Abstract: Described herein are methods for diagnosing prostate cancer using microRNAs. Also described are methods and compositions for the diagnosis and treatment of solid cancers. Methods of identifying inhibitors of tumorigenesis are also provided.
Type:
Application
Filed:
September 20, 2013
Publication date:
January 16, 2014
Applicant:
The Ohio State University
Inventors:
Carlo M. Croce, George A. Calin, Stefano Volinia
Abstract: Metal-organic framework (MOF) materials are provided and are selectively adsorbent to xenon (Xe) over another noble gas such as krypton (Kr) and/or argon (Ar) as a result of having framework voids (pores) sized to this end. MOF materials having pores that are capable of accommodating a Xe atom but have a small enough pore size to receive no more than one Xe atom are desired to preferentially adsorb Xe over Kr in a multi-component (Xe—Kr mixture) adsorption method. The MOF material has 20% or more, preferably 40% or more, of the total pore volume in a pore size range of 0.45-0.75 nm which can selectively adsorb Xe over Kr in a multi-component Xe—Kr mixture over a pressure range of 0.01 to 1.0 MPa.
Type:
Application
Filed:
August 23, 2013
Publication date:
January 16, 2014
Applicant:
Northwestern University
Inventors:
Patrick J. Ryan, Omar K. Farha, Linda J. Broadbelt, Randall Q. Snurr, Youn-Sang Bae
Abstract: The invention described in the application relates to a panel of gene expression markers for node-negative, ER-positive, HER2-negative breast cancer patients. The invention thus provides methods and compositions, e.g., kits and/or microarrays, for evaluating gene expression levels of the markers and methods of using such gene expression levels to evaluate the likelihood of relapse of a node-negative, ER-positive, HER2-negative breast cancer patient. Such information can be used in determining treatment options for patients.
Type:
Application
Filed:
April 5, 2013
Publication date:
January 16, 2014
Applicants:
Oregon Health and Science University, The Regents of the University of California
Inventors:
The Regents of the University of California, Oregon Health and Science University
Abstract: “A computer-implemented method and system (“Legion”) for capturing and outsourcing an existing graphical user interface (“GUI”) of an application to a crowd for their collaborative real-time control using an input device are provided. A crowd refers to a dynamic pool of one or a plurality of anonymous worker of varying skill level and/or reliability. The pool is dynamic because workers are able to come and go at their leisure and no specific worker can be relied upon to be available at a given time or to continue working on a job for a specific amount of time. Mediation strategies for integrating the input of multiple crowd workers in real-time is also provided.
Type:
Application
Filed:
July 10, 2012
Publication date:
January 16, 2014
Applicant:
University of Rochester, Office of Technology Transfer
Inventors:
Jeffrey Philip BIGHAM, Walter Stephen LASECKI, Kyle Ian MURRAY, Samuel Christopher WHITE
Abstract: A simple method was developed to extract adipose-derived stromal stem cells (ASCs) without using enzymatic digestion of the collagen in adipose tissue. The resulting ASCs isolated by the simple wash method have lower levels of CD34 expression, a hematopoietic stem cell marker, as compared to ASCs isolated using conventional enzymatic digestion using collagenase. This characteristic is consistent with non-enzymatically treated stem cells obtained from bone marrow aspirates, which are negative for CD34. Additionally, the washed ASCs have higher levels of CD44 expression, a hyaluronate receptor, and lower levels of contaminating hematopoietic cells, as evidenced by low CD45 expression, as compared to enzymatically digested cells. The cells produced by this simple method can be used therapeutically for allogenic or autologous tissue regeneration, and can be administered using any pharmaceutically acceptable carrier.
Type:
Application
Filed:
December 13, 2012
Publication date:
January 16, 2014
Applicant:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventors:
Jeffrey M. Gimble, Forum S. Shah, Xiying Wu
Abstract: The present invention provides a device for suppressing common-mode radiation comprising: at least one resonator embedded into a plate, wherein the at least one resonator defines a plane having a normal direction parallel and perpendicular, respectively, to a longitudinal direction and a thickness direction of the plate. The embedment of the resonator into the plate enables a magnetic field, which is generated by a cable conductor when the device for suppressing common-mode radiation wraps the cable conductor therein, to perpendicularly pass through the plane so that the magnetic field and the resonator resonate together to generate a strong diamagnetism and thereby to suppress the common-mode radiation.
