Abstract: Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticcacaulis excentricus, and methods of making and using same. Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticcacaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.
Abstract: It is disclosed herein that ssAAV and scAAV vectors of the same serotype administered by injection into the cerebrospinal fluid (CSF) via the intracerebroventricular (ICV) or intrathecal (cisternal or lumbar) route exhibit different cellular tropisms in the central nervous system. Thus, a subject can be treated by injection into the CSF of ssAAV or scAAV vector encoding a therapeutic protein, such as an ssAAV9 or scAAV9 vector. The therapeutic protein can be targeted to specific cells using these vectors. In some embodiments, scAAV9 is utilized to achieve superior transduction in the hippocampus, cerebellum and cerebral cortex where both neurons, particularly Purkinje neurons, and glial cells (such as astrocytes) are transduced. In other embodiments, ssAAV9 is utilized to minimize transduction of astrocytes. In further embodiments, an immunosuppressive agent is also administered to the subject.
Abstract: Methods and apparatuses for providing a k-nearest neighbor for location based services are provided. A method can include querying a database to detect a plurality of interest points within a predetermined distance of the user device using a kNN algorithm, organizing the interest points within a Voronoi tree, and continuously return a position specific result of relevant interest points.
Type:
Grant
Filed:
April 24, 2018
Date of Patent:
February 5, 2019
Assignee:
The Florida International University Board of Trustees
Abstract: Systems and methods for throughput enhancement including asynchronous neighbor discovery among ultra-low power wireless network devices are provided. Specifically, techniques for discovering neighboring wireless devices within an energy-harvesting and/or energy constrained wireless communication network are provided such that the wireless devices are able to discover the greatest number of neighboring devices without exceeding the energy that they have accumulated by, for example, harvesting ambient sources or their allocated energy budget (e.g., battery/capacitor levels). Such devices are capable of transmitting and receiving data such as discovery messages and alternate between different operation states (e.g., listen, sleep, transmit) and are able to compute transitions rates in a centralized and/or distributed manner using either homogeneous or heterogeneous wireless devices.
Type:
Grant
Filed:
July 15, 2016
Date of Patent:
February 5, 2019
Assignee:
The Trustees of Columbia University in the City of New York
Inventors:
Daniel Rubenstein, Gil Zussman, Javad Ghaderi, Robert Margolies, Tingjun Chen, Guy Grebla
Abstract: A controlling device having an activity mode corresponding to a controllable activity in which activation of a command key within a logical group of command keys of the controlling device causes a transmission of command data to control one or more functional operations of an intended target appliance. For a controllable activity the controlling device has a memory in which is stored a plurality of predetermined appliance to logical group of command keys mappings. To configure the controlling device for the controllable activity one or more predetermined keys of the controlling device are activated to thereby designate one or more intended target appliances for the controllable activity.
Abstract: The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.
Type:
Grant
Filed:
July 17, 2017
Date of Patent:
February 5, 2019
Assignee:
Vanderbilt University
Inventors:
Corey R. Hopkins, Charles C. Hong, Craig W. Lindsley, Darren W. Engers
Abstract: A balloon reflector antenna for a satellite, including a spherical balloon with a surface transparent to electromagnetic waves and a reflective surface opposite the transparent surface. The balloon reflector antenna may further include a feed system extending from the center of the balloon that receives electromagnetic waves reflected off the reflective surface and/or outputs electromagnetic waves that are reflected off the reflective surface.
Type:
Grant
Filed:
May 13, 2016
Date of Patent:
February 5, 2019
Assignees:
The Arizona Board Of Regents On Behalf Of The University of Arizona, Southwest Research Institute
Inventors:
Christopher K. Walker, Ira Steve Smith, Jr.
Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to mixed disulfide conjugates of thienopyridine compounds, and their use as therapeutics for the treatment, amelioration, and prevention of cardiovascular diseases.
