Abstract: A microscope apparatus is disclosed. The microscope apparatus comprises a microscope module and an image capture device. The microscope module comprises a housing, a lens element, a sampling assembly, and a light guide element. The lens element is mounted on the housing. The sampling assembly is accommodated in the housing. The light guide element is mounted in the sampling assembly. The sampling assembly is configured to sample a specimen and comprises a cover body and a base body received in the cover body. The cover body has a first top plate and a first anchoring structure connected to the top plate. The base body has a second opt plate and a second anchoring structure connected to the second top plate. The second top plate faces the first top plate to define a holding space for the specimen.
Type:
Application
Filed:
December 16, 2013
Publication date:
June 19, 2014
Applicant:
National Taiwan University
Inventors:
Andrew Man Chung Wo, Cheng-Ming Lin, Shu-Sheng Lin, Chang-Yu Chen, Tsun-Chao Chiang
Abstract: The present invention provides methods of detecting a nucleic acid analyte in a sample. The methods generally involve modifying immobilized nucleic acids from a sample onto an insoluble support in a substantially elongated configuration, where modification generates an identifying feature that identifies the analyte; and detecting the identifying feature(s) using scanning probe microscopy, to detect the analyte. The present invention further provides a method for assigning a profile of a feature to a nucleic acid. The present invention further provides a computer program product for use in a subject method. The present invention further provides a system for detecting a nucleic acid in a sample; and a system for assigning a profile of a feature to a nucleic acid. The present invention further provides a method for immobilizing a nucleic acid onto an insoluble support; and further provides insoluble support having nucleic acid(s) immobilized thereon.
Type:
Application
Filed:
September 24, 2013
Publication date:
June 19, 2014
Applicants:
New York University, The Regents of the University of California
Inventors:
James K. Gimzewski, Bhubaneswar Mishra, Jason C. Reed
Abstract: The present invention provides a recombinant polypeptide comprising a first portion and a second portion, wherein the sequence of the first portion is fully identical to amino acids 1 to 248 of the sequence set forth as SEQ ID NO:1 and the sequence of the second portion is other than amino acids 249 to 511 of the sequence set forth as SEQ ID NO:1.
Type:
Application
Filed:
December 12, 2013
Publication date:
June 19, 2014
Applicant:
The Research Foundation for The State University of New York
Inventors:
Natasha M. NESBITT, Roger A. JOHNSON, Elizabeth M. BOON
Abstract: This invention describes the structure and the fabrication method of a flexible memory. The flexible memory includes eight layers. The three function layers are a flexible layer of hall unit, a flexible layer of horizontal lines, and a flexible layer of vertical lines. The main fabrication process of the flexible memory includes the following: the function layers are made on the hard substrates by the traditional nano-micro methods, and then the function layers are transferred on the flexible substrates, finally the whole layers are packaged to form the flexible memory.
Abstract: As described below, the present invention features compositions and methods for treating or preventing lung disease (e.g., chronic obstructive pulmonary disease (COPD), emphysema, and other conditions associated with cigarette smoke exposure) are urgently required.
Abstract: The present invention relates to techniques for lowering friction between moving surfaces of, for example, an internal combustion engine. Friction reduction is achieved by adding texture modifications to surfaces that come in contact with each other. Texture modifications that reduce friction in accordance with the present invention include dimples of varying geometries and depths ion the surfaces of components. The present invention also relates to the fabrication technique for applying the textures to the surfaces. In another embodiment, the patterned soft mask is applied onto a large surface (flat or curved including cylindrical rollers surfaces) to be followed by electrochemical etching to imprint the textures onto the component. And, in another embodiment, a diamond-like-carbon (DLC) film may be applied to the turbine component to also reduce friction.
Type:
Application
Filed:
February 21, 2012
Publication date:
June 19, 2014
Applicant:
The George Washington University
Inventors:
Stephen M. Hsu, Yang Jing, Yufei Mo, Dongyun Hua, Ming Chen
Abstract: Systems, constructs, and methods for reprogramming cells are provided. In one aspect, for example, a transformation construct for generating iPS cells can include an expression vector having a plurality of reprogramming factors, each reprogramming factor being under control of a separate promoter.
