Abstract: Provided are minimal hammerhead ribozymes and catalytic strands thereof. Aspects of the present disclosure include a catalytic strand of a minimal hammerhead ribozyme, the catalytic strand including a catalytic core region, a stem I-forming region, a stem II region, and a stem III-forming region. The catalytic strand hybridizes to a target strand via the stem I-forming region and the stem III-forming region. A nucleotide (e.g., an adenine, cytosine, or a natural or non-natural nucleotide base having hydrogen bond donor and acceptor functionalities at positions analogous to those of adenine or cytosine) present in a stem II loop base pairs with a nucleotide (e.g., uracil or cytosine) at position 1.7 of the target strand. Also provided are compositions that include the catalytic strands, and methods of using the catalytic strands, e.g., in a variety of different applications, as well as kits that find use in practicing embodiments of the methods.

Abstract: Provided are a flexible display device and a method of manufacturing the same. More particularly, the method of manufacturing the flexible display device according to the present invention includes a step of forming a first polyimide-based layer by coating a polyimide-based solution on a carrier substrate; a step of forming an oxide thin film transistor array on the first polyimide-based layer; a step of forming a second polyimide-based layer by coating a polyimide-based solution on the oxide thin film transistor array; a step of forming an organic light emitting diode on the second polyimide-based layer; and a step of removing the carrier substrate, wherein, in the step of forming the oxide thin film transistor array, the oxide thin film transistor array is disposed between the first polyimide-based layer and the second polyimide-based layer.

Abstract: Embodiments herein generally relate to methods, compositions and uses of CaMKII inhibitors. Other embodiments relate to methods, compositions and uses of agents that target CaMKII. Yet further embodiments relate to compositions, methods and uses of CaMKIIN-derived molecules and other CaMKII inhibitor molecules that inhibit autonomous CaMKII activity. In accordance with these embodiments, compositions that inhibit autonomous CaMKII activity may be used for treating conditions causing neuronal cell death, for treating cancer or for treating neurodegenerative disorders.

Abstract: An article may include a substantially perpendicularly magnetized free layer having a first magnetic orientation in the absence of an applied magnetic field. The article may also include a spin Hall channel layer configured to conduct a spin current configured to subject the perpendicularly magnetized free layer to a magnetic switching torque and a substantially in-plane magnetized bias layer configured to bias the substantially perpendicularly magnetized free layer to a second magnetic orientation. The second magnetic orientation is different than the first magnetic orientation and is out of a plane of the substantially perpendicularly magnetized free layer.

Abstract: Treatment of neurological injury through motor relearning. A game-based sensorimotor rehabilitator that enables individuals to interact with the functional objects using the appropriate amount of force, tilt, finger movement, and muscle activity to regain lost skill due to injury.

Abstract: Disclosed are small molecule non-peptidic compounds, as well as methods and compositions for the treatment of angiotensin-related diseases and disorders, including cardiovascular diseases, metabolic diseases, gastrointestinal diseases, renal diseases, inflammatory/autoimmune diseases, neurological diseases, bone marrow diseases and cancer. In particular, the invention provides compounds, methods and compositions for the treatment of metabolic diseases and disorders, such as diabetes mellitus, diabetes-related cardiovascular disorders, diabetes-related dermal ulcerations, diabetes related hypertension, and diabetes-related ophthalmic diseases.

Abstract: A gravitational radiation communication system. The system includes a gravitational radiation transmitter and a gravitational radiation receiver. Each of the transmitter and the receiver includes a first cylindrical superconducting cavity, having a first length, a first diameter, and an entrance aperture for electromagnetic radiation; a second cylindrical superconducting cavity, having a second length, a second diameter, and a first aperture for gravitational radiation, the second cavity being coaxial with and adjacent the first cavity; and a superconducting movable membrane positioned between the first cavity and the second cavity and configured to provide parametric amplification of electromagnetic fields in the second cavity. The first aperture is configured to pass gravitational radiation.

Abstract: The present invention relates to compounds that are useful as metal ligands and which either contain a molecular recognition moiety or can be bound to a molecular recognition moiety and methods of making these compounds. Once the compounds that contain a molecular recognition moiety are coordinated with a suitable metallic radionuclide, the coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging. The invention therefore also relates to methods of diagnosis and therapy utilizing the radiolabelled compounds of the invention.

