Abstract: The present disclosure relates to triazole derivatives of melampomagnolide B, their synthesis, and their use as anti-cancer compounds.

Abstract: The present invention relates to a first intraocular lens (120) embodiment having a retainer plate (124) with an annular region surrounding a central opening and an optical lens (122) removably attached to the retainer plate within the central opening. Also disclosed is a second intraocular lens embodiment having a retainer plate with a porous or perforated annular region surrounding a central opening. An optical lens (122) is integral with the retainer plate (124) within the central opening. Methods of implanting these intraocular lens (120) embodiments into a patient's eye are disclosed. Also described here are methods of replacing the first intraocular lens embodiment after it has been implanted in a patient's eye.

Abstract: Disclosed herein are porous asymmetric silicon membranes. The membranes are characterized by high structural stability, and as such are useful as anode components in lithium ion batteries.

Abstract: The present invention relates to chimeric antigen receptors (CARs) specific to ICAM-1 comprising I domain of the ?L subunit of human lymphocyte function-associated antigen 1 (LFA-1). The invention particularly relates to CARs comprising human I domains having different affinities (1 mM to 1 nM Kd) to ICAM-1. CAR T cells comprising human I domain having a low affinity (1 to 200 ?M Kd) to ICAM-1 can avoid targeting healthy tissues with basal ICAM-1 expression while simultaneously exhibiting increased potency and long-term efficacy against tumor tissues with high ICAM-1 expression. The present invention also relates to an adoptive cell therapy method for treating cancer by administering the CAR-T cells comprising human I domain to a subject suffering from cancer, whereby the CAR T cells bind to the cancer cells overexpressing ICAM-1 and kill the cancer cells.

Abstract: The present invention provides assays utilizing SPR to detect protein-ligand interactions as well as compositions utilized is such assays.

Abstract: A tracking and navigation system is provided. The system includes an imaging or treatment device, a tracker device, and a fiducial marker. At least part of the imaging or treatment device is movable relative to a patient. The tracker device is mounted on the imaging or treatment device and is movable therewith relative to the patient. The fiducial marker may be fixed relative to the patient to define a patient coordinate system. The fiducial marker is detectable by the tracker device to substantially maintain registration between the tracker device and the patient coordinate system. A tracking and navigation kit including the tracker device and at least one fiducial marker may also be provided, for example, for retrofitting to existing imaging or treatment devices.

Abstract: Improved correction of MRI images is provided making use of three main principles. First, a hybrid representation of the image reconstruction problem is used where the raw MRI data is Fourier transformed in x to provide a x-ky-kz representation. Second, blip-up blip-down acquisition is performed to provide data having equal and opposite regular k-space encoding. Third, joint least squares reconstruction is performed using a singular value decomposition of a joint blip-up, blip-down encoding matrix. The encoding matrix includes at least the effects of regular k-space encoding and known phase variations due to system non-ideality. Preferably, suitable regularization of the encoding matrix based on its singular values is used to automatically remove poorly conditioned parts of the data.

Abstract: The present disclosure provides antibodies that bind the surface of Toxoplasma gondii oocysts, methods for using such antibodies and kits and devices for practicing such methods. Such antibodies, methods, kits and devices find use in detection of T. gondii oocysts and the isolation of such oocysts from samples including environmental samples, food-based samples, diagnostic samples, and the like.

Abstract: The disclosure relates to a temperature sensitive system. The system includes a powder, a detector, a first electrode, a second electrode and an actuator. The powder, the detector, the first electrode, the second electrode and the actuator are connected to form a loop circuit. The actuator can deform in response to temperature change so that the circuit to be on or off. The detector is connected to the actuator in parallel or in series and configured to show the current change of the loop circuit to the user. The actuator includes a carbon nanotube layer and a vanadium dioxide layer (VO2) layer stacked with each other. Because the drastic, reversible phase transition of VO2, the actuator has giant deformation amplitude and fast response and the temperature sensitive system has high sensitivity.

Abstract: Grafted triglycerides comprising a triglyceride grafted with a fatty acid residue containing 4 to 30 carbon atoms are reacted with an epoxide resin and an amine curing agent to yield an epoxy thermoset. The grafted triglyceride is prepared by reaction of an epoxidized triglyceride with a fatty acid. By varying the length of the fatty residue, the number of fatty residues per triglyceride, the identity of the epoxy resin and the amine curing agent, it is possible to prepare epoxy thermosets that exhibit superior physical properties compared to the properties of epoxy thermosets prepared without the grafted triglyceride, or as compared to epoxy thermosets wherein the epoxidized triglyceride is used in place of the grafted triglyceride.

