Abstract: A computer-implemented method for simultaneously analyzing antegrade and retrograde blood flow is provided. The method is implemented using a computing device including a processor in communication with a memory. The method includes receiving a first plot of blood velocities over time and determining a first amount of blood flow based on the first plot. The first amount is associated with antegrade blood flow. The method additionally includes determining a second amount of blood flow based on the first plot. The second amount is associated with retrograde blood flow. Additionally, the method includes determining a mean amount of blood flow based at least in part on the first amount of blood flow and the second amount of blood flow, and storing at least one of the first amount, the second amount, and the mean amount of blood flow in the memory.

Abstract: A new photonic integrated circuit in the form of an optical pulse-train generator utilizes a time-interleaved architecture. The circuit can generate multiple optical pulses sequentially from a single trigger pulse, with the timing and amplitude of each pulse determined by circuit design. The circuit has application in optical arbitrary waveform generation and ultrafast electro-optic modulation.

Abstract: Liquid or solid electrolyte compositions are described that comprise a homogeneous solvent system and an alkali metal salt dissolved in said solvent system. The solvent system may comprise a fluoropolymer, having one or two terminal carbonate groups covalently coupled thereto. Batteries containing such electrolyte compositions are also described.

Abstract: A method of treating a disease associated with mutation of LRRK2 protein is presented herein. It was found that administering hexachlorophene to cells expressing endogenous LRRK2 or overexpressing wild-type or mutant LRRK2 reduced the total LRRK2 level in the cells.

Abstract: The polynucleotide construct of (1) or (2) below is used to perform ribosome display, CIS display and/or mRNA display in order to screen a Fab against an antigen of interest: (1) a polynucleotide construct which monocistronically comprises a ribosome-binding sequence, Fab first chain-coding sequence, linker peptide-coding sequence, Fab second chain-coding sequence and scaffold-coding sequence in this order, and further comprises at its 3?-end a structure necessary for maintaining a complex with the Fab encoded by itself; and (2) a polynucleotide construct which comprises a Fab first chain-expressing cistron and a Fab second chain-expressing cistron each containing a ribosome-binding sequence, a Fab first chain-coding sequence or Fab second chain-coding sequence, and a scaffold-coding sequence in this order, the first Fab-expressing cistron further comprising at its 3?-end a ribosome stall sequence, said Fab second chain-expressing cistron further comprising at its 3?-end a structure necessary for maintaining

Abstract: The present invention relates to compounds of formula (I) that are inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and compositions thereof in the treatment of TNF-? mediated conditions: Formula (I)

Abstract: A method of separating a lignin-rich solid phase from a solution suspension, by pretreating a lignocellulosic biomass with a pretreatment fluid having remove soluble components, colloidal material and primarily lignin containing particles; separating the pretreated lignocellulosic biomass from the pretreatment fluid with soluble components, colloidal material and primarily lignin containing particles; flocculating the separated pretreatment fluid with soluble components, colloidal material and primarily lignin containing particles using polyethylene oxide (i.e., PEO) or cationic Poly acrylamide (i.e., CPAM) as a flocculating agent; and filtering the flocculated separated pretreatment fluid with soluble components, colloidal material and primarily lignin containing particles to remove agglomerates.

Abstract: The present invention relates to a composition for treatment or metastasis suppression of cancers which includes a p34 expression inhibitor or activity inhibitor as an active ingredient. According to the present invention, the p34 protein knock-down causes monoubiquitination of PTEN and accordingly nuclear localization of PTEN is induced, as a result, an Akt pathway which is related to survival, proliferation, invasive properties and metastatic properties of tumors is inhibited, and thus there is an effect of significantly reducing clonogenic potential and tumor forming potential of various cancer cells which simultaneously express PTEN and NEDD4-1. Consequently, the p34 gene expression inhibitor or p34 protein activity inhibitor according to the present invention can be effectively used as a treatment agent or a metastasis suppression agent for cancers.

Abstract: An object of the present invention is to provide a liquid electrolyte for a fluoride ion battery with improved fluoride ion stability. By providing a liquid electrolyte for a fluoride ion battery comprising a fluoride salt and a diol compound in which one or two ether bonds are disposed between two OH groups, the present invention achieves the aforementioned object.

Abstract: Embodiments of a system are provided for forming enhanced seismic array traces using virtual seismic sensors in addition to the real seismic sensors to form a virtual seismic array. The system receives the signal responses from the real sensors, processes the signal responses from the sensors to define virtual signals using a narrowband decomposition of the complex envelope of the sensor signal responses, calculates second- and fourth-order statistics to derive steering vectors for the array of real sensors, and forms a virtual seismic array in response thereto. Machines, computer program product, and computer-implemented methods are provided for forming enhanced seismic array traces by receiving the array responses from sensors, processing the signals to define virtual sensor signals and a virtual seismic array, and forming an array response for the virtual seismic array to form a seismic trace of enhanced resolution.

