Abstract: Some embodiments provide methods, systems and computer-readable media that employ adaptive binning and dissimilarity scores based on a quadratic form distance for multidimensional data for matching clusters in data corresponding to different sample. Some embodiments provide methods, systems and computer-readable media for rendering a first interactive display including a two-dimensional plot of at least a portion of a multidimensional data set and a corresponding second interactive display including a plurality of single parameter charts or histograms, each displaying information corresponding to one-dimensional measurements of a different parameter in the multidimensional data set.

Abstract: Techniques and systems are described for detecting malware's bulk transformation of a user's data before the malware is able to complete the data transformation. Included are methods and systems for enabling malware detection by monitoring the file operations of a computer application or process for particular kinds of suspicious data transformation indicators. Indicators include primary indicators, such as file-type signature changes, notable changes in file data entropy, and out-of-range similarity measurements between the read and write versions of file data, as well as secondary indicators, such as a large number of file deletions and a large reduction in the number of file-types written versus read by a process over time. When indicators are triggered by a process, an adjustment to the process' malware score is made; in the event that the process' malware score reaches a malware detection threshold, the process is marked as malware and appropriate actions are taken.

Abstract: Compounds discovered through a high-throughput screen, along with methods of use of the compounds, are provided. The compounds can be used to strongly inhibit key drug targets found in protozoan parasites, e.g., the target Trypanosoma cruzi glucokinase. Compounds include derivatives of N-phenylbenzenesulfonamide, barbituric acid, (R)-3-(piperidin-2-yl)pyridine, 3-nitro-2-phenyl-2H-chromene, 6-amino-3-methyl-4-phenyl-1,4-dihydropryranole[2,3-c]pyrazole-5-carbonitrile, and gossypol (2,2?-Bis(formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene).

Abstract: A thin film valve includes at least one chamber for storing a fluid required for biological/chemical analysis, a plurality of chamber for performing a biological/biochemical reaction, or connecting, at least one chamber performing the biological or biochemical reaction to enable a movement of the fluid flow, a flow path arranged to communicate with the hole on the flow path, a thin film closing membrane for closing the fluid hole, a thin film valve including the hole and the fluid hole closing membrane, a multilayered plurality of substrates forming the fluid path, the fluid hole and the chamber, a rotatable disk forming the fluid path, fluid hole, the plurality of chambers, a heat generator, laser beam generator heating the thin film valves, a light detector for detecting amount of light passing through the membrane and closing the fluid hole, and a feedback controller for controlling the focusing actuator.

Abstract: An encoding method for encoding input information bits using an encoder implemented with concatenation of a CRC-? coder and a polar coder is provided. The method includes performing Cyclic Redundancy Check (CRC) coding on as many information bits as a determined number of CRC coding bits among input information bits and performing polar coding on the CRC-coded information bits and other information bits than the CRC-coded information bits.

Abstract: A stable immunogenic or vaccine composition comprising a complex or polyhedra comprising same comprising an antigen of a pathogen or other antigen against which a immune response is sought in a human or non-human animal subject and a polyhedrin protein derived from a cytoplasmic polyhedrosis virus (CPV). Delivery of the complex to a subject in substantially polyhedral form induces an immune response thereto. Methods of using same to elicit an immune response.

Abstract: The present invention provides methods, processes, and systems for the manufacture of three-dimensional articles of polymer materials using 3D printing. A syringe or an inkjet print head prints a solution of prepolymer onto a build plate. The printed prepolymer is exposed to a stimulus whereby the prepolymer is converted to the polymer. After a predetermined time, sequential layers are printed to provide the three-dimensional article. The three-dimensional article can be cured to produce the 3D article made from the final polymer.

Abstract: A cathode material for a solid oxide fuel cell comprises a perovskite type complex oxide which is represented by Formula 1: Gd1-xMxCoO3-?.In Formula 1, M represents an alkali metal, x is larger than 0 and not more than 0.75, and ? ranges from 0 to 2.

Abstract: An e-fuse for use in a semiconductor device includes first and second electrodes; a gate metal coupling the first and second electrodes with each other; a first oxide layer formed under the gate metal; and a gate oxide layer formed between a bottom end of the gate metal and a top end of the first oxide layer.

