Abstract: The present invention provides a thin and flexible device and method of use thereof for wound treatment and infection control. The integrated surface stimulation device may comprise a complete wireless stimulation system in a disposable and/or reusable flexible device for widespread use in multiple therapeutic applications. The invention would be situated on the skin surface of a patient and would be activated so as to reduce the overall occurrence of infections and/or increase wound healing rates. As provided, the device will comprise an integrated power supply and pre-programmable stimulator/control system on a flexible polymeric substrate layer with areas of stimulating electrodes, applied using techniques such as those found in additive manufacturing processes. The device is especially valuable in treating biofilm-based infections.

Abstract: Disclosed herein, inter alia, are polymerized metal organic framework compositions and polymer compositions, and methods of making and using the same.

Abstract: The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of MIF expression and treat disorders associated with high or low levels of MIF expression.

Abstract: The present invention provides a cantilever for a scanning type probe microscope, the cantilever including a support portion, a lever portion extending from the support portion, a protrusion portion formed on a free end side of the lever portion, an apex angle of the protrusion portion being an acute angle, and a probe in which a fine wire formed at a distal end of the protrusion portion is coated with a functional film, and a major axis/minor axis ratio of a cross-sectional shape of the probe is smaller than a major axis/minor axis ratio of a cross-sectional shape of the fine wire.

Abstract: Methods and apparatuses are disclosed for quantifying regional organ perfusion with low radiation dose using whole-organ CT in a patient comprising obtaining a computed tomography scan of the patient and determining perfusion of the organ using a first-pass analysis method in conjunction with conservation of mass for perfusion measurement.

Abstract: Disclosed herein are compositions of tricarbazole triazolophane (tricarb) of Formulas (I), (II) and (III): wherein R of Formula (I) is selected from a group consisting of alkyl (for example, C6-C18), alkyl-substituted phenyl derivatives, and substituted glycol derivatives, among others, or a combination thereof, and R, R? and R? of Formulas (II) and (III) are independently selected from a group consisting of alkyl (for example, C6 to C18), alkyl-substituted phenyl derivatives, and substituted glycol derivatives, or a combination thereof. The disclosure presents examples of thin films composed of the same as well as methods of binding anions from the same.

Abstract: Congenital abnormalities of the kidney or the urinary tract (CAKUT) are the most common cause of pediatric kidney failure. These disorders are highly heterogenous, and their etiology is poorly understood. Dual serine/threonine and tyrosine protein kinase (DSTYK) mutations were detected in 2.2% of patients with congenital abnormalities of the kidney and urinary tract, suggesting that DSTYK is a major determinant of human urinary development, downstream of fibroblast growth factor (FGF) signaling. Methods and kits are provided for identifying and treating subjects at greater risk of developing CAKUT based on the presence of DSTYK mutations. Techniques include obtaining a biological sample from a subject and determining if the biological sample indicates a mutation of a gene for DSTYK. If it is determined that the biological sample indicates the mutation of the gene for DSTYK, then it is determined that the subject has or is at risk of developing CAKUT.

Abstract: A method of monitoring glucose transport and/or metabolism in a tissue or an organ of a subject using spin-locking magnetic resonance (MR) includes acquiring pre-glucose MR data by executing a pre-glucose chemical exchange spin-lock (CESL) pulse sequence a number of times each including applying pre-glucose chemical exchange spin-lock pulse sequence irradiation to the tissue or the organ, administering glucose to the subject, acquiring post-glucose MR data by executing a post-glucose chemical exchange spin-lock (CESL) pulse sequence a number of times each including applying post-glucose chemical exchange spin-lock (CESL) pulse sequence irradiation to the tissue or the organ, and using the pre-glucose MR data and the post-glucose MR data to generate a measure of glucose transport, glucose metabolism or both glucose transport and glucose metabolism in the tissue or the organ.

Abstract: An apparatus comprises an optical detecting signal generator configured to provide an optical spectrum comprising two frequency carriers, the two frequency carriers having two different nominal carrier frequencies, and the output port of the optical detecting signal generator being further configured to be coupled to a device under test (DUT); an optical to electrical converter configured to generate a first electrical current based on the optical spectrum without the optical spectrum passing through the DUT; and generate a second electrical current based on the optical spectrum after the optical spectrum passes through the DUT; and a data processor coupled to the optical to electrical converter, the data processor being configured to determine a transfer function of the DUT at an average of the two different nominal carrier frequencies based on the first electrical current and the second electrical current.

Abstract: An antenna module (22) has an antenna (21) that is formed on a ferrite substrate (31), and the ferrite substrate is positioned within a small direct current (DC) magnetic field. The magnetic loss tangent of the ferrite is controlled by application of the small DC magnetic field, thereby improving antenna radiation efficiency and increasing the bandwidth of the antenna.

