Abstract: The present invention presents the isolation, characterization and synthesis of oligosaccharides of Bacillus anthracis. Also presented are antibodies that bind to such saccharide moieties and various methods of use for such saccharide moieties and antibodies.

Abstract: The present invention is directed to a method of alkylating a thiol group (R—S—H) or seleno group (R—Se—H) in a target molecule wherein the method comprises: reacting a target molecule comprising at least one thiol group with a compound of formula (I) or (II): wherein R is an acetyl group or any other acyl group or is a group comprising any one of: or wherein R in formula (II) can also be an alkyl group; and wherein R? is selected from a group consisting of a hydrogen, a methyl group and an ethyl group. In certain cases, the described methods may be used to install acetylated lysine analogs in target molecules (e.g., peptides, proteins).

Abstract: An endoprosthesis is proved which includes an elongate housing having a drive secured through a threaded drive shaft to an extension shaft therein, the drive operable to cause the extension shaft to move axially with respect to the body, and the extension shaft and housing configured to be securable to a bone to act as a prosthetic replacement for removed bone. An operating system for the endoprosthesis is also provided.

Abstract: A z-axis gyroscope design is presented with a 2-degree of freedom (DOF) sense mode allowing interchangeable operation in either precision (mode-matched) or robust (wide-bandwidth) modes. This is accomplished using a complete 2-DOF coupled system which allows for the specification of the sense mode resonant frequencies and coupling independent of frequency. By decoupling the frame connecting the sense system to a central anchor, x-y symmetry is preserved while enabling a fully coupled 2-DOF sense mode providing control over both the bandwidth and the amount of coupling independent of operational frequency. The robust mode corresponds to operation between the 2-DOF sense mode resonant frequencies providing a response gain and bandwidth controlled by frequency spacing. Precision mode of operation, however, relies on mode-matching the drive to the second, anti-phase sense mode resonant frequency which can be designed to provide a gain advantage over a similar 1-DOF system.

Abstract: Non-invasive methods are provided herein for the diagnosis of melioidosis with specific antibodies capable of detecting molecules associated with melioidosis in a biological fluid, such as urine or serum. These molecules can be identified using proteomic methods, including but not limited to antibody based methods, such as an enzyme-linked immunosorbant assay (ELISA), a radioimmunoassay (RIA), or a lateral flow immunoassay. Methods of inducing an immune response to melioidosis are also disclosed. The methods include the use of the immunogenic melioidosis polypeptides, nucleic acids encoding these polypeptides, and/or viral vectors encoding an immunogenic melioidosis polypeptide, alone or in conjunction with other agents, such as traditional melioidosis therapies. Also disclosed are methods for treating a subject having melioidosis.

Abstract: An active catheter device is provided. At least one elongate catheter segment includes an elongate flexible tube member defining an axis, and a pair of ferrule members operably engaged with and spaced apart along the tube member. The ferrule members are not rotatable about the axis relative to each other. At least one articulation member is operably engaged with and extends at least between the ferrule members along the tube member. Each articulation member is configured to be actuatable to cause a change in a distance between the ferrule members so as to articulate the tube member. Associated systems and methods are also provided.

Abstract: A video surveillance system includes a plurality of video sources, at least one processing server in communication with the video sources, and at least one monitoring station viewing video from the video sources. The video sources are distributed over a target area to be monitored by the surveillance system and are attached to a video network. The processing server allocates bandwidth to the video sources with an accuracy function which provides event/object detection accuracy as a function of image/video quality transferred over the network. The image accuracy is the accuracy with which the processing server identifies features in a video image. Bandwidth is allocated by optimizing the overall event/object detection accuracy by adjusting image/video quality for each video source optionally subject to the dynamic network conditions experienced by each video source.

Abstract: A phase oscillating device for affecting movement of a limb or a primary body includes a sensor coupled to the primary body. A physical state of the primary body is measured using the sensor. A phase angle of the primary body is determined based on the physical state measurement. The physical state measurement includes position, velocity, or acceleration. The phase angle of the primary body is filtered using a sine function. An actuator is coupled to the primary body. The actuator is triggered based on the phase angle of the primary body to provide a force or torque to assist or resist movement of the primary body. A secondary body is coupled to the primary body. The secondary body is oscillated using the actuator, which is triggered in phase with a gait step. Alternatively, a fan is coupled to the primary body and actuator to provide the oscillating force.

Abstract: Age-estimation of a face of an individual is represented in image data. In one embodiment, age-estimation techniques involves combining a Contourlet Appearance Model (CAM) for facial-age feature extraction and Support Vector Regression (SVR) for learning aging rules in order to improve the accuracy of age-estimation over the current techniques. In a particular example, characteristics of input facial images are converted to feature vectors by CAM, then these feature vectors are analyzed by an aging-mechanism-based classifier to estimate whether the images represent faces of younger or older people prior to age-estimation, the aging-mechanism-based classifier being generated in one embodiment by running Support Vector Machines (SVM) on training images. In an exemplary binary youth/adult classifier, faces classified as adults are passed to an adult age-estimation function and the others are passed to a youth age-estimation function.

