Abstract: A method of restoring activity in phenylalanine hydroxylase is provided. The method comprises exposing the phenylalanine hydroxylase to shikimic acid, a functionally equivalent analog thereof, a pharmaceutically acceptable salt of shikimic acid or analog thereof, or combinations thereof.

Abstract: There is provided a state-monitory system of a moving apparatus which is capable of deducing an abnormality and cause of breakdown of the moving apparatus by Equationematical analysis only by measuring vibration of a casing or object to be monitored and which requires no large-scaled apparatus. An equivalent model of the moving apparatus 1 is formed, which is adapted to replace the vibration of a monitored object of the moving apparatus 1 with the vibration of a viscoelastic member such as an elastic spring etc. and which is adapted to be capable of outputting virtual vibration data having synthesized vibration equivalent to the vibration of the viscoelastic member, and the equivalent model is Equationematically analyzed, thereby estimating the abnormality and cause of breakdown of the moving apparatus 1 only by measuring vibration of the casing 8 or a monitored object.

Abstract: A method for designing off-axial three-mirror optical system with freeform surfaces is provided. A first initial surface, a second initial surface, and a third initial surface are established. A plurality of feature rays are selected, while the first initial surface and the third initial surface remain unchanged; a plurality of first feature data points are calculated to obtain a third freeform surface equation by surface fitting the plurality of first feature data points. A third freeform surface and the second initial surface are remained unchanged; a plurality of second feature data points are calculated to obtain a first freeform surface equation by surface fitting the plurality of second feature data points. The third freeform surface and a first freeform surface are remained unchanged; a plurality of third feature data points are calculated to obtain a second freeform surface equation by surface fitting the plurality of third feature data points.

Abstract: The disclosure relates to a thin film transistor and a method for making the same. The thin film transistor includes a substrate; a semiconductor layer on the substrate, wherein the semiconductor layer includes nano-scaled semiconductor materials; a source and a drain, wherein the source and the drain are on the substrate, spaced apart from each other, and electrically connected to the semiconductor layer; a dielectric layer on the semiconductor layer, wherein the dielectric layer includes a first sub-dielectric layer and a second sub-dielectric layer stacked on one another, and the first sub-dielectric layer is a first oxide dielectric layer grown by magnetron sputtering; and a gate in direct contact with the first sub-dielectric layer. The thin film transistor almost has no current hysteresis.

Abstract: Provided herein are methods and devices for accurate sequencing and detection of epigenetic information from template polynucleotides. Also provided are methods for long-range strand displacement amplification of polynucleotides, microfluidic devices with selectively permeable barriers for multistep processing, and methods for polynucleotide amplification using the microfluidic devices.

Abstract: The present invention relates to a methods and systems for monitoring and/or characterizing multi-component tablets and for monitoring punch and die surfaces and, more particularly, to methods and systems for in-die and out-of-die monitoring and/or characterizing multi-component tablets based on acoustic and vibrational spectroscopy and for detecting and monitoring stiction and tooling material modifications on punch and die surfaces during compaction based on acoustic/ultrasonic waves.

Abstract: An expansible cardiovascular graft system for replacing vasculature such as a portion of the aorta. The portion of the aorta may include but is not limited to the ascending aorta, the aortic arch, or the descending aorta. The system features a graft conduit with a proximal anchor disposed at the proximal end and a distal anchor disposed at the distal end and an expansible portion disposed between the proximal anchor and the distal anchor. At least a portion of the expansible system is adapted to gradually expand.

Abstract: This disclosure provides systems, methods, and apparatus related to laser plasma accelerators. In one aspect a block of material defines a gas inlet, a chamber in fluid communication with the gas inlet, a throat in fluid communication with the chamber, a channel in fluid communication with the throat, and a gas outlet in fluid communication with the channel. The throat is configured to generate a supersonic flow of a gas when the gas flows through the throat. The channel includes a ramp that is positioned proximate the gas outlet, with the ramp being inclined at an angle with respect to a direction of a flow of the gas proximate a surface of the channel prior to the ramp at the gas outlet.

Abstract: Described herein are methods of transdifferentiating preadipocytes, populations of transdifferentiated preadipocytes, and methods of using the transdifferentiated preadipocytes.

Abstract: Disclosed are methods of manufacturing a SH surface including: creating a master with SH features by: depositing a rigid material onto a first surface, wherein the first surface is a shrinkable platform; shrinking the first surface by heating to create a SH surface, wherein the SH surface has micro- and nano-scale structural features that trap air pockets and prevent water from wetting the surface; forming the master by molding an epoxy with the shrunken first surface having a SH surface, wherein the master acquires the SH features of the first surface; and imprinting the SH features of the master onto a second surface to impart the SH features of the master onto the second surface. Some embodiments relate to a superhydrophobic (SH) surface, an article including a SH surface as disclosed, such as a microfluidic device or a food container.

