Abstract: The present invention discloses a preparation method for an amphiphilic nanosheet. The preparation method comprises the following steps: mixing choline chloride and urea, and heating to prepare a choline chloride-urea based deep eutectic solvent; adding styrene, divinylbenzene and azobisisobutyronitrile into a higher alkane solvent, stirring and dissolving to obtain an oil phase solvent, wherein an addition amount of the divinylbenzene is greater than 5% by mass of a styrene monomer; and adding a hydrophilic monomer, cetyltrimethylammonium chloride and the oil phase solvent into the deep eutectic solvent, stirring and mixing, ventilating and deoxidizing, then heating to 70° C., reacting for at least 6 h, and then crushing and centrifuging to obtain the amphiphilic nanosheet.

Abstract: Disclosed are methods, devices, kits, components, and compositions for detecting a target molecule in a test sample using a cell-free protein synthesis (CFPS) reaction. The methods, devices, kits, components, and compositions may be utilized for detecting target molecules which may include small molecules and/or metabolites of small molecules. The components and compositions used in the disclosed methods, devices, and kits may be dried or lyophilized and may be present or immobilized on a paper substrate, for example, as a paper test article.

Abstract: Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided.

Abstract: A method of preventing cadmium-induced renal toxicity using a plant product derived from Achillea millefolium L. In an embodiment, the plant product is selected from an extract of Achillea millefolium L and an essential oil of Achillea millefolium L.

Abstract: Embodiments of the present disclosure provide methods, apparatus, systems, and computer program products for using an image of an integrated circuit (IC) including a plurality of cells to locate one or more target cells within the IC. Accordingly, in various embodiments, a footprint for each cell of the plurality of cells is encoded to transform the image of the IC into a two-dimensional string matrix. A string search algorithm is then applied on each encoded dopant region found in the two-dimensional string matrix using an encoded target layout cell to identify one or more candidate regions of interest within the image. Finally, a mask window is slid over each candidate region of interest while performing matching using match criteria to identify any target cells in the one or more target cells that are located within the candidate region of interest.

Abstract: Various embodiments disclosed relate to methods of manufacturing textured surfaces nanoimprint lithography with nanoparticulate inks. The present invention provides methods that allow flexible patterning of substrates with features having complex geometries.

Abstract: The invention provides a compound of formula I and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the formula I compounds, as well as methods of using such as therapeutic agents for the treatment of pain-related disorders and diseases and in combination with other therapeutic agents.

Abstract: An smart air duct/vent cover plate for air conditioning and ventilation can be implemented either as a nested three cylinder device which or as a cover frame with a flexible layer perforated with through holes. Either device provides selectivity in terms of the amount of airflow provided to an interior ambient air space. The functionality of both devices can be controlled by a wireless handheld remote control.

Abstract: The invention discloses a preparation method of a carbon nitride (CN) electrode material. The preparation method comprises the following steps: (1) preparing a precursor film: immersing a clean conductive substrate A into a hot saturated CN precursor aqueous solution, then immediately taking out, after the surface being dried, a uniform precursor film layer on the conductive substrate A was formed. This step can be repeated several times to get different layers of precursor film on the substrate A; (2) preparing the CN electrode: the dry precursor film obtained in step (1) was encapsulated in a glass tube filled with N2. Then the glass tube was inserted into a furnace with N2 atmosphere to calcinate. After calcination, the uniform CN film electrode was obtained. The method provided by the invention is simple and easy to implement, and convenient in used equipment, suitable for industrial application and popularization.

Abstract: Energy harvesting devices and methods for converting the mechanical energy of a flowing ionic solution, such as rainwater or seawater, into electric energy are provided. The energy harvesting devices include an electric current generating device that includes a metal layer and an amphoteric metal oxide film disposed over a surface of the metal layer. By moving an electric double layer across the surface of the amphoteric metal oxide film, an electric current is generated in the metal layer.

Abstract: The disclosure provides constructs comprising a first fusion protein, a second fusion protein, and a linker, wherein the first fusion protein and the second fusion protein each include an affinity reagent and a reactive enzyme, and the linker includes a first and second functional groups specific for irreversibly inhibiting the first and second fusion protein reactive enzymes. The disclosure further provides a method including (a) contacting a first fusion protein including an affinity reagent and a reactive enzyme with a linker including a functional group specific for irreversibly inhibiting the first fusion protein reactive enzyme thereby coupling the first fusion protein and the linker, and (b) contacting a second fusion protein including an affinity reagent and a reactive enzyme with the linker, the linker including a functional group specific for irreversibly inhibiting the second fusion protein reactive enzyme thereby coupling the second fusion protein and the linker.

Abstract: The subject disclosure presents systems and computer-implemented methods for assessing a risk of cancer recurrence in a patient based on a holistic integration of large amounts of prognostic information for said patient into a single comparative prognostic dataset. A risk classification system may be trained using the large amounts of information from a cohort of training slides from several patients, along with survival data for said patients. For example, a machine-learning-based binary classifier in the risk classification system may be trained using a set of granular image features computed from a plurality of slides corresponding to several cancer patients whose survival information is known and input into the system. The trained classifier may be used to classify image features from one or more test patients into a low-risk or high-risk group.

