Abstract: Provided are methods and compositions for treatment of cancer. In particular, these methods and compositions may include a compound that induces the translocation of cyclin C from the cell nucleus to the cytoplasm. Also provided are methods of screening tumor cells for susceptibility to compounds that induce the translocation of cyclin C.

Abstract: A muscular strength assisting apparatus includes a drive means held by a first attachment tool attached to a torso, and a transmission means for transmitting a force output by the drive means to a second attachment tool attached to an upper arm. The transmission means includes an output shaft member coupled to the second attachment tool, and a switching means capable of switching between transmission and interruption of a force from the drive means to the output shaft member. The switching means is disposed on a rear, upper or laterally outer side of the output shaft member.

Abstract: Methods for detecting single nucleotide polymorphisms in nucleotide sequences using LAMP reactions are provided herein. Generally, two sets of LAMP primers, a wild-type primer that matches expected DNA sequences and an SNP primer that matches the expected SNP DNA are provided. One method includes providing the wild-type primer and the SNP primer in separate wells of a multi-well microfluidic array device, adding the sample nucleotide sequence into the wells seeded with the primers, and initiating LAMP reactions within the wells. The method includes observing the reaction differential between the primers and determining the status of the DNA with regard to that particular SNP. A second method includes providing the primers with tags in a mixture, adding the sample nucleotide sequence to the mixture, and initiating LAMP reactions.

Abstract: Some embodiments of the present invention intend to provide a method and an apparatus for diagnosing health state of a 3D printer which collects collection data in a 3D printing process by using sensors attached to the 3D printer (for example, an acceleration sensor and an acoustic emission sensor), extracts feature elements of the sensor data, applies machine learning to an equipment health state diagnosis model based on the extracted feature elements, and thereby enables diagnosing equipment health state of 3D printer components in an objective and consistent manner.

Abstract: This disclosure provides systems, methods, and apparatus related to a vapor phase photo-electrochemical cell. In one aspect, a device includes a photovoltaic cell, a cathode disposed on the photovoltaic cell, an ionomer membrane disposed on the cathode, and an anode disposed on the ionomer membrane. The cathode includes a cathode catalyst. The ionomer membrane is in contact with the cathode catalyst. The anode includes an anode catalyst. The anode catalyst is in contact with the ionomer membrane. The anode, the ionomer membrane, and the cathode are transmissive to the solar radiation spectrum.

Abstract: A method and device for judging intercity transportation modes based on mobile phone data solves the problems of difficult data acquisition and low data processing efficiency in the existing solutions. The method includes: obtaining the trajectory of each user from the mobile phone data; extracting an intercity traffic sub-trajectory in the trajectory of each user; and judging the transportation mode of the intercity traffic sub-trajectory. The solution has the advantages of easy data acquisition, high data processing efficiency and capability of achieving long-term monitoring.

Abstract: Provided is a file management/search system based on a block chain capable of identifying a data name and an owner of a data. In the file management/search system, a generated data is stored, and a data name together with an IP address and port number of a node in which the data is stored is transmitted in a form of a transaction to other nodes. The nodes receiving the transaction generates blocks on the basis of the transaction and links the blocks to the block chain, so that the data name and the owner information of the owner generating the data are shared by all users. Since this information is recorded in the block chain and all the nodes share the same information, a malicious node which is to arbitrarily change contents needs to change the contents of the block chain held by all the nodes.

Abstract: Method of constructing a vault of a large storage tank for liquefied natural gas by first modeling the vault with a 3-D modeling software application, then partially building the vault with a framework and a first set of covering panels fixed on the framework where the panels do not touch each other, but leave a number of gaps between them, measuring the dimensions of the actual gaps between the panels using a 3-D scanner, producing a second set of panels according to the scanned dimensional data, and finally filled the gaps between the first set of panels with the second set of panels, which are much smaller than the first set of panels, making the building process earlier and more accurate, which are difficult issues in building large tanks for liquefied natural gas.

Abstract: A particle focusing system includes an inlet; an inertial focusing microchannel disposed in a substrate and connected to the inlet; and a pressure/flow source configured to drive a particle-containing fluid through the inertial focusing microchannel, where the inertial focusing microchannel includes a side wall having an irregular surface. The side wall includes a first irregularity protruding from a baseline surface away from a longitudinal axis of the inertial focusing microchannel. Alternatively or additionally, the first irregularity and the baseline surface form an angle more than or equal to 135 degrees. The inertial focusing microchannel may have a substantially rectangular cross-section having a height and a width, and a ratio of height to width is approximately 5:4 to 4:1. The system may also include a downstream expanding region having a side wall, where the side wall has a stepped surface.

Abstract: The present disclosure describes a device that can be implanted into the left atrial appendage for occlusion. The device can prevent or reduce thrombus formation in this anatomic region for patients with atrial fibrillation. This device includes a patient-specific inflatable device that represents a patient's anatomy or morphological class. The inflatable device can be designed by imaging (e.g., computed tomography, magnetic resonance imaging) the patient's anatomy. Through a catheter (or surgically), the inflatable device can be filled with an inflation fluid to occlude the appendage in a patient-specific fashion.

