Abstract: The present invention relates to rice plants, seeds, and cells that include a promoter responsive to a basic helix-turn-helix red anthocyanin transcription factor operably linked to a heterologous nucleic acid molecule.
Abstract: The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. An amino terminal extension is presented, which comprises four genomic exons. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. More specifically, this invention is directed to a CA125 cDNA sequence which can be introduced into animal or human cells to achieve transcription or expression of the cDNA.
Type:
Grant
Filed:
June 1, 2009
Date of Patent:
January 31, 2017
Assignee:
The Board of Trustees of the University of Arkansas
Inventors:
Timothy O'Brien, John Beard, Lowell Underwood
Abstract: Provided is a catalyst for producing hydrogen, which catalyst has higher performance than conventional catalysts since, for example, it exhibits a certain high level of activity in an aqueous formic acid solution at high concentration even without addition of a solvent, amine and/or the like. The metal phosphine complex is a metal phosphine complex represented by General Formula (1): MHm(CO)Ln, wherein M represents an iridium, iron, rhodium or ruthenium atom; in cases where M is an iridium or rhodium atom, m=3 and n=2, and in cases where M is an iron or ruthenium atom, m=2 and n=3; and the number n of Ls each independently represent a tri-substituted phosphine represented by General Formula (2): PR1R2R3. The catalyst for producing hydrogen comprises the metal phosphine complex as a constituent component.
Type:
Grant
Filed:
November 24, 2011
Date of Patent:
January 31, 2017
Assignee:
National University Corporation Okayama University
Abstract: The disclosure relates to a superhydrophobic surface. Methods of fabrication are disclosed including laminating an optically transparent polymer sheet with hydrophobic nanoparticles such that the nanoparticles are partially embedded and partially exposed. The resulting assembly remains optically transparent. Additional methods include the lamination of nanoparticles to flexible fabrics and the production of molded articles using nanoparticle-treated molds.
Type:
Grant
Filed:
March 20, 2014
Date of Patent:
January 31, 2017
Assignee:
Research Foundation of the City University of New York
Abstract: Provided is a device for iontophoretic delivery of a drug to or into a tissue, including an arrangement that prevents operation of the device at a current density that is higher than a predetermined value, the arrangement including first means responsive to a first data item, indicative of the surface area through which the current is to pass, as to set the maximal current allowed at the surface area indicated by the data item. Also provided is a method for iontophorectivally administering drug to or into a tissue, including determining a maximal allowed level of current density and preventing application of current density above the maximal allowed level.
Type:
Grant
Filed:
January 15, 2014
Date of Patent:
January 31, 2017
Assignees:
Hadasit Medical Research Services & Development Limited, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Abraham J. Domb, Joseph Frucht-Pery, Mervyn Shapiro
Abstract: A method for manufacturing a permanent-magnet motor rotor includes manufacturing a rotary shaft, a permanent magnet, a front end cover, a rear end cover, and a magnetic yoke unit, where the magnetic yoke unit contains multiple pole shoe parts and one iron core part, where each pole shoe part and the iron core part are connected therebetween via a connecting strip; manufacturing a rotor spacer; all positioning holes of the magnetic yoke unit correspond to the permanent-magnet through hole of the rotor spacer to form a permanent-magnet passage; inserting the permanent magnet into the permanent-magnet passage; inserting tightening bolts; cutting off the mid-section of each connecting strip, overlapping the pole shoe parts to form a rotor pole shoe, overlapping the iron core parts to form a rotor iron core; and arranging respectively the front end cover and the rear end cover on a front end and a rear end.
Abstract: In alternative embodiments, the invention provides articles of manufacture comprising biocompatible nanostructures comprising PolyEther EtherKetone (PEEK) surface-modified (surface-nanopatterned) to exhibit nanostructured surfaces that promote osseointegration and bone-bonding for, e.g., joint (e.g., knee, hip and shoulder) replacements, bone or tooth reconstruction and/or implants, including their use in making and using artificial tissues and organs, and related, diagnostic, screening, research and development and therapeutic uses, e.g., as primary or ancillary drug delivery devices. In alternative embodiments, the invention provides biocompatible nanostructures that promote osseointegration and bone-bonding for enhanced cell and bone growth and e.g., for in vitro and in vivo testing, restorative and reconstruction procedures, implants and therapeutics.
Type:
Grant
Filed:
April 13, 2015
Date of Patent:
January 31, 2017
Assignee:
The Regents of the University of California
Abstract: The present invention provides methods and devices for obtaining percutaneous access, maintaining hemostasis, and providing closure of openings in tissues of the body. In particular, the present invention provides methods and devices for maintaining hemostasis and providing closure surgical incisions of the left ventricular apex of the heart.
Type:
Grant
Filed:
September 29, 2014
Date of Patent:
January 31, 2017
Assignee:
Northwestern University
Inventors:
Patrick M. McCarthy, Swaminadhan Gnanashanmugam, Usha Periyanayagam, Ingrid Lin, Leah Ralph, Christopher Lubeck
Abstract: An adapter provides a link between a digital media player having a memory on which is stored digital media files, a display device, and a remote control. The adapter receives from the digital media player data which is used to generate a representation of a user interface which is provided to the display device for display. The adapter also receives from the remote control data for use in generating commands for controlling operations of the digital media player whereby a change in state of the digital media player resulting from a performance of an operation caused by the remote control will be reflected in the user interface on the display device.
Type:
Grant
Filed:
May 21, 2014
Date of Patent:
January 31, 2017
Assignee:
Universal Electronics Inc.
