Abstract: The present disclosure relates to salts of heterocyclic compounds and methods that inhibit HIF pathway activity. The compounds are designed to treat or prevent cancer and other hypoxia-mediated diseases.

Abstract: The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor (“FGF”) and the C-terminus includes a C-terminal portion of an FGF23 molecule. The portion of the paracrine FGF is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification. The present invention also relates to pharmaceutical compositions including chimeric proteins according to the present invention, methods for treating a subject suffering from a disorder, and methods of screening for compounds with enhanced binding affinity for the ?Klotho-FGF receptor complex involving the use of chimeric proteins of the present invention.

Abstract: There is provided a method, a system and a computer program product for supporting a decision making process. The system receives a decision model from a decision maker, the decision model used for determining a solution to a decision problem based on attributes and uncertainties of the decision problem. The decision problem includes information about a plurality of outcome vectors that represent all possible outcomes and the uncertainties associated with the decision problem. The system determines whether the received decision model can be solved without receiving any preference information from the decision maker. The system receives partially specified preference information from the decision maker if the received decision model cannot be solved without any preference information. The system solves the decision model with the partially specified preference information. The system recommends, based on the solution, one or more decisions to the decision maker.

Abstract: A method for evaluating performance of a sensor network. The method includes selecting, a sensor distribution pattern for a geographical region and determining a location for a base station. A plurality of sensor clusters are generated, each sensor cluster being formed by one of a first and second grouping mechanism. Further, the method allocates, for each sensor a time-slot within a time-frame to transmit a data packet from the sensor to the base station, and evaluates the performance of the first grouping mechanism and the second grouping mechanism for the selected sensor distribution pattern and base station location, by computing at least a ratio of delivered data packets to the base station to a total energy consumption, and a first delay and a second delay incurred by each data packet.

Abstract: Described herein is an approximate dynamic programming (ADP) vector controller for control of a permanent magnet (PM) motor. The ADP controller is developed using the full dynamic equation of a PM motor and implemented using an artificial neural network (ANN). A feedforward control strategy is integrated with the ANN-based ADP controller to enhance the stability and transient performance of the ADP controller in both linear and over modulation regions. Simulation and hardware experiments demonstrate that the proposed ANN-based ADP controller can track large reference changes with high efficiency and reliability for PM motor operation in linear and over modulation regions.

Abstract: Improved methods of making anhydrosugars by pyrolysis of a substrate sugar to remove at least one water molecule thereby producing a desired anhydrosugar and side products, the improvement being either 1) protecting one hydroxyl group of the substrate sugar before pyrolysis; or (2) pretreating the substrate sugar with a metal salt and optional acid before pyrolysis, wherein lower amounts of said side products are produced by said improved method.

Abstract: A photocatalytic nanocomposite hollow sphere comprising a shell surrounding a hollow core, and the shell comprising zirconium dioxide, hydroxyapatite, and platinum, as well as a method for producing the nanocomposite hollow sphere and a method employing the nanocomposite hollow sphere in reducing an aromatic nitro compound to an aromatic amine compound under visible light are disclosed.

Abstract: The present invention relates to a composition for use in the treatment of a detached retina, comprising an oil and an additive capable of increasing the extensional viscosity of the oil. The present invention also relates to a method and kit of parts for producing the composition.

Abstract: The present disclosure provides supercapacitors that may avoid the shortcomings of current energy storage technology. Provided herein are electrochemical systems, comprising three dimensional porous reduced graphene oxide film electrodes. Prototype supercapacitors disclosed herein may exhibit improved performance compared to commercial supercapacitors. Additionally, the present disclosure provides a simple, yet versatile technique for the fabrication of supercapacitors through the direct preparation of three dimensional porous reduced graphene oxide films by filtration and freeze casting.

Abstract: Provided herein are methods, compounds, and compositions for reducing expression of an AGPAT5 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing lipids, insulin resistance and/or glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate a cardiometabolic disease, disorder or condition, or a physiological marker thereof, in an individual in need.

