Abstract: The present invention provides a slit-scan multi-wavelength confocal lens module, utilizing at least two lenses having chromatic aberration for splitting a broadband light into continuously linear spectral lights having different focal length respectively. The present invention utilizes the confocal lens module employing slit-scan confocal principle and chromatic dispersion techniques and the confocal microscopy with optical sectioning ability and high resolution in spectral dispersion to establish a confocal microscopy method and system with long DOF and high resolution, capable of modulating a broadband light to produce the axial chromatic dispersion and focus on different depths toward an object's surface for obtaining the reflected light spectrum from the surface.

Abstract: A fluid communication device is configured to provide fluid flow between first and second chambers separated by tissue. The fluid communication device includes a member configured for insertion through and engagement of the tissue. The member includes a first opening near a first end of the member for fluidic communication with the first chamber and a second opening near a second end of the member for fluidic communication with the second chamber, the fluid member including a fluid passage that provides fluidic communication between the first and second chambers. The fluid communication device is configured to be positioned with the eye to provide fluid communication between an anterior chamber of the eye and Schlemm's canal.

Abstract: A large volume preconcentrator device for concentrating analytes. A housing accepts an analyte vapor flow, and a plurality of collection surfaces are disposed within the housing. A selectively actuatable heater is disposed on each of the plurality of collection surfaces. At least one selectively actuatable damper is disposed within the housing for selectively restricting a collection flow.

Abstract: A novel structural class of highly N-methylated linear lipopeptide compounds useful for the treatment of parasitic disease.

Abstract: In one aspect, the invention relates to indole compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A Graphene Flash Memory (GFM) device is disclosed. In general, the GFM device includes a number of memory cells, where each memory cell includes a graphene channel, a graphene storage layer, and a graphene electrode. In one embodiment, by using a graphene channel, graphene storage layer, and graphene electrode, the memory cells of the GFM device are enabled to be scaled down much more than memory cells of a conventional flash memory device. More specifically, in one embodiment, the GFM device has a feature size less than 25 nanometers, less than or equal to 20 nanometers, less than or equal to 15 nanometers, less than or equal to 10 nanometers, or less than or equal to 5 nanometers.

Abstract: Methods and systems for predicting statistically probable systematically assigned identifiers are disclosed, as are methods and systems for determining the likelihood that a systematically assigned identifier provided by a purported assignee of the identifier is legitimate. In one example, determining the likelihood of legitimacy includes determining the likelihood that the provided identifier is a valid identifier and determining the likelihood that the provided identifier was assigned to the purported assignee. To accomplish this validation, the present disclosure employs patterns of assignment discernable for systematically assigned identifiers in combination with statistical methods.

Abstract: The present invention involves a sparse matrix processing system and method which uses sparse matrices that are compressed to reduce memory traffic and improve performance of computations using sparse matrices.

Abstract: Described are compositions and methods useful for modulating the immune system of a subject. Also included are diagnostic methods for monitoring an immunologic condition. In particular the invention relates to antagonists of interferon proteins and associated methods of use as well as methods to develop neutralizing antibodies against IFN antagonists to treat viral infections.

Abstract: The present invention provides a method of delivering RNA interference molecules to a cell or a cell in a subject, which comprises contacting the cell with a protein-double stranded RNA complex, the complex comprising the double stranded RNA segment containing a double stranded RNA of interest and a protein, the protein comprising (1) a targeting moiety, which will specifically bind to a site on a target cell, and (2) a binding moiety linked thereto, which will bind to the double stranded RNA, wherein the double stranded RNA segment is delivered to a cell and effects RNA interference of the target RNA in the cell.

Abstract: Synchronous CDMA/spread spectrum methods, devices, and systems are used to suppress crosstalk in clock-forwarded on-chip interconnects. Transmitting a spread spectrum signal across on-chip interconnects for recovery at the terminus permit integrated chip designers to overcome the effects of capacitive cross-talk between adjacent data bus lines. The methods, devices, and systems provided herein improve cross-talk immunity between adjacent high speed signal lines by applying synchronous CDMA spread spectrum techniques to some or all of the high speed signal lines. Other methods, devices, and systems provided herein apply synchronous CDMA spread spectrum techniques to the concept of sending phantom signals to reduce the number of signal lines used to carry data.

