Patents Assigned to University
  • Methods for the production of nanoscale heterostructures
    Patent number: 8685841
    Abstract: The present invention is directed to a novel synthetic method for producing nanoscale heterostructures, and particularly nanoscale heterostructure particles, rods and sheets, that comprise a metal core and a monocrystalline semiconductor shell with substantial lattice mismatches between them. More specifically, the invention concerns the use of controlled soft acid-base coordination reactions between molecular complexes and colloidal nanostructures to drive the nanoscale monocrystalline growth of the semiconductor shell with a lattice structure incommensurate with that of the core. The invention also relates to more complex hybrid core-shell structures that exhibit azimuthal and radial nano-tailoring of structures. The invention is additionally directed to the use of such compositions in semiconductor devices.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: April 1, 2014
    Assignee: University of Maryland College Park
    Inventors: Jiatao Zhang, Yun Tang, Min Ouyang
  • Retractor device with oximeter sensor and force sensor
    Patent number: 8688186
    Abstract: A retractor device has an oximeter sensor at its tip, which allows measuring of oxygen saturation of a tissue being retracted by the retractor. The retractor device also has a force sensor which can measure an amount of force that is applied to the retracted tissue by the tip of the retractor device. The tip includes one or more openings for at least one source and detector. A specific implementation is a spinal nerve root retractor with an oximeter sensor and a force sensor.
    Type: Grant
    Filed: January 18, 2010
    Date of Patent: April 1, 2014
    Assignees: ViOptix, Inc., Regents of the University of California
    Inventors: Jimmy Jian-min Mao, Robert E. Lash, Shane Burch
  • Internal dry containment vessel for a nuclear reactor
    Patent number: 8687759
    Abstract: A power module assembly includes a reactor core immersed in a coolant and a reactor vessel housing the coolant and the reactor core. An internal dry containment vessel submerged in liquid substantially surrounds the reactor vessel in a gaseous environment. During an over-pressurization event the reactor vessel is configured to release the coolant into the containment vessel and remove a decay heat of the reactor core through condensation of the coolant on an inner surface of the containment vessel.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: April 1, 2014
    Assignee: The State of Oregon Acting by and Through the State Board of Higher Education on Behalf of Oregon State University
    Inventors: Jose N. Reyes, Jr., John T. Groome
  • Use of aromatase inhibitors for treatment of ectopic pregnancy
    Patent number: 8685950
    Abstract: Following a diagnosis of ectopic pregnancy, at least one aromatase inhibitor, is administered to a patient, either alone or in combination with other aromatase inhibitors or therapeutic agents or as an adjuvant to conservative surgical treatment, such as laparoscopy, to prevent the establishment and/or continuation of the ectopic pregnancy. In certain preferred embodiments, the aromatase inhibitor is administered in conjunction with methotrexate.
    Type: Grant
    Filed: October 4, 2005
    Date of Patent: April 1, 2014
    Assignee: Wayne State University
    Inventors: Mohamed F. M. Mitwally, Michael P. Diamond, Robert F. Casper
  • Method for producing indole derivative
    Patent number: 8685673
    Abstract: The present invention provides a method for in vitro producing an indole derivative in a one-pot reaction. The method for producing a rhamnosylated indolocarbazole compound includes the steps of transforming a plasmid carrying a gene encoding N-glycosyltransferase into a bacterial strain; expressing the gene encoding N-glycosyltransferase in the bacterial strain; lysing the bacterial strain to obtain a crude enzyme extract; and adding TDP-glucose, an indolocarbazole aglycone and a metal ion in the crude enzyme extract for performing an enzymatic reaction to form the rhamnosylated indolocarbazole compound. Alternatively, the method for producing an indole-3-carboxaldehyde analog includes the steps of transforming a plasmid carrying a gene encoding NokA of Nocardiopsis sp.
    Type: Grant
    Filed: August 2, 2010
    Date of Patent: April 1, 2014
    Assignee: National Chiao Tung University
    Inventor: Hsien-Tai Chiu
  • Kit containing stem cells and cytokines for use in attenuating immune responses
    Patent number: 8685728
    Abstract: The present invention relates to a composition and methods of treatment for inflammation comprising of adult stem cells and inflammatory cytokines. The invention further relates to the treatment of inflammation associated with autoimmune disorders, allergies, sepsis, cancer as well as to preventing, reducing or treating transplant rejection and/or graft-versus-host disease (GvHD).
