Abstract: Digital communication coding methods resulting in rate-compatible low density parity-check (LDPC) codes built from protographs. Described digital coding methods start with a desired code rate and a selection of the numbers of variable nodes and check nodes to be used in the protograph. Constraints are set to satisfy a linear minimum distance growth property for the protograph. All possible edges in the graph are searched for the minimum iterative decoding threshold and the protograph with the lowest iterative decoding threshold is selected. Protographs designed in this manner are used in decode and forward relay channels.
Type:
Grant
Filed:
June 10, 2011
Date of Patent:
April 1, 2014
Assignees:
California Institute of Technology, Board of Regents, The University of Texas System
Inventors:
Thuy V. Nguyen, Aria Nosratinia, Dariush Divsalar
Abstract: Amidine analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumor cells.
Type:
Grant
Filed:
October 2, 2010
Date of Patent:
April 1, 2014
Assignee:
University of Virginia Patent Foundation
Inventors:
Kevin R. Lynch, Timothy L. Macdonald, Yugesh Kharel, Thomas P. Mathews, Brian R. Wamhoff
Abstract: Compositions and methods comprising bacteriophages are provided. In particular, the present invention includes novel and customized T4 bacteriophages uniquely designed for effective antigen and foreign particle presentation. The present invention also provides in vitro methods for the making of customized T4 bacteriophages. The compositions and methods of the present invention may be used for effective vaccine delivery systems.
Abstract: The present invention provides methods for guiding preservation of neurons or nerves during surgery by administering a fluorescently-labeled peptide or aptamer that specifically binds to the neurons or nerves. The invention further provides targeting molecules of fluorescently-labeled peptides or aptamers that specifically bind to neurons or nerves and for compositions thereof.
Type:
Grant
Filed:
April 15, 2010
Date of Patent:
April 1, 2014
Assignee:
The Regents of the University of California
Inventors:
Roger Y. Tsien, Quyen T. Nguyen, Michael Whitney
Abstract: A method for protecting a message or document. The method comprises encrypting the message using a first key associated with a first party; sending the encrypted message to a second party; encrypting the message using a second key associated with the second party, so that it is encrypted with two keys simultaneously; sending the encrypted message to the first party; decrypting the message using the first key; sending the message to the second party, the message being encrypted with the second key, and using the second key to decrypt the encrypted message, thereby exposing the original message.
Type:
Grant
Filed:
July 20, 2009
Date of Patent:
April 1, 2014
Assignee:
University Court of the University of St Andrews
Abstract: The present invention relates to systems and methods for dehumidifying air by establishing humidity gradients in a plurality of dehumidification units, which are arranged in series and/or in parallel. Water vapor from air entering each stage of the plurality of dehumidification units is extracted by the dehumidification units without substantial condensation into low pressure water vapor chambers. For example, in one embodiment, the water vapor is extracted through water vapor permeable membranes of the dehumidification units into the low pressure water vapor chambers. As such, the air exiting each of the dehumidification units is less humid than the air entering the dehumidification units. The low pressure water vapor extracted from the air is subsequently compressed to a slightly higher pressure (i.e., just high enough to facilitate condensation), condensed, and removed from the system at ambient conditions.
Type:
Grant
Filed:
November 12, 2010
Date of Patent:
April 1, 2014
Assignee:
The Texas A&M University System
Inventors:
David E. Claridge, Charles H. Culp, Jeffrey S. Haberl
Abstract: The present disclosure provides a series of compounds which exhibit isoform selective inhibition of GRP94, a homologue of Hsp90 that is localized to the endoplasmic recticulum. Through GRP94 inhibition, these compounds are likely to manifest anti-cancer, anti-inflammatory, anti-metastasis, and immunosuppressive activities, as well as utility in the treatment of neurodegenerative diseases, and diabetes.
Abstract: A method for forming a silicon layer according to inventive concept comprises: preparing an SOI substrate; applying an etchant or vapor of the etchant to the SOI substrate; and irradiating a light to the SOI substrate.
