Abstract: The present invention discloses a design for a molecular delivery vehicle capable of delivering a molecular payload to a target cell and its intracellular compartments. Also disclosed are highly pH-sensitive nanoconstruct that takes advantage of the requirement of cationic charge for internalization of CPPs to mask the non-specific internalization, compositions containing nanoconstruct, and methods for forming the same.

Abstract: Systems and methods are provided for fabricating pyrite thin films from molecular inks. A process is provided that comprises dissolving simple iron-bearing and sulfur-bearing molecules in an appropriate solvent and then depositing the solution onto an appropriate substrate using one of several methods (roll-to-roll coating, spraying, spin coating, etc.), resulting in a solid film consisting of the molecules. These molecular precursor films are then heated to 200-600° C. in the presence of sulfur-bearing gases (e.g., S2, H2S) to convert the molecular films into films of crystalline iron pyrite (FeS2).

Abstract: A non-volatile bistable nano-electromechanical switch is provided for use in memory devices and microprocessors. The switch employs carbon nanotubes as the actuation element. A method has been developed for fabricating nanoswitches having one single-walled carbon nanotube as the actuator. The actuation of two different states can be achieved using the same low voltage for each state.

Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA) and/or pain. In accordance with the present invention, an antagonist of c-Fms is effective in the treatment of osteoarthritis and/or pain. An antagonist of M-CSF includes, but is not limited to, an antibody that is specific for M-CSF, IL-34 or c-Fms.

Abstract: A method of enhancing the activity of lysosomal ?-Galactosidase A (?-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds.

Abstract: A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.

Abstract: A system and method for making adjustments to output effort from a spindle driver using a multi-stage nested control loop of an active controller to provide constant power to a friction stir zone during a friction stir operation. Providing constant power facilitates temperature control within the friction stir zone and thereby improves the result of the operation such as a weld.

Abstract: Novel compounds comprising heteroleptic iridium complexes are provided. The compounds have a particular combination of ligands which includes a single pyridyl dibenzo-substituted ligand. The compounds may be used in organic light emitting devices, particularly as emitting dopants, to provide devices having improved efficiency, lifetime, and manufacturing.

Abstract: An isotope labeled asymmetric cross-linker is provided for the detection of cross-linked peptides. A cross-linking and mass spectrometry strategy, referred to as isotope tagging of interacting proteins (iTIP), improves the specificity of detecting cross-linked peptides and accurate identification of the interacting peptide sequences via the incorporation of isotopic signatures that are readily observed in the MS/MS spectrum. Isotope tagged peptides can be identified using mass spectrometry based on doublet peaks in a spectrum. Spectra can be subjected to database search strategies available for the sequencing of linear or non-cross-linked peptides.

Abstract: Disclosed are compounds effective for inhibiting cellular apoptosis and for protecting cells and tissues from the apoptotic effects of chemotherapeutic agents and/or ionizing radiation. Compounds of the invention act as agonists of the LPA2 receptor. Compounds of the invention comprise non-lipid benzoic acid derivatives. Further disclosed is a pharmacophore of LPA2 receptor.

Abstract: A method for manufacturing a composite is disclosed. The method includes steps of (a) providing a powder in a first weight ratio, a graphene oxide in a second weight ratio, a first modifying agent having a first electric charge, and a second modifying agent having a second electric charge; (b) reacting the first modifying agent with the powder so that a surface of the powder has the first electric charge; (c) reacting the second modifying agent with the graphene oxide so that a surface of the graphene oxide has the second electric charge; and (d) mixing the powder having the first electric charge and the graphene oxide having the second electric charge to form a composite, wherein the first and the second electric charges are of opposite electrical polarities.

Abstract: Provided is a multi-core device. The multi-core device includes: a plurality of cores outputting a test response value by receiving a test pattern value; a majority analyzer outputting a value corresponding to a majority of the test response value by analyzing the test response value; and a determination unit determining a core outputting a test response value different from the value corresponding to the majority among the plurality of cores.

