Abstract: Disclosed herein is a class of chiral binuclear metal complexes for stereoselective hydrolysis of saccharides and glycosides, and more particular chiral binuclear transition metal complex catalysts that discriminate epimeric glycosides and ?- and ?-glycosidic bonds of saccharides in aqueous solutions at near physiological pHs. The chiral binuclear metal complexes include a Schiff-base-type ligand derived from a chiral diamino building block, and a binuclear transition metal core, each which can be varied for selectivity. The metal core is a Lewis-acidic metal ion, such as copper, zinc, lanthanum, iron and nickel. The Schiff-base may be a reduced or non-reduced Schiff-base derived from aliphatic linear, aliphatic cyclic diamino alcohols or aromatic aldehydes. The ligand can be a penta- or heptadentate ligand derived from pyridinecarbaldehydes, benzaldehydes, linear or cyclic diamines or diamino alcohols.

Abstract: Described herein are apparatus comprising: a first layer comprising a first microfluidic channel; a second layer comprising a second microfluidic channel; and a membrane for culturing cells; along with methods of making and using same.

Abstract: Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.

Abstract: The present invention relates to a light-emitting device for light amplification using graphene quantum dots and a method of manufacturing the same, which includes a first conductive semiconductor base layer; a plurality of nanowires disposed on the first conductive semiconductor base layer and including a first conductive semiconductor core, an active layer, and a second conductive semiconductor layer sequentially formed from inside to outside; and a graphene quantum dot coating layer disposed on one or both of a surface and an interior of the nanowire, thereby providing a light-emitting device which maximizes light extraction and light amplification.

Abstract: Apparatus and methods for controlling a radiotherapy electron beam. Exemplary embodiments provide for focusing the electron beam at different depths by altering parameters of a plurality of magnets. Exemplary embodiments can also provide for focusing the electron beam at different depths while maintaining the energy level of the electron beam at a consistent level.

Abstract: Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal.

Abstract: Provided is a mutant of an endostatin. The mutant has improved ATPase activity and improved activity of inhibiting angiogenesis and inhibiting tumors. Further provided is use of the mutant in treatment of angiogenesis related diseases such as tumors.

Abstract: Provided are systems and methods for cloaking an object on a ground plane. A thin dielectric metasurface is used to reshape the wavefronts distorted by the object in order to mimic the reflection pattern of a flat ground plane. To achieve such “carpet cloaking”, the reflection angle is made equal to the incident angle everywhere on the object by providing a graded metasurface with a designed phase gradient. This provides additional phase to the wavefronts to compensate for the phase difference amongst lightpaths induced by the geometrical distortion. One exemplary metasurface is described which is designed for the microwave range using highly sub-wavelength dielectric resonators. The approach can be applied to hide any scatterer under a metasurface of class C1 (first derivative continuous) on a groundplane not only in the microwave regime, but also at other frequencies, including higher frequencies, up to the visible.

Abstract: The apparatus for removing haze from an image using a fuzzy membership function includes memory configured to store computer-readable instructions; and a processor configured to execute the instructions, wherein the processor calculates a hazy value and a transmission map using an input image including a hazy component and generates a restored image from which the hazy component has been removed using the hazy value and the transmission map, and wherein the processor selects a first area in the input image, calculates a fuzzy membership function of pixels of the input image with respect to the hazy value using brightness values of the pixels of the input image and brightness values of pixels of the first area, and calculates the transmission map using the brightness values of pixels of the first area and the fuzzy membership function.

Abstract: A low-dropout (LDO) regulator. The LDO regulator includes a pass transistor, a charge pump connected to the pass transistor, and an error amplifier connected through the charge pump to the pass transistor, wherein the error amplifier receives a voltage VO from the pass transistor and generates a voltage VE based on the voltage VO, wherein the charge pump receives the voltage VE from the error amplifier, generates a voltage VE* that is lower than VE by an offset and supplies the voltage VE* as a gate voltage to the pass transistor.