Abstract: Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed. The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.

Abstract: A system and method used to configure a smart device to command functional operations of a target appliance. The smart device retrieves from a controllable appliance, such as a settop box, data indicative of a codeset identity of the target appliance wherein the codeset identity was determined during a process used to configure a conventional universal remote control to command functional operations of the target appliance and wherein the process used to configure the conventional universal remote control is performed in cooperation with the controllable appliance. A remote control application resident on the smart device then uses the data indicative of the codeset identity retrieved from the controllable appliance to also configure the smart device to command functional operations of the target appliance.

Abstract: Systems and methods for determining body weight predictions and human conditions are disclosed. A body weight may be predicted by capturing at least one image of a human, and determining, from the image, a body weight prediction of the human by processing the at least one image with a data processor. The body weight prediction may further be based on an age-based weight factor. A model such as a neural network model may be used to predict body weight.

Abstract: Isolated polynucleotides comprising an OLIG1 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, guide RNA, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.

Abstract: A waveguide slotted array antenna comprises a feed layer and a radiation layer, wherein the feed layer is located below the radiation layer, and the radiation layer comprises a first radiation unit, a second radiation unit, a third radiation unit and a fourth radiation unit which are stacked from bottom to top; the first radiation unit comprises a first flat metal plate and a first radiation array arranged on the first flat metal plate, the second radiation unit comprises a second flat metal plate and a second radiation array arranged on the second flat metal plate, the third radiation unit comprises a third flat metal plate and a third radiation array arranged on the third flat metal plate, and the fourth radiation unit comprises a fourth flat metal plate and a fourth radiation array arranged on the fourth flat metal plate. The waveguide slotted array antenna has the advantages of low sidelobes and low cost while ensuring broad bands and high gains, and can be made small.

Abstract: A capacitive micromachined ultrasonic transducer (CMUT) and methods of forming the same are disclosed herein. In one implementation, the CMUT comprises a glass substrate having a cavity; a patterned metal bottom electrode situated within the cavity of the glass substrate; and a vibrating plate comprising at least a conducting layer, wherein the vibrating plate is anodically bonded to the glass substrate to form an air-tight seal between the vibrating plate and the substrate and wherein a pressure inside the cavity is less than atmospheric pressure (i.e., a vacuum). In another implementation, the CMUT comprises a glass substrate with Through-Glass-Via (TGV) interconnects, wherein a metal electrode is electrically connected to a TGV and wherein said metal electrode can be in the bottom of a cavity of the glass substrate or on the vibrating plate.

Abstract: Methods of optically marking and sorting adherent cells are provided. The methods include providing a plurality of adherent cells attached to a substrate, each adherent cell of the plurality of adherent cells having an optical marker. The methods also include selectively applying light energy to a subset of the plurality of adherent cells, and detaching the plurality of adherent cells from the substrate. These methods also provide the sorting of the plurality of adherent cells.

Abstract: A method and device for coding and decoding are disclosed. The method includes: dividing a picture to be encoded into several slices, each containing macroblocks continuous in a designated scanning sequence in the picture; dividing slices in the picture into one or more slice sets according to attribute information of the slices, each slice set containing one or more slices; and encoding the slices in the slice sets according to slice and slice set division information to get a coded bit stream of the picture. The decoding method includes: obtaining slice and slice set division information from a bit stream to be decoded and decoding the bit stream according to the obtained slice and slice set division information. The invention improves the performance of video transmission effectively and realizes region based coding. The implementation of coding and decoding is simple and the complexity of coding and decoding systems is reduced.

Abstract: A photoactive device that includes a photovoltaic device having electrodes and at least one photoactive layer between the electrodes. One or more other layers may be included between the electrodes. The device includes a substrate positioned below the photovoltaic device, and a nanostructure backreflective layer positioned below the substrate such that at least some of the incident light impinging on the photovoltaic device passes through the photovoltaic device and the substrate and is backscattered through the substrate to the photovoltaic device.

Abstract: The concepts and technologies disclosed herein are directed to parallelism for virtual network functions (“VNFs”) in service function chains (“SFCs”). According to one aspect, a packet processing system can receive instructions to process, in parallel, at least a portion of a plurality of data packets associated with an SFC including a plurality of VNFs. The system can create a copy of at least the portion of the data packets. The system can send the copy of at least the portion of the data packets to at least two VNFs. The at least two VNFs can process, in parallel, the copy of at least the portion of the data packets. The system can receive, from the at least two VNFs, processed packets including the copy of at least the portion of the data packets and processed, in parallel, by the at least two VNFs. The system can combine the processed packets.