Abstract: Genetically modified non-human animals expressing human EPO from the animal genome are provided. Also provided are methods for making non-human animals expressing human EPO from the non-human animal genome, and methods for using non-human animals expressing human EPO from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human erythropoiesis and erythrocyte function; in modeling human pathogen infection of erythrocytes; in in vivo screens for agents that modulate erythropoiesis and/or erythrocyte function, e.g. in a healthy or a diseased state; in in vivo screens for agents that are toxic to erythrocytes or erythrocyte progenitors; in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on erythrocytes or erythrocyte progenitors; in in vivo screens of erythrocytes or erythrocyte progenitors from an individual to predict the responsiveness of an individual to a disease therapy.

Abstract: The present invention relates to a redox fuel cell comprising an anode and a cathode separated by an ion selective polymer electrolyte membrane; means for supplying a fuel to the anode region of the cell; means for supplying an oxidant to the cathode region of the cell; means for providing an electrical circuit between the anode and the cathode; a non-volatile catholyte solution flowing in fluid communication with the cathode, the catholyte solution comprising a polyoxometallate redox couple being at least partially reduced at the cathode in operation of the cell, and at least partially re-generated by reaction with the oxidant in a regeneration zone after such reduction at the cathode, the catholyte solution further comprising one or more vanadium species that result from the speciation of the polyoxometallate at an elevated temperature and/or pressure, wherein the polyoxometallate is represented by the formula: Xa[ZbMcOd] wherein X is selected from hydrogen, alkali metals, alkaline earth metals, ammonium,

Abstract: The present invention provides an apparatus and a method for detecting a piping alignment using image information and laser sensors capable of precisely and accurately measuring and aligning the alignment of the entire pipes. The apparatus includes: a fixed plate installed on a base stage and having a reference pipe located thereon; a movable plate installed on the base stage along three axes to face the reference pipe and has an aligning pipe located thereon; a circular stage installed between the reference and aligning pipes and is configured to rotate and move along three axes so as to detect levelness and deformations of the reference and aligning pipes; a laser sensor and an imaging device installed on an upper side of the circular stage; and a controller configured to control the laser sensor and the imaging device and determine an alignment of the aligning pipe.

Abstract: In some embodiments, the compositions and methods relate to compounds isolated from plants in the Salviniaceae family, pharmaceutical compositions comprising the same, and methods of using the same.

Abstract: The present invention relates to novel pharmaceutical formulations. More specifically, the present invention relates to novel pharmaceutical formulations that are suitable for intraocular administration. The present invention also relates to the use of these formulations for the treatment of collagenic eye disorder such as, for example, the treatment of keratoconus.

Abstract: Certain examples provide systems and methods to identify placement for an electric charging station infrastructure. Certain examples provide systems and methods to generate a deployment plan for one or more electric vehicle charging stations. An example method includes gathering data for a specified geographic area and forecasting a demand for electric vehicles for the specified area. The example method includes modeling driving patterns in the specified area using available data and improving a charging infrastructure model based on the driving pattern and demand forecast information for the specified area. The example method includes generating and providing a recommendation regarding an electric vehicle charging infrastructure and deployment strategy for the specified area based on the improved charging infrastructure model.

Abstract: There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture substrate, wherein the capture substrate is in fluid communication with the protein produced by the cell and wherein the capture substrate is operable to bind the protein produced by the cell; flowing a fluid volume comprising the biomolecule through the chamber via said aperture, wherein the fluid volume is in fluid communication with the capture substrate; and determining a binding interaction between the protein produced by the cell and the biomolecule.

Abstract: Provided is a preparation method of copper nanostructures, characterized in that a copper precursor including halide is reacted with polyethyleneimine (PEI) and a reducing agent in an aqueous solution. According to this method, the copper nanostructures may be easily prepared in a sphere, wire, or plate form, and high-quality copper nanostructures may be produced with a high production yield of 90% or more. This method is also appropriate for large-scale production.

Abstract: A dental treatment method is provided. In this method, a tooth of a patient is extracted and prepared to provide a root part. A root canal in the extracted tooth is prepared and treated. A post of an abutment is fitted into the root canal to attach the root part to the abutment. The abutment having the root part is attached to a dental implant. With the root part attached to the abutment, periodontal connective tissue maintains the jaw bone associated with the extracted tooth, without significant hard tissue loss.

