Abstract: A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.
Type:
Application
Filed:
March 7, 2014
Publication date:
July 24, 2014
Applicants:
University of Tennessee Research Foundation, UT-Battelle, LLC
Inventors:
Stacy A. Hutchens, Jonathan Woodward, Barbara R. Evans, Hugh M. O'Neill
Abstract: The gene responsible for encoding SERT has a functional polymorphism at the 5?-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3? UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders.
Type:
Application
Filed:
February 25, 2014
Publication date:
July 24, 2014
Applicant:
University of Virginia Patent Foundation
Abstract: Novel compounds comprising heteroleptic iridium complexes are provided. The compounds have a particular combination of ligands which includes a single pyridyl dibenzo-substituted ligand. The compounds may be used in organic light emitting devices, particularly as emitting dopants, to provide devices having improved efficiency, lifetime, and manufacturing.
Type:
Application
Filed:
March 26, 2014
Publication date:
July 24, 2014
Applicant:
Universal Display Corporation
Inventors:
Chuanjun Xia, Raymond C. Kwong, Suman Layek
Abstract: An isotope labeled asymmetric cross-linker is provided for the detection of cross-linked peptides. A cross-linking and mass spectrometry strategy, referred to as isotope tagging of interacting proteins (iTIP), improves the specificity of detecting cross-linked peptides and accurate identification of the interacting peptide sequences via the incorporation of isotopic signatures that are readily observed in the MS/MS spectrum. Isotope tagged peptides can be identified using mass spectrometry based on doublet peaks in a spectrum. Spectra can be subjected to database search strategies available for the sequencing of linear or non-cross-linked peptides.
Type:
Application
Filed:
January 22, 2014
Publication date:
July 24, 2014
Applicant:
The University of North Carolina at Chapel Hill
Abstract: Disclosed are compounds effective for inhibiting cellular apoptosis and for protecting cells and tissues from the apoptotic effects of chemotherapeutic agents and/or ionizing radiation. Compounds of the invention act as agonists of the LPA2 receptor. Compounds of the invention comprise non-lipid benzoic acid derivatives. Further disclosed is a pharmacophore of LPA2 receptor.
Type:
Application
Filed:
March 21, 2014
Publication date:
July 24, 2014
Applicant:
University of Tennessee Research Foundation
Inventors:
Renukadevi Patil, James Fells, Duane Miller, Gabor Tigyi
Abstract: Systems and methods are provided for fabricating pyrite thin films from molecular inks. A process is provided that comprises dissolving simple iron-bearing and sulfur-bearing molecules in an appropriate solvent and then depositing the solution onto an appropriate substrate using one of several methods (roll-to-roll coating, spraying, spin coating, etc.), resulting in a solid film consisting of the molecules. These molecular precursor films are then heated to 200-600° C. in the presence of sulfur-bearing gases (e.g., S2, H2S) to convert the molecular films into films of crystalline iron pyrite (FeS2).
Type:
Application
Filed:
March 13, 2013
Publication date:
July 24, 2014
Applicant:
The Regents Of The University Of California
Inventors:
Matthew Law, Amanda S. Weber, Sean Seefeld, James Puthussery
Abstract: A non-volatile bistable nano-electromechanical switch is provided for use in memory devices and microprocessors. The switch employs carbon nanotubes as the actuation element. A method has been developed for fabricating nanoswitches having one single-walled carbon nanotube as the actuator. The actuation of two different states can be achieved using the same low voltage for each state.
Type:
Application
Filed:
December 26, 2013
Publication date:
July 24, 2014
Applicant:
Northeastern University
Inventors:
Sivasubramanian Somu, Ahmed Busnaina, Nicol McGruer, Peter Ryan, George G. Adams, Xugang Xiong, Taehoon Kim
Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA) and/or pain. In accordance with the present invention, an antagonist of c-Fms is effective in the treatment of osteoarthritis and/or pain. An antagonist of M-CSF includes, but is not limited to, an antibody that is specific for M-CSF, IL-34 or c-Fms.
Type:
Application
Filed:
July 17, 2012
Publication date:
July 24, 2014
Applicants:
MorphoSys AG, The University of Melbourne
Inventors:
Stefan Steidl, John Allan Hamilton, Andrew David Cook
Abstract: A method of enhancing the activity of lysosomal ?-Galactosidase A (?-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds.
Type:
Application
Filed:
December 20, 2013
Publication date:
July 24, 2014
Applicant:
Mount Sinai School of Medicine of New York University
Abstract: A system and method for managing a communication link between a consumer electronic device adapted for two-way, wireless communications with at least one peripheral. The communication link is managed using a controller that is associated with the consumer electronic device that functions to assign communication slots to the peripheral to facilitate communications between the peripheral and the consumer electronic device.
Abstract: A system and method for making adjustments to output effort from a spindle driver using a multi-stage nested control loop of an active controller to provide constant power to a friction stir zone during a friction stir operation. Providing constant power facilitates temperature control within the friction stir zone and thereby improves the result of the operation such as a weld.
Abstract: A method for determining an Eyes-Off-The-Road (EOTR) condition exists includes capturing image data corresponding to a driver from a monocular camera device. A detection of whether the driver is wearing eye glasses based on the image data using an eye glasses classifier. When it is detected that the driver is wearing eye glasses, a driver face location is detected from the captured image data and it is determined whether the EOTR condition exists based on the driver face location using an EOTR classifier.
