Abstract: The invention provides kinase substrates and methods comprising their use.

Abstract: Embodiments of a deep learning enabled generative sensing and feature regeneration framework which integrates low-end sensors/low quality data with computational intelligence to attain a high recognition accuracy on par with that attained with high-end sensors/high quality data or to optimize a performance measure for a desired task are disclosed.

Abstract: Described are flexible electronics incorporating a bacterial cellulose paper substrate and methods of making and using the flexible electronics. Example devices disclosed include photovoltaic cells constructed over bacterial cellulose paper substrates.

Abstract: The present disclosure describes two click reactions to sequentially polymerize and then functionalize hydrogel microparticles to provide therapeutic agent-functionalized crosslinked hydrogel microparticles. The two click reactions have one common reactive group, and are non-interfering with respect to one another. The therapeutic agents can be released from the hydrogel microparticles over time as the hydrogel degrades, or the therapeutic agents can be released from the hydrogel microparticles by enzymatic degradation or hydrolysis. In some embodiments, the biological function of the therapeutic agents can be preserved or enhanced when covalently bound to the hydrogel microparticles. The present disclosure also provides methods for the production of hydrogel cell culture substrates. The methods overcome the hurdle of protein functionalization through the implementation of an advanced but simple chemical strategy that involves modifying a protein of interest with chemical groups (e.g.

Abstract: To provide a layer such as a charge transport layer having a refractive index significantly lowered without impairing electrical conductivity and surface roughness, and a method for producing it. A deposited film composition obtained by co-depositing a fluorinated polymer having a saturated vapor pressure at 300° C. of at least 0.001 Pa and an organic semiconductor material.

Abstract: Systems and methods of use and fabrication are described for a non-volatile resistive random access memory (RRAM) multi-terminal device including a first electrode, a second electrode, a metal oxide disposed between the first electrode and the second electrode, and an at least first gate configured to apply a voltage bias to change a resistive state in the metal oxide.

Abstract: The present invention provides a high voltage ESD protection device including a P-type substrate; a first NWELL region located on the left of the upper part of the P-type substrate; an NP contact region located on the upper part of the first NWELL region; an N+ contact region located on the right of the upper part of the P-type substrate apart from the first NWELL region; a P+ contact region tangential to the right side of the N+ contact region; a NTOP layer arranged on the right of the NP contact region inside the first NWELL region. The NP contact region is connected to a metal piece to form a metal anode. The N+ contact region and the P+ contact region are connected by a metal piece to form a metal cathode.

Abstract: A non-contact photoacoustic spectrophotometry system is configured to measure an absorption spectrum of a material. The system includes a modulated light source such as tunable pulsed laser that generates laser pulses to produce photoacoustic signals in the material. A non-contact detector monitors the surface of the container for the material. The detector includes a second light source, such as a continuous wave laser, focused on the surface of the container, and transmits reflected light to an interferometer, for example, a Sagnac interferometer. The interferometer produces an interference signal from the received light that is proportional to the acoustic pressure, which is transmitted to a computer to calculate an absorption coefficient. Using a plurality of wavelengths from the tunable pulsed laser, an absorption spectrum may be generated.

Abstract: The present invention provides a compound having the structure:

Abstract: The present invention relates to human IgG Fc domain variants with improved effector function and uses thereof.

Abstract: A pulsed beam of NIR excitation light is projected into a sample (345) at an oblique angle and scanned by a scanning element through a volume in the sample. 2-photon excitation excites fluorescence within the sample. The fluorescence is imaged onto an intermediate image plane that remains stationary regardless of the orientation of the scanning element. The image is captured by a linear array of light detecting elements (392) or a linear portion of a rectangular array. At any given position of the scanning element, the linear array (or portion) images all depths simultaneously. A plurality of images are captured for each of a plurality of different orientations of the scanning element. The orientation of the scanning element is controlled to move in a two dimensional pattern, which causes the beam of excitation light to sweep out a three dimensional volume within the sample.

