Abstract: Auxetic fabric structures, of the sort which can be useful in conjunction with composite materials, and related methods of fabrication.

Abstract: Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.

Abstract: Provided herein are methods for quantitating glutamate carboxypeptidase II activity in a biological sample, such as a skin biopsy sample, and for determining whether an agent is inhibiting GCP in a subject.

Abstract: The present invention provides a slit-scan multi-wavelength confocal lens module, utilizing at least two lenses having chromatic aberration for splitting a broadband light into continuously linear spectral lights having different focal length respectively. The present invention utilizes the confocal lens module employing slit-scan confocal principle and chromatic dispersion techniques and the confocal microscopy with optical sectioning ability and high resolution in spectral dispersion to establish a confocal microscopy method and system with long DOF and high resolution, capable of modulating a broadband light to produce the axial chromatic dispersion and focus on different depths toward an object's surface for obtaining the reflected light spectrum from the surface.

Abstract: A fluid communication device is configured to provide fluid flow between first and second chambers separated by tissue. The fluid communication device includes a member configured for insertion through and engagement of the tissue. The member includes a first opening near a first end of the member for fluidic communication with the first chamber and a second opening near a second end of the member for fluidic communication with the second chamber, the fluid member including a fluid passage that provides fluidic communication between the first and second chambers. The fluid communication device is configured to be positioned with the eye to provide fluid communication between an anterior chamber of the eye and Schlemm's canal.

Abstract: A large volume preconcentrator device for concentrating analytes. A housing accepts an analyte vapor flow, and a plurality of collection surfaces are disposed within the housing. A selectively actuatable heater is disposed on each of the plurality of collection surfaces. At least one selectively actuatable damper is disposed within the housing for selectively restricting a collection flow.

Abstract: A novel structural class of highly N-methylated linear lipopeptide compounds useful for the treatment of parasitic disease.

Abstract: In one aspect, the invention relates to indole compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A Graphene Flash Memory (GFM) device is disclosed. In general, the GFM device includes a number of memory cells, where each memory cell includes a graphene channel, a graphene storage layer, and a graphene electrode. In one embodiment, by using a graphene channel, graphene storage layer, and graphene electrode, the memory cells of the GFM device are enabled to be scaled down much more than memory cells of a conventional flash memory device. More specifically, in one embodiment, the GFM device has a feature size less than 25 nanometers, less than or equal to 20 nanometers, less than or equal to 15 nanometers, less than or equal to 10 nanometers, or less than or equal to 5 nanometers.

Abstract: Methods and systems for predicting statistically probable systematically assigned identifiers are disclosed, as are methods and systems for determining the likelihood that a systematically assigned identifier provided by a purported assignee of the identifier is legitimate. In one example, determining the likelihood of legitimacy includes determining the likelihood that the provided identifier is a valid identifier and determining the likelihood that the provided identifier was assigned to the purported assignee. To accomplish this validation, the present disclosure employs patterns of assignment discernable for systematically assigned identifiers in combination with statistical methods.

Abstract: The present invention relates to a method for preparing composites of substrate-molecular sieve, in particular, to a method for preparing a composite of substrate-molecular sieve, which comprises applying a physical pressure to molecular sieve crystals against a substrate to form a chemical bond between the molecular sieve crystal and the substrate. The present invention requiring no solvents, reactors and other equipments enables molecular sieve crystals to be stably attached to the surface of substrates through various chemical bonds, particularly ionic present invention ensures the synthesis of substrate-molecular sieve composites with enhanced attachment rate, degree of lateral close packing (DCP) and attachment strength in more time-saving and energy-saving manners. The present method works well for molecular sieve crystals with lager sizes (e.g., more than 3 ?m) with no generation of parasitic crystals.

Abstract: A method for fabricating a III-nitride based semiconductor device, including (a) growing one or more buffer layers on or above a semi-polar or non-polar GaN substrate, wherein the buffer layers are semi-polar or non-polar III-nitride buffer layers; and (b) doping the buffer layers so that a number of crystal defects in III-nitride device layers formed on or above the doped buffer layers is not higher than a number of crystal defects in III-nitride device layers formed on or above one or more undoped buffer layers. The doping can reduce or prevent formation of misfit dislocation lines and additional threading dislocations. The thickness and/or composition of the buffer layers can be such that the buffer layers have a thickness near or greater than their critical thickness for relaxation. In addition, one or more (AlInGaN) or III-nitride device layers can be formed on or above the buffer layers.

Abstract: Disclosed herein is a device that functions as a glucose sensor. The device has a reference electrode; a counter electrode, a working electrode; an electrically conducting membrane; an enzyme layer; a semi-permeable membrane; a first layer of a first hydrogel in operative communication with the working electrode; the first layer of the first hydrogel being operative to store oxygen; wherein the amount of stored oxygen is proportional to the number of freeze-thaw cycles that the hydrogel is subjected to; and a second layer of the second hydrogel. Disclosed too is a method that comprises using periodically biased amperometry towards interrogation of implantable glucose sensors to improve both sensor's sensitivity and linearity while at the same time enable internal calibration against sensor drifts that originate from changes in either electrode activity or membrane permeability as a result of fouling, calcification and/or fibrosis.

Abstract: The present invention relates to methods for treating cell proliferation disorders comprising (1) administering to the subject at least one activatable pharmaceutical agent that is capable of activation by a simultaneous two photon absorption event and of effecting a predetermined cellular change when activated, (2) administering at least one plasmonics-active agent to the subject, and (3) applying an initiation energy from an initiation energy source to the subject, wherein the plasmonics-active agent enhances or modifies the applied initiation energy, such that the enhanced or modified initiation energy activates the activatable pharmaceutical agent by the simultaneous two photon absorption event in situ, thus causing the predetermined cellular change to occur, wherein said predetermined cellular change treats the cell proliferation related disorder, and the use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation

Abstract: The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular cancer or predisposition to cancer.

Abstract: A coupling device which is configured such that respective explosives for blasting work are coupled to front and rear sections thereof. The coupling device includes cylindrical bodies, one of the bodies being movable away from or close to another one of the bodies, a partition provided inside a predetermined one of the bodies to divide an inner space of the predetermined body, and an expandable support section provided between the bodies to connect the bodies to each other. The expandable support section forms a cylindrical shape together with the bodies when one body is moved away from the other body and is radially expanded when one body is moved close to the other body. The explosives can be easily inserted into a blasting hole and be positioned in the center of the blasting hole, thereby increasing the efficiency of blasting work.

Abstract: The invention provides inhibitors of ghrelin O-acyltransferase, and methods of making and using them. In some embodiments, the invention provides bisubstrate analog inhibitors of ghrelin O-acyltransferase, which can be effective in treating, for example, obesity and diabetes mellitus.

Abstract: Disclosed are (1) a method of preparing a polyimide membrane, including cross-linking polyimides via thermal labile side chains and decomposition of the thermal labile side chains; and (2) polyimide membranes thus prepared.

Abstract: Subject matter disclosed herein relates to a series of palladium based materials, their preparation method and their applications in an organic light-emitting diode (OLED).

Abstract: This invention relates to a new and distinct June-bearing (short day responsive) strawberry plant named ‘Walker’ primarily adapted to the growing conditions of the west central New York and other regions of similar climate. The new plant is primarily characterized by longer than broad fruit, conical fruit shape, uniformity in shape between primary and secondary fruit, reflexed calyx, dark red-purple fruit color and glossy fruit skin.