Abstract: Structural and functional analysis of peptide inhibitor binding to the cyclin D1 groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including cancer and inflammation.

Abstract: The present invention provides radiotherapeutic agents and compositions and methods for making and using the same. In some embodiments, the radiotherapeutic agent is a nanoparticle comprising a radionuclide and a carrier moiety. In some embodiments, the radionuclide is produced by activating a stable activatable particle via neutron activation.

Abstract: An organic vapor jet printing system includes a pump for increasing the pressure of an organic flux.

Abstract: Disclosed herein are peptides which exhibit hepcidin activity and methods of making and using thereof.

Abstract: An imaging system and method in which the system carries out the method which includes the steps of: (a) determining an incident field, (b) using the incident field and a volume integral equation (VIE) to determine a total field, (c) predicting voltage ratio measurement at a receiving antenna by using the volume integral equation (VIE), wherein the VIE includes a vector Green's function, (d) collecting voltage ratio measurements from one or more receiving antennas, and (e) comparing the predicted voltage ratio measurements to the collected voltage ratio measurements to determine one or more properties of the object being evaluated. An S-parameter based inverse scattering method using the vector Green's function and VIE as its core is also described.

Abstract: The present invention provides four keto acid transporter encoding sequences selected from 6611 protein coding sequences of Yarrowia lipolytica CLIB122 database. Also provided are recombinant Yarrowia lipolytica strains overexpressing the keto acid transporters, which have increased extracellular secretion of ?-ketoglutarate. The present invention can be used to increase extracellular levels of ?-ketoglutarate during the fermentation process and lower downstream purification cost for ?-ketoglutarate production.

Abstract: The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.

Abstract: The present invention relates to anionically modified microfibrillated plant fibers used for obtaining a thermosetting resin molding material having excellent mechanical strength, a method for manufacturing the same, a molding material containing the anionically modified microfibrillated plant fibers and a thermosetting resin, and a method for manufacturing the same. Specifically, the present invention provides a molding material containing anionically modified microfibrillated plant fibers that are anionically modified in the presence of a base by a carboxylic acid represented by formula (I): X—(CH2)n—COOH (I), wherein X represents halogen and n is 1 or 2, and/or by a salt thereof, and a thermosetting resin, and the molding material contains the anionically modified microfibrillated plant fibers in an amount of 10 to 900 parts by weight per 100 parts by weight of the thermosetting resin.

Abstract: The present invention is related to a social system and process used for bringing virtual social network into real life, which is allowed for gathering and analyzing a social message of at least one interlocutor from virtual social network so as to generate at least one recommended topic, allowing a user to talk with the interlocutor through the utilization of the recommended topic, and then capturing and analyzing at least one speech and behavior and/or physiological response of the interlocutor during talking so as to generate an emotion state of the interlocutor. The user is allowed to determine whether the interlocutor is interested in the recommended topic through the emotion state of interlocutor. Thus, it is possible to bring the social message on virtual network into real life, so as to increase communication topics between persons in real life.

Abstract: The present invention provides a composition for delivering a protein vaccination candidate to a mammalian subject having a Leishmania transfected for expressing a cDNA sequence for encoding the protein vaccination candidate, and the Leishmania containing a photosensitizer.

Abstract: The present invention is directed toward core-shell nanoparticles, each comprising a ligand-capped metal shell surrounding a plurality of discrete, nonconcentric, metal-containing cores. Methods of making and using these nanoparticles are also disclosed.

Abstract: Agents, compositions, and medicaments that pertain to modulating the activity of muscle specific kinase receptor (MuSK) and methods and uses thereof to modulate MuSK activity are encompassed herein. Also encompassed are screening assays to identify modulators of MuSK activity. Agents identified using the screening assays described herein are envisioned for use as therapeutics, alone or in compositions or in medicaments, to alleviate or delay motor dysfunction in subjects afflicted with a disorder associated with nerve terminal loss or fragmentation, such as amyotrophic lateral sclerosis, sarcopenia, or anti-MuSK myasthenia gravis.

Abstract: An all-photonic method to cause a WGM resonator to self-tune to a given wavelength is described. Such all photonic approaches include simply superimposing intense light of a wavelength in a range different from that of a signal wave. The wavelength of the pass band for the signal wavelength can be tuned by adjusting the wavelength (and/or the intensity) of the intense light.

Abstract: Systems, methods, and media for on-line boosting of a classifier are provided, comprising: receiving a training sample; for each of a plurality of features, determining a feature value for the training sample and the feature, using the feature value to update a histogram, and determining a threshold for a classifier of the feature; for each of the plurality of features, classifying the training sample using the threshold for the classifier of the feature and calculating an error associated with the classifier; selecting a plurality of best classifiers from the classifiers; and, for each of the plurality of best classifiers, assigning a voting weight to the one of the plurality of best classifiers.

Abstract: The invention provides a homogeneous composition comprising a hemostatically effective amount of a charged oxide, wherein the composition has an isoelectric point, as measured in calcium chloride, below 7.3 or above 7.4. Typically, the charged oxide is selected from the group consisting of silaceous oxides, titanium oxides, aluminum oxides, calcium oxides, zinc oxides, nickel oxides and iron oxides. In some embodiments, the composition further comprises a second oxide selected from the group consisting of calcium oxide, sodium oxide, magnesium oxide, zinc oxide, phosphorus oxide and alumina. In a typical embodiment of the invention, the charged oxide is silaceous oxide, the second oxide comprises calcium oxide and the ratio, by molar ratio, of silaceous oxide to calcium oxide is 0.25 to 15. Optionally, the composition further comprises phosphorous oxide. Also described are methods of making and using such compositions.

Abstract: A composition containing a macrophage inhibitor may be administered in an effective amount to prevent, inhibit or reduce restenosis, thrombus or aneurysm formation in implanted polymeric vascular grafts. The composition may be administered prior to vascular graft implantation, at the same time as vascular graft implantation, following vascular graft implantation, or any combination thereof. Exemplary macrophage inhibitors include bisphosphonates, anti-folate drugs and antibodies, preferably in a controlled release or liposomal formulation.

Abstract: Provided are methods of treatment in subjects having progeroid diseases and related conditions which rely upon LMNA-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced LMNA mRNA isoforms that encode progerin.

Abstract: Compounds of the formulae, (I), wherein each variable is as defined herein are provided which are useful in (i) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention together with a pharmaceutically acceptable carrier, excipient, and/or diluent; (3) methods for inhibiting or treating prostrate cancer; and (4) methods for blocking or destabilizing neovasculature of a tumor.

Abstract: Methods of applying dicyclopropene compounds and compositions thereof to block ethylene receptors in plants are disclosed. Methods include applying to the plant an effective ethylene response-inhibiting amount of a dicyclopropene compound or composition thereof. Dicyclopropene compounds, enantiomers, stereoisomers or salts thereof are also provided.

Abstract: A vertical electro-optical component and a method for forming the same are provided. The vertical electro-optical component includes a substrate, a first electrode layer formed on the substrate, a patterned insulating layer formed on the first electrode layer, a metal layer formed on the patterned insulating layer, a semiconductor layer formed on the first electrode layer, and a second electrode layer formed on the semiconductor layer, wherein the semiconductor layer encapsulates the patterned insulating layer and the metal layer. The vertical electro-optical component thus has a low operational voltage of a vertical transistor and a high reaction speed of a photo diode, and may be used to form light-emitting transistors.