Abstract: Systems and methods are described for an edible capacitive power source such as a supercapacitor device. The capacitive power source includes an anode electrode, an anode current collector, a cathode electrode, and a cathode current collector, arranged in layers with a separator layer positioned between the anode electrode and the cathode electrode forming a symmetrical electrical double-layer capacitor. The anode electrode, the anode current collector, the cathode electrode, the cathode current collector, and the separator layer are all constructed of non-toxic, edible materials. The packaging material, the conductive anode tab, and the conductive cathode tab are all also constructed of non-toxic, edible materials forming a completely edible capacitive power source package.

Abstract: A novel method to stimulate electrically active biological cells using visible wavelength light and metallic nanoparticles possessing plasmonic properties is presented herein. Using this technology, prosthetic devices such as cochlear and retinal implants and cardiac pacemakers can be developed to have superior properties as compared to the currently utilized electrical stimulation designs. These properties include improved spatial resolution; less or non-invasive devices; and higher fidelity of transduction. An additional advantage of using visible light wavelengths is the avoidance of unwanted heating of surrounding tissue that occurs with infrared stimulation.

Abstract: The present disclosure provides an aluminum alloy with enhanced penetration resistance for a heat exchanger, the alloy containing copper (Cu), silicon (Si), and iron (Fe) equal to or smaller than predetermined contents respectively, and further containing zirconium (Zr) and the remainder being aluminum (Al). Further, the present disclosure provides an aluminum extruded tube and/or an aluminum fin with enhanced penetration resistance made of the alloy respectively. Further, the present disclosure provides a heat exchanger comprising the tube and/or fin. Addition and content-control of the alloy element may spread corrosion initiations and suppress intergranular corrosion to create uniform corrosion. In this manner, the present alloy have superior corrosion resistance compared to pitting corrosion of a previous alloy for a heat exchanger, and, at the same time, have an extrusion rate equal to that of the previous A1070.

Abstract: The present application relates to a pharmaceutical composition containing compound 5-fluoro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]-4-3H)-quinazolinone, and a pharmaceutically acceptable salt thereof for preventing and treating liver cancer, and the composition of the present application inhibits ROS-PI3K-AKT-TERT signal transduction, and thus can be favorably used in the treatment of a liver cell cancer, in which a protein involved in the signal transduction is overexpressed, especially, advanced liver cell cancer.

Abstract: Transformed plants are disclosed with enhanced resistance to abiotic stresses, such as salt stress, water stress, or temperature stress. Also disclosed are vectors useful for making such transformed plants, and methods of transforming plants to enhance resistance to abiotic stresses, such as salt stress, water stress, or temperature stress. For example, the Spartina alterniflora ADF gene SaADF2 enhances resistance when transformed into rice Oryza sativa. Transgenic rice plants that expressed higher levels of Spartina ADF were more resistant to salt, drought, and cold. There was improved growth, higher photosynthesis, and increased grain yield as compared to wild-type (WT) rice.

Abstract: A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

Abstract: The invention provides novel amphiphilic drug-drug conjugates useful as cancer therapeutics, and compositions and methods thereof.

Abstract: A method for controlling the operation of a plurality of consumer electronic devices by displaying a plurality of broadcast channel identifiers each corresponding to a broadcast channel in a display of a controlling device adapted to command at least channel tuning operations of the plurality of consumer electronic devices. Input is accepted into the controlling device that functions to designate one of the plurality of broadcast channel identifiers and the controlling device uses the designation of the one of the plurality of broadcast channel identifiers to cause a transmission of a wireless signal from the controlling device to a one of the plurality of consumer electronic devices to thereby cause the one of the plurality of consumer electronic devices to tune to the broadcast channel corresponding to the designated one of the plurality of broadcast channel identifiers.

Abstract: Described is a method of stabilizing blood vessel wall abnormality. The method includes ultrasonically heating at least a portion of the blood vessel wall having the abnormality; monitoring a parameter related to a property of at least a portion of the heated portion of the blood vessel wall; and stopping the heating when the monitored parameter changes by a predetermined factor or after the monitored parameter changes in a slow enough rate. The slow enough rate may be, for instance, a predetermined fraction of a maximal rate change observed during heating.

Abstract: A new variety of Pennisetum alopecuroides plant named ‘Tift PA5’ produces a reduced number of seeds, making it less invasive.

Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.