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: April 1, 2014
    Assignee: Rutgers The State University of New Jersey
    Inventors: Yufang Shi, Guangwen Ren, Liying Zhang
  • Drug composition cytotoxic for pancreatic cancer cells
    Patent number: 8685941
    Abstract: Disclosed herein are compositions comprising a drug combination that comprises ZD and S3I-201, Das and S3I-201, ZD and AG490, or Das and AG490. The disclosed drug combinations target two or more functional elements such as EGFR or Src and Stat3 or Jaks in pancreatic cancer cells. Also disclosed herein are methods of using the disclosed compositions to cytotoxically affect pancreatic cancer cells and methods of making the disclosed compositions.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: April 1, 2014
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: James Turkson
  • Controlled release tissue graft combination biomaterials
    Patent number: 8685432
    Abstract: In one aspect, the invention relates to tissue graft combination biomaterials capable of controlled release of bioactive agents or pharmaceutically active agents through a rate-controlling polymer coating encapsulating the graft material, methods for preparing same, methods of controlled release using same, and methods for treating tissue defects. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: March 23, 2009
    Date of Patent: April 1, 2014
    Assignee: University of Utah Research Foundation
    Inventors: Bruce G. Evans, David Christopher Evans, Paul C. Hogrebe, David W. Grainger, Amanda Elaine Brooks
  • Shape memory polymer intraocular lenses
    Patent number: 8685089
    Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: April 1, 2014
    Assignee: The Regents of the University of Colorado
    Inventors: Malik Y. Kahook, Naresh Mandava, Robin Shandas, Bryan Rech
  • Genetic constructs and compositions comprising RRE and CTE and uses thereof
    Patent number: 8685407
    Abstract: Genetic constructs that comprise a coding sequence for HIV-1 Rev, and a coding sequence for a desired protein are disclosed. Compositions that comprise at least two nucleic acid molecules in which at least one nucleic acid molecule comprises a coding sequence for HIV-1 Rev, and at least one nucleic acid molecule comprises a coding sequence for a desired protein are disclosed. In such genetic constructs and compositions comprising nucleic acid molecules, the coding sequence for the desired protein comprises at least a portion of coding sequence for an HIV structural protein that includes an RRE and at least one CTE. Methods of inducing an immune response against an immunogen in an individual, methods of delivering proteins to an individual and methods of producing proteins are also disclosed.
    Type: Grant
    Filed: November 20, 2008
    Date of Patent: April 1, 2014
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David B Weiner, Karuppiah Muthumani
  • Open-and-close controllable odor compound release device and method of manufacture
    Patent number: 8685338
    Abstract: An odor compound release device includes a support that is deformed when an external stimulus is applied, and when the external stimulus is not applied, restored to its original state. A plurality of spaces are located in the support, have upper portions closed by the support, and are to be filled with odor compounds, wherein the upper portions are opened or closed by deformation or restoration of the support due to the application of the external stimulus. A member that is located in the support or on a surface of the support and applies the external stimulus to the support.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: April 1, 2014
    Assignees: Samsung Electronics Co., Ltd., The Rgegents of The University of California
    Inventors: Jong-jin Park, Sung-ho Jin, Kyu-hyun Im, Jong-min Kim
  • Method for selecting sensor nodes
    Patent number: 8687058
    Abstract: The present invention relates to a method for selecting sensor nodes, the method is adopted for calculating the value of a contribution function for a plurality of objects contributed by a plurality of sensor nodes, wherein the contribution function value is calculated by way of determining a coverage level of the objects made by the sensor nodes, or by means of arranging a sub sensor node group capable of sensing covering an object group and calculating the value of the contribution function for the objects contributed by the sensor nodes; Therefore, through the method, the sensor nodes having maximum contribution to the objects can be selected and arranged in a specific environment, and the sensing direction of those sensor nodes can be adjusted for making the sensor node group performs the best efficiency.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: April 1, 2014
    Assignee: National Tsing Hua University
    Inventors: Po-Yu Chen, Yu-Chee Tseng, Wen-Tsuen Chen
  • Spectinamides as anti-tuberculosis agents
    Patent number: 8685978
    Abstract: Novel 3?-deoxy-3?-acylaminospectinomycin compounds are described. Also described are methods of using the 3?-deoxy-3-acylaminospectinomycin compounds and other spectinomycin analogs in treating tuberculosis and in treating microbial infections.