Abstract: The present invention provides a solar water heating apparatus which includes concentric inner and outer vessels defining an annular cavity therebetween, within which cavity a phase change material is located, and which is vaporised when solar radiation is incident on the outer vessel, in order to transfer heat to a water store contained in the inner vessel, this water store being fed fresh unheated water while the heated water is extracted therefrom for domestic or other purposes.
Abstract: A poly(N-alkylcarbazole) columnar structure having electroconductivity is provided. The poly(N-alkylcarbazole) columnar structure having electroconductivity may be produced by electrolytically polymerizing an N-alkylcarbazole in a particular solvent.
Type:
Grant
Filed:
March 4, 2011
Date of Patent:
January 14, 2014
Assignees:
National University Corporation Chiba University, JNC Corporation
Abstract: Methods and apparatuses for detecting deviations from legitimate operation on a wireless network. The method includes detecting a sequence of observable events related to operation of an entity in the wireless network, and determining from the detected sequence of observable events for a particular entity in the wireless network what number of idle slots occurred between two consecutive observable events to provide a first output. The method further includes obtaining a second output corresponding to the number of idle slots between two consecutive observable events for legitimate operation of any entity in the wireless network using the network transmission protocol, and comparing a function of the first output with a function of the second output to determine whether or not the particular entity is deviating from legitimate operation of the network transmission protocol.
Type:
Grant
Filed:
April 26, 2007
Date of Patent:
January 14, 2014
Assignee:
The Trustees of Columbia University in the City of New York
Abstract: A laser system capable of phase and/or amplitude manipulation of the output pulses is provided. In another aspect, a laser system includes a self-referenced pulse characterization method. A further aspect uses spectral amplitude modulation to isolate spectral bands by scanning one or more transmission slits or openings, and measuring and/or calculating the first derivative of a phase (group delay) across an entire spectrum. A single-beam pulse shaper-based technique for spectrometer-free measurement and compensation of laser pulse phase distortions is also provided in an additional aspect.
Type:
Grant
Filed:
February 28, 2011
Date of Patent:
January 14, 2014
Assignee:
Board of Trustees of Michigan State University
Abstract: Treatment systems are described which uncouple the solids retention time (SRT) of the recycling bacteria from the wasting bacteria. Elevated recycling bacteria SRTs increase concentrations of nitrifying bacteria in the aeration basin and Anammox bacteria in the anoxic basin, improving nitrification and anaerobic ammonium oxidation. Fluorescence in situ hybridizations were used to identify and determine the abundance of nitrifying bacteria and Anammox bacteria (recycling bacteria) in freshly settled sludge of biological nutrient removal (BNR) secondary clarifiers. An uneven distribution was observed for recycling bacteria in two BNR systems. Settling patterns suggest microcolony formation processes are sensitive to the internal recycle rate, which allow for rapid recycling bacteria microcolony growth by increasing circulation of flocs through the aeration and anoxic basins. Uncoupling the SRT enhances aeration and/or anoxic basin utilization and reduces the overall hydraulic residence time.
Abstract: The present invention relates to a membrane protein expression vector containing the major envelope protein P9 of Cystovirus phi6 as a fusion partner, to cells transformed by the expression vector, and to a process for producing membrane proteins using the cells. Target proteins can be effectively expressed by the expression vector of the present invention.
Type:
Grant
Filed:
August 13, 2009
Date of Patent:
January 14, 2014
Assignee:
Foundation of Soongsil University—Industry Cooperation
Abstract: Disclosed herein are viral vectors suitable for transfection into woody trees for purposes of delivering and expressing beneficial genes with increased stability. Specifically exemplified herein are vectors for transfecting citrus trees. The vectors allow for the expression of useful proteins, such as those that can protect the tree from disease.