Abstract: Nanoscale stress-sensing can be used across fields ranging from detection of incipient cracks in structural mechanics to monitoring forces in biological tissues. We demonstrate how tetrapod quantum dots (tQDs) embedded in block-copolymers act as sensors of tensile/compressive stress. Remarkably, tQDs can detect their own composite dispersion and mechanical properties, with a switch in optomechanical response when tQDs are in direct contact. Using experimental characterizations, atomistic simulations and finite-element analyses, we show that under tensile stress, densely-packed tQDs exhibit a photoluminescence peak shifted to higher energies (“blue-shift”) due to volumetric compressive stress in their core; loosely-packed tQDs exhibit a peak shifted to lower energies (“red-shift”) from tensile stress in the core. The stress-shifts result from the tQD's unique branched morphology in which the CdS arms act as antennas that amplify the stress in the CdSe core.

Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A computer-implemented control system is operated to automatically identify a neural fulcrum zone based on a monitored patient physiological response. Ongoing neurostimulation therapy is delivered within the neural fulcrum zone.

Abstract: Provided herein are monoclonal antibodies that recognize, bind to, and block interactions of other molecules with AGR2 and C4.4A. Also provided herein are methods of using anti-AGR2 and anti-C4.4A antibodies to treat cancer.

Abstract: A monoclonal antibody to KIR2DS1 or a fragment containing an antigen-binding region thereof has VL having an amino acid sequence of SEQ ID NO: 1 or an amino acid sequence having the same amino acid sequence as the amino acid sequence except that one or several amino acids are conservatively substituted as CDR1, having an amino acid sequence of SEQ ID NO: 2 or an amino acid sequence having the same amino acid sequence as the amino acid sequence except that one or several amino acids are conservatively substituted as CDR2, and having an amino acid sequence of SEQ ID NO: 3 or an amino acid sequence having the same amino acid sequence as the amino acid sequence except that one or several amino acids are conservatively substituted as CDR3; and VH having an amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 5 or an amino acid sequence having the same amino acid sequence as the amino acid sequence except that one or several amino acids are conservatively substituted as CDR1, having an amino acid sequence of SEQ ID NO

Abstract: Disclosed is a method and apparatus for IP-based hybrid 3DTV content transmission and reception. According to one aspect of the present disclosure, an IP-based hybrid 3DTV content reception apparatus includes: a receiving unit receiving multiplexed 3DTV content information; an additional data obtaining unit obtaining service layer signaling information from the received 3DTV content information, and obtaining additional data based on the obtained service layer signaling information; a decoding unit decoding the received 3DTV content information by using the obtained additional data; and a playing back unit playing back the decoded 3DTV content.

Abstract: The disclosure relates to a method for detecting surface electric field distribution of nanostructures. The method includes the following steps of: providing a sample located on an insulated surface of a substrate; spraying first charged nanoparticles to the insulated surface; and blowing vapor to the insulated surface to observe a distribution of the first charged nanoparticles via an optical microscope.

Abstract: During shock wave therapy, a determination is made that a kidney stone has begun to fracture, and then a progress of its fragmentation is assessed. This determination can reduce the number of shock waves used to disintegrate kidney stones, and thereby reduce dose-dependent tissue damage. The identification of fracture is possible through the detection and analysis of resonant acoustic scattering, which is the radiation caused by reverberations within a stone particle that is struck by a shock wave. The scattering frequency can provide both an indication that the kidney stone has fragmented, and an indication of the relative sizes of the fragments. Related concepts employ displacement measurements of kidney stones/fragments to provide both an indication that the kidney stone has fragmented, and an indication of the relative sizes of the fragments. Such techniques can be combined with vibro-acoustography based gating that better targets the stone.

Abstract: System and method directed towards providing full and even illumination of a patient's retina through lighting integrated into a handheld fundus lens. By integrating the lighting, the method and system reduces and even eliminate many lens artifacts and reflections. By increasing the accuracy, quality, and field of view 10 afforded during clinical examination of the retina, the method and system will allow practitioners to make more accurate diagnoses and will increase safety during retinal surgical procedures.

Abstract: Various systems and methods are implemented for in vivo use in a living animal. One such method involves stimulating target cells having light-responsive proteins and includes providing an elongated light-delivery structure in a narrow passageway in the animal, the elongated light-delivery structure having separately-activatable light sources located along the length of the elongated light-delivery structure. The method also includes activating less than all the light sources to deliver light to light-responsive proteins adjacent to the activated light sources along the length of the elongated light-delivery structure, thereby stimulating target cells in vivo.

Abstract: Methods and apparatus for deep microscopic super resolution imaging use two independent and variable focal planes. Movements of fiducial markers imaged using one focal plane are monitored and used to provide real-time or near real-time correction for sample drift. A second focal plane may be used to collect light for super-resolution imaging of a sample. A prototype embodiment has produced low drift when imaging many microns deeper than the fiducial markers.