Abstract: Provided is an elastic band for correcting a joint deformity and enhancing a joint function, the elastic band including: a first band to be attached to an outer part of a joint of a finger or toe and to the back of a hand or the top of a foot, and having a strip shape; a second band to be attached to an inner part of a last joint of the finger or toe while surrounding the inner part, and having a width increasing towards an end to surround side parts of the finger or toe together; and a connecting portion disposed between the first band and the second band to integrally connect the first band and the second band, and having a width gradually decreasing and then increasing from the first band towards the second band, and a mounting device of the elastic band.

Abstract: Methods are described for generating autologous tissue grafts, including generating grafts at the point of care, which include isolated cell populations that are enriched with stem cells and are mixed with biological fillers including hyaluronic acid and derivatives thereof. The hyaluronic acid localizes the cells to a desired injection site and stimulates collagen production thus enhancing the viability and the longevity of the graft.

Abstract: The present invention relates to a polymeric hollow fiber membrane and a carbon molecular sieve hollow fiber membrane, both of which have excellent gas separation performance, and processes for preparing the same. Specifically, the present invention relates to a hybrid polymeric hollow fiber membrane that comprises a glassy polymer containing fluorine and a ladder-structured polysilsesquioxane, a hybrid carbon molecular sieve hollow fiber membrane prepared by pyrolysis thereof, and processes for preparing the same. The hybrid polymeric hollow fiber membrane and the hybrid carbon molecular sieve hollow fiber membrane according to the embodiments of the present invention are excellent in gas flux and selectivity and can have a large surface area per unit volume. Thus, they can be advantageously used for separating gases with a high energy efficiency on a large scale.

Abstract: Cutin-based devices, coatings and methods of producing such devices and coatings are presented herein. Cutin-like materials (CLMs) are presented which mimic and adapt coatings found in nature for the next generation of functional coatings. Cutin has several advantages including excellent UV resistance, natural resistance to bacteria and viruses, noncorrosive, and stability under abrupt changes in temperature and environment. CLMs can be engineered at the nanoscale and readily impregnated with metals and metal oxides materials.

Abstract: The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method.

Abstract: The invention relates to utilising red marine macroalgae to provide improvements in growth performance of livestock, particularly ruminant animals for red meat production, especially cattle, in pasture and feedlot farming systems. There is provided a method for improving the growth performance of a livestock animal in a farming system including: providing a red marine macroalgae to a farming system to enable consumption of the red marine macroalgae by a livestock animal in the farming system; thereby improving the growth performance of the livestock animal in the system.

Abstract: A composition comprises: a base oil; an additive comprising a copolymer comprising hydrophobic and hydrophilic units; and a drug. The copolymer may for example have a comb structure in which the hydrophobic units and hydrophilic units are pendant chains on a backbone of the copolymer. The hydrophobic units and hydrophilic units may for example comprise polydimethylsiloxane moieties and ethylene glycol residues respectively. The composition may for example be used as a tamponade or as a component for a tamponade administered to the eye. The invention is useful for solubilising and/or releasing drugs.

Abstract: A tester for evaluating pullout load capacity and bond quality of anchor bolts embedded in concrete includes a Schmidt hammer for measuring a rebound number and an ultrasonic pulse velocity tester for measuring the transit time of a pulse transmitted through concrete surrounding an anchor bolt. The rebound number and the transit time are combined and matched against a database record which identifies the pullout load capacity and the bond quality. The transit time is matched to thresholds of transit times associated with porosity, internal cracking, air voids, and water pockets located around the embedded anchor bolt. The Schmidt hammer is further modified by the incorporation of a digital level for measuring the vertical and horizontal angles of inclination of the plunger with the concrete surface, a guide tube for supporting the plunger, and by using a convex plunger tip for improved registration with anchor bolt head.

Abstract: A polymer nanoparticle includes a polymer having repeating units of formula (I) wherein X, L1, and R1 are as defined herein. Methods of preparing the polymer nanoparticles and compositions comprising the nanoparticles are also disclosed. The polymers nanoparticles described herein are particularly useful for the treatment of bacterial biofilms.

Abstract: Methods and formulations for antimicrobial and anti-biofouling coating comprising: a hollow round colloidal structure, comprising: an active polymer shell; and an active or inert core; wherein the active polymer shell comprises one and more polymers with antimicrobial and anti-biofouling activities selected from the group consisting of polyethylenimine (PEI), functionalized chitosan (CHI), polyquaternium, poly(diallyldimethylammonium chloride) (PDDA) and polyhexamethylene biguanide (PHMD); wherein the active or inert core contains one and more disinfectants, biocides, fragrances or inert solvent; and wherein the hollow round colloidal structure is stable for at least 3 months.