Type:
Grant
Filed:
July 16, 2008
Date of Patent:
January 14, 2014
Assignee:
University of Florida Research Foundation, Inc.
Inventors:
William O. Dawson, Svetlana Y. Folimonova, Alexey S. Folimonov
Abstract: A polypeptide, designated as “Streptococcus uberis Adhesion Molecule” (SUAM), and fragments of SUAM, prevent internalization and adherence of Streptococcus uberis and other streptococcal pathogens to cells. The SUAM polypeptide and fragments may be used diagnostically and therapeutically. Nucleic acid sequences encoding the SUAM polypeptide and fragments are included in the invention.
Type:
Grant
Filed:
June 7, 2010
Date of Patent:
January 14, 2014
Assignee:
University of Tennessee Research Foundation
Inventors:
Stephen P. Oliver, Raul A. Almeida, Douglas A. Luther, Hee-Myung Park
Abstract: A device for identifying infection by the malaria parasite includes a microfluidic device having an inlet and an outlet and a diagnostic channel interposed between the inlet and the outlet. The diagnostic channel includes a contact surface and a sample pump configured to pump a RBC-containing sample into the inlet. The contact surface may be at least one of hydrophilic and roughened. Malaria infected RBCs (miRBCs) interact with the contact surface and become immobilized thereon whereas non-infected RBCs continue to flow downstream in the diagnostic channel.
Type:
Grant
Filed:
January 10, 2012
Date of Patent:
January 14, 2014
Assignee:
The Regents of the University of California
Abstract: Provided are a touch screen and a method for compensating sensing capacitance variations and offset variations thereof. The touch screen includes: a touch panel where a plurality of driving lines and a plurality of sensing lines intersect and are wired; a driving unit for activating the driving lines sequentially; an input unit for measuring a sensing capacitance formed in a sensing line corresponding to an activated driving line; a multiplexer for serializing and outputting the measured sensing capacitance; an analog-to-digital converter for sampling the sensing capacitance outputted from the multiplexer by reflecting an initial sensing capacitance as an offset and performing analog-to-digital conversion for the sampling result; and a host processor for determining a touch event in response to the analog-to-digital conversion result.
Type:
Grant
Filed:
September 9, 2010
Date of Patent:
January 14, 2014
Assignees:
Electronics and Telecommunications Research Institute, Industry-University Cooperation Foundation Hanyang Univ.
Inventors:
Oh-Kyong Kwon, Jang Hyun Park, Yea Chul Roh, Chang Sun Kim
Abstract: Aspects of the disclosure are directed to an apparatus that is used to provide a circuit layer via a supportive substrate or material layer having an upper surface and having edge surfaces configured and arranged to define patterned aperture channels. The material layer includes an array of patterned islands which provide an upper surface of the material layer for securing and supporting circuitry. The patterned islands are flexible due, for example, to patterned flexures located between and connecting the islands.
Type:
Grant
Filed:
March 4, 2010
Date of Patent:
January 14, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Rostam Dinyari, Peter Peumans, Kevin Huang
Abstract: The present invention relates generally to the treatment of non-proliferative cystic disease of the breast. More particularly, the present invention relates generally to the treatment of non-proliferative cystic disease of the breast in BRCA1 mutant carriers. Accordingly, the invention relates to the use and application of compounds or agents, including somatostatin analogs, that inhibit insulin-like growth factor I (IGF-I) or insulin-like growth factor I receptor signaling for the treatment of non-proliferative cystic disease of the breast. The invention further relates to the use and application of these compounds or agents for the treatment of non-proliferative cystic disease of the breast in BRCA1 patients. The invention also relates to use of somatostatin analog SOM230 in treatment of non-proliferative cystic disease of the breast and more particularly, to use of somatostatin analog SOM230 in treatment of BRCA1 associated non-proliferative cystic disease.
Abstract: Briefly, embodiments of methods or structures for reconstruction of uniform digital signal sample values from nonuniform digital signal sample values are disclosed.