Abstract: In one aspect, the invention relates to substituted 4-(1H-pyrazol-4-yl)benzyl analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present invention provides a system for engaging a fluid flow. The system comprising one or more foil members operationally connected to a feedback control loop system. In one embodiment, the foil member is a hydrofoil member or an airfoil member. The foil members are configured for one or more degrees of freedom of oscillatory movement within the fluid flow. The feedback control loop system comprises a sensor system, actuator system, and a controller system. The feedback control loop system configured for actuating the foil members and thereby optimizing the operation of the foil members to attain one or more optimization objectives. In operation, the foil members are situated in the fluid flow and are manipulated to attain one or more optimization objectives.

Abstract: The present invention provides a quantitative, automated system and method for assessing the correlation level of two rendered images, thereby removing subjectivity from such evaluation. The objective metric of the present invention determines whether two static images are correlated enough to be undetectable by a human observer. The performance of this method is optimized based upon the capabilities and limitations of the human visual system. Therefore, the resulting assessments are not overly sensitive and reduce the resources required to assess rendered images within a networked simulation environment. Additionally, the simplicity of the method lends itself to implementation within existing and emerging simulation systems with relatively little effort compared to current assessment methods. The system and method of the present invention provide benefits to multiple organizations, such as those engaged in human-in-the-loop simulators, distributed learning, and training applications.

Abstract: Peptide nucleic acids containing thymidine and 2-aminopyridine (M) nucleobases formed stable and sequence selective triple helices with double stranded RNA at physiologically relevant conditions. The M-modified PNA displayed unique RNA selectivity by having two orders of magnitude higher affinity for the double stranded RNAs than for the same DNA sequences. Preliminary results suggested that nucleobase-modified PNA could bind and recognize double helical precursors of microRNAs.

Abstract: A method for modifying a surface of a powder is provided. The method includes steps of providing a polar aprotic solvent; and mixing the polar aprotic solvent with the powder so that the polar aprotic solvent adheres to the surface of the powder.

Abstract: Implementations and techniques for coupled asymmetric quantum confinement structures are generally disclosed.

Abstract: Methods and materials for producing organic syringomycin, the methods include culturing a culture of Pseudomonas syringae and a growth medium including glucose, mannitol, histidine, a magnesium source, an iron source, and a buffer with a pH of from about 6.5 to 7; extracting syringomycin from the culture to yield an extract; and purifying the extract to yield syringomycin.

Abstract: Nucleases and methods of using these nucleases for alteration of a CFTR gene and generation of cells and animal models.

Abstract: Provided is a cassette for deleting a target gene comprising (a) a promoter-specific homologous region having a sequence identity to a portion of a promoter region of the target gene, wherein the degree of sequence identity is sufficient to drive homologous recombination therebetween, (b) a marker gene operably linked to the promoter-specific homologous region, and (c) a gene-specific homologous region adjacent to 3?-end of the marker gene and having a sequence identity to at least a portion of the target gene, wherein the degree of sequence identity is sufficient to drive homologous recombination therebetween.

Abstract: Provided herein are reagents for improving PCR accuracy.

Abstract: Diagnostic methods relating to a cardiac ventricular dysfunction are provided. In some embodiments, the diagnostic method is a method of diagnosing diastolic dysfunction in the absence of systolic dysfunction in a subject. The method comprises assaying a sample obtained from the subject for evidence of activation of renin-angiontensin system (RAS), evidence of oxidative stress, a level of adiponectin, or a combination thereof, wherein, when there is a lack of evidence of RAS activation, a lack of evidence of oxidative stress, a reduction in the level of adiponectin, or a combination thereof, as compared to a control subject, the subject is diagnosed with diastolic dysfunction in the absence of systolic dysfunction. Also provided are methods of diagnosing a type of cardiac ventricular dysfunction, methods of determining a therapeutic regimen for a subject suffering from a cardiac ventricular dysfunction, and methods of treating diastolic dysfunction in the absence of systolic dysfunction.

Abstract: In an apparatus for providing a multimedia streaming service, a server transmits a Media Presentation Description (MPD) including information about media data to a client, receives a partial request message requesting a part of media data having a range according to a defined range in the MPD, and transmits to the client a segment having the range in response to the partial request message. The segment includes at least one fragment, segment index information indicating the position of the at least one fragment in the segment, and fragment index information including information indicating the position of each of a plurality of samples included in the at least one fragment and information about a total size of the samples.