Abstract: Mutations located within the gene encoding the homeobox transcription factor, ENGRAILED 2 (EN2), have now been identified as molecular markers associated with susceptibility for autism and related disorders. Thus, the present invention relates to compositions in the form of diagnostic kits, primers and target sequences, for use in methods for determining the predisposition, the onset or the presence of autism spectrum disorder in a mammal. Moreover, therapeutic methods for treating a person inflicted with, or predisposed to, an autism spectrum disorder based upon modulating the level or activity of EN2 are also provided.

Abstract: Methods, articles of manufacture, and devices related to generating six degree of freedom (DOF) haptic feedback are provided. A computing device can receive first depth data about an environment. The computing device can generate a first plurality of points from the first depth data. The computing device can determine a virtual tool, where the virtual tool is specified in terms of a translation component for the virtual tool and a rotation component for the virtual tool. The computing device can determine a first force vector between the virtual tool and the first plurality of points. The computing device can send a first indication of haptic feedback based on the first force vector.

Abstract: Low noise amplifiers (LNAs) are provided, the LNAs comprising: a common gate matching network; a capacitord; a resistord; a coild, wherein a side1 of coild is coupled to a side1 of capacitord, a side1 of resistord, and a V+ and a side2 of the coild is coupled to a side2 of capacitord, a side2 of resistord, and a network input; a capacitors; a resistors; a coils, wherein a side1 of coils is coupled to an LNA input, a side1 of capacitors, a side1 of resistors, and a network output and a side2 of coils is coupled to a side2 of the capacitors, a side2 of resistors, and ground; and an output coil that is magnetically coupled to coild and coils and having a side1 coupled to a first terminal of an LNA output and a side2 coupled to a second terminal of the LNA output.

Abstract: A system for radiation therapy includes a radiation planning system. The radiation planning system includes a data processor that is adapted to receive information concerning an intended radiation treatment region of a body, receive a calculated initial energy released per unit mass for a plurality of locations within the body, compute a radiation dose at a plurality of locations within the radiation treatment region based on the calculated initial energy released per unit mass and including radiation dose contributions due to scattering from other locations within the body, and determine radiation therapy parameters for providing radiation treatment to the intended radiation treatment region based on the radiation dose computed at the plurality of locations within the radiation treatment region. Including radiation dose contributions due to scattering from other locations within the body take into account density discontinuities in the body.

Abstract: The present invention provides a kit for determining male fertility including a container system containing a plurality of enzyme-linked antibodies one of each capable of binding to analytes Atp6v0a2, G-CSF, MIP 1?, and MCP-1. The kit further includes suitable packaging and a set of instructions for using the enzyme-linked antibodies with a seminal sample to determine the fertility of the sample.

Abstract: An alignment tool device for use in aligning a manway cover to a manway body/flange during installation of the manway cover includes a body/flange plate having a flange plate body with a plurality of flange plate openings and an alignment support structure, a cover plate having a cover plate body with a plurality of cover plate openings, and a height adjuster extending through the alignment support structure where the height adjuster is adapted to change a position of the cover plate relative to the flange plate to substantially align the manway cover openings with corresponding manway flange openings.

Abstract: The present invention discloses a feedback type voltage regulator, including a voltage reference circuit for providing a reference voltage, distributed series feedback amplifiers electrically coupled to the voltage reference circuit and a power transistor which gate is electrically connected to the distributed series feedback amplifiers. The distributed series feedback amplifiers comprises three set of amplifiers serially connected with each other, wherein the relation of the gain of the first amplifier (A1), the second amplifier (A2), and the third amplifier (A3) is A1>A2>A3, wherein the relation of the bandwidth of the first amplifier (B1), the second amplifier (B2), and the third amplifier (B3) is B1<B2<B3.

Abstract: Disclosed are selective histone deactylase inhibitors (HDACi) that having Formula I. Specifically, the disclosed subject matter relates to compounds having activity as selective HDAC6 inhibitors, methods of making and using the compounds, and compositions comprising the compounds. In still further aspects, the disclosed subject matter relates to methods for treating oncological disorders in a patient. Methods of making and using these inhibitors for the treatment of cancer, in particular melanoma are also disclosed.

Abstract: A flue gas treatment apparatus has a flue gas inlet, a treated gas outlet downstream of the flue gas inlet, and a gas flow path therebetween. The flue gas treatment apparatus comprises a particulate removal device. A first heater is downstream of the particulate removal device. The first heater heats the flue gas to a first treatment temperature. A first catalytic converter is downstream of the first heater for eliminating at least some CO and SO2 from the flue gas. A second heater is downstream of the first catalytic converter for heating the flue gas to a second treatment temperature. A second catalytic converter is downstream of the second heater for eliminating at least some NOx from the flue gas. At least a first fan forces the flue gas from the flue gas inlet to the treated gas outlet.

Abstract: Disclosed is a polynucleotide for cell surface expression. The polynucleotide of the invention comprises a promoter, a secretion signal sequence, a sequence encoding an intended protein, and a sequence encoding a cell surface-localized protein or a cell membrane-binding domain thereof, wherein the promoter is a promoter of a gene encoding the cell surface-localized protein. Provided is a polynucleotide for cell surface expression allowing the production of yeast displaying an enzyme on the cell surface with a high activity.