Type:
Grant
Filed:
November 29, 2011
Date of Patent:
April 1, 2014
Assignee:
Industry-Academic Corporation Foundation, Yonsei University
Inventors:
Taeyoon Lee, Ja Hoon Koo, Sang Wook Lee, Ka Young Lee
Abstract: The invention relates to inhibition of ornithine aminotransferase (OAT) for suppression of tumor cells proliferation. More particularly, the invention relates to methods of treatment of proliferative disorders by the selective inhibition of OAT, and further provides the use of OAT inhibitors, specifically, 5-amino-1,3-hexadienyl-carboxylic acid (Gabaculine), and Gabaculine analogue 8, for compositions and methods for the treatment of proliferative disorders such as hepatocellular carcinoma. The invention further provides methods and kits for the diagnosis of a pathologic proliferative disorder in a mammalian subject, based on determining the level of OAT expressed in a biological sample obtained from a subject.
Type:
Grant
Filed:
May 31, 2012
Date of Patent:
April 1, 2014
Assignees:
Hadasit Medical Research Services & Development, Ltd., Northwestern University
Inventors:
Yaron Ilan, Ehud Zigmond, Richard B. Silverman, Hejun Lu
Abstract: An image diagnostic processing device includes peripheral region specifying means which specifies a peripheral region connecting to an abnormal candidate region included in an image representing the inside of a subject, and judging means which judges whether the abnormal candidate region is an anatomic abnormal region or not, based on a first feature quantity of the abnormal candidate region and a second feature quantity of the peripheral region.
Type:
Grant
Filed:
January 13, 2012
Date of Patent:
April 1, 2014
Assignees:
National University Corporation Kobe University, Toshiba Medical Systems Corporation
Abstract: A yellow pigments generation deficient Sphingomonas strain (Sphingomonas sp. ZD001) and application thereof in preparing gellan gum by microbial fermentation are provided. The strain is preserved in China Center for Type Culture Collection (CCTCC) with the address of Wuhan University, Wuhan, 430072, China, the preservation date of the strain is 10 Sep. 2009, and the preservation serial number is CCTCC No: M 209298. The main beneficial effect of the present invention is that the fermented liquor contains no yellow pigments but is milky white, colorless superior gellan gum can be obtained by only depositing polysaccharide with a small quantity of ethanol or isopropanol, so that the post purification and de-coloration techniques of gellan gum production can be simplified, the yield can be enhanced, and the production cost can be reduced.
Abstract: Compositions and methods for reducing inflammation in the central nervous system (CNS) of a mammal that has been subjected to a stroke, traumatic injury to the CNS such as traumatic brain injury (TBI), spinal cord injury (SCI), or having an autoimmune or CNS disease have been developed. The compositions and methods described herein include antibodies that specifically bind to at least one component (e.g., ASC, NALP1) in a mammalian inflammasome (e.g., the NALP1 inflammasome) and have use as treatments for SCI, TBI, stroke, and autoimmune and CNS diseases in a mammal. In a rodent model of SCI, therapeutic neutralization of ASC using a polyclonal antibody that specifically binds to ASC inhibited the inflammasome, reduced caspase-1 activation, XIAP cleavage, and interleukin processing, resulting in significant tissue sparing and functional improvement. Additionally, in a rodent model of TBI, neutralization of ASC after TBI reduced caspase-1 activation and XIAP cleavage.
Type:
Grant
Filed:
July 30, 2008
Date of Patent:
April 1, 2014
Assignee:
University of Miami
Inventors:
Robert W. Keane, W. Dalton Dietrich, Juan Pablo De Rivero Vaccari, Helen M. Bramlett
Abstract: Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.
