Abstract: Iridium compounds and their uses are disclosed herein. For example, carbazole containing iridium compounds are disclosed. The compounds are useful in many devices, including, but not limited to, electroluminescent devices.

Abstract: A manufacturing method of a sensor device integrated with ultrasonic transducer and microphone is to form a first support structure, a back plate, a second support structure, a membrane and electrodes on a substrate. The substrate is divided into a first region and a second region. The first electrode, the third electrode, a part of the back plate, a part of the second support structure and a part of the membrane that are above the first region form the ultrasonic transducer. The first support structure, the second electrode, the fourth electrode, a part of the back plate, a part of the second support structure and a part of the membrane that are above the second region form the microphone. The ultrasonic transducer and the microphone are simultaneously manufactured.

Abstract: The invention provides functionalized monosaccharides and disaccharides suitable for use in synthesizing a lipid A derivative, as well as methods for synthesizing and using a synthetic lipid A derivative.

Abstract: GB1 peptidic compounds that specifically bind to a hemagglutinin target protein, and libraries that include the same, as well as methods of making and using the same, are provided. Also provided are methods and compositions for making and using the compounds. Also provided are hemagglutinin mimics and fragments and methods of using the same, including methods of screening for GB1 peptidic compounds and methods of using conjugates the mimics as influenza A vaccines. Aspects of the invention include methods of screening libraries of L-peptidic compounds for specific binding to a D-peptidic hemagglutinin target protein. Once a L-peptidic compound has been identified that specifically binds to the D-peptidic hemagglutinin target protein, the D-enantiomer of the selected L-peptidic compound may be produced. In some embodiments, the D-enantiomer of the selected L-peptidic compound binds to, and in some instances, neutralizes influenza virus particles.

Abstract: A new class of anti-microbial agents and methods for preventing or reducing the risk of sexually transmitted infections and/or diseases is provided. Preferably, these anti-microbial agents are also contraceptive and, thus, also prevent or reduce the risk of unplanned pregnancies. The anti-microbial agents comprise a delivery vector having anti-microbial activity (and preferably contraceptive activity) coupled with a nitric oxide donor moiety.

Abstract: Polymeric conjugates comprising a polymeric backbone having attached thereto a bone targeting moiety and a therapeutically active agent, wherein the bone targeting moiety is attached to one end of the polymeric backbone via a branching unit such that a molar ratio of the bone targeting moiety to the polymer is at least 2:1, are disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.

Abstract: Disclosed herein are a heterogeneous catalyst for the preparation of 3-hydroxypropionic acid (3-HPA) from allyl alcohol, and a method for the preparation of 3-HPA from allyl alcohol using the catalyst. In the presence of the heterogeneous catalyst containing gold on a carrier, a liquid-phase reaction is conducted to produce 3-HPA from allyl alcohol at high yield.

Abstract: The invention provides compositions comprising an alkene epoxidase and a selective epoxide hydrolase, such as a recombinant microorganism comprising a first heterologous nucleic acid encoding an alkene epoxidase and a second heterologous nucleic acid encoding a selective epoxide hydrolase. Exemplary alkene epoxidases include StyAB, while exemplary selective epoxide hydrolases include epoxide hydrolases from Sphingomonas, Solanum tuberosum, or Aspergillus. The invention also provides non-toxic methods of making enantiomerically pure vicinal diols or enantiomerically pure alpha-hydroxy carboxylic acids using these compositions and microorganisms.

Abstract: The present invention provides an eye surgery training simulator that can reduce learning cost and simulate the eyes in a more real way to allow surgery performers in practice to increase the success rate of surgery. The surgery training simulator compromise: a base with the accommodating tank, a hollow sphere inside said accommodating tank with a punched hole at the center of its top to simulate the eyeball rotation; a thin film covering the punched hole of said hollow sphere to simulate anterior capsule; a positioning sheet attached to the top surface of the hollow sphere with a hole corresponding to the punched hole; a positioning plug-in at the side of said punched hole that can limit the displacement of the capsulorhexis forceps; and at least an elastic component that can simulate eyeball muscle by pulling the hollow sphere and restore it after the rotation of the hollow sphere.

Abstract: Provided is a Co—Ni-based alloy in which a crystal is easily controlled, a method of controlling a crystal of a Co—Ni-based alloy, a method of producing a Co—Ni-based alloy, and a Co—Ni-based alloy having controlled crystallinity. The Co—Ni-based alloy includes Co, Ni, Cr, and Mo, in which the Co—Ni-based alloy has a crystal texture in which a Goss orientation is a main orientation. The Co—Ni-based alloy preferably has a composition including, in terms of mass ratio: 28 to 42% of Co, 10 to 27% of Cr, 3 to 12% of Mo, 15 to 40% of Ni, 0.1 to 1% of Ti, 1.5% or less of Mn, 0.1 to 26% of Fe, 0.1% or less of C, and an inevitable impurity; and at least one kind selected from the group consisting of 3% or less of Nb, 5% or less of W, 0.5% or less of Al, 0.1% or less of Zr, and 0.01% or less of B.

Abstract: The present application relates to compositions comprising an iodinated contrast agent and indocyanine green co-encapsulated inside a liposomal carrier, various uses thereof as well as methods for their preparation.