Abstract: A method of inducing local cell death in patient tissue is provided. The method includes generating first and second radiation, conveying the radiation to a focusing element, and focusing the radiation on a target with the focusing element. A system for inducing local cell death in patient tissue is also provided. The system includes a power source for generating narrowband and/or ultra-wideband radiation, and a focusing element for focusing the radiation on a target.

Abstract: The kit for measuring vertical dimension for dental impression provides a tool for measuring a difference between a dental patient's desired vertical dimension and the patient's vertical dimension prior to a dental restoration procedure. The kit includes a base, a plurality of measurement sheets, and dental impression wax. The base includes a planar member having first and second longitudinally opposed ends and opposed upper and lower surfaces. The upper surface has at least one longitudinally extending groove defined therein. First and second legs are secured to the first and second longitudinally opposed ends of the planar member and extend downward from the lower surface. Each measurement sheet has opposed upper and lower surfaces and at least one longitudinally extending rib formed on the lower surface and at least one longitudinally extending groove defined in the upper surface. Each of the plurality of measurement sheets has a known thickness.

Abstract: Methods, systems, and media for automatically authenticating a user account using multiple services are provided. In accordance with some embodiments of the disclosed subject matter, methods for authenticating a user using multiple services are provided, the methods comprising: receiving, from a client device, first credentials for a target service account; authenticating the target service account based on the first credentials; issuing a redirecting request that directs the client device to at least one vouching service in response to authenticating the target service account; receiving a vouching response indicating that the client device has authenticated a vouching service account with the at least one vouching service, wherein the vouching response includes a vouching token; and providing the client device with access to the target service account in response to determining that the vouching service account is associated with the target service account.

Abstract: The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an anti-inflammatory cytokine. Compositions including the same are also provided.

Abstract: The present invention relates to a method for pretreating lignocellulose by using an acid-base mixture catalyst. The method pretreats lignocellulose, by using a mixture catalyst of an acid and a base, so as not to pass through additional neutralization steps, and carries out pretreatment and simultaneous saccharification and fermentation through an identical single reactor process, thereby having an effect of producing ethanol in an excellent production yield from lignocellulosic biomass while simplifying the total process and reducing equipment costs and total processing costs.

Abstract: The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids.

Abstract: The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.

Abstract: Disclosed are a method and an apparatus for image encoding/decoding. The method for image decoding includes comparing whether a size of a current transform block and a size of a smallest transform block (smallest transform unit (STU)) are the same as each other, and decoding information indicating whether transformation is performed on the current transform block and determining whether to perform inverse transformation on the current transform block based on the decoded information indicating whether the transformation is performed when the size of the current transform block and the size of a smallest transform block are the same as each other.

Abstract: The present invention relates to the 14-3-3 protein which is a non-alcoholic fatty liver regulating factor. According to the present invention, two isoform proteins of 14-3-3, i.e., 14-3-3? and 14-3-3?, are different regulating factors for regulating the transcriptional activity of PPAR?2. 14-3-3? increases the transcriptional activity of PPAR?2 by binding to PPAR?2, on the other hand, 14-3-3? plays a role in decreasing the transcriptional activity of PPAR?2. Thus, 14-3-3? and 14-3-3?, which are PPAR?2 regulating factors, are proteins that play a vital role in lipid metabolism, and may be used as a target for the prevention or treatment of fatty liver.

Abstract: This disclosure provides systems, methods, and apparatus related to deposition techniques using laser ablation. In one aspect, an optical fiber and target of a material to be deposited on a first region of an interior surface of a hollow component are positioned in the hollow component. A first end of the optical fiber is coupled to a laser system. A second end of the optical fiber is proximate the target. The material is deposited on the first region of the interior surface of the hollow component by directing a first laser pulse from the laser system through the optical fiber to impinge on the target.