Abstract: Highly selective 5-HT(2C) receptor agonists receptors are disclosed. The 5-HT(2C) receptor agonists are used in the treatments of disease and conditions wherein modulation of 5-HT(2C) receptors provides a benefit, such as obesity and psychiatric disorders.

Abstract: The invention relates to molecules for treatment and diagnosis of tumors and malignancies, comprising a tumor seeking biomolecule, which is coupled to an intercalating moiety, which is capable of complexing a metal, which metal is preferably a radioactive metal, to the use of these molecules and to therapeutic and diagnostic compositions containing them.

Abstract: Disclosed are processes of forming a compound (33), (35) or (37)

Abstract: A radiation sensor including a scintillation layer configured to emit photons upon interaction with ionizing radiation and a photodetector including in order a first electrode, a photosensitive layer, and a photon-transmissive second electrode disposed in proximity to the scintillation layer. The photosensitive layer is configured to generate electron-hole pairs upon interaction with a part of the photons. The radiation sensor includes pixel circuitry electrically connected to the first electrode and configured to measure an imaging signal indicative of the electron-hole pairs generated in the photosensitive layer and a planarization layer disposed on the pixel circuitry between the first electrode and the pixel circuitry such that the first electrode is above a plane including the pixel circuitry. A surface of at least one of the first electrode and the second electrode at least partially overlaps the pixel circuitry and has a surface inflection above features of the pixel circuitry.

Abstract: A handover method according to one embodiment of the present invention comprises the steps of receiving the result of a cell measurement for a neighbor cell from a terminal, judging whether the neighbor cell is a near neighbor cell in accordance with the result of the cell measurement, calculating the ratio of the near neighbor cell to the total neighbor cells, and transmitting a command for a handover to a target cell to the terminal if the ratio exceeds the handover threshold value. The handover method of the present invention reduces interference between cells, and efficiently uses radio resources.

Abstract: A bubble removal method is for removing a bubble from liquid whose viscosity is reduced when shear occurs. A vessel, including a liquid inlet and multiple liquid outlets, whose volumetric capacity is variable and a means for giving resistance to the passage of liquid between the inside and the outside of the vessel are used. The liquid is passed through the vessel against resistance and the volumetric capacity of the vessel is increased and reduced. The interior of the vessel is depressurized and pressurized by the means for giving resistance to the passage of liquid in conjunction with increase and reduction in the volumetric capacity of the vessel.

Abstract: The present invention relates to a portable apparatus for warming biocompatible fluids for use in the treatment of injured patients and a method of heating a biocompatible fluid to treat a patient experiencing hypothermia. The present invention may be used to warm intravenous fluids for trauma resuscitation or to warm air from a ventilator circuit. The portable nature of the present invention makes it highly suitable for field applications, such as a forward surgical hospital near a combat zone.

Abstract: The present invention provides isolated peptides with at least two cysteine residues capable of forming one or more disulfide bonds. Pharmaceutical compositions comprising the isolated peptides of the present invention are also provided. The invention also provides methods for inhibiting, preventing or improving the pathological or clinical manifestations of cancer or an inflammatory disease or disorder in a subject, comprising administering a peptide of the invention.

Abstract: Disclosed herein are methods of enhancing repair of vascular lesions involving the administration of cells in which TGF-? expression and/or activity has been transiently blocked. Other methods involve the administration of a TGF-? blocking agent to a subject who has a vascular lesion or is at risk of developing a vascular lesion. Alternatively, a TGF-? blocking agent and treated cells are co-administered to a subject in need thereof.

Abstract: In one aspect, the invention is directed to a method of identifying an individual that has amyotrophic lateral sclerosis (ALS) or is at risk of developing ALS comprising detecting one or more alterations in a profilin 1 (PFN1) sequence of an individual in need thereof compared to a wild type profilin sequence. In another aspect, the invention is directed to a method of identifying an individual that has amyotrophic lateral sclerosis (ALS) or is at risk of developing ALS comprising selectively sequencing a profilin 1 (PFN1) sequence of an individual in need thereof; and detecting one or more alterations in the PFN1 sequence of the individual. If the one or more alterations are detected then the individual has ALS.

Abstract: Disclosed are molecular and polymeric compounds having desirable properties as semiconducting materials. Such compounds can exhibit desirable electronic properties and possess processing advantages including solution-processability and/or good stability. Organic transistor and photovoltaic devices incorporating the present compounds as the active layer exhibit good device performance.