Abstract: A method for magnetic resonance (MR) imaging or spectroscopy on a MR scanner to detect tissue physiological parameters in one or more tissue areas in a human or non-human subject includes administering to the subject a contrast enhancing physiologically tolerable amount of a sugar that is non-labeled, subjecting the subject to an MR procedure capable of generating MR signals encoding at least one tissue area in the subject in which the sugar either passes or is taken up, detecting a temporal variation in the MR signals in the at least one tissue area after the administering the sugar, determining at least one tissue-related parameter from the temporal variation, and ascertaining whether the at least one tissue-related parameter is abnormal.

Abstract: The present invention concerns compounds derived from the anaesthetic propofol that are useful as analgesics and methods of using the same. The compounds act as co-activators of strychnine-sensitive glycine receptors and may have greater activity at those glycine receptors than at GABAA.

Abstract: The invention provides a system and method for integrating multimedia descriptions in a way that allows humans, software components or devices to easily identify, represent, manage, retrieve, and categorize the multimedia content. In this manner, a user who may be interested in locating a specific piece of multimedia content from a database, Internet, or broadcast media, for example, may search for and find the multimedia content. In this regard, the invention provides a system and method that receives multimedia content and separates the multimedia content into separate components which are assigned to multimedia categories, such as image, video, audio, synthetic and text. Within each of the multimedia categories, the multimedia content is classified and descriptions of the multimedia content are generated. The descriptions are then formatted, integrated, using a multimedia integration description scheme, and the multimedia integration description is generated for the multimedia content.

Abstract: Systems, methods and instrumentalities are disclosed for superposed signaling for bandwidth efficiency in wireless communications. Homogeneous and heterogeneous signals may be superposed on the same channel. Superposed signals may comprise, for example, multi carrier, frequency division and code division signals, including multiple access, e.g., OFDMA and CDMA, signals. Data for various receivers may be dynamically selected for signal superpositioning, for example, based on radio access technology, communication rate (e.g. high and low rates), distance between transmitter and receiver (e.g. near and far signals). Communication rate and power may be allocated to superposed signals. Interference nulling may be applied, for example, by selecting or excluding spreading codes and/or subcarriers. Nulled locations may be used to transmit critical information. Interference shaping may be applied to modify interference, e.g., by transmitting interference symbols using reserved spreading codes. Support information, e.

Abstract: A game-based method for physical rehabilitation that includes authenticating a user with authentication information input through a communication interface, identifying therapeutic movements by referencing a look-up table stored in a memory, the therapeutic movements being prescribed for the user or associated with a diagnosis of a predetermined physical condition, obtaining a user rehabilitation status stored in the memory, generating a game based on the therapeutic movements and the user status wherein the game includes controlling browsing of a map by detecting the therapeutic movements performed by the user, providing the game to the user, receiving a data stream from a motion-sensing device that monitors an actual movement of the user in correspondence to the therapeutic movements, analyzing the data stream to calculate information metrics that are associated with the correspondence of the actual movements to the therapeutic movements, and updating the user rehabilitation status based on the information

Abstract: An AC-to-DC converter includes a multi-resonant switching circuit including an AC-AC stage soft-switched LC network that converts a low-frequency low-amplitude alternating input voltage into a higher-frequency higher-amplitude alternating voltage and an AC-DC stage rectifying the higher-frequency higher-amplitude alternating voltage into a DC output voltage via a soft-switched diode. An AC-to-DC converter system includes at least two multi-resonant switching circuits that include at least two AC-AC stages and an AC-DC stage. A control system for the AC-to-DC converter includes at least two resonant gate drivers that each includes: one MOSFET gate configured to transmit a gate voltage signal to an AC-to-DC converter; an on/off logic module electrically coupled to the MOSFET gate; a resonant tank LC circuit electrically coupled to the on/off logic module; and a voltage bias module electrically coupled to the resonant tank LC circuit.

Abstract: Disclosed herein are support column structures which can be used to support bridges, buildings or other structures. In some cases, a support column structure can be deconstructable and include one or more removable elements. In some cases, a support column structure can include shape memory alloy reinforcing bars. In some cases, a removable element of a support column structure can include an engineered cementitious composite. In some cases, a removable element includes one or more sleeves to separate an engineered cementitious composite from one or more shape memory alloy reinforcing bars. Methods include assembling and disassembling a support column structure.

Abstract: A vertical type light emitting diode includes a nitride semiconductor having a p-n conjunction structure with a transparent material layer formed on a p type clad layer, the transparent material layer having a refractive index different from that of the p type clad layer and having a pattern structure of mesh, punched plate, or one-dimensional grid form, etc. A reflective metal electrode layer is formed on the transparent material layer as a p-electrode. A stereoscopic pattern is formed in the transparent material layer and the p-electrode deposited, and thereby forming the pattern in the p-electrode. Depositing the p-electrode on only 10 to 70% of the upper portion of the p type clad layer in an ultraviolet ray light emitting diode such that an area where the p type clad layer is exposed is wide increases the transmittance of ultraviolet rays through an area where the p-electrode is not deposited.

Abstract: Systems for converting aldose sugars to ketose sugars and separating and/or concentrating these sugars using differences in the sugars' abilities to bind to specific affinity ligands are described.