Abstract: Methods and compositions are provided for reducing transmission and/or infection of HIV in a subject by increasing the bioavailability of a drug in the subject. The methods and compositions provided herein include an efflux transporter inhibitor and a drug effective for reducing the transmission and/or infection of HIV in a subject. The efflux transporter inhibitor is effective to reduce the efflux of the drug through at least one of P-glycoprotein (Pgp), breast cancer resistant protein (BCRP), and multidrug resistant associated protein 1-9 (MRP1-9).

Abstract: The present invention provides minimally invasive methods of detecting, diagnosing, and assessing neuronal damage associated with traumatic brain injury (TBI) or chronic traumatic encephalopathy (CTE). Specific species of microRNAs (miRNA), small, noncoding RNA molecules that play gene regulatory functions, are correlated with cellular damage and oxidative stress following TBI or CTE, allowing for rapid, minimally-invasive diagnosis and assessment of brain injury. The early identification and longitudinal assessment of neuronal damage in subjects suffering from or at risk of suffering from a TBI (e.g., football players, boxers, military personnel, fall victims) will improve clinical outcomes by guiding critical medical and behavioral decision making.

Abstract: The multi-purpose cap for a tube dispenser includes a cap for sealing an open end of a squeezable tube dispenser. The multi-purpose cap is formed as a hollow body having a closed upper end and an open lower end. A cylindrical retaining member is mounted, substantially centrally, to a lower face of the closed upper end within the hollow body. The cylindrical retaining member is adapted for releasably receiving and sealing a spout of a squeezable tube dispenser. The multi-purpose cap can have a first sidewall having a flat planar contour and a second sidewall having an arcuate contour. The flat, planar first sidewall of the hollow body is adapted for pressing against the squeezable tube dispenser to selectively manually manipulate contents thereof. Alternatively, the multi-purpose cap can have a substantially cylindrical sidewall and a squeezing member attached to an exterior surface thereof.

Abstract: A method is provided for digital Simultaneous Information and Energy Transfer (SIET), comprising the steps of receiving a serial SIET analog signal, and converting the serial SIET analog signal received into a parallel SIET analog signal, extracting an analog information signal and an analog energy signal from the parallel SIET analog signal, performing analog-to-digital conversion on the analog information signal to obtain a digital information signal, and performing information demodulation, parallel-to-serial conversion and decoding on the digital information signal in digital domain, and pre-processing the analog energy signal in analog domain and storing the preprocessed analog energy signal. As the information signal is processed in the digital domain and the energy signal is processed in the analog domain, the energy in the SIET signal can be full collected in receiving side.

Abstract: A system and method are described to automatically assess description-to-permission fidelity of applications. The system and method can employ techniques in natural language processing and a learning-based algorithm to relate description with permissions.

Abstract: Isolated pluralities of T cells which recognize at least one epitope of an intestinal cancer antigen or CNS cancer antigen and pharmaceutical compositions comprising the same are disclosed. Methods of making a plurality of T cells that recognize at least one epitope of an intestinal cancer antigen or CNS cancer antigen are also disclosed. Methods of treating an individual who has been diagnosed with cancer of a mucosal tissue or preventing such cancer in an individual at elevated risk are disclosed as are nucleic acid molecules that comprise a nucleotide sequence that encode proteins that recognize at least one epitope of an intestinal cancer antigen or CNS cancer antigen and T cells comprising such nucleic acid molecules.

Abstract: Disclosed herein is an antibody that binds to a voltage sensor paddle (VSP) of Nav1.7. Also disclosed herein are methods of treating pain, itch, neurogenic inflammation, or cough in a subject in need thereof. The methods include administrating the antibody to the subject.

Abstract: The present invention provides method of treating a K-Ras-expressing cancer in a subject comprising administering to the subject a therapeutic amount of prostratin or a prostratin analog, or a salt or isomer thereof. Compositions and kits for treating a K-Rasexpressing cancer in a subject are also provided.

Abstract: Embodiments of the invention include aerosol impactors comprising one or more micromechanical resonators. Impactors according to embodiments of the invention can provide size classification and/or concentration of aerosol particulate. Aerosol impactors can use an air flow device, such as a pump, to create a constant flow of air. Nozzles of varying diameters are used to separate particulate of varying sizes and the particles that pass through strike a measuring device. MEMS resonators can be integrated into arrays to provide mass sensitivity in a small, lightweight and cost effective package, which will effectively allow for the measurement of the mass of every micro/nanoscale particle landing on the surface.

Abstract: Systems, methods, and apparatus provide integration of microscopic imaging and liquid chromatography-mass spectrometry on a microfluidic device. In one aspect, an apparatus includes a first wafer, a second wafer, and an emitter. The emitter is disposed between the first wafer and the second wafer. The first wafer defines a sample input hole. The first wafer and the second wafer define a first channel, the first channel including a first end and a second end. The first end of the first channel is proximate the sample input hole. The first channel is configured to contain separation media. The second end of the first channel is proximate the emitter.