Abstract: Disclosed herein is a stellarator comprising two sets of coils, namely a set of encircling coils which encircle the plasma axis, and a set of shaping coils which do not encircle any other coil or the plasma. In some embodiments, the encircling coils include a structural element to maintain their shape under magnetic forces. In some embodiments, the shaping coils are mounted onto one or more structural elements which, together with the shaping coils, constitute a field shaping unit. Also disclosed is a controller which may modify the electrical current flowing in one or more subsets of the coils in order to achieve target plasma parameters. Also disclosed is a method of designing a set of shaping coils by discretizing a surface dipole or current potential distribution.

Abstract: In related-art methods of differentiating pluripotent stem cells into a desired cell type, there has not been established a differentiation induction method using human ES/iPS cells and being highly efficient. Many attempts have been made, including a stepwise differentiation induction method based on the control of culture conditions or the addition of, for example, various cell growth factors/differentiation factors to a culture solution, but the use of complicated culture steps is a big problem. A method of inducing differentiation into a desired cell type within a short period of time and with high efficiency by use of a pluripotent stem cell that actively undergoes cell differentiation, which is obtained by reducing an undifferentiated state of the pluripotent stem cell, has been developed, and thus the present invention has been completed.

Abstract: A three-tandem (3T) perovskite/silicon (PVT)-based tandem solar cell (TSC) includes an antireflection coating (ARC), a first transparent conductive oxide layer (TCO), a hole transport layer (HTL), a perovskite (PVT) layer, a second transparent conductive oxide layer (TCO), an electron transport layer (ETL), a plurality of buried contacts, a p-type Si layer, a p-type wafer-based homo-junction silicon solar cell, a n+ silicon layer, a back contact layer. The solar cell further includes a top sub-cell, a bottom sub-cell and a middle contact-based tandem. The top sub-cell includes the PVT layer. The bottom sub-cell includes the silicon solar cell. The middle contact-based tandem includes the second TCO layer to be used as the middle contact-based tandem, as well as a recombination layer for current collection. Further, a conduction and a valence band edge are employed at a front surface of the ETL.

Abstract: A method of producing a carbon nanotube may include heating a convergent flow nozzle and a flow chamber of a carbon nanotube reactor, flowing a vaporized reactant stream through the nozzle and collecting a carbon nanotube product from an outlet of a heated flow chamber disposed downstream of the heated convergent flow nozzle. The vaporized reactant stream may include a carbon nanotube nucleation carbon source, a carbon nanotube growth carbon source, and a carbon nanotube catalyst precursor. The nozzle may have a nozzle contraction ratio of from 3:1 to 300:1.

Abstract: A method for chemically reducing carbon dioxide (CO2) with a red mud catalyst composition is provided includes introducing a gaseous mixture of CO2 and H2 into a reactor containing particles of the red mud catalyst composition. The method further includes reacting at least a portion of the CO2 and H2 in the gaseous mixture in the presence of the red mud catalyst composition at a temperature of 200 to 800° C., and under a pressure ranging from 5 to 100 bar to form a gaseous product including a chemical reduction product of the CO2. A volume ratio of the CO2 to the H2 in the gaseous mixture is in a range of 1:10 to 10:1.

Abstract: The present disclosure relates to the field of new materials, and aims at providing an A-site high-entropy nanometer metal oxide with high conductivity, and a preparation method thereof. The metal oxide has molecular formula of Gd0.4Er0.3La0.4Nd0.5Y0.4)(Zr0.7, Sn0.8, V0.5)O7 and is a powder, and has microstructure of the metal oxide as a square nanometer sheet with a side length of 4-12 nm and a thickness of 1-3 nm. Compared with an existing high-entropy oxide, the product in the present disclosure has high conductivity, and can be well applied to a conductive alloy, an electrical contact composite material, a conductive composite material, a multifunctional bio-based composite material, a conductive/antistatic composite coating and the like.

Abstract: A probiotic-encapsulating gum Arabic (GA) composite fiber/capsule, including: lactic acid bacteria and an electrospun fiber or electrosprayed capsule, where the lactic acid bacteria are encapsulated in the electrospun fiber or electrosprayed capsule by electro-hydro dynamics (EHD) technology. The electrospun fiber or electrosprayed capsule is prepared by compounding a polymer matrix with GA, and the polymer matrix is polyvinyl alcohol (PVOH), polyvinylpyrrolidone (PVP), whey protein concentrate (WPC) or maltodextrin (MD). A preparation method and an application of the composite fiber/capsule are also provided.

Abstract: Methods and systems for image segmentation and analysis are described. A predictive model may be trained to identify and/or extract a rich set of image features with extensive prognostic value. For example, the predictive model may be trained to identify and/or extract features that that may be visualized to identify areas of interest (e.g., high-risk regions, etc.) within or adjacent to an object of interest, such a tumor. The predictive model may be trained to identify and/or extract features that that may predict a health related outcome, such as cancer patient survival/death, and modify therapeutic outcomes, such as diagnosis and treatment.