    Type: Grant
    Filed: July 26, 2010
    Date of Patent: April 1, 2014
    Assignee: University of Tennessee Research Foundation
    Inventors: Richard E. Lee, Jianjun Qi, Julian G. Hurdle, Bernd Meibohm, Vnr Pavan Kumar Vaddady, Rakesh, Jiuyu Liu
  • Insulin-like growth factor signaling and integrin
    Patent number: 8685403
    Abstract: Interaction between insulin-like growth factor 1 (IGFI) and integrin is involved in integrin-mediated cellular signaling, such as enhanced proliferation of cells expressing integrins, especially integrin alpha v beta 3, alpha 6 beta. 1 and alpha 6. beta. 4. A method for inhibiting integrin signaling by using an inhibitor of IGFI-integrin binding is disclosed A method for identifying inhibitors of IGFI-integrin binding is also described. Further disclosed are polypeptides, nucleic acids, and corresponding compositions for inhibiting integrin signaling.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: April 1, 2014
    Assignee: The Regents of the University of California
    Inventors: Yoshikazu Takada, Jun Saegusa
  • Voice-controlled clinical information dashboard
    Patent number: 8688459
    Abstract: A method provides a display area of a computer system for displaying a set of data. The data includes clinical data for one or more medical patients. The method provides multiple controls for performing multiple functions. The method provides an audio interface for controlling at least one of the controls through audio commands.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: April 1, 2014
  • Method of analytical placement with weighted-average wirelength model
    Patent number: 8689164
    Abstract: A computer-implemented method to generate a placement for a plurality of instances for an integrated circuit (IC) by utilizing a novel weighted-average (WA) wirelength model, which outperforms a well-known log-sum-exp wirelength model, to approximate the total wirelength. The placement is determined by performing an optimization process on an objective function which includes a wirelength function approximated by the WA wirelength model. The method can be extended to generate a placement for a plurality of instances for a three-dimensional (3D) integrated circuit (IC) which considers the sizes of through-silicon vias (TSVs) and the physical positions for TSV insertion. With the physical positions of TSVs determined during placement, 3D routing can easily be accomplished with better routed wirelength, TSV counts, and total silicon area.
    Type: Grant
    Filed: October 18, 2011
    Date of Patent: April 1, 2014
    Assignee: National Taiwan University
    Inventors: Valeriy Balabanov, Meng-Kai Hsu, Yao-Wen Chang
  • Compositions and methods for cytoprotection
    Patent number: 8685951
    Abstract: The present invention provides compositions and methods for cytoprotection. In particular, it provides zinc chelate compositions comprising at least one zinc ion and at least one aminothiol ligand.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: April 1, 2014
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Alexei G. Basnakian, Richard B. Walker, John R. J. Sorenson deceased, Anne S. Martin
  • Rotavirus antigens
    Patent number: 8685411
    Abstract: The present invention relates to novel recombinant polypeptide antigens that may comprise subunit vaccines against rotavirus infection. Further, the present invention relates to methods for use of said antigens in the diagnosis, treatment and prevention of rotavirus infection.
    Type: Grant
    Filed: January 3, 2007
    Date of Patent: April 1, 2014
    Assignees: Children's Medical Center Corporation, The Board of Trustees of the Leland Stanford Junior University, The United States of America as represented by the National Institutes of Health (NIH), The United States of America as represented by the Dept. of Health and Human Services (DHHS)
    Inventors: Philip R. Dormitzer, Stephen C. Harrison, Harry B. Greenberg, Joshua Yoder
  • Time-to-digital converter and digital-controlled clock generator and all-digital clock generator
    Patent number: 8686756
    Abstract: An all-digital clock generator includes a digitally-controlled clock generator and a processing unit. The digitally-controlled clock generator generates a clock signal in response to an enable signal and a digital signal. The processing unit has a frequency multiplier and a reference signal having a period, digitizes the period to generate a quantized signal, generates the digital signal according to the quantized signal and the frequency multiplier, and generates the enable signal according to the reference signal, the clock signal and the frequency multiplier.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: April 1, 2014
    Assignee: National Chiao Tung University
    Inventors: Terng-Yin Hsu, Yuan-Te Liao, Kai-Shu Su
  • Methods and compositions for the detection of cancer
    Patent number: 8686112
    Abstract: A molecular probe for use in detection of cancer cells expressing an Ig superfamily cell adhesion molecule that binds in a homophilic fashion in a subject includes a targeting agent that specifically binds to and/or complexes with a proteolytically cleaved extracellular fragment of the Ig superfamily cell adhesion molecule.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: April 1, 2014
    Assignee: Case Western Reserve University
    Inventor: Susann Brady-Kalnay