Type:
Grant
Filed:
June 23, 2017
Date of Patent:
February 5, 2019
Assignee:
The Regents of the University of Michigan
Abstract: A technique for forming a material including nanotwinned silver crystals in solid solution with a solute that exhibits enhanced strength and desirable electrical conductivity, as compared to coarse-grained material. Synthesis of nanotwinned silver alloy material is achieved by cooling of a substrate and co-deposition of silver and the solute. Controlling the processing conditions of synthesis allows for tailoring of the nanostructure and mechanical properties of the nanotwinned silver alloy material. A material including nanotwinned silver crystals in solid solution with a solute also is described.
Type:
Grant
Filed:
March 20, 2015
Date of Patent:
February 5, 2019
Assignee:
Iowa State University Research Foundation, Inc.
Abstract: Electrode configurations for electric-field enhanced performance in catalysis and solid-state devices involving gases are provided. According to an embodiment, electric-field electrodes can be incorporated in devices such as gas sensors and fuel cells to shape an electric field provided with respect to sensing electrodes for the gas sensors and surfaces of the fuel cells. The shaped electric fields can alter surface dynamics, system thermodynamics, reaction kinetics, and adsorption/desorption processes. In one embodiment, ring-shaped electric-field electrodes can be provided around sensing electrodes of a planar gas sensor.
Type:
Grant
Filed:
May 18, 2015
Date of Patent:
February 5, 2019
Assignee:
University of Florida Research Foundation, Inc.
Inventors:
Bryan M. Blackburn, Eric D. Wachsman, Frederick Martin Van Assche, IV
Abstract: Methods and systems for three-dimensional (3D) reconstruction of endoscopic data in accordance with embodiments of the invention are described. In one embodiment, a method for processing a plurality of images captured by an endoscope includes preprocessing a plurality of images captured by an endoscope and including at least a portion of an organ. In many embodiments of the invention, the preprocessing includes estimating variations in light intensity within scenes captured by the plurality of images, and generating a set of color-adjusted images based on those variations. The method according to some embodiments of the invention may include generating a 3D point cloud representing points on a surface of the organ based on the set of color-adjusted images, defining a mesh representing the surface of the organ based on the 3D point cloud, and generating a texture of the surface of the organ based on the set of color-adjusted images.
Type:
Grant
Filed:
August 10, 2016
Date of Patent:
February 5, 2019
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Kristen L. Lurie, Dimitar V. Zlatev, Joseph Chihping Liao, Audrey K. Bowden, Roland Angst
Abstract: The present invention discloses a shift register capable of defending against DPA attack, comprising 4 master-slave D flip-flops, 12 two-input NAND/AND gates, 4 three-input NOR/OR gates and 40 inverters; the 4 master-slave D flip-flops are provided with reset function; it is based on TSMC 65 mm CMOS technique; as indicated by Spectre simulation verification, the shift register of the present invention has correct logic function with NED and NSD below 2.66% and 0.63% respectively under multi PVT combinations, which is provided with significant performance in defense differential power consumption analysis.
Type:
Grant
Filed:
August 28, 2017
Date of Patent:
February 5, 2019
Assignee:
Ningbo University
Inventors:
Pengjun Wang, Haoyu Qian, Huihong Zhang, Gang Li
Abstract: A method of controlling a datacenter (1), for example a cloud datacenter, and a computer management system (3) for managing a datacenter comprising a plurality of servers (2) configured to execute a plurality of jobs is provided. The method comprises receiving a request to execute a job from a user (4), determining an allocated server (2) on which to execute the job, and executing the job on the allocated server (2). The determining the allocated server (2) on which to execute the job comprises: classifying the job according to its resource requirement, selecting a subset of the servers (2) that fulfill the resource requirements of the job, determining the allocated server (2) that can execute the job with a favorable energy efficiency, wherein a total resource estimate for all jobs running on the server (2) from time to time exceeds the resources of at least one of the servers (2).
