Abstract: Circuits for reducing out-of-band-modulated transmitter self-interference are provided. In some embodiments, receivers are provided, the receivers comprising: a low noise amplifier (LNA) having an input, a first output, and a second output, wherein the LNA includes: a common source transistor having a gate coupled to an input signal, a drain coupled to the first output of the LNA, and a source coupled to ground; and a common gate transistor having a gate coupled to a transmitter replica signal, a source coupled to the gate of the common source transistor, and a drain coupled to the second output of the LNA.

Abstract: Compounds can be used for treating polycystic kidney disease (PKD). As such, these compounds can be used in associated methods. The methods can include: method of modulating (e.g., activating) Liver kinase B1 (LKB1); method of modulating (e.g., decreasing activity) mammalian target of rapamycin (mTOR). The methods may include introducing the compound in a therapeutically effective amount to a subject having PKD. The methods may include introducing the compound in a therapeutically effective amount to a subject having Autosomal Dominant PKD. The compounds can be used in methods of treating a disease modulated by a mTOR pathway, which can include introducing the compound in a therapeutically effective amount to a subject having the disease modulated by the mTOR pathway.

Abstract: Increased sensitivity of spectrometers through reducing noise in independent voltage signals via a differential voltage analyzer utilizing a reference wavelength from a wavelength region in which the optical absorption of the sample is negligible. In an embodiment, a grating permits selection of a reference wavelength. In another embodiment, filters permit selection of a reference wavelength. In yet another embodiment, both a grating and a filter permit selection of a reference wavelength. In an aspect, the differential voltage analyzer reduces noise by minimizing a differential voltage between the independent voltage signals and the reference voltage signal by adjusting the value of a cancellation coefficient.

Abstract: A system, method, and apparatus for simulating the detection of radiation comprise at least one simulated radioactive source, a simulated radiation detector, and an emulating module configured to simulate a detection level for the at least one simulated radioactive source according to a radiation level associated with the simulated radioactive source, wherein the simulated detection level is provided on the simulated radiation detector.

Abstract: Identification and evaluation of a set of first-in-class potent inhibitors targeting a new cancer target, Grb2-associated binder˜1 (GAB1), which integrates signals from different signaling pathways and is frequently over-expressed in cancer ceils. Intensive computational modeling is utilized to understand the structure of the GAB1 pleckstrin homology (PH) domain and screened five million compounds. Upon biological evaluation, several inhibitors were found that induced large conformational changes of the target structure exhibited strong selective binding to GAB1 PH domain. Particularly, these inhibitors demonstrated potent and tumor-specific cytotoxicity in breast cancer cells. This targeting GAB1 signaling may be used for cancer therapy, especially for triple negative breast cancer patients.

Abstract: An amorphous thin metal film can include a combination of metals or metalloids including: 5 at % to 74 at % of a metalloid selected from the group of carbon, silicon, and boron; 5 at % to 74 at % of a first metal; 5 at % to 74 at % of a second metal; and 5 at % to 70 at % of a dopant. The first and second metals can be independently selected from the group of titanium, vanadium, chromium, iron, cobalt, nickel, zirconium, niobium, molybdenum, ruthenium, rhodium, palladium, hafnium, tantalum, tungsten, osmium, iridium, or platinum, wherein the first metal and the second metal can be different metals. The dopant can be selected from the group of oxygen, nitrogen, or combinations thereof. The metalloid, first metal, second metal, and dopant can account for at least 70 at % of the amorphous thin metal film.

Abstract: Provided are novel human-derived antibodies specifically recognizing polyomavirus polypeptides, preferably capable of binding to polyomaviruses of the type of JC virus (JCV) and/or BK virus (BKV) as well as methods related thereto. Furthermore, assays and kits related to antibodies specific for polyomaviruses, polyomavirus VP1 and or polyomavirus VP1 Virus-Like Particles (VLPs), preferably of the type of JCV and/or BKV, are disclosed. The human-derived antibodies as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for polyomavirus targeted immunotherapy and diagnostics.

Abstract: A voice interaction apparatus incudes voice recognition means for recognizing a voice of a user, response-sentence generation means for generating a response sentence to the voice of the user based on the recognized voice, filler generation means for generating a filler word to be inserted in a conversation, output means for outputting the generated response sentence and the generated filler word, and classification means for classifying the generated response sentence into one of predetermined speech patterns indicating predefined speech types. When the output means outputs, after the user utters a voice subsequent to the first response sentence, the filler word and outputs a second response sentence, the classification means classifies the first response sentence into one of the speech patterns, and the filler generation means generates the filler word based on the speech pattern into which the first response sentence has been classified.

Abstract: Gene therapy based combination therapy for malignant pleural mesothelioma (“MPM”) that is resistant to or recurrent after chemotherapy employing a viral vector containing a human interferon transgene, followed by standard first- or second-line cytotoxic chemotherapy. Overall survival rate was significantly higher than historical controls in the second-line group.