Abstract: A system includes acquisition of a three-dimensional image based on at least two two-dimensional images, identification of a tumor based on the three-dimensional image, identification of sub-volumes of the tumor, determination of a first two or more tissue sampling locations based on the sub-volumes, determination of a first tissue sampling device entry point and a first one or more device trajectories associated with the first entry point based on the first tissue sampling locations, movement of a tissue sampling device into the patient volume through patient skin at the first entry point, and movement of the device along the first one or more device trajectories to acquire tissue samples from the first tissue sampling locations, wherein the tissue samples are acquired from the first tissue sampling locations between entry of the device at the first entry point and removal of the device from the first entry point.

Abstract: The invention discloses a resource optimization method for a mobile browser based on cloud-client cooperation.

Abstract: A wastewater to chemical fuel conversion device is provided that includes a housing having a first chamber and a second chamber, where the first chamber includes a bio-photoanode, where the second chamber includes a photocathode, where a backside of the bio-photoanode abuts a first side of a planatized fluorine doped tin oxide (FTO) glass, where a backside of the photocathode abuts a second side of the FTO glass, where a proton exchange membrane separates the first chamber from the second chamber, where the first chamber includes a wastewater input and a reclaimed water output, where the second chamber includes a solar light input and a H2 gas output, where the solar light input is disposed for solar light illumination of the first chamber and the second chamber.

Abstract: The invention generally relates to a purified inactivated Zika virus (ZIKV), methods for producing the purified inactivated ZIKV, immunogenic compositions and vaccines comprising the purified inactivated ZIKV and methods for the prevention and/or treatment of infection by ZIKV.

Abstract: An injection molding apparatus including a mold and an injection device is provided. The mold includes a fixed portion and a movable portion. A molding concavity is formed between the fixed portion and the movable portion, and the movable portion is adapted to move relative to the fixed portion to change a volume of the molding cavity, so that a pressure inside the molding concavity is adjusted between a pressurized state and a non-pressurized state. The injection device is adapted to inject a material into the molding concavity. The material includes a supercritical fluid, the supercritical fluid is prevented from being gasified in the pressurized state, and the supercritical fluid is gasified in the non-pressurized state. In addition, an injection molding method is also provided.

Abstract: This invention relates generally to the discovery of an improved method to differentiate histiocytic malignancy from lymphoma or hemangiosarcoma in dogs.

Abstract: Electrochemical sensors have great promise for point-of-care and in vivo measurement of medically relevant molecules. However, the need for calibrating individual sensors limits the practical applicability of these sensing platforms. The invention provides a novel method of operating electrochemical sensors which obviates the need to calibrate individual sensors against a sample of known concentration. The invention exploits the frequency dependence of electrochemical output signals and the dependence of output signals on the inherent electron transfer kinetics of a selected sensor design. By use of signals generated at a nonresponsive frequency, a normalizing output value is generated that accounts for sensor-to-sensor variation and which enables an accurate calculation of target concentration. The scope of the invention also includes pre-calibrated sensors that may be utilized without calibration steps.

Abstract: This invention provides an device for electrical stimulation of the spinal cord. The device has an electrode assembly with a sufficiently thin profile to be implanted between the pial surface of the spinal cord and the dura mater, and secured to the dura. Electrodes on the electrode assembly are directed towards the surface of the spinal cord, and connected through the dura to a signal generator located outside the dura. Following implantation, the subject is treated by transmitting electrical signals from the signal generator through the leads to the electrodes, stimulating the subject's spinal cord.

Abstract: Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. The compounds comprise compstatin analogs in which the N-terminus and/or C-terminus contains an added component that improves (1) the peptide's solubility at physiological pH; (2) the peptide's plasma half-life; (3) the peptide's intraocular retention; and/or (4) the peptide's binding affinity to C3 or its fragments as compared to an unmodified compstatin peptide under equivalent conditions. Pharmaceutical compositions and methods of using the compounds are also disclosed.

Abstract: A system and computerized method for managing faculty resources includes providing an input/output interface, a memory, and one or more processors communicably coupled to the input/output interface and the memory, providing a faculty database structure communicably coupled to the one or more processors and one or more databases, wherein the faculty database structure comprises a faculty profile for each faculty member that links personal data, position data, evaluation criteria and performance data together for the faculty member, selecting one or more of the faculty profiles using the input/output interface, determining a performance score for each selected faculty profile by comparing the performance data to the evaluation criteria using the one or more processors, and providing the performance score for each selected faculty profile to the input/output interface.

Abstract: An inter-vehicle communication method and an apparatus for performing the same. The inter-vehicle communication method may include a reception node receiving at least one vehicle-to-vehicle (V2V) message from at least one transmission node and the reception node transmitting a relay V2V message on the basis of the at least one V2V message, wherein the at least one V2V message may include information about adjacent vehicles discovered by the at least one transmission node.