Type:
Application
Filed:
August 23, 2013
Publication date:
June 19, 2014
Applicant:
University of Utah Research Foundation
Inventors:
Stefan M. Pulst, Sharan Paul, Warunee Dansithong
Abstract: The present invention discloses a DAC circuit and a weight error estimation/calibration method thereof. In the method, an output switching circuit dynamically selects several conversion cells (at least containing know weight conversion cells (KWCC)) as a reference conversion cell group (RCCG) from all conversion cells, and dynamically selects at least one unknown weight conversion cell (UWCC) from all UWCCs. An ADC digitalizes the difference of the output of RCCG and the sum of the outputs of the UWCCs, and inputs the result to a digital controller. The digital controller controls the input of the RCCG according to the output of the ADC to make the output of the RCCG approximate the output of the UWCC. The digital controller uses the outputs of the ADC to work out the actual weights of the UWCCs and stores the actual weights in a calibration memory.
Abstract: Apparatus, methods, and other embodiments associated with nuclear magnetic resonance (NMR) fingerprinting using echo splitting are described. One example apparatus includes an NMR logic configured to repetitively and variably sample a (k, t, E) space associated with an object to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include the number of echo splitting pulses, spacings between echo splitting pulses, flip angle of echo splitting pulses, echo time, RF amplitude, and other parameters. The NMR apparatus may also include a signal logic configured to produce an NMR signal evolution from the NMR signals, and a characterization logic configured to characterize a resonant species in the object as a result of comparing acquired signals to reference signals.
Type:
Application
Filed:
September 12, 2013
Publication date:
June 19, 2014
Applicant:
Case Western Reserve University
Inventors:
Renate Jerecic, Mark Griswold, Yun Jiang, Dan Ma
Abstract: The invention provides a method to prevent, inhibit or treat one or more neurological symptoms associated with a lysosomal storage disease in a mammal in need thereof, which includes intranasally administering to the mammal a composition comprising an effective amount of a lysosomal storage enzyme or a recombinant adeno-associated virus vector comprising an open reading frame encoding a lysosomal storage enzyme. Also provided are compositions and devices useful in the methods.
Type:
Application
Filed:
December 11, 2013
Publication date:
June 19, 2014
Applicants:
HealthPartners Research & Education, Regents of the University of Minnesota
Inventors:
Daniel A. Wolf, William H. Frey, II, R. Scott McIvor, Leah R. Hanson
Abstract: Small organic molecule semi-conducting chromophores containing a pyridalthiadiazole, pyridaloxadiazole, or pyridaltriazole core structure are disclosed. Such compounds can be used in organic heterojunction devices, such as organic small molecule solar cells and transistors.
Type:
Application
Filed:
November 22, 2011
Publication date:
June 19, 2014
Applicant:
The Regents of the University of California
Inventors:
Gregory C. Welch, Corey V. Hoven, Thuc-Quyen Nguyen, Guillermo B. Bazan
Abstract: A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.
Type:
Application
Filed:
August 30, 2013
Publication date:
June 19, 2014
Applicant:
The Ohio State University Research Foundation
Inventors:
Periannan Kuppusamy, Ramasamy P. Pandian, Narasimham L. Parinandi, Jay L. Zweier
Abstract: A method and apparatus for managing a memory in a portable terminal including a main memory, a secondary memory, and a plurality virtual machines allocated by partitioning the main memory are provided. The method includes generating, by the virtual machines, monitoring information by monitoring access to the main memory and the secondary memory and swapping out with respect to the secondary memory; determining memory allocation amounts for each of the virtual machines by using the monitoring information; and allocating the main memory to the virtual machines in a partitioning scheme based on the determined memory allocation amounts.
Type:
Application
Filed:
February 25, 2013
Publication date:
June 19, 2014
Applicants:
Sungkyunkwan University Foundation for Corporate Collaboration, Samsung Electronics Co., Ltd.
Inventors:
Changwoo MIN, Inhyeok KIM, Taehyoung KIM, Young Ik EOM
Abstract: Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Also provided are bioresorbable nanoparticles prepared without the use of organic solvents, and methods for therapeutically using such bioresorbable nanoparticles.