Type:
Application
Filed:
September 30, 2013
Publication date:
July 24, 2014
Applicants:
Carnegie Mellon University, GM Global Technology Operations LLC
Inventors:
WENDE ZHANG, Dan Levi, Debbie E. Nachtegall, Fernando De La Torre, Franscisco Vicente
Abstract: The present disclosure relates to a porous carbon particle of which a pore size can be controlled by using a copolymer that allows selective cross-linking of a polymer particle and selective carbonization of a polymer particle, and a producing method of the porous carbon particle and a photo electrode including a porous layer containing the porous carbon particle and a dye-sensitized solar cell including the photo electrode.
Type:
Application
Filed:
January 24, 2014
Publication date:
July 24, 2014
Applicant:
Sogang University Research Foundation
Inventors:
Jun Hyuk Moon, Hae Min Yoo, Da Young Kang
Abstract: Colorless distributed combustion (CDC) reactors or green combustion gas turbine combustors having a combustion chamber are presented for improved performance of gas turbine combustion engines. The combustors are configured and designed for providing a superior pattern factor (uniform thermal field in the combustion zone) and a reduction or complete elimination of pollutants emission from the combustor (i.e., zero emission gas turbine combustor) and uniform thermal field in the entire combustion zone to provide significantly improved pattern factor. Colorless distributed combustion is achieved with fuel and air entering the combustion chamber via one or more injection ports as non-premixed, or premixed. Rectangular, cylindrical, stadium and elliptical shaped combustors are presented with injection ports and exit ports located in various locations of the combustors.
Abstract: A method and apparatus for managing and controlling wireless connection of a HyperText Transfer Protocol (HTTP) proxy device in a wireless communication network are provided. The method includes receiving one of information indicating a wireless connection deactivation of an HTTP client performing HTTP communication and information indicating a change in an Internet Protocol (IP) address of the HTTP client from a predetermined node of the wireless communication network; and deactivating a connection with an HTTP server if the received information indicates the wireless connection deactivation of an HTTP client performing the HTTP communication; and maintaining a connection with an HTTP server if the received information indicates the change in the Internet Protocol (IP) address of the HTTP client.
Type:
Application
Filed:
January 22, 2014
Publication date:
July 24, 2014
Applicants:
University-Industry Cooperation Group of Kyung hee University, Samsung Electronics Co., Ltd.
Inventors:
Hanna LIM, Sungwon LEE, Jicheol LEE, Hyungho LEE
Abstract: A positioning control system for an actuator provided with a strain wave gearing is provided with: a semi-closed feedback controller FB(s) that controls a load shaft position ?l on the basis of a feedback motor shaft position ?m; and a feedforward linearization compensator configured by incorporating a nonlinear plant model for an object to be controlled into a feedback linearization compensator using an exact linearization technique. The feedforward linearization compensator uses a forward-calculated state quantity estimated value x* to calculate a feedforward current instruction i*ref and a feedforward motor position instruction ?*m to be input into the feedback controller FB(s). A positioning error caused by a non-linear element (non-linear spring property, relative rotational synchronization component, and non-linear friction) of the strain wave gearing is compensated for by the feedforward linearization compensator.
Type:
Application
Filed:
October 24, 2011
Publication date:
July 24, 2014
Applicants:
National University Corporation Nagoya Institute of Technology, Harmonic Drive Systems Inc.
Abstract: Described herein are methods for increasing insulin sensitivity and for treating Diabetes (Type I and Type II). Also described herein are methods for increasing the amount of brown fat in a subject and for treating metabolic disorders, including obesity.
Type:
Application
Filed:
June 15, 2012
Publication date:
July 24, 2014
Applicant:
The John Hopkins University
Inventors:
Jonathan D. Powell, Bo Xiao, Paul Worley, Gregg M. Delgoffe, Adam Waickman
Abstract: A compound of Formula I, Formula IA, Formula IB, or Formula II, or an acid or base addition salt thereof, and use of these compounds as antioxidants. In one embodiment, a compound of Formula II, wherein each of X, Y, and Z are independently a carbon or nitrogen atom; R1 and R2 are each independently a hydrogen or an electron donating group, but are not both hydrogen, and wherein R1, and R2 are each bonded to a carbon atom in their own respective aryl ring.
Type:
Application
Filed:
June 4, 2012
Publication date:
July 24, 2014
Applicants:
UNIVERSITA DI BOLOGNA, Queen's University at Kingston
Inventors:
Derek A. Pratt, Jason J. Hanthorn, Luca Valgimigli
Abstract: Molecular markers are described for determining the presence or absence of a gene conferring resistance to tomato yellow leaf curl virus from S. chilense (Ty-1) in a host plant. Also described, are methods for producing a host plant comprising a gene conferring resistance to tomato yellow leaf curl virus from S. chilense (Ty-1), including the analysis of the presence or absence of the molecular markers. A plant, and parts thereof, obtained by such a method are also described.
Type:
Application
Filed:
March 12, 2012
Publication date:
July 24, 2014
Applicants:
University of Florida Research Foundation Incorporated, WAGENINGEN UNIVERSITEIT
Inventors:
Yuling Bai, Maarten Gertjan Verlaan, Samuel Hutton