Abstract: A method for determining an Eyes-Off-The-Road (EOTR) condition exists includes capturing image data corresponding to a driver from a monocular camera device. A detection of whether the driver is wearing eye glasses based on the image data using an eye glasses classifier. When it is detected that the driver is wearing eye glasses, a driver face location is detected from the captured image data and it is determined whether the EOTR condition exists based on the driver face location using an EOTR classifier.

Abstract: The present disclosure relates to a porous carbon particle of which a pore size can be controlled by using a copolymer that allows selective cross-linking of a polymer particle and selective carbonization of a polymer particle, and a producing method of the porous carbon particle and a photo electrode including a porous layer containing the porous carbon particle and a dye-sensitized solar cell including the photo electrode.

Abstract: Colorless distributed combustion (CDC) reactors or green combustion gas turbine combustors having a combustion chamber are presented for improved performance of gas turbine combustion engines. The combustors are configured and designed for providing a superior pattern factor (uniform thermal field in the combustion zone) and a reduction or complete elimination of pollutants emission from the combustor (i.e., zero emission gas turbine combustor) and uniform thermal field in the entire combustion zone to provide significantly improved pattern factor. Colorless distributed combustion is achieved with fuel and air entering the combustion chamber via one or more injection ports as non-premixed, or premixed. Rectangular, cylindrical, stadium and elliptical shaped combustors are presented with injection ports and exit ports located in various locations of the combustors.

Abstract: A method and apparatus for managing and controlling wireless connection of a HyperText Transfer Protocol (HTTP) proxy device in a wireless communication network are provided. The method includes receiving one of information indicating a wireless connection deactivation of an HTTP client performing HTTP communication and information indicating a change in an Internet Protocol (IP) address of the HTTP client from a predetermined node of the wireless communication network; and deactivating a connection with an HTTP server if the received information indicates the wireless connection deactivation of an HTTP client performing the HTTP communication; and maintaining a connection with an HTTP server if the received information indicates the change in the Internet Protocol (IP) address of the HTTP client.

Abstract: A positioning control system for an actuator provided with a strain wave gearing is provided with: a semi-closed feedback controller FB(s) that controls a load shaft position ?l on the basis of a feedback motor shaft position ?m; and a feedforward linearization compensator configured by incorporating a nonlinear plant model for an object to be controlled into a feedback linearization compensator using an exact linearization technique. The feedforward linearization compensator uses a forward-calculated state quantity estimated value x* to calculate a feedforward current instruction i*ref and a feedforward motor position instruction ?*m to be input into the feedback controller FB(s). A positioning error caused by a non-linear element (non-linear spring property, relative rotational synchronization component, and non-linear friction) of the strain wave gearing is compensated for by the feedforward linearization compensator.

Abstract: Described herein are methods for increasing insulin sensitivity and for treating Diabetes (Type I and Type II). Also described herein are methods for increasing the amount of brown fat in a subject and for treating metabolic disorders, including obesity.

Abstract: A compound of Formula I, Formula IA, Formula IB, or Formula II, or an acid or base addition salt thereof, and use of these compounds as antioxidants. In one embodiment, a compound of Formula II, wherein each of X, Y, and Z are independently a carbon or nitrogen atom; R1 and R2 are each independently a hydrogen or an electron donating group, but are not both hydrogen, and wherein R1, and R2 are each bonded to a carbon atom in their own respective aryl ring.

Abstract: Molecular markers are described for determining the presence or absence of a gene conferring resistance to tomato yellow leaf curl virus from S. chilense (Ty-1) in a host plant. Also described, are methods for producing a host plant comprising a gene conferring resistance to tomato yellow leaf curl virus from S. chilense (Ty-1), including the analysis of the presence or absence of the molecular markers. A plant, and parts thereof, obtained by such a method are also described.