Type:
Grant
Filed:
September 27, 2004
Date of Patent:
April 1, 2014
Assignee:
Rutgers, The State University of of New Jersey
Inventors:
Donald K. Brandom, Eric Schmid, Joan Zeltinger, Durgadas Bolikal, Joachim B. Kohn
Abstract: The present invention provides enzyme catalysts for Diels-Alder reactions, including intermolecular Diels-Alder reactions, as well as protein scaffolds for making such enzyme catalysts. In other aspects, the invention provides methods of making the enzyme catalysts, including by de novo computational design. The present invention thereby provides enzyme catalysts capable of catalyzing a desired Diels-Alder reaction, including with a specified or desired stereo-selectivity.
Type:
Grant
Filed:
November 19, 2009
Date of Patent:
April 1, 2014
Assignee:
University of Washington
Inventors:
David Baker, Alexandre Zangellini, Justin Siegel, Jennifer St. Clair
Abstract: The present invention generally relates to methods and systems for analysis of real-time user-generated text messages. The methods and systems allow analysis to be performed using term associations and geographical and temporal constraints.
Type:
Grant
Filed:
February 16, 2011
Date of Patent:
April 1, 2014
Assignee:
Wright State University
Inventors:
Amit Sheth, Karthik Gomadam, Meenakshi Nagarajan
Abstract: A method for reconstructing an image from emission data includes generating a compressed point-spread function matrix, generating an accumulated attenuation factor; and performing at least one image projection operation on an image matrix of the emission data using the compressed point-spread function matrix and the accumulated attenuation factor. The image projection operation can include rotating an image matrix and an exponential attenuation map to align with a selected viewing angle. An accumulated attenuation image is then generated from the rotated image matrix and rotated exponential attenuation map and a projection image is generated for each voxel by multiplying the accumulated attenuation image and point spread function matrix for each voxel. The rotating and multiplying operations can be performed on a graphics processing unit, which may be found in a commercially available video processing card, which are specifically designed to efficiently perform such operations.
Type:
Grant
Filed:
November 30, 2006
Date of Patent:
April 1, 2014
Assignee:
The Research Foundation of State of University of New York
Abstract: The present invention relates to compounds with activity as BACE1 and NF?B modulators, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease. The present invention is also directed to the treatment of diseases related to dysfunction of cell proliferation, the immune system and/or inflammation using such compounds or pharmaceutical compositions containing such candidate compounds.
Type:
Grant
Filed:
April 26, 2011
Date of Patent:
April 1, 2014
Assignee:
The Trustees of Columbia University in the city of New York
Inventors:
Donald W. Landry, Shi Xian Deng, Gangli Gong, Yuli Xie, Yidong Liu, K. Alison Rinderspacher
Abstract: A slide member includes a substrate that is made of a metal material and has a sliding surface with a plurality of microdimples formed therein. Each of the microdimple has a circular opening, the microdimples are arranged in regular intervals in a hexagonal close-packed configuration, and the area ratio of the openings of all the microdimples to the entire sliding surface is in the range of 50 to 80%.
Type:
Grant
Filed:
September 12, 2011
Date of Patent:
April 1, 2014
Assignees:
Toyota Jidosha Kabushiki Kaisha, Tohoku University
Abstract: A feedback light tuning device and the optical communication system and method using the same are provided. By tuning the feedback light, the mechanism can completely correct the mean-wavelength drift up to 30 nm or 19400 ppm. The mechanism can be applied to various harsh environments which cause the mean-wavelength drift, so as to achieve a required stable mean-wavelength for the light source and to increase the acceptable range of radiation dose.
Abstract: A platform is proposed for automated analysis of retinal images, for obtaining from them information characterizing retinal blood vessels which may be useful in forming a diagnosis of a medical condition. A first aspect of the invention proposes that a plurality of characteristics of the retina are extracted, in order to provide data which is useful for enabling an evaluation of cardiovascular risk prediction, or even diagnosis of a cardiovascular condition. A second aspect uses fractal analysis of retinal images to provide vascular disease risk prediction, such as, but not limited to, diabetes and hypertension.