Type:
Grant
Filed:
May 19, 2015
Date of Patent:
February 5, 2019
Assignee:
University of Leeds
Inventors:
Ismael Solis Moreno, Paul Michael Townend, Peter Michael Garraghan, Jie Xu
Abstract: Provided is an isolated recombinant polypeptide comprising an immunoglobulin domain and a canine OX40L extracellular domain polypeptide fragment or a biological equivalent thereof and compositions comprising: an isolated recombinant polypeptide comprising an immunoglobulin domain and a canine OX40L extracellular domain polypeptide fragment; and a pharmaceutically acceptable carrier. Also provided are methods for treating or ameliorating the symptoms of cancer in a canine comprising administering an effective amount of the isolated recombinant polypeptide of the disclosure and/or a composition of the disclosure to a canine in need thereof.
Abstract: The present invention provides for heterologous expression of polypeptides encoded by wild-type and codon-optimized cbh2 genes from the organisms Cochliobolus heterostrophus, Gibberella zeae, Irpex lacteus, Volvariella volvacea, and Piromyces sp. in host cells, such as the yeast Saccharomyces cerevisiae. The expression in such host cells of the corresponding genes, and variants and combinations thereof, result in improved specific activity of the expressed cellobiohydrolases. Thus, such genes and expression systems are useful for efficient and cost-effective consolidated bioprocessing systems.
Abstract: Object is to provide a method of constructing a library of peptides having, at a desired position in the random sequence of each peptide, an amino acid having a portion capable of binding to a target. The invention provides a method of producing a library of peptides having, at a designated position in the random sequence of each peptide, a special amino acid having a portion capable of binding to a target, including (i) preparing a library of mRNAs having, in the mRNA sequence coding for a random amino acid sequence, a base sequence having an altered codon encoding the special amino acid, (ii) preparing an aminoacyl tRNA with the special amino acid linked to a tRNA encoded by the altered codon, and (iii) translating the mRNAs by using a cell-free translation system containing the aminoacyl tRNA to obtain a library of peptides having, in the random sequence thereof, a predetermined special amino acid.
Abstract: Described herein are methods and system that use electromagnetic heating to heat wellbores and the fluids therein. The heating is achieved by placing one or more permanent magnets in the wellbore and moving a metallic component and/or the one or more permanent magnets relative to each other. This generates eddy currents in the metallic component, which heat the metallic component. This heat is transferred to the fluids in the wellbore from the metallic component by convection.
Type:
Grant
Filed:
February 12, 2016
Date of Patent:
February 5, 2019
Assignee:
Board of Regents of the University of Texas System
Inventors:
Mukul M. Sharma, Raymond C. Zowarka, Siddharth Pratap
Abstract: Provided is a composition for preventing or treating oxidative brain injury and brain dysfunction including an extract of Astragali Radix and Salvia Miltiorrhizae Radix as an active ingredient, the composition having a highly outstanding preventive or therapeutic effect in animal models simulating brain-tissue damage and brain dysfunction induced by acute and long-term excessive stress generated in actual clinical practice, which is effectively usable as a therapeutic agent thereof.
Type:
Grant
Filed:
December 27, 2012
Date of Patent:
February 5, 2019
Assignee:
Daejeon University Industry-University Cooperation Foundation
Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. In a specific embodiment, present inventors have developed and applied a new technology and associated computation methods enabling simultaneous genome-scale analysis of genetic (copy number) and epigenetic (total methylation (TM) and allele-specific methylation (ASM) alternation, This method, called MBD-SNP, features affinity enrichment or methylated genomic DNA fragments using a methyl-binding domain polypeptide.
Type:
Grant
Filed:
May 18, 2017
Date of Patent:
February 5, 2019
Assignee:
The Johns Hopkins University
Inventors:
Srinivasan Yegnasubramanian, G. Steven Bova, Martin Aryee, William B. Isaacs, William G. Nelson
Abstract: The present invention provides microparticles that deliver in vivo predictable release profiles of at least one chemokine to create a biomimetic chemokine concentration gradient that induces the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.
Type:
Grant
Filed:
August 1, 2013
Date of Patent:
February 5, 2019
Assignee:
University Of Pittsburgh—Of The Commonwealth System of Higher Education
Inventors:
Steven R. Little, Riccardo Gottardi, Mintai Peter Hwang, Daniel DeSantis