Abstract: Disclosed is a device for revaporizing natural gas. Provided is a device for revaporizing natural gas hydrate pellets, comprising: a pellet charging portion for charging pellets which is formed with an upper valve and a lower valve so as to divide space for adjusting pressure; a storing portion, which communicates with the lower portion of the pellet charging portion, for receiving pellets when the lower valve is opened; a transfer screw, one end of which couples to the lower portion of the storing portion, for transferring the pellets in the storing portion; and a dissolving reaction tub, which is coupled to the other end of the transfer screw, receives pellets from the lower portion of the dissolving reaction tub, and which accommodates heating water.

Abstract: Provided are methods, circuits and apparatuses for detecting pressure variations. The circuit can comprise at least two pressure sensors electrically coupled in parallel. At least one pressure sensor can have a differential input and a differential output. The circuit can also comprise a first switching mechanism electrically coupled to the differential input of the at least one pressure sensor. The first switching mechanism can be configured to electrically couple a first current source to the at least one pressure sensor according to a first reference signal. The circuit can also comprise a second switching mechanism electrically coupled to the differential output of the at least one pressure sensor. The second switching mechanism can be configured to electrically couple a second current source to the at least one pressure sensor according to a second reference signal.

Abstract: Certain embodiments provide a method for capturing a genomic fragment. The method may comprise: obtaining a substrate comprising a first population of surface-bound oligonucleotides and a second population of surface-bound oligonucleotides; hybridizing a first member of the first population of surface-bound oligonucleotides to a selection oligonucleotide comprising a region that hybridizes with the first member and a region that contains a genomic sequence; extending the first member of the first population of surface-bound oligonucleotides to produce a support-bound selection primer that comprises a sequence that is complementary to the genomic sequence; hybridizing the support-bound selection primer to a nucleic acid fragment comprising the genomic sequence; extending the support-bound selection primer to produce an extension product that contains a sequence that flanks the genomic sequence, e.g., in a genome; and amplifying the extension product on the substrate.

Abstract: Antibacterial IspF inhibitor compounds and compositions are described. Methods include administering described compounds and compositions to treat bacterial or parasitic infections and to inhibit or parasite or bacterial growth.

Abstract: Antiviral protease inhibitors, including macrocylic transition state inhibitors and peptidomimetics are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, sapoviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.

Abstract: This disclosure describes recombinant Caldicellulosiruptor bescii microbes designed to produce greater amounts of acetate, H2, and/or ethanol than a comparable wild type control. this disclosure also describes methods that generally include growing such recombinant microbes under conditions effective for the recombinant microbes to produce acetate, H2, and/or ethanol.

Abstract: In general, various embodiments of the present invention comprise an external fixation device, an internal fixation device, and a lower extremity stabilizer. The external fixation device is connected to the lower extremity stabilizer and the external fixation device is adjustably connected to the internal fixation device. The internal fixation device is capable of being attached to at least one bone in a patient's foot, ankle, and/or lower extremity.

Abstract: The invention provides novel polymer compositions and methods for preparing such compositions. The invention also provides methods for polymerizing various unsaturated monomers, including naturally occurring or plant biomass-derived renewable acrylic monomers. The monomers can be rapidly polymerized using various organic catalysts or organometallic catalysts, as described herein. In one embodiment, nearly perfectly isotactic polymers (mmmm>99%) can be prepared using a C2-symmetric zirconocenium catalyst.

Abstract: Substituted indole derivatives of formula (I) wherein the radicals have e. g. the following meaning: R1 is hydrogen, —C1-6-alkyl, R2 is hydrogen, —C1-6-alkyl or cycloC3-12-alkyl; R3 is OR R4 is hydrogen or halogen, R5 is hydrogen, —C1-6-alkyl R6 is hydrogen, —C1-6-alkyl R is hydrogen or —C1-6-alkyl; X is a group —C(O)CH2— or —CH?CH—; R7 is hydrogen are potent inhibitors of Abeta peptide polymerization and can be used for the treatment of e.g. Alzheimers disease or ocular disorders.

Abstract: The present invention relates to a method for the production of cross-linked carbon nanotube networks which are selected from aerogels and xerogels with improved performance and characteristics thereof. The invention is also concerned with carbon nanotube networks which are selected from aerogels and xerogels produced by such processes and uses thereof.

Abstract: A new cultivar of hybrid Rhododendron plant named ‘UMNAZ 502’ that is characterized by its irregularly rounded and compact plant habit reaching 1.4 m in height and width after 15 years of growth, its abundance of flowers that are dark red in color in mid to late May in Minnesota with the red color retained throughout the bloom period without substantial fading prior to abscission, its good cold hardiness with flower buds that are resistant to cold damage and consistently bloom even when exposed to temperatures as low as ?30° F., and its good foliar tolerance to powdery mildew and other foliar diseases.