Type:
Application
Filed:
September 30, 2013
Publication date:
June 19, 2014
Applicants:
Drexel University, The Children's Hospital of Philadelphia
Inventors:
Robert J. Levy, Boris Polyak, Michael Chorny, Ilia Fishbein, Ivan Alferiev, Gennady Friedman, Darryl Williams
Abstract: This invention is in the field of road construction as it relates to improving the quality and lifetime of asphalt roads and pavement surfaces. The invention relates to methods and compositions utilizing co-polymers in combination with soil to form improved subgrade soil binder compositions for supporting asphalt roads and pavement surfaces.
Type:
Application
Filed:
December 10, 2013
Publication date:
June 19, 2014
Applicant:
The Texas A&M University System
Inventors:
Howard J.M. Hanley, Eyad A. Masad, Srinath R. Iyengar, Ana K. Rodriguez, Hassan S. Bazi
Abstract: The present disclosure provides modified bacteria and modified peptidoglycan comprising modified D-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using the modified bacteria or peptidoglycan. The modified D-amino acids include a bioorthogonal functional group such as an azide, an alkyne or a norbornene group. Also provided are modified peptidoglycans conjugated to a molecule of interest via a linker.
Type:
Application
Filed:
November 27, 2013
Publication date:
June 19, 2014
Applicant:
The Regents of the University of California
Inventors:
Carolyn R. Bertozzi, Mary Sloan Siegrist Palmore, John C. Jewett, Chelsea G. Gordon, Peyton Shieh
Abstract: Disclosed herein are isolated polypeptides, antibody preparations, treatment methods, diagnostic methods, and screening methods related to tauopathy. Generally, the isolated polypeptide includes a core pentapeptide, with the proviso that the isolated polypeptide is not a native full-length tau protein. Generally, the antibody preparations include antibody that specifically binds to SEQ ID NO:12. Generally, the treatment methods include administering to a subject a composition that includes the isolated polypeptide. Generally, the diagnostic methods includes contacting a sample from a subject with an antibody preparation that includes antibody that specifically binds to SEQ ID NO:12, and then detecting a ligand in the sample that specifically binds the antibody preparation.
Type:
Application
Filed:
December 18, 2013
Publication date:
June 19, 2014
Applicant:
Regents of the University of Minnesota
Inventors:
Karen Hsiao Ashe, Xiaohui Zhao, Michael Anthony Walters, Derek John Hook, Morgan Clotaire Paul Le Naour
Abstract: Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.
Type:
Application
Filed:
December 19, 2012
Publication date:
June 19, 2014
Applicant:
Board of Regents, The University of Texas System
Inventors:
Taner Akkin, Thomas E. Milner, Digant P. Dave, H. Grady Rylander, III
Abstract: A system and method used to configure a smart device to command functional operations of a target appliance. The smart device retrieves from a controllable appliance, such as a settop box, data indicative of a codeset identity of the target appliance wherein the codeset identity was determined during a process used to configure a conventional universal remote control to command functional operations of the target appliance and wherein the process used to configure the conventional universal remote control is performed in cooperation with the controllable appliance. A remote control application resident on the smart device then uses the data indicative of the codeset identity retrieved from the controllable appliance to also configure the smart device to command functional operations of the target appliance.
Abstract: A method for color correction of a pair of colorful stereo microscope images is provided, which transmits the color information of the foreground areas and the background area of the reference image to the aberrated image separately for avoiding transmission error of the color information of the varied areas of the pair of the images, thus sufficiently improves the accuracy of the color correction, reduces the difference between the color of the reference image and the color of the aberrated image, and well prepares for the stereo matching of the pair of colorful stereo microscope images as well as for the three-dimensional reconstruction and three-dimensional measurement; on the other hand, during the correction, the correcting procedure is provided automatically without manual work.
Type:
Application
Filed:
September 18, 2013
Publication date:
June 19, 2014
Applicant:
Ningbo University
Inventors:
Gangyi Jiang, Xiangjun Liu, Mei Yu, Feng Shao, Zongju Peng, Yigang Wang