Inventors:
Nicholas Kalayjian, David Isbister, Michael Hirsch
Abstract: The invention provides apparatus for separation of particles and methods for using the apparatus. In an embodiment, the apparatus includes three arms extending radially from a central reservoir, each arm being associated with a separation electrode. At least one on the arms includes a separation medium. Using a sequence of driving and mobility-changing voltages, target particles can be separated from closely related particles within a sample. For example, single point mutations can be resolved from a sample containing predominantly wild type nucleic acids.
Abstract: A thin film transistor includes a source electrode, a drain electrode, a semiconducting layer, an insulating layer and a gate electrode. The drain electrode is spaced apart from the source electrode. The semiconductor layer is electrically connected with the source electrode and the drain electrode. The gate electrode is insulated from the source electrode, the drain electrode, and the semiconductor layer by the insulating layer. The semiconductor layer includes a carbon nanotube composite layer. The carbon nanotube composite layer includes a number of semiconductor particles and a plurality of carbon nanotubes.
Type:
Grant
Filed:
April 22, 2015
Date of Patent:
January 31, 2017
Assignees:
Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
Inventors:
Yuan-Hao Jin, Qun-Qing Li, Shou-Shan Fan
Abstract: A portable self medication management system and method of provided. For example, the system may include a removable tote and docking station. The removable tote including a plurality of receptacles, communicating section for transferring data to and from a docking station and a power reception station for receiving power from the docking station. The docking station including a scanner, a display screen, a controller, a storage device, communicating sections for transmitting data to the removable tote and other external devices and a power transmitting section for transferring power to the removable tote.
Type:
Grant
Filed:
July 1, 2015
Date of Patent:
January 31, 2017
Assignee:
The Research Foundation for The State University of New York
Inventors:
Craig Lehmann, John Brittelli, Chang Hong Chen, Tim Kehoe, Robert Barnikel
Abstract: A chimeric polyvalent recombinant protein for use as a vaccine and diagnostic for Lyme disease is provided. The chimeric protein comprises epitopes of the loop 5 region and/or the alpha helix 5 region of outer surface protein C (OspC) types. The OspC types may be associated with mammaliran Borrelia infections.
Type:
Grant
Filed:
August 1, 2014
Date of Patent:
January 31, 2017
Assignee:
Virgina Commonwealth University
Inventors:
Richard T. Marconi, Christopher Earnhart
Abstract: The present invention provides tricyclic compounds, pharmaceutically acceptable salts, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.
Abstract: The invention relates to low-molecular-weight compounds which are capable of inducing differentiation of mesenchymal stem cell into hepatocytes.
Type:
Grant
Filed:
April 2, 2012
Date of Patent:
January 31, 2017
Assignees:
National University Corporation Torrori University, Tokyo Women's Medical University
Abstract: Nanoparticles for use as magnetic resonance imaging contrast agents are described. The nanoparticles are made up of a polymeric support and a manganese-oxo or manganses-iron-oxo cluster having magnetic properties suitable of a contrast agent. The manganese-oxo clusters may be Mn-12 clusters, which have known characteristics of a single molecule magnet. The polymer support may form a core particle which is coated by the clusters, or the clusters may be dispersed within the polymeric agent.
Type:
Grant
Filed:
October 21, 2009
Date of Patent:
January 31, 2017
Assignee:
Georgetown University
Inventors:
Sarah Stoll, Julie Mertzman, Edward Van Keuren, Christopher Albanese, Stanley Fricke
Abstract: A system and method used to configure a smart device to command functional operations of a target appliance. The smart device retrieves from a controllable appliance, such as a settop box, data indicative of a codeset identity of the target appliance wherein the codeset identity was determined during a process used to configure a conventional universal remote control to command functional operations of the target appliance and wherein the process used to configure the conventional universal remote control is performed in cooperation with the controllable appliance. A remote control application resident on the smart device then uses the data indicative of the codeset identity retrieved from the controllable appliance to also configure the smart device to command functional operations of the target appliance.
Type:
Grant
Filed:
May 5, 2014
Date of Patent:
January 31, 2017
Assignee:
Universal Electronics Inc.
Inventors:
Paul D. Arling, Patrick H. Hayes, Arsham Hatambeiki
Abstract: A system and method for global routing that includes receiving nets that need to be routed and capacity constraints, ordering, using processing circuitry, the nets, routing, using the processing circuitry, the nets based on a maze routing with framing method, determining, using the processing circuitry, whether the routing is congestion free, selecting, using the processing circuitry, a subset of the nets based on a game theory method when the routing is not congestion free, applying a rip-up and re-route process on the subset of the nets, and repeating the selecting and applying steps until the routing is congestion free.
Type:
Grant
Filed:
September 8, 2015
Date of Patent:
January 31, 2017
Assignee:
King Fahd University of Petroleum and Minerals
Abstract: P-Selectin on platelets and endothelium binds cell surface chondroitin sulfate (CS) proteoglycans, which are abundantly and stably expressed on the surface many cancer cells. Binding of the cancer cells through the CS moieties may be blocked to inhibit the interaction of cancer cells with platelets and endothelium. The present inventors disclose compositions and methods for the inhibition of cancer metastasis.
Type:
Grant
Filed:
April 5, 2012
Date of Patent:
January 31, 2017
Assignee:
The Board of Trustees of The University of Arkansas
Inventors:
Behjatolah M. Karbassi, Thomas Kieber-Emmons
Abstract: A device and method for separating boron from carbonate are provided. The device in some embodiments, includes a first half having a heating section, a second half having a cooling section and a plurality of vials disposed therebetween. The second half is opposite the first half. The plurality of vials are adapted to receive boron and an alkaline matrix such that, during heating of the first half and cooling of the second half, boron is sublimated and condensed on a closed end of each of the plurality of vials.
Type:
Grant
Filed:
March 3, 2015
Date of Patent:
January 31, 2017
Assignee:
The Regents Of The University Of Michigan