Abstract: Solid particulate measuring devices, systems, and methods for using the devices and systems are provided for easier and more accurate measurement of specific volumes. For example, a specific dose of a pharmaceutical multiparticulate composition can be measured out accurately and easily in a variety of settings using the devices and systems described herein.

Abstract: A storage memory device includes a vertical field effect transistor including a semiconductor substrate; a pillar extending upwardly from the substrate and containing a source, a drain, and a channel disposed therebetween; a first insulating layer surrounding the channel; a stacked structure surrounding the first insulating layer; and a gate unit. The stacked structure includes a charge trapping layer and a composite element. The composite element includes a ferroelectric layer made of a doped hafnium oxide-based material that has a predominantly orthorhombic phase and exhibits a negative capacitance; and an antiferroelectric layer made of a zirconium oxide-based material that has a predominantly tetragonal phase.

Abstract: The present invention relates to compounds that are useful as metal ligands and which either contain a molecular recognition moiety or can be bound to a molecular recognition moiety and methods of making these compounds. Once the compounds that contain a molecular recognition moiety are coordinated with a suitable metallic radionuclide, the coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging. The invention therefore also relates to methods of diagnosis and therapy utilising the radiolabelled compounds of the invention.

Abstract: Described are devices, systems and techniques for implementing atomic memory objects in a multi-writer, multi-reader setting. In an embodiment, the devices, systems and techniques use maximum distance separable (MDS) codes, and may be specifically designed to optimize a total storage cost for a given fault-tolerance requirement. Also described is an embodiment to handle the case where some of the servers can return erroneous coded elements during a read operation.

Abstract: The invention is directed to a composition that safely removes a cured dental cement or resin from metal brackets, metal braces, and enamel surfaces of teeth. It contains eugenol, isoeugenol, methyl-eugenol or an isomer thereof. A method for removing orthodontic fixtures adhered with a dental cement or resin to the enamel surfaces of teeth from these surfaces by contacting the dental cement or resin with a composition containing eugenol.

Abstract: A dialog method carried out by a dialog system includes an agent that performs a dialog with a user. The dialog method carried out by the dialog system includes a speech receiving step in which the dialog system receives input of a user speech which is a speech of the user, a first presentation step in which when the dialog system cannot obtain any recognition result of a desired level corresponding to the user speech, the dialog system presents a speech which does not include any content words as a first agent speech which is a speech of the agent uttered immediately after the user speech and a second speech step in which the dialog system presents a speech generated or selected not based on the user speech as a second agent speech which is a speech of an agent uttered after uttering the first agent speech.

Abstract: The invention is directed to compositions and methods for treating or reducing the likelihood of the development of epilepsy in an individual. The method comprises administering to the central nervous system of an individual in need of such treatment a therapeutically effective amount of an agent capable of increasing the expression and/or activity of miR-128.

Abstract: Disintegrin variants that bind specifically to one or more of ?5?1 and ?v integrins, such as ?v?1, ?v?3, ?v?5, ?v?6 and ?v?8, but with reduced binding activity to ?IIb?3, are described. Also described are uses of the disintegrin variants for the treatment or prevention of a disease associated with an ?v integrin or an ?5?1 integrin.

Abstract: A method for selective metallization includes: selectively adsorbing catalytic nanoparticles onto an imprint mold to form a selectively adsorbed catalytic nanoparticle (SACN) mold; using the SACN mold in an imprinting process to synchronously transfer a pattern and the catalytic nanoparticles onto a film; separating the film from the SACN mold; and selectively depositing metal onto the film based on the pattern transferred to the film.

Abstract: The present invention provides a method of making carboxylic acids from levulinic acid, such as succinic acid and 3-hydroxypropanoic acid, by reacting levulinic acid with an oxidant such as hydrogen peroxide under acidic or basic conditions.