Abstract: The invention provides processes for the preparation of HU-910, which are scalable to industrial purposes, using safer reagents and having high yield and pure product and a crystalline structure of HU-910, which is a unique product thereof.

Abstract: Stable monomeric phosphaplatins, namely, (pyrophosphato)platinum(II) or platinum(IV) complexes containing a cis-cyclohexanediamine ligand or enantiomerically enriched or enantiopure trans-cyclohexanediamine ligands, and synthesis of these complexes, are provided. Efficacies and toxicities of the phosphaplatin compounds are determined toward a variety of cancers, including sensitive and resistant ovarian cancers, head and neck, and colon cancers. Compositions comprising the platinum complexes, and methods for treatment of proliferative diseases or disorders by means of the complexes or the compositions comprising them are disclosed.

Abstract: A composite dry adhesive includes (a) an adhesive layer comprising a shape memory polymer and (b) a resistive heating layer comprising a shape memory polymer composite on the adhesive layer. The shape memory polymer composite includes conductive particles dispersed in a shape memory polymer matrix, where the conductive particles have a concentration sufficient to form a conductive path through the resistive heating layer.

Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.

Abstract: Semiconductor layers useable for minimizing or preventing the growth of metal whiskers, as well as devices and methods utilizing the same and kits for making the same, are described.

Abstract: A stress-transfer method in tunnel with high ground pressure based on fracturing ring. According to the stress source of the tunnel, fracturing by drilling holes to form artificial weaken zones in surrounding rocks, that's named fracturing ring. The fracturing ring is the weaken zone with some width, whose inner boundary is the protective circle. The fracturing ring with small width is called the cutting and interruption circle and the cutting or interruption arc. The radius of the protective circle is determined by setting a certain width of safety coal pillar barriers at the edge of a support body. The radius of the fracturing ring is determined by the surrounding rock structure and the stress conditions as well as the construction technology. Usually, the higher the stress, the wider the radius of the fracturing ring. The cutting and interruption circle or arc could cut off all of the targeted rock which transmits the stress.

Abstract: Disclosed are cyclopentene compounds for use as inhibitors of gamma-aminobutyric acid (GABA) aminotransferase (AT) and/or ornithine aminotransferase (OAT). The disclosed cyclopentene compounds include 3-carbon substituted 4-aminocyclopent-1-ene-carboxylic acid compounds which may be formulated in pharmaceutical composition for treating diseases and disorders associated with GABA-AT and/or OAT activity, including epilepsy, addiction, and hepatocellular carcinoma (HCC).

Abstract: A device comprising: a plurality of gold nanoparticles coupled with an intertwined ZnO nanorods network, wherein the device is configured for detecting light in the visible wavelength.

Abstract: An automatic arranging machine for membrane fiber which comprises a workbench, and a membrane fiber reel, a membrane fiber guide plate, a first membrane fiber traction apparatus, a membrane fiber cutter, a membrane fiber bracket and a second membrane fiber traction apparatus which are sequentially arranged and mounted on the workbench. The invention provides an automatic arranging machine for membrane fiber and a membrane module production device, which mainly rely on a membrane fiber automatic filling machine to accurately control the membrane fiber, and realize passing the automatic membrane fiber through the membrane fiber bracket into a membrane tube by using the membrane fiber traction apparatus to cooperate with a related mechanical walking structure.

Abstract: Disclosed is a process for separating suspended particles based on size. When confined in a tube, a bubble moves relative to the liquid as a small fraction of the liquid leaks backwards through a very thin gap between the bubble and the internal wall of the tube. The lubricating film formed around the bubble can be fine-tuned by simply changing the average flow speed. With this thin film of liquid, the confined air bubble can be used to separate particles in, for example, poly-disperse microspheres suspensions. As the bubble passes through the suspension, only particles smaller than the liquid gap thickness can leak through the gap towards the back of the bubble, resulting a filtered particle suspension containing only small particles at the back of the bubble. Compared to the traditional methods, this particle separation process is easy to perform, and is flexible in filtering different suspensions with one set-up.

Abstract: A wound dressing is made from a tubular inner layer and at least one outer layer disposed radially beyond the inner layer. The inner layer permits egress of fluid from weeping wounds, prevents desiccation of skin disposed beneath the inner layer, and prevents desiccation of ointment disposed between the inner layer and the skin. The at least one outer layer absorbs fluids that leak through the inner layer, protects the inner layer from outside contaminants, and prevents fluids from escaping. The at least one outer layer is affixed to the inner layer, and each of the layers is elastic in at least the radial direction. Optionally, a layer of ointment may be applied to an inner surface of the inner layer. Note that the tubular inner layer may be either pre-formed or formed at the time of application.