Abstract: Disclosed are systemic and intravaginal non-hormonal contraceptives comprising a spermicidal triterpenoid. The contraceptive may be in the form of a foam, cream or gel, or in unit form of a pill, vaginal contraceptive film (VCF), suppository, sponge, transdermal or hypodermal patches or a slow release intravaginal device or intrauterine device such as a drug-impregnated silicone elastomer vaginal ring or polymeric IUD.

Abstract: The present invention relates to a use of leucine-zipper protein for diagnosis or treatment of fatty liver. According to the present invention, it could be confirmed that a particular fragment present at the leucine-zipper protein, especially, the N-terminal region thereof, plays an important role in the lipid metabolism in liver tissue by regulating transcriptional activity of Apolipoprotein A4, and therefore, the protein of the present invention or a fragment thereof can be utilized as a target for diagnosis, prevention, or treatment of fatty liver.

Abstract: The present application discloses a terahertz based self-feedback system for detecting atmospheric high-risk chemical. In the system, a detecting device is configured to detect information of an atmospheric high-risk chemical. A mechanical adjusting device is configured to adjust a height and an orientation of the detecting device to obtain the information at different heights and orientations. A mobile carrying device is configured to drive the detecting device to move to obtain the information of the atmospheric high-risk chemical at different locations. A processing device is configured to process the information and feedback an instruction to adjust the height and the orientation of the detecting device and control the mobile carrying device to move. The processing device is also configured for imaging the information of the atmospheric high-risk chemical. The present application also discloses terahertz based methods for detecting a distribution and a leakage source of the atmospheric high-risk chemical.

Abstract: The present invention provides methods for treating or alleviating one or more symptoms of depression and/or anxiety in a subject comprising administering an effective amount of an NCAM peptide mimetic to the subject. The symptoms of depression and/or anxiety are typically observed in or associated with a neurological condition. The present invention also provides methods for treating a neurological condition such as a psychiatric disorder in a subject comprising administering an effective amount of an NCAM peptide mimetic to the subject.

Abstract: A multichannel stethographic device includes a plurality of individual stethoscopes that may be embedded in a foam pad or surface mounted on a thin flexible substrate. Additional stethoscopes for the heart and thorax may also be utilized. The system may include a signal conditioning circuit, wireless DAQ module, and software (algorithms). The systems may be configured to identify and diagnose various disease conditions such as pneumonia, chronic obstructive pulmonary disease (COPD), asthma, congestive heart failure (CHF), interstitial pulmonary fibrosis (IPF), and vocal cord dysfunction (VCD).

Abstract: Systems and methods of use and fabrication are described for a non-volatile resistive random access memory (RRAM) multi-terminal device including a first electrode, a second electrode, a metal oxide disposed between the first electrode and the second electrode, and an at least first gate configured to apply a voltage bias to change a resistive state in the metal oxide.

Abstract: The present invention relates to methods for regulating prohormone convertase (PC1) and compounds and treatments which increase PC1 levels, for treating Prader-Willi Syndrome (PWS).

Abstract: A multi-degree-of-freedom (Multi-DOF) 3D printing device includes a printer mechanism, a rotatable platform, a visual inspection system, and a control system. The printing mechanism includes a print head. The printing mechanism and the rotatable platform are combined to have three degrees of freedom of translation, and the rotatable platform has two degrees of freedom of rotation. The visual inspection system includes a camera mounted to nearby the print head and the relative position of camera and print head remains constant. The control system is configured to implement the printing process. The model is decomposed into several components, each of which could be printed in a single direction. After one component is printed out, the platform is then rotated so that the cutting plane for the component will be printed is horizontal.

Abstract: The present invention relates to a method for pretreating lignocellulose by using an acid-base mixture catalyst. The method pretreats lignocellulose, by using a mixture catalyst of an acid and a base, so as not to pass through additional neutralization steps, and carries out pretreatment and simultaneous saccharification and fermentation through an identical single reactor process, thereby having an effect of producing ethanol in an excellent production yield from lignocellulosic biomass while simplifying the total process and reducing equipment costs and total processing costs.