Abstract: Apparatus and methods are disclosed for generating and outputting physiological event results from physiological data related to a patient. Physiological event results include results predicting and/or detecting individual physiological events related to a medical condition of the patient.

Abstract: A method for promoting proliferation and/or migration of skin cells includes providing a composition containing a compound of formula (I) below; and administrating to the skin cells the composition.

Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-acrylate) that is crosslinked by at least one hydrolysable monomer or crosslinking agent. The present invention is also directed to a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent (the crosslinking agent may be absent in the case of non-crosslinked particles). The present invention is still further directed to a polymer particle comprising a crosslinked copolymer, where the crosslinked copolymer includes structures represented by Formulas (I), (II), and (III), as defined in the specification. Other embodiments of the present invention also include methods of manufacturing polymer particles.

Abstract: Therapeutic agents which target heat shock protein (hsp) 27 in vivo are used to provide treatment to individuals, particularly human individuals, suffering from prostate cancer and other cancers that overexpress hsp27. A therapeutic agent, for example an antisense oligonucleotide or RNAi nucleotide inhibitor with sequence specificity for hsp27 mRNA, for example human hsp27 mRNA, is administered to an individual suffering from prostate cancer or some other cancer expressing elevated levels of hsp 27 in a therapeutically effective amount. The therapeutic agent is suitably formulated into a pharmaceutical composition which includes a pharmaceutically acceptable carrier, and packaged in dosage unit form. A preferred dosage unit form is an injectable dosage unit form.

Abstract: A method of forming a nanowire structure is disclosed. The method comprises applying on a surface of carrier liquid a layer of a liquid composition which comprises a surfactant and a plurality of nanostructures each having a core and a shell, and heating at least one of the carrier liquid and the liquid composition to a temperature selected such that the nanostructures are segregated from the surfactant and assemble into a nanowire structure on the surface.

Abstract: The present invention provides methods of treating humans and animals with terpenes and terpenoids in order to rejuvenate the skin and increase the protective layer against irradiation by ultraviolet radiation (UVR). More specifically it provides terpenes and terpenoids as ingredients that work as persistent UVR blockers. Terpenes and terpenoid compounds support the growth of skin, skin tissue and keratinocytes and additional UVR-blocking by reason of increased stratum corneum thickness and loricrin content. Both terpenes and terpenoids may be applied topically or orally at oral or topical concentrations from about 6 mg to about 600 mg per kilogram of body weight per day effective to stimulate growth of the skin layer and prevent damage from ultraviolet radiation (UVR).

Abstract: A method and apparatus for classifying possibly malignant lesions from sets of DCE-MRI images includes receiving a set of MRI slice images obtained at respectively different times, where each slice image includes voxels representative of at least one region of interest (ROI). The images are processed to determine the boundaries of the ROIs and the voxels within the identified boundaries in corresponding regions of the images from each time period are processed to extract kinetic texture features. The kinetic texture features are then used in a classification process which classifies the ROIs as malignant or benign. The malignant lesions are further classified to separate TN lesions from non-TN lesions.

Abstract: A method and system to “pump” radiation therapy (RT) images and associated patient information on an Image Guided Radiation Therapy (IGRT) system to a Record and Verify (R&V) system via a standard DICOM connection to allow remote image viewing. Targeted image files in IGRT systems are searched for and transferred automatically. The user identifies the “inlet,” i.e. the source from which the image files are searched, and the “outlet,” i.e., the DICOM server to which the “pumped” imaged are directed. The images can be sent in their original form or fused. The “input” source is scanned periodically at a user-determined time interval. In order not to send the same image multiple time, a time filter skips images generated before a user-selected time and date.

Abstract: This invention relates to a new and distinct June-bearing (short day responsive) strawberry plant named ‘Walker’ primarily adapted to the growing conditions of the west central New York and other regions of similar climate. The new plant is primarily characterized by longer than broad fruit, conical fruit shape, uniformity in shape between primary and secondary fruit, reflexed calyx, dark red-purple fruit color and glossy fruit skin.