Abstract: Provided are a magneto resistive effect element with a stable magnetization direction perpendicular to a film plane and with a controlled magnetoresistance ratio, and a magnetic memory using the magneto resistive effect element. Ferromagnetic layers 106 and 107 of the magneto resistive effect element are formed from a ferromagnetic material containing at least one type of 3d transition metal such that the magnetoresistance ratio is controlled, and the film thickness of the ferromagnetic layers is controlled on an atomic layer level such that the magnetization direction is changed from a direction in the film plane to a direction perpendicular to the film plane.

Abstract: In one aspect, methods of imaging are described herein. In some embodiments, a method of imaging described herein comprises disposing a population of ultrasound-switchable fluorophores in a biological environment, the fluorophores having a switching threshold between an off state and an on state; exposing the biological environment to an ultrasound beam to create an activation region within the biological environment; switching at least one of the fluorophores within the activation region from the off state to the on state; exciting the at least one fluorophore with a beam of electromagnetic radiation; and detecting light emitted by the fluorophore. In some embodiments, the activation region has a maximum negative pressure and/or maximum temperature and the switching threshold of the at least one fluorophore is at least about 50 percent of the maximum negative pressure or at least about 50 percent of the maximum temperature of the activation region.

Abstract: A suspension system for a train vehicle includes at least one inerter to minimize track wear. Track wear may be measured by direct measures such as wear work, or indirect measures such as yaw stiffness. “Minimizing” track wear means that such measures are reduced below values which are achievable with conventional technology while maintaining acceptable values of other performance metrics, such as ride comfort or least damping ratio. The suspension system may comprise at least one damper connected in series with the at least one inerter. The suspension system may be the primary or the secondary suspension system of a train vehicle.

Abstract: The present invention discloses a method for uplink multi-user cooperation communication, which is applied in a system at least including a first source node, a second source node and a target node, wherein there is a direct transmission link between either the first or the second source node and the target node.

Abstract: Blood flow rates can be calculated using diffuse speckle contrast analysis in spatial and time domains. In the spatial domain analysis, a multi-pixel image sensor can be used to detect a spatial distribution of speckles in a sample caused by diffusion of light from a coherent light source that is blurred due to the movement of scatterers within the sample (e.g., red blood cells moving within a tissue sample). Statistical analysis of the spatial distribution can be used to calculate blood flow. In the time domain analysis, a slow counter can be used to obtain time-series fluctuations in light intensity in a sample caused by diffusion of light in the sample that is smoothened due to the movement of scatterers. Statistical analysis of the time-series data can be used to calculate blood flow.

Abstract: Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-targeted diagnostic and therapeutic constructs for use in tumor intervention. Antibody-therapeutic agent conjugates and constructs that bind to aminophospholipids are particularly provided, as are methods of specifically delivering therapeutic agents, including toxins and coagulants, to the stably-expressed aminophospholipids of tumor blood vessels, thereby inducing thrombosis, necrosis and tumor regression.

Abstract: A first device comprising a first organic light emitting device (OLED) is described. The first OLED includes an anode, a cathode, and an emissive layer disposed between the anode and the cathode. The emissive layer includes a phosphorescent emissive dopant and a host material. The host material includes inorganic nanocrystals where (i) at least 50% of ligands bonded to said nanocrystals are compact ligands, (ii) an average interparticle distance between adjacent nanoparticles is ?1 nm, or (iii) both. Also described are a method of making the emissive layer and a composition that includes the phosphorescent emissive dopant with the host materials that include the electronically-coupled inorganic nanocrystal host material.

Abstract: A fast device discovery protocol with a high success rate for device-to-device (D2D) communication in LTE-A networks is proposed. With the proposed protocol, device discovery is done by monitoring a randomly transmitted beacon from other devices within a pre-defined period. In one embodiment, an eNB receives scheduling requests from D2D UEs and in response allocates a distributed uplink resource for random access of beacon transmission by the D2D UEs. The distributed resource is dynamically allocated based on the number of requesting D2D UEs, a discovery period, and a target discovery probability to minimize the required resource.