Abstract: A de-coupling mechanism includes a link slidably received in a link aperture of a bracket. A pin is slidably received in a pin bore of the link and a receiving bore of the bracket. A first block is connected to the bracket and includes an initiator receiving passage in communication with the pin bore. An initiator is positioned in the initiator receiving passage and retained against a connecting passage edge and oppositely contacts an end face of a cap connected to the first block. A second block connected to the bracket includes a longitudinal channel having a channel diameter larger than a pin diameter so the pin is freely displaceable into the longitudinal channel. An end face of a retaining cap is connected to a second block end wall. The retaining cap includes a stepped portion having a step diameter smaller than the channel diameter and the pin diameter.

Abstract: In accordance with some embodiments of the present invention, systems and methods that protect an application from attacks are provided. In some embodiments of the present invention, input from an input source, such as traffic from a communication network, can be routed through a filtering proxy that includes one or more filters, classifiers, and/or detectors. In response to the input passing through the filtering proxy to the application, a supervision framework monitors the input for attacks (e.g., code injection attacks). The supervision framework can provide feedback to tune the components of the filtering proxy.

Abstract: Myeloid differentiating agents can be used in the treatment of myeloid proliferative disorders.

Abstract: The present disclosure features a strain-promoted [2+2+2] reaction that can be carried out under physiological conditions. In general, the reaction involves reacting a pi-electrophile with a low lying LUMO with a quadricyclane on a biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo and in vitro. The reaction is compatible with modification of living cells. In certain embodiments, the pi-electrophile can comprise a molecule of interest that is desired for delivery to a quadricyclane-containing biomolecule via [2+2+2] reaction.

Abstract: A method for manufacturing a sensor packaging according to an exemplary embodiment of the present disclosure includes: forming a via hole penetrating a main substrate by etching each of both surfaces of the main substrate; forming an insulating layer on a wall surface of the via hole and the both surfaces of the main substrate; combining a sub-substrate on which a metallic seed layer and a bonding layer having a pattern for exposing a part of the seed layer are laminated with the main substrate; forming a filling layer configured to cover an upper surface of the main substrate by filling metal in the via hole; and removing the sub-substrate from the main substrate.

Abstract: The present disclosure relates to a technical field of a security detection device, and particularly, to a security detection system, comprising one or more detection devices, wherein the detection device comprises a first ray emitter, a ray receiver, and a movable frame, wherein the first ray emitter comprises a first ray source for generating first detection rays and is provided at a bottom portion of the movable frame, so that the first detection rays can penetrate through a detected object from a bottom of the detected object; the ray receiver comprises a ray detector provided on the movable frame, for correspondingly receiving the first detection rays having penetrated through the detected object; and the movable frame is movable in a direction in which the first ray emitter and the ray receiver are capable of moving through a detection region for the detected object.

Abstract: The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.

Abstract: Provided herein are reagents for improving PCR accuracy.

Abstract: A vehicle includes a body providing structural support and defining a fuselage perimeter and including a plurality of bands, a plurality of antennas integrated into the plurality of bands, and a transceiver operatively connected to each of the plurality of antennas. The transceiver is configured to power selected sub-sets of the plurality of antennas to generate a directional antenna beam.

Abstract: A device for measuring size distributions of particles and droplets includes a gel electrophoresis component that has a gel chamber that is suitable to receive a gel in which at least one of particles or droplets propagate in a liquid medium during operation; an illumination source arranged to illuminate said at least one of particles or droplets such that the at least one of particles or droplets absorbs, scatters or emits light; an imaging device configured to obtain image data from the absorbed, scattered, or emitted light from the at least one of particles or droplets while the at least one of particles or droplets propagate through the gel; and a computing device configured to receive and process the image data to provide information concerning a size distribution of the at least one of particles or droplets.

Abstract: Provided is a hyperbranched polymer having such a backbone that is readily decomposable by an acid. The hyperbranched polymer is derived from, via reaction, monomers including a monomer (X) and a monomer (Y). The monomer (X) contains three or more hydroxy groups per molecule. The monomer (Y) contains two or more groups represented by General Formula (y) per molecule. The monomer (X) includes at least one compound selected from the group consisting of cyclodextrins, compounds represented by General Formula (I), pillararenes, compounds represented by General Formula (II), compounds represented by General Formula (III), and compounds represented by General Formula (IV). The monomer (Y) includes a compound represented by General Formula (1).

Abstract: In one aspect of the present disclosure, there is provided an electrolyte solution for a thermoelectric device, the solution comprising: a redox couple; water; and a polar organic solvent.