Abstract: Novel polymer compositions which provide controlled end-group functionalization for polythiophenes including regioregular polythiophenes including alkenyl and alkynyl functionalization. Monocapped polymers are formed and can be converted to block copolymers. Conditions and reagents can be selected to provide more monocapping than dicapping of the polymer. Devices, films, and blends can be prepared.

Abstract: The disclosure provides compositions that can be used to make films to increase the efficiency of producing plants and plant parts. The films are designed in part to be environmentally friendly and/or edible. Also provided are methods of using such compositions as well as plants and plant parts comprising such compositions.

Abstract: An object of the present invention is to provide a substance which is able to be an active ingredient for the improvement of dysfunction caused by nerve damage. An improving agent for dysfunction due to nerve damage of the present invention as a means for resolution thereof is characterized in that it comprises an endo-?-N-acetylglucosaminidase type enzyme which hydrolyzes an N-acetylglucosamide bond in a keratan sulfate backbone as an active ingredient. When the improving agent of the present invention is administered, clinical improvement is achieved in motor neuron dysfunction and sensory neuron dysfunction such as neuropathic pain represented by a pain caused by allodynia and hyperalgesic reaction of the object to be treated.

Abstract: Planar lenses and reflectors are described comprising subwavelength high-contrast gratings (HCG) having high index of refraction grating elements spaced apart from one another in straight and/or curved segments and surrounded by low index material. The high-contrast grating is configured to receive an incident wave which excites multiple modes within the high-contrast grating and is focused for reflection and/or transmission by said high contrast grating. The width of the high contrast grating bars vary along a distribution direction of the grating bars which is perpendicular to the length of the grating bars and/or varies along the length of one or more grating bars to focus said reflection and/or transmission. The HCG is configured to provide double focusing, whose use is exemplified within a vertical cavity surface emitting laser (VCSEL) structure using focusing HCG structures for both the top and bottom mirrors.

Abstract: Input bits are stored in memory cells by mapping the input bits into a larger number of transformed bits using a shaping encoding that has a downward asymptotic bias with respect to a mapping of bit patterns to cell states and programming some of the cells according to that mapping of bit patterns to cell states. The programmed cells are erased before being programmed to store any other bits. The invention sacrifices memory capacity to increase endurance.

Abstract: A mouth guard including a top mouth piece for engaging the top teeth and a bottom mouth piece for engaging the bottom teeth. The mouth guard also includes a central section having one or more ports for receiving an endotracheal tube, oral gastric tube, and/or oral suction tube. In a first preferred embodiment, a top portion of the central section is attached to the top mouth piece, and a bottom portion of the central section is attached to the bottom mouth piece. In a second preferred embodiment, the entire central section is attached to the bottom mouth piece. The top and bottom mouth pieces are capable of interlocking via male engaging members and female recesses.

Abstract: [Problems] To provide a means and method for providing a pulverized extracted tooth product without causing the extracted teeth to lose their original properties. To provide a new material, originated from the pulverized extracted tooth product and imbued with new properties suited to the regeneration and the like of the alveolar bone. [Solving means] A method for preparing a pulverized product of extracted tooth, comprising the pulverizing of extracted tooth with a pulverizing apparatus to obtain a pulverized product of an extracted tooth. The pulverizing apparatus comprises a sealable pulverizing chamber and freely rotating pulverizing blade within said pulverizing chamber, and the extracted tooth are pulverized by said pulverizing apparatus together with pieces of physiological saline ice. A method of preparing a demineralized powder originated from an extracted tooth by means of an acid treatment of the pulverized product of extracted tooth obtained by the above method to obtain a demineralized powder.

Abstract: Techniques are generally described related to a composite material with dielectric properties and the preparation method thereof. One example composite material may include a core having a first polymer and an ionic salt and a shell having a second polymer, where the core is electrically conductive and the shell electrically insulates and substantially surrounds the core, wherein the first polymer has a first polarity and the second polymer has a second polarity, and the first polarity is greater than the second polarity.

Abstract: A method for use in forming a molded part includes providing a mold having a cavity and a movable pin, injecting a moldable material into the cavity, biasing the movable pin to maintain an end of the movable pin in contact with the moldable material in the cavity during the curing of the moldable material and until the moldable material is cured, and monitoring movement of the biased movable pin during curing of the moldable material in the mold. Also disclosed is a sensor engageable with an end of a movable pin of a mold for monitoring the forming of a moldable part, and systems employing the same.