the deleted file based on a result of the second analysis.
Type:
Grant
Filed:
January 9, 2018
Date of Patent:
November 5, 2019
Assignee:
Foundation of Soongsil University-Industry Cooperation
Inventors:
Souhwan Jung, Jungsoo Park, Seongeun Kang
Abstract: Methods and compositions are described for use in encouraging angiogenesis and skin healing as may be utilized in wound treatment as well as in encouragement of angiogenesis in disease. Compositions include an effective amount of a natural pimarane diterpenoid extract of Hymenocrater elegans, or a derivative, analogue, or homolog thereof. Compounds based upon this natural extract have been found to be highly effective in vascular formation and skin closure while exhibiting low toxicity.
Type:
Grant
Filed:
June 11, 2018
Date of Patent:
November 5, 2019
Assignee:
University of South Carolina
Inventors:
Ehsan Jabbarzadeh, Sara Eslambolchimoghada
Abstract: A direct dyeing type color fused deposition modeling three-dimensional printing apparatus includes a forming stage, a forming unit, and a color-inkjet unit. The forming unit is located above the forming stage for providing forming-material layers on the forming stage in sequence. The color-inkjet unit is located above the forming stage for providing color-ink layers on the forming-material layers in sequence, wherein the forming-material layers and the color-ink layers are stacked alternately in sequence to form a colored three-dimensional object. A direct dyeing type color fused deposition modeling three-dimensional printing method is also provided.
Type:
Grant
Filed:
August 10, 2016
Date of Patent:
November 5, 2019
Assignee:
National Taiwan University of Science and Technology
Abstract: The present invention relates to a wavelength-tunable type etalon comprising a liquid crystal layer, which comprises: a first substrate; a second substrate; a reflective coating film; a transparent electrode; an alignment layer, which is independently formed while covering the opposing surface of the transparent electrode; a liquid crystal layer, which is disposed in a space between each of the alignment layer s; and a sealing member, which is provided for sealing of the liquid crystal layer; and a method for manufacturing the same.
Type:
Grant
Filed:
July 12, 2017
Date of Patent:
November 5, 2019
Assignee:
Research & Business Foundation Sungkyunkwan University
Abstract: The present invention relates to a method and apparatus for encoding/decoding a video, the method being applied with a method of using video padding and removing the padded area after decoding in order to effectively encode the video in a video compression technology for a high-definition security camera.
Type:
Grant
Filed:
February 13, 2018
Date of Patent:
November 5, 2019
Assignee:
Kwangwoon University Industry-Academic Collaboration Foundation
Abstract: An oil-in-water emulsion comprises an emulsifier which is a non-gelled branched polymer (e.g. a branched vinyl polymer), wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. This is useful in, for example, facilitating the carrying of hydrophobic materials within aqueous systems, to enhance oral drug delivery. The oil-in-water emulsion may be prepared by mixing an oil phase with an aqueous phase in the presence of an emulsifier, wherein said emulsifier is a non-gelled branched polymer, wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm.
Type:
Grant
Filed:
February 3, 2016
Date of Patent:
November 5, 2019
Assignee:
The University of Liverpool
Inventors:
Steve Rannard, Andrew Owen, James Hobson, Neill Liptrott, Pierre Chambon
Abstract: The present invention provides tricyclic compounds, pharmaceutically acceptable salts, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.
Abstract: A dynamic signal to noise ratio tracking system enables detection of vehicles within the field of view of the tracking system. The tracking system may include an emitter configured to emit electromagnetic radiation within an area, a detector configured to detect electromagnetic radiation reflected back from vehicles within the area, and a control unit configured to evaluate signals from the detector and control various automated devices as a result of this evaluation.
Type:
Grant
Filed:
July 16, 2018
Date of Patent:
November 5, 2019
Assignee:
Universal City Studios LLC
Inventors:
Robert J. Cortelyou, Christopher Oliver
Abstract: The present invention discloses a maltooligosyl trehalose trehalohydrolase (MTHase) mutant and application thereof, belonging to the technical fields of gene engineering and enzyme engineering. The present invention provides a series of MTHase mutants to prepare trehalose, having a better effect. Further, the MTHase mutant is expressed in Escherichia coli BL21 (DE3) and the enzyme is optimized by fermentation, which can significantly increase the yield of enzymes.
Abstract: The invention discloses a method for increasing the yield of L-arginine by knocking out flavin reductases, and belongs to the technical field of amino acid production by microbial fermentation. Genes frd1 and frd2 for encoding hypothetic NADPH-dependent FMN reductase in Corynebacterium crenatum SDNN403 are over-expressed in E. coli BL21 and are purified to form target proteins Frd181 and Frd188, and functions of the target proteins are identified to obtain a result showing that the proteins Frd181 and Frd188 both are NAD(P)H-dependent flavin reductases producing H2O2. By taking a genome of the Corynebacterium crenatum SDNN403 as a template, frd1 and frd2 gene deletion fragments are obtained by overlap extension PCR; connecting pK18mobsacB to obtain knockout plasmids pK18mobsacB-?frd1 and pK18mobsacB-?frd2; carrying out electric shock to transform the Corynebacterium crenatum SDNN403; and carrying out secondary screening to obtain recombinant strains 403?frd1 and 403?frd2.
Abstract: Methods, systems, and devices are disclosed for implementing electro-optical modulators in which a resonating cavity structure is coupled to a transmission waveguide. In one example, the resonating structure includes a ring resonator whose coupling strength is controlled via an electrical control signal. The ring resonator is made of a capacitor comprising monolayer graphene sheets separated by a thick layer of dielectric material.
Abstract: A method for detecting and quantifying haloether contamination in aqueous samples. A flow state is artificially induced upon an aqueous sample and a solid phase microextraction (SPME) fiber, upon which an electric potential is applied, is exposed to the flowing aqueous sample in direct immersion mode. Halide ions liberated from electrophoretically dehalogenated haloether compounds contained in the aqueous sample are absorbed upon the SPME fiber, then later desorbed at a gas chromatograph, separated into individual halide ions and analyzed by mass spectrometry. Effects of various parameters such as absorption time, sample pH, salt content, applied voltage, SPME fiber type, flow rate and background matrix are also described.
Type:
Grant
Filed:
April 23, 2019
Date of Patent:
November 5, 2019
Assignee:
King Fahd University of Petroleum and Minerals
Abstract: The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.
Type:
Grant
Filed:
May 1, 2018
Date of Patent:
November 5, 2019
Assignee:
The Regents of the University of Colorado, A Body Corporate
Inventors:
Xuedong Liu, Gan Zhang, Daniel